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Entry version 187 (16 Oct 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Rho-type GTPase-activating protein 1

Gene

RGA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection.

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processPheromone response
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33652-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-194840 Rho GTPase cycle
R-SCE-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho-type GTPase-activating protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGA1
Synonyms:DBM1, THE1
Ordered Locus Names:YOR127W
ORF Names:O3290, YOR3290W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOR127W

Saccharomyces Genome Database

More...
SGDi
S000005653 RGA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi37C → S: Bipolar budding. 1 Publication1
Mutagenesisi40C → S: Bipolar budding. 1 Publication1
Mutagenesisi98C → S: Bipolar budding. 1 Publication1
Mutagenesisi101C → S: Bipolar budding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758991 – 1007Rho-type GTPase-activating protein 1Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei278PhosphothreonineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei532PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39083

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39083

PRoteomics IDEntifications database

More...
PRIDEi
P39083

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39083

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34522, 136 interactors

Database of interacting proteins

More...
DIPi
DIP-1559N

Protein interaction database and analysis system

More...
IntActi
P39083, 14 interactors

Molecular INTeraction database

More...
MINTi
P39083

STRING: functional protein association networks

More...
STRINGi
4932.YOR127W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 66LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST54
Domaini70 – 122LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini791 – 1006Rho-GAPPROSITE-ProRule annotationAdd BLAST216

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000788

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39083

KEGG Orthology (KO)

More...
KOi
K19839

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGHAYEL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001781 Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412 LIM, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 2 hits
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 2 hits
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39083-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTAPNEQF PSCVRCKEFI TTGHAYELGC DRWHTHCFAC YKCEKPLSCE
60 70 80 90 100
SDFLVLGTGA LICFDCSDSC KNCGKKIDDL AIILSSSNEA YCSDCFKCCK
110 120 130 140 150
CGENIADLRY AKTKRGLFCL SCHEKLLAKR KYYEEKKRRL KKNLPSLPTP
160 170 180 190 200
VIDNGHTDEV SASAVLPEKT FSRPASLVNE IPSGSEPSKD IETNSSDIVP
210 220 230 240 250
HFITGYNDSD DNSGSSKFGS NVSIDVIGPE ENSTEHVNDD VKEEAEAPSA
260 270 280 290 300
NMSLNVATDP TLSCKEPPSH SRNLLNKTPL RNSSGQYLAK SPSSYRQGII
310 320 330 340 350
VNDSLEESDQ IDPPNNSSRN ASELLTSVLH SPVSVNMKNP KGSNTDIFNT
360 370 380 390 400
GEISQMDPSL SRKVLNNIVE ETNALQRPVV EVVKEDRSVP DLAGVQQEQA
410 420 430 440 450
EKYSYSNNSG KGRKISRSLS RRSKDLMINL KSRATGKQDS NVKLSPASKV
460 470 480 490 500
TSRRSQDLMR DNDSHTGLDT PNSNSTSLDI LVNNQKSLNY KRFTDNGTLR
510 520 530 540 550
VTSGKETALE EQKNHSFKSP SPIDHLLQSP ATPSNVSMYR TPPLDSSLTF
560 570 580 590 600
DRRNGSSYSN QNYSIPSWQK TPKTQLENSD NFEEQKETLY ENSESRNDPS
610 620 630 640 650
LDKEIVTAEH YLKQLKINLK ELESQREELM KEITEMKSMK EALRRHIESY
660 670 680 690 700
NSEKNKLYLD SNELSNNPPM INEISLGESP PVKHVATASS VARSSVKPKF
710 720 730 740 750
WKFFSSAKPQ TEQSIQGVST NNTNSIVKSA PVLLSAPSSG SNSGRLEISP
760 770 780 790 800
PVLQNPNEFS DVRLVPIEND ANMGQSKDGE EYLDGSNLYG SSLVARCNYE
810 820 830 840 850
NNEIPMILSV CIDFIESDEE NMRSEGIYRK SGSQLVIEEI EKQFSAWKVQ
860 870 880 890 900
QNTETPNILT EQDLNVVTGV LKRYLRKLPN PIFTFQIYEP LMRLVKSKKM
910 920 930 940 950
MENLPFVGGK LSLEAKNSDT YMSSKSALKN ILEDLPREHY RVLRVLSEHI
960 970 980 990 1000
EKVTRYSHWN RMTLYNLALV FAPGLIRDFS GEKDIIDMKE RNYIVAFIFG

NYKDILT
Length:1,007
Mass (Da):112,832
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC805411B57553791
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti457D → E in CAA62445 (PubMed:7498791).Curated1
Sequence conflicti507T → P in CAA62445 (PubMed:7498791).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti866V → A. 1
Natural varianti898K → R. 1
Natural varianti926S → G. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07421 mRNA Translation: AAA16875.1
X90950 Genomic DNA Translation: CAA62445.1
X90518 Genomic DNA Translation: CAA62108.1
X94335 Genomic DNA Translation: CAA64046.1
Z75035 Genomic DNA Translation: CAA99326.1
L02617 Genomic DNA Translation: AAA35153.1
BK006948 Genomic DNA Translation: DAA10901.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48535

NCBI Reference Sequences

More...
RefSeqi
NP_014770.1, NM_001183546.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR127W_mRNA; YOR127W; YOR127W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854294

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR127W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07421 mRNA Translation: AAA16875.1
X90950 Genomic DNA Translation: CAA62445.1
X90518 Genomic DNA Translation: CAA62108.1
X94335 Genomic DNA Translation: CAA64046.1
Z75035 Genomic DNA Translation: CAA99326.1
L02617 Genomic DNA Translation: AAA35153.1
BK006948 Genomic DNA Translation: DAA10901.1
PIRiS48535
RefSeqiNP_014770.1, NM_001183546.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34522, 136 interactors
DIPiDIP-1559N
IntActiP39083, 14 interactors
MINTiP39083
STRINGi4932.YOR127W

PTM databases

iPTMnetiP39083

Proteomic databases

MaxQBiP39083
PaxDbiP39083
PRIDEiP39083

Genome annotation databases

EnsemblFungiiYOR127W_mRNA; YOR127W; YOR127W
GeneIDi854294
KEGGisce:YOR127W

Organism-specific databases

EuPathDBiFungiDB:YOR127W
SGDiS000005653 RGA1

Phylogenomic databases

HOGENOMiHOG000000788
InParanoidiP39083
KOiK19839
OMAiTGHAYEL

Enzyme and pathway databases

BioCyciYEAST:G3O-33652-MONOMER
ReactomeiR-SCE-194840 Rho GTPase cycle
R-SCE-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39083

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 2 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 2 hits
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGA1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39083
Secondary accession number(s): D6W2I5, P39934
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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