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Entry version 212 (13 Nov 2019)
Sequence version 2 (31 Aug 2004)
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Protein

Basigin

Gene

BSG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen
LigandLectin, Mannose-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
R-HSA-70268 Pyruvate metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.23.1.1 the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basigin
Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name:
EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name:
TCSF
CD_antigen: CD147
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BSG
ORF Names:UNQ6505/PRO21383
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1116 BSG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109480 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35613

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini138 – 323ExtracellularSequence analysisAdd BLAST186
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 385CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi327P → A: Loss of interaction with PPIL2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
682
MIMi111380 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25433

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35613

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580492

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BSG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51704273

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001451822 – 385BasiginAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 203Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi160N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi242 ↔ 301Combined sources1 Publication
Glycosylationi268N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei362PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-319
CPTAC-320

Encyclopedia of Proteome Dynamics

More...
EPDi
P35613

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35613

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35613

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35613

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35613

PeptideAtlas

More...
PeptideAtlasi
P35613

PRoteomics IDEntifications database

More...
PRIDEi
P35613

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55113 [P35613-1]
55114 [P35613-2]
55115 [P35613-3]
55116 [P35613-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P35613-1 [P35613-1]
P35613-2 [P35613-2]
P35613-3 [P35613-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1027

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35613

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35613

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P35613

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P35613

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172270 Expressed in 230 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35613 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35613 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002427
HPA036048
HPA074870

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3.

Forms a complex with MMP1 at the tumor cell surface.

Interacts with ATP1B2, MAG and L1CAM (By similarity).

Interacts with AJAP1.

Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer.

Interacts with PPIL2; regulates BSG transport to the cell membrane.

Interacts with SLC16A11 (PubMed:28666119).

Interacts with SLC16A12 (PubMed:21778275).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107147, 203 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P35613

Database of interacting proteins

More...
DIPi
DIP-50310N

Protein interaction database and analysis system

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IntActi
P35613, 130 interactors

Molecular INTeraction database

More...
MINTi
P35613

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35613

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35613

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 219Ig-like C2-typeAdd BLAST82
Domaini221 – 315Ig-like V-typeAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 359Poly-Asp4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJET Eukaryota
ENOG4111V1Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263411

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35613

KEGG Orthology (KO)

More...
KOi
K06535

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYECRAS

Database of Orthologous Groups

More...
OrthoDBi
1021787at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35613

TreeFam database of animal gene trees

More...
TreeFami
TF326759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR027112 Neuroplastin/Basigin

The PANTHER Classification System

More...
PANTHERi
PTHR10075:SF5 PTHR10075:SF5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35613-1) [UniParc]FASTAAdd to basket
Also known as: Long, Basigin-2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP
60 70 80 90 100
VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE
110 120 130 140 150
EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG
160 170 180 190 200
SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE
210 220 230 240 250
YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV
260 270 280 290 300
TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR
310 320 330 340 350
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK
360 370 380
PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS
Length:385
Mass (Da):42,200
Last modified:August 31, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD74C37455BF26685
GO
Isoform 2 (identifier: P35613-2) [UniParc]FASTAAdd to basket
Also known as: Basigin-1

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Show »
Length:269
Mass (Da):29,221
Checksum:i0C9D6BEB966AC258
GO
Isoform 3 (identifier: P35613-3) [UniParc]FASTAAdd to basket
Also known as: Basigin-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:176
Mass (Da):19,438
Checksum:i1FF03934256AE63E
GO
Isoform 4 (identifier: P35613-4) [UniParc]FASTAAdd to basket
Also known as: Basigin-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:205
Mass (Da):22,764
Checksum:i27B3348C16A690BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUV8A0A087WUV8_HUMAN
Basigin
BSG
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDZ0A0A2R8YDZ0_HUMAN
Basigin
BSG
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2B5A0A087X2B5_HUMAN
Basigin
BSG
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L192I3L192_HUMAN
Basigin
BSG
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X215A0A087X215_HUMAN
Basigin
BSG
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMX5R4GMX5_HUMAN
Basigin
BSG
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN83R4GN83_HUMAN
Basigin
BSG
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti328F → L in BAC76828 (PubMed:1783610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013574208E → K in Ok(A-). 1 PublicationCorresponds to variant dbSNP:rs104894669EnsemblClinVar.1
Natural variantiVAR_011720269G → V. Corresponds to variant dbSNP:rs1803203Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0432251 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0432261 – 11MAAALFVLLGF → MKQSDASPQER in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04322712 – 191Missing in isoform 4. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_01150124 – 139Missing in isoform 2. 3 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64364 mRNA Translation: CAA45716.1
D45131 mRNA Translation: BAA08109.1
L10240 mRNA Translation: AAA68936.1
M87879 mRNA Translation: AAA91084.1
L20471 mRNA Translation: AAB41120.1
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA Translation: AAD10704.1
AB072923 mRNA Translation: BAB88938.1
AB085790 mRNA Translation: BAC76828.1
AF548371 mRNA Translation: AAN40694.1
GU557064 mRNA Translation: ADD31881.1
GU557065 mRNA Translation: ADD31882.1
AY358113 mRNA Translation: AAQ88480.1
AY942196 Genomic DNA Translation: AAX20110.1
AC005559 Genomic DNA Translation: AAC33279.1
CH471242 Genomic DNA Translation: EAW61181.1
CH471242 Genomic DNA Translation: EAW61185.1
BC009040 mRNA Translation: AAH09040.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12032.1 [P35613-4]
CCDS12033.1 [P35613-1]
CCDS12034.1 [P35613-2]
CCDS58635.1 [P35613-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A46506

