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Entry version 212 (31 Jul 2019)
Sequence version 2 (27 May 2002)
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Protein

Stress-70 protein, mitochondrial

Gene

HSPA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1268020 Mitochondrial protein import
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-8949613 Cristae formation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P38646

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stress-70 protein, mitochondrial
Alternative name(s):
75 kDa glucose-regulated protein
Short name:
GRP-75
Heat shock 70 kDa protein 9
Mortalin
Short name:
MOT
Peptide-binding protein 74
Short name:
PBP74
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPA9
Synonyms:GRP75, HSPA9B, mt-HSP70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5244 HSPA9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600548 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P38646

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anemia, sideroblastic, 4 (SIDBA4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of sideroblastic anemia, a bone marrow disorder defined by the presence of pathologic iron deposits in erythroblast mitochondria. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. SIDBA4 has been reported to be inherited as an autosomal recessive disease, with a pseudodominant pattern of inheritance in some families.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076665212S → P in SIDBA4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs768283289Ensembl.1
Natural variantiVAR_076666388G → S in SIDBA4; unknown pathological significance. 1 Publication1
Natural variantiVAR_076667415E → K in SIDBA4; unknown pathological significance. 1 Publication1
Natural variantiVAR_076668458 – 459Missing in SIDBA4. 1 Publication2
Even-plus syndrome (EVPLS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by epiphyseal and vertebral dysplasia, prenatal-onset short stature, a distinct craniofacial phenotype with microtia, a flat facial profile with flat nose and triangular nares, cardiac malformations, and additional findings such as anal atresia, hypodontia, aplasia cutis, and others.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076662126R → W in EVPLS. 1 PublicationCorresponds to variant dbSNP:rs751478142EnsemblClinVar.1
Natural variantiVAR_076663128Y → C in EVPLS. 1 PublicationCorresponds to variant dbSNP:rs765368797EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi489G → E: Significant loss of interaction with FXN and ISCU. Significant increase in interaction with NFS1. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
3313

MalaCards human disease database

More...
MalaCardsi
HSPA9
MIMi182170 phenotype
616854 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113013

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
260305 Autosomal recessive sideroblastic anemia
496751 EVEN-plus syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391712

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSPA9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21264428

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 46Mitochondrion3 PublicationsAdd BLAST46
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001356347 – 679Stress-70 protein, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76N6-acetyllysineBy similarity1
Modified residuei87PhosphothreonineCombined sources1
Modified residuei135N6-acetyllysine; alternateCombined sources1
Modified residuei135N6-succinyllysine; alternateBy similarity1
Modified residuei138N6-acetyllysine; alternateCombined sources1
Modified residuei138N6-succinyllysine; alternateBy similarity1
Modified residuei143N6-acetyllysineCombined sources1
Modified residuei206N6-acetyllysine; alternateBy similarity1
Modified residuei206N6-malonyllysine; alternate1 Publication1
Modified residuei206N6-succinyllysine; alternateBy similarity1
Modified residuei234N6-acetyllysineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Modified residuei300N6-acetyllysine; alternateCombined sources1
Modified residuei300N6-succinyllysine; alternateBy similarity1
Modified residuei368N6-succinyllysineBy similarity1
Modified residuei394N6-succinyllysineBy similarity1
Modified residuei408PhosphoserineCombined sources1
Modified residuei513Omega-N-methylarginineCombined sources1
Modified residuei567N6-acetyllysine; alternateCombined sources1
Modified residuei567N6-succinyllysine; alternateBy similarity1
Modified residuei600N6-acetyllysine; alternateBy similarity1
Modified residuei600N6-succinyllysine; alternateBy similarity1
Modified residuei610N6-succinyllysineBy similarity1
Modified residuei612N6-acetyllysineBy similarity1
Modified residuei646N6-acetyllysine; alternateCombined sources1
Modified residuei646N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P38646

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P38646

MaxQB - The MaxQuant DataBase

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MaxQBi
P38646

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38646

PeptideAtlas

More...
PeptideAtlasi
P38646

PRoteomics IDEntifications database

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PRIDEi
P38646

ProteomicsDB human proteome resource

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ProteomicsDBi
55304

Consortium for Top Down Proteomics

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TopDownProteomicsi
P38646

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P38646

USC-OGP 2-DE database

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OGPi
P38646

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00007765

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P38646

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P38646

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P38646

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P38646

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P38646

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113013 Expressed in 235 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P38646 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P38646 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005219
HPA000898

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts strongly with the intermediate form of FXN and weakly with its mature form (PubMed:17331979, PubMed:26702583).

Interacts with HSCB (PubMed:20668094). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:22114354).

Interacts with DNLZ, the interaction is required to prevent self-aggregation (PubMed:23462535).

