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Entry version 151 (18 Sep 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Protein Mpv17

Gene

MPV17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9033241 Peroxisomal protein import

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.192.1.1 the mpv17/pmp22 4 tms putative porin (mpv17) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Mpv17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPV17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:7224 MPV17

Online Mendelian Inheritance in Man (OMIM)

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MIMi
137960 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P39210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial DNA depletion syndrome 6 (MTDPS6)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease due to mitochondrial dysfunction. It is characterized by infantile onset of progressive liver failure, often leading to death in the first year of life, peripheral neuropathy, corneal scarring, acral ulceration and osteomyelitis leading to autoamputation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02621750R → Q in MTDPS6; may cause protein instability and decay. 3 PublicationsCorresponds to variant dbSNP:rs121909721EnsemblClinVar.1
Natural variantiVAR_02621850R → W in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs121909723EnsemblClinVar.1
Natural variantiVAR_07619988K → E in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607256EnsemblClinVar.1
Natural variantiVAR_07620088Missing in MTDPS6. 1 Publication1
Natural variantiVAR_07620191Missing in MTDPS6. 1 Publication1
Natural variantiVAR_07620294G → R in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607257EnsemblClinVar.1
Natural variantiVAR_07620398P → L in MTDPS6. 2 PublicationsCorresponds to variant dbSNP:rs267607258EnsemblClinVar.1
Natural variantiVAR_076204162A → D in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607259EnsemblClinVar.1
Natural variantiVAR_026219166N → K in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs121909722EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neuropathy, Primary mitochondrial disease

Organism-specific databases

DisGeNET

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DisGeNETi
4358

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MPV17

MalaCards human disease database

More...
MalaCardsi
MPV17
MIMi256810 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115204

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
255229 Navajo neurohepatopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30929

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPV17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189271 – 176Protein Mpv17Add BLAST176

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P39210

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P39210

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P39210

MaxQB - The MaxQuant DataBase

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MaxQBi
P39210

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39210

PeptideAtlas

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PeptideAtlasi
P39210

PRoteomics IDEntifications database

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PRIDEi
P39210

ProteomicsDB human proteome resource

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ProteomicsDBi
55316

Consortium for Top Down Proteomics

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TopDownProteomicsi
P39210

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P39210

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P39210

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P39210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115204 Expressed in 104 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P39210 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P39210 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110498, 51 interactors

Protein interaction database and analysis system

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IntActi
P39210, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369383

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1944 Eukaryota
ENOG4111SYH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160891

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039675

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P39210

KEGG Orthology (KO)

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KOi
K13348

Database of Orthologous Groups

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OrthoDBi
1324608at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P39210

