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Entry version 165 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Iron transporter FTH1

Gene

FTH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity iron transporter probably involved in transport of intravacuolar stores of iron.1 Publication

Miscellaneous

Present with 486 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • endocytosis Source: SGD
  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion transmembrane transport Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29146-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.108.1.4 the iron/lead transporter (ilt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron transporter FTH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTH1
Ordered Locus Names:YBR207W
ORF Names:YBR1446
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YBR207W

Saccharomyces Genome Database

More...
SGDi
S000000411 FTH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11VacuolarSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 135CytoplasmicSequence analysisAdd BLAST103
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 170VacuolarSequence analysisAdd BLAST14
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 289CytoplasmicSequence analysisAdd BLAST98
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 358VacuolarSequence analysisAdd BLAST48
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 465CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001596501 – 465Iron transporter FTH1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei449PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38310

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38310

PRoteomics IDEntifications database

More...
PRIDEi
P38310

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38310

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FET5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32903, 87 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-869 FET5-FTH1 high affinity iron exporter complex

Database of interacting proteins

More...
DIPi
DIP-4165N

Protein interaction database and analysis system

More...
IntActi
P38310, 63 interactors

Molecular INTeraction database

More...
MINTi
P38310

STRING: functional protein association networks

More...
STRINGi
4932.YBR207W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000159782

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38310

KEGG Orthology (KO)

More...
KOi
K07243

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNGELQD

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004923 FTR1/Fip1/EfeU

The PANTHER Classification System

More...
PANTHERi
PTHR31632 PTHR31632, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03239 FTR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38310-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFEDYFSFQ IFFIFLRESL EIVVIVSILL TIVKQGLSVE DDSPFEGSSS
60 70 80 90 100
SAGLPSPNTN TNADSTTAFL QAGPSDGNAI GTSATAANNK SRPLNVEEEE
110 120 130 140 150
EIYEYSNELR DQDRESDEHT ADNVKLYQKL KIQILAGGAF GLLLCMLIGG
160 170 180 190 200
AFVSIFYHIG TDLWTLSEHY YEGVLSLVAS VIISVMGLFF LRMGKLREKF
210 220 230 240 250
RVKLASIIYS KDNNLLGNKT QKGVKFSEKY SFFILPFITT LREGLEAVVF
260 270 280 290 300
IGGIGIDQPL SSIPLSMVLA TAISTVFGIF FFRYSSSLSL KICLVVATCF
310 320 330 340 350
LYLIAAGLFS KGVWQLELQD YVNKCNGQDM SEVGNGPGSY DISRSVWHVN
360 370 380 390 400
CCNGEKDGGW MIFTAIFGWT NSATVGSVIS YNAYWLVLIC ALKLLMIEEK
410 420 430 440 450
YGYIPYLPIS WQKKRIMKRL SIAKASLDLK HHTSELNSST SEPDSQRRSK
460
DSSVPLIIDS SGSAN
Length:465
Mass (Da):51,420
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B4E620ABC39A053
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18E → K in CAA79694 (PubMed:8368014).Curated1
Sequence conflicti18E → K in CAA85171 (PubMed:7813418).Curated1
Sequence conflicti36G → D in CAA79694 (PubMed:8368014).Curated1
Sequence conflicti36G → D in CAA85171 (PubMed:7813418).Curated1
Sequence conflicti228E → Q in CAA79694 (PubMed:8368014).Curated1
Sequence conflicti228E → Q in CAA85171 (PubMed:7813418).Curated1
Sequence conflicti249 – 250VF → YS in CAA79694 (PubMed:8368014).Curated2
Sequence conflicti249 – 250VF → YS in CAA85171 (PubMed:7813418).Curated2
Sequence conflicti334G → E in CAA79694 (PubMed:8368014).Curated1
Sequence conflicti334G → E in CAA85171 (PubMed:7813418).Curated1
Sequence conflicti389 – 390IC → KY in CAA79694 (PubMed:8368014).Curated2
Sequence conflicti389 – 390IC → KY in CAA85171 (PubMed:7813418).Curated2
Sequence conflicti399 – 401EKY → GKC in CAA79694 (PubMed:8368014).Curated3
Sequence conflicti399 – 401EKY → GKC in CAA85171 (PubMed:7813418).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177330 Genomic DNA Translation: AAD53168.1
Z21487 Genomic DNA Translation: CAA79694.1
Z36076 Genomic DNA Translation: CAA85171.1
BK006936 Genomic DNA Translation: DAA07324.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S34929

NCBI Reference Sequences

More...
RefSeqi
NP_009766.4, NM_001178555.4

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR207W_mRNA; YBR207W; YBR207W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR207W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177330 Genomic DNA Translation: AAD53168.1
Z21487 Genomic DNA Translation: CAA79694.1
Z36076 Genomic DNA Translation: CAA85171.1
BK006936 Genomic DNA Translation: DAA07324.2
PIRiS34929
RefSeqiNP_009766.4, NM_001178555.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi32903, 87 interactors
ComplexPortaliCPX-869 FET5-FTH1 high affinity iron exporter complex
DIPiDIP-4165N
IntActiP38310, 63 interactors
MINTiP38310
STRINGi4932.YBR207W

Protein family/group databases

TCDBi2.A.108.1.4 the iron/lead transporter (ilt) family

PTM databases

iPTMnetiP38310

Proteomic databases

MaxQBiP38310
PaxDbiP38310
PRIDEiP38310

Genome annotation databases

EnsemblFungiiYBR207W_mRNA; YBR207W; YBR207W
GeneIDi852506
KEGGisce:YBR207W

Organism-specific databases

EuPathDBiFungiDB:YBR207W
SGDiS000000411 FTH1

Phylogenomic databases

HOGENOMiHOG000159782
InParanoidiP38310
KOiK07243
OMAiCNGELQD

Enzyme and pathway databases

BioCyciYEAST:G3O-29146-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38310

Family and domain databases

InterProiView protein in InterPro
IPR004923 FTR1/Fip1/EfeU
PANTHERiPTHR31632 PTHR31632, 1 hit
PfamiView protein in Pfam
PF03239 FTR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTH1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38310
Secondary accession number(s): D6VQK4, Q9URQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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