Interacts with TESPA1 (PubMed:23501103).

Interacts with PDPN (PubMed:23541579).

Interacts with NFU1, NFS1 and ISCU (PubMed:26702583).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109545, 269 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P38646

Database of interacting proteins

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DIPi
DIP-32936N

Protein interaction database and analysis system

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IntActi
P38646, 91 interactors

Molecular INTeraction database

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MINTi
P38646

STRING: functional protein association networks

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STRINGi
9606.ENSP00000297185

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1679
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38646

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P38646

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 432Interaction with NFS11 PublicationAdd BLAST432
Regioni432 – 679Interaction with FXN and ISCU1 PublicationAdd BLAST248

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0102 Eukaryota
COG0443 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00920000149123

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38646

KEGG Orthology (KO)

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KOi
K04043

Identification of Orthologs from Complete Genome Data

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OMAi
ISIKRHM

Database of Orthologous Groups

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OrthoDBi
288077at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P38646

TreeFam database of animal gene trees

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TreeFami
TF105046

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.10, 1 hit
2.60.34.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00332 DnaK, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam

The PANTHER Classification System

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PANTHERi
PTHR19375 PTHR19375, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00012 HSP70, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00301 HEATSHOCK70

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100920 SSF100920, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02350 prok_dnaK, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P38646-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISASRAAAA RLVGAAASRG PTAARHQDSW NGLSHEAFRL VSRRDYASEA
60 70 80 90 100
IKGAVVGIDL GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL
110 120 130 140 150
VGMPAKRQAV TNPNNTFYAT KRLIGRRYDD PEVQKDIKNV PFKIVRASNG
160 170 180 190 200
DAWVEAHGKL YSPSQIGAFV LMKMKETAEN YLGHTAKNAV ITVPAYFNDS
210 220 230 240 250
QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI AVYDLGGGTF
260 270 280 290 300
DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK
310 320 330 340 350
DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDSSGPK HLNMKLTRAQ
360 370 380 390 400
FEGIVTDLIR RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ
410 420 430 440 450
DLFGRAPSKA VNPDEAVAIG AAIQGGVLAG DVTDVLLLDV TPLSLGIETL
460 470 480 490 500
GGVFTKLINR NTTIPTKKSQ VFSTAADGQT QVEIKVCQGE REMAGDNKLL
510 520 530 540 550
GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG REQQIVIQSS
560 570 580 590 600
GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK
610 620 630 640 650
DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM
660 670
AYKKMASERE GSGSSGTGEQ KEDQKEEKQ
Length:679
Mass (Da):73,680
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90969A8D06757753
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA73D6RA73_HUMAN
Stress-70 protein, mitochondrial
HSPA9
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJI2D6RJI2_HUMAN
Stress-70 protein, mitochondrial
HSPA9
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITI4A0A3B3ITI4_HUMAN
Stress-70 protein, mitochondrial
HSPA9
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDH7D6RDH7_HUMAN
Stress-70 protein, mitochondrial
HSPA9
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8K0H0Y8K0_HUMAN
Stress-70 protein, mitochondrial
HSPA9
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8S0H0Y8S0_HUMAN
Stress-70 protein, mitochondrial
HSPA9
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBG6H0YBG6_HUMAN
Stress-70 protein, mitochondrial
HSPA9
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCD7D6RCD7_HUMAN
Stress-70 protein, mitochondrial
HSPA9
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITN1A0A3B3ITN1_HUMAN
Stress-70 protein, mitochondrial
HSPA9
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48S → P AA sequence (PubMed:7498169).Curated1
Sequence conflicti66C → S AA sequence (PubMed:7498169).Curated1
Sequence conflicti176E → V in BAG37618 (PubMed:14702039).Curated1
Sequence conflicti184H → R in AAH00478 (PubMed:15489334).Curated1
Sequence conflicti184H → R in AAH24034 (PubMed:15489334).Curated1
Sequence conflicti249T → A in BAD96478 (Ref. 4) Curated1
Sequence conflicti385L → P in BAD96478 (Ref. 4) Curated1
Sequence conflicti540G → R in AAA67526 (PubMed:7829505).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04648274Q → R1 PublicationCorresponds to variant dbSNP:rs17856004Ensembl.1
Natural variantiVAR_076662126R → W in EVPLS. 1 PublicationCorresponds to variant dbSNP:rs751478142EnsemblClinVar.1
Natural variantiVAR_049622127R → G. Corresponds to variant dbSNP:rs35091799Ensembl.1
Natural variantiVAR_076663128Y → C in EVPLS. 1 PublicationCorresponds to variant dbSNP:rs765368797EnsemblClinVar.1
Natural variantiVAR_046483184H → Y1 Publication1
Natural variantiVAR_076664200S → L1 PublicationCorresponds to variant dbSNP:rs199715716Ensembl.1
Natural variantiVAR_076665212S → P in SIDBA4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs768283289Ensembl.1
Natural variantiVAR_049623225A → G. Corresponds to variant dbSNP:rs34558740Ensembl.1
Natural variantiVAR_076666388G → S in SIDBA4; unknown pathological significance. 1 Publication1
Natural variantiVAR_076667415E → K in SIDBA4; unknown pathological significance. 1 Publication1
Natural variantiVAR_076668458 – 459Missing in SIDBA4. 1 Publication2
Natural variantiVAR_076669539T → K1 Publication1
Natural variantiVAR_076670573R → W1 PublicationCorresponds to variant dbSNP:rs147723579Ensembl.1
Natural variantiVAR_076671577E → K1 PublicationCorresponds to variant dbSNP:rs905439101Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11066 mRNA No translation available.
L15189 mRNA Translation: AAA67526.1
AK315177 mRNA Translation: BAG37618.1
AK222758 mRNA Translation: BAD96478.1
DQ531046 Genomic DNA Translation: ABF50973.1
CH471062 Genomic DNA Translation: EAW62129.1
BC000478 mRNA Translation: AAH00478.1
BC024034 mRNA Translation: AAH24034.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4208.1

