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Entry version 146 (31 Jul 2019)
Sequence version 4 (10 Oct 2018)
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Protein

Interferon alpha-inducible protein 27, mitochondrial