NCBI Reference Sequences

More...
RefSeqi
NP_001309172.1, NM_001322243.1 [P35613-2]
NP_001719.2, NM_001728.3 [P35613-1]
NP_940991.1, NM_198589.2 [P35613-2]
NP_940992.1, NM_198590.2 [P35613-3]
NP_940993.1, NM_198591.2 [P35613-4]
XP_016882662.1, XM_017027173.1 [P35613-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333511; ENSP00000333769; ENSG00000172270 [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270 [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270 [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270 [P35613-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:682

UCSC genome browser

More...
UCSCi
uc002loy.5 human [P35613-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64364 mRNA Translation: CAA45716.1
D45131 mRNA Translation: BAA08109.1
L10240 mRNA Translation: AAA68936.1
M87879 mRNA Translation: AAA91084.1
L20471 mRNA Translation: AAB41120.1
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA Translation: AAD10704.1
AB072923 mRNA Translation: BAB88938.1
AB085790 mRNA Translation: BAC76828.1
AF548371 mRNA Translation: AAN40694.1
GU557064 mRNA Translation: ADD31881.1
GU557065 mRNA Translation: ADD31882.1
AY358113 mRNA Translation: AAQ88480.1
AY942196 Genomic DNA Translation: AAX20110.1
AC005559 Genomic DNA Translation: AAC33279.1
CH471242 Genomic DNA Translation: EAW61181.1
CH471242 Genomic DNA Translation: EAW61185.1
BC009040 mRNA Translation: AAH09040.1
CCDSiCCDS12032.1 [P35613-4]
CCDS12033.1 [P35613-1]
CCDS12034.1 [P35613-2]
CCDS58635.1 [P35613-3]
PIRiA46506
RefSeqiNP_001309172.1, NM_001322243.1 [P35613-2]
NP_001719.2, NM_001728.3 [P35613-1]
NP_940991.1, NM_198589.2 [P35613-2]
NP_940992.1, NM_198590.2 [P35613-3]
NP_940993.1, NM_198591.2 [P35613-4]
XP_016882662.1, XM_017027173.1 [P35613-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
4U0QX-ray3.10B/D1-385[»]
5X0TX-ray2.50E/F138-217[»]
5XF0NMR-A215-321[»]
SMRiP35613
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107147, 203 interactors
CORUMiP35613
DIPiDIP-50310N
IntActiP35613, 130 interactors
MINTiP35613
STRINGi9606.ENSP00000333769

Chemistry databases

ChEMBLiCHEMBL3580492

Protein family/group databases

TCDBi8.A.23.1.1 the basigin (basigin) family

PTM databases

GlyConnecti1027
iPTMnetiP35613
PhosphoSitePlusiP35613
SwissPalmiP35613

Polymorphism and mutation databases

BioMutaiBSG
DMDMi51704273

Proteomic databases

CPTACiCPTAC-319
CPTAC-320
EPDiP35613
jPOSTiP35613
MassIVEiP35613
MaxQBiP35613
PaxDbiP35613
PeptideAtlasiP35613
PRIDEiP35613
ProteomicsDBi55113 [P35613-1]
55114 [P35613-2]
55115 [P35613-3]
55116 [P35613-4]
TopDownProteomicsiP35613-1 [P35613-1]
P35613-2 [P35613-2]
P35613-3 [P35613-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P35613

The DNASU plasmid repository

More...
DNASUi
682

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270 [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270 [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270 [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270 [P35613-3]
GeneIDi682
KEGGihsa:682
UCSCiuc002loy.5 human [P35613-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
682
DisGeNETi682

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BSG
HGNCiHGNC:1116 BSG
HPAiCAB002427
HPA036048
HPA074870
MIMi109480 gene
111380 phenotype
neXtProtiNX_P35613
OpenTargetsiENSG00000172270
PharmGKBiPA25433

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00940000159142
HOGENOMiHOG000263411
InParanoidiP35613
KOiK06535
OMAiMYECRAS
OrthoDBi1021787at2759
PhylomeDBiP35613
TreeFamiTF326759

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
R-HSA-70268 Pyruvate metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BSG human
EvolutionaryTraceiP35613

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Basigin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
682
PharosiP35613
PMAP-CutDBiP35613

Protein Ontology

More...
PROi
PR:P35613

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172270 Expressed in 230 organ(s), highest expression level in apex of heart
ExpressionAtlasiP35613 baseline and differential
GenevisibleiP35613 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR027112 Neuroplastin/Basigin
PANTHERiPTHR10075:SF5 PTHR10075:SF5, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBASI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35613
Secondary accession number(s): A6NJW1
, D3YLG5, Q7Z796, Q8IZL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 31, 2004
Last modified: November 13, 2019
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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