TreeFam database of animal gene trees

More...
TreeFami
TF324070

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007248 Mpv17_PMP22

The PANTHER Classification System

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PANTHERi
PTHR11266 PTHR11266, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04117 Mpv17_PMP22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P39210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWRAYQRA LAAHPWKVQV LTAGSLMGLG DIISQQLVER RGLQEHQRGR
60 70 80 90 100
TLTMVSLGCG FVGPVVGGWY KVLDRFIPGT TKVDALKKML LDQGGFAPCF
110 120 130 140 150
LGCFLPLVGA LNGLSAQDNW AKLQRDYPDA LITNYYLWPA VQLANFYLVP
160 170
LHYRLAVVQC VAVIWNSYLS WKAHRL
Length:176
Mass (Da):19,733
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CD9A46F4498C4AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MPV4A8MPV4_HUMAN
Protein Mpv17
MPV17
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC53B5MC53_HUMAN
MpV17 transgene, murine homolog, gl...
MPV17 hCG_23713
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J473C9J473_HUMAN
Protein Mpv17
MPV17
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX18E7EX18_HUMAN
Protein Mpv17
MPV17
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCF8B5MCF8_HUMAN
Protein Mpv17
MPV17
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6M5H0Y6M5_HUMAN
Protein Mpv17
MPV17
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9F5G5E9F5_HUMAN
MpV17 transgene, murine homolog, gl...
MPV17 hCG_23713
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC10B5MC10_HUMAN
MpV17 mitochondrial inner membrane ...
MPV17
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEL3F8WEL3_HUMAN
Protein Mpv17
MPV17
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MTD3A8MTD3_HUMAN
Protein Mpv17
MPV17
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02621750R → Q in MTDPS6; may cause protein instability and decay. 3 PublicationsCorresponds to variant dbSNP:rs121909721EnsemblClinVar.1
Natural variantiVAR_02621850R → W in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs121909723EnsemblClinVar.1
Natural variantiVAR_07619988K → E in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607256EnsemblClinVar.1
Natural variantiVAR_07620088Missing in MTDPS6. 1 Publication1
Natural variantiVAR_07620191Missing in MTDPS6. 1 Publication1
Natural variantiVAR_07620294G → R in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607257EnsemblClinVar.1
Natural variantiVAR_07620398P → L in MTDPS6. 2 PublicationsCorresponds to variant dbSNP:rs267607258EnsemblClinVar.1
Natural variantiVAR_076204162A → D in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs267607259EnsemblClinVar.1
Natural variantiVAR_026219166N → K in MTDPS6. 1 PublicationCorresponds to variant dbSNP:rs121909722EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S68430
, S68417, S68418, S68419, S68420, S68421, S68422 Genomic DNA Translation: AAD14014.1
X76538 mRNA Translation: CAA54047.1
HQ205986 Genomic DNA Translation: ADP91854.1
HQ205987 Genomic DNA Translation: ADP91855.1
HQ205988 Genomic DNA Translation: ADP91856.1
HQ205989 Genomic DNA Translation: ADP91857.1
HQ205990 Genomic DNA Translation: ADP91858.1
HQ205991 Genomic DNA Translation: ADP91859.1
HQ205992 Genomic DNA Translation: ADP91860.1
HQ205993 Genomic DNA Translation: ADP91861.1
HQ205994 Genomic DNA Translation: ADP91862.1
HQ205995 Genomic DNA Translation: ADP91863.1
HQ205996 Genomic DNA Translation: ADP91864.1
HQ205997 Genomic DNA Translation: ADP91865.1
HQ205998 Genomic DNA Translation: ADP91866.1
HQ205999 Genomic DNA Translation: ADP91867.1
HQ206000 Genomic DNA Translation: ADP91868.1
HQ206001 Genomic DNA Translation: ADP91869.1
HQ206002 Genomic DNA Translation: ADP91870.1
HQ206003 Genomic DNA Translation: ADP91871.1
HQ206004 Genomic DNA Translation: ADP91872.1
HQ206005 Genomic DNA Translation: ADP91873.1
HQ206006 Genomic DNA Translation: ADP91874.1
HQ206007 Genomic DNA Translation: ADP91875.1
HQ206008 Genomic DNA Translation: ADP91876.1
HQ206009 Genomic DNA Translation: ADP91877.1
HQ206010 Genomic DNA Translation: ADP91878.1
HQ206011 Genomic DNA Translation: ADP91879.1
HQ206012 Genomic DNA Translation: ADP91880.1
HQ206013 Genomic DNA Translation: ADP91881.1
HQ206014 Genomic DNA Translation: ADP91882.1
HQ206015 Genomic DNA Translation: ADP91883.1
HQ206016 Genomic DNA Translation: ADP91884.1
HQ206017 Genomic DNA Translation: ADP91885.1
HQ206018 Genomic DNA Translation: ADP91886.1
HQ206019 Genomic DNA Translation: ADP91887.1
HQ206020 Genomic DNA Translation: ADP91888.1
HQ206021 Genomic DNA Translation: ADP91889.1
HQ206022 Genomic DNA Translation: ADP91890.1
HQ206023 Genomic DNA Translation: ADP91891.1
HQ206024 Genomic DNA Translation: ADP91892.1
HQ206025 Genomic DNA Translation: ADP91893.1
AC013413 Genomic DNA Translation: AAY24298.1
CH471053 Genomic DNA Translation: EAX00600.1
CH471053 Genomic DNA Translation: EAX00602.1
BC001115 mRNA Translation: AAH01115.1
BC016289 mRNA Translation: AAH16289.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS1748.1

Protein sequence database of the Protein Information Resource

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PIRi
S45343

NCBI Reference Sequences

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RefSeqi
NP_002428.1, NM_002437.4
XP_005264383.1, XM_005264326.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233545; ENSP00000233545; ENSG00000115204
ENST00000380044; ENSP00000369383; ENSG00000115204