Protein sequence database of the Protein Information Resource

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PIRi
B48127

NCBI Reference Sequences

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RefSeqi
NP_004125.3, NM_004134.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297185; ENSP00000297185; ENSG00000113013
ENST00000649126; ENSP00000496940; ENSG00000113013

Database of genes from NCBI RefSeq genomes

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GeneIDi
3313

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3313

UCSC genome browser

More...
UCSCi
uc003ldf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11066 mRNA No translation available.
L15189 mRNA Translation: AAA67526.1
AK315177 mRNA Translation: BAG37618.1
AK222758 mRNA Translation: BAD96478.1
DQ531046 Genomic DNA Translation: ABF50973.1
CH471062 Genomic DNA Translation: EAW62129.1
BC000478 mRNA Translation: AAH00478.1
BC024034 mRNA Translation: AAH24034.1
CCDSiCCDS4208.1
PIRiB48127
RefSeqiNP_004125.3, NM_004134.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N8EX-ray2.80A/B439-597[»]
4KBOX-ray2.80A52-431[»]
6NHKX-ray2.78A/B54-429[»]
6P2UX-ray2.00A52-431[»]
SMRiP38646
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109545, 269 interactors
CORUMiP38646
DIPiDIP-32936N
IntActiP38646, 91 interactors
MINTiP38646
STRINGi9606.ENSP00000297185

PTM databases

iPTMnetiP38646
PhosphoSitePlusiP38646
SwissPalmiP38646

Polymorphism and mutation databases

BioMutaiHSPA9
DMDMi21264428

2D gel databases

DOSAC-COBS-2DPAGEiP38646
OGPiP38646
REPRODUCTION-2DPAGEiIPI00007765
SWISS-2DPAGEiP38646
UCD-2DPAGEiP38646

Proteomic databases

EPDiP38646
jPOSTiP38646
MaxQBiP38646
PaxDbiP38646
PeptideAtlasiP38646
PRIDEiP38646
ProteomicsDBi55304
TopDownProteomicsiP38646

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P38646

The DNASU plasmid repository

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DNASUi
3313
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297185; ENSP00000297185; ENSG00000113013
ENST00000649126; ENSP00000496940; ENSG00000113013
GeneIDi3313
KEGGihsa:3313
UCSCiuc003ldf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3313
DisGeNETi3313

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HSPA9
HGNCiHGNC:5244 HSPA9
HPAiCAB005219
HPA000898
MalaCardsiHSPA9
MIMi182170 phenotype
600548 gene
616854 phenotype
neXtProtiNX_P38646
OpenTargetsiENSG00000113013
Orphaneti260305 Autosomal recessive sideroblastic anemia
496751 EVEN-plus syndrome
PharmGKBiPA162391712

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0102 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00920000149123
InParanoidiP38646
KOiK04043
OMAiISIKRHM
OrthoDBi288077at2759
PhylomeDBiP38646
TreeFamiTF105046

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-8949613 Cristae formation
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP38646

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HSPA9 human
EvolutionaryTraceiP38646

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HSPA9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3313

Protein Ontology

More...
PROi
PR:P38646

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113013 Expressed in 235 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiP38646 baseline and differential
GenevisibleiP38646 HS

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRP75_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38646
Secondary accession number(s): B2RCM1
, P30036, P31932, Q1HB43, Q53H23, Q6GU03, Q9BWB7, Q9UC56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: July 31, 2019
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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