Database of genes from NCBI RefSeq genomes

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GeneIDi
4358

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4358

UCSC genome browser

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UCSCi
uc002rjr.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68430
, S68417, S68418, S68419, S68420, S68421, S68422 Genomic DNA Translation: AAD14014.1
X76538 mRNA Translation: CAA54047.1
HQ205986 Genomic DNA Translation: ADP91854.1
HQ205987 Genomic DNA Translation: ADP91855.1
HQ205988 Genomic DNA Translation: ADP91856.1
HQ205989 Genomic DNA Translation: ADP91857.1
HQ205990 Genomic DNA Translation: ADP91858.1
HQ205991 Genomic DNA Translation: ADP91859.1
HQ205992 Genomic DNA Translation: ADP91860.1
HQ205993 Genomic DNA Translation: ADP91861.1
HQ205994 Genomic DNA Translation: ADP91862.1
HQ205995 Genomic DNA Translation: ADP91863.1
HQ205996 Genomic DNA Translation: ADP91864.1
HQ205997 Genomic DNA Translation: ADP91865.1
HQ205998 Genomic DNA Translation: ADP91866.1
HQ205999 Genomic DNA Translation: ADP91867.1
HQ206000 Genomic DNA Translation: ADP91868.1
HQ206001 Genomic DNA Translation: ADP91869.1
HQ206002 Genomic DNA Translation: ADP91870.1
HQ206003 Genomic DNA Translation: ADP91871.1
HQ206004 Genomic DNA Translation: ADP91872.1
HQ206005 Genomic DNA Translation: ADP91873.1
HQ206006 Genomic DNA Translation: ADP91874.1
HQ206007 Genomic DNA Translation: ADP91875.1
HQ206008 Genomic DNA Translation: ADP91876.1
HQ206009 Genomic DNA Translation: ADP91877.1
HQ206010 Genomic DNA Translation: ADP91878.1
HQ206011 Genomic DNA Translation: ADP91879.1
HQ206012 Genomic DNA Translation: ADP91880.1
HQ206013 Genomic DNA Translation: ADP91881.1
HQ206014 Genomic DNA Translation: ADP91882.1
HQ206015 Genomic DNA Translation: ADP91883.1
HQ206016 Genomic DNA Translation: ADP91884.1
HQ206017 Genomic DNA Translation: ADP91885.1
HQ206018 Genomic DNA Translation: ADP91886.1
HQ206019 Genomic DNA Translation: ADP91887.1
HQ206020 Genomic DNA Translation: ADP91888.1
HQ206021 Genomic DNA Translation: ADP91889.1
HQ206022 Genomic DNA Translation: ADP91890.1
HQ206023 Genomic DNA Translation: ADP91891.1
HQ206024 Genomic DNA Translation: ADP91892.1
HQ206025 Genomic DNA Translation: ADP91893.1
AC013413 Genomic DNA Translation: AAY24298.1
CH471053 Genomic DNA Translation: EAX00600.1
CH471053 Genomic DNA Translation: EAX00602.1
BC001115 mRNA Translation: AAH01115.1
BC016289 mRNA Translation: AAH16289.2
CCDSiCCDS1748.1
PIRiS45343
RefSeqiNP_002428.1, NM_002437.4
XP_005264383.1, XM_005264326.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi110498, 51 interactors
IntActiP39210, 1 interactor
STRINGi9606.ENSP00000369383

Protein family/group databases

TCDBi9.B.192.1.1 the mpv17/pmp22 4 tms putative porin (mpv17) family

PTM databases

iPTMnetiP39210
PhosphoSitePlusiP39210
SwissPalmiP39210

Polymorphism and mutation databases

BioMutaiMPV17

Proteomic databases

EPDiP39210
jPOSTiP39210
MassIVEiP39210
MaxQBiP39210
PaxDbiP39210
PeptideAtlasiP39210
PRIDEiP39210
ProteomicsDBi55316
TopDownProteomicsiP39210

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233545; ENSP00000233545; ENSG00000115204
ENST00000380044; ENSP00000369383; ENSG00000115204
GeneIDi4358
KEGGihsa:4358
UCSCiuc002rjr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4358
DisGeNETi4358

GeneCards: human genes, protein and diseases

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GeneCardsi
MPV17
GeneReviewsiMPV17
HGNCiHGNC:7224 MPV17
MalaCardsiMPV17
MIMi137960 gene
256810 phenotype
neXtProtiNX_P39210
OpenTargetsiENSG00000115204
Orphaneti255229 Navajo neurohepatopathy
PharmGKBiPA30929

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
GeneTreeiENSGT00940000160891
HOGENOMiHOG000039675
InParanoidiP39210
KOiK13348
OrthoDBi1324608at2759
PhylomeDBiP39210
TreeFamiTF324070

Enzyme and pathway databases

ReactomeiR-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MPV17 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MPV17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4358

Pharos

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Pharosi
P39210

Protein Ontology

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PROi
PR:P39210

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115204 Expressed in 104 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP39210 baseline and differential
GenevisibleiP39210 HS

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPV17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39210
Secondary accession number(s): D6W555, Q53SY2, Q96B08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 18, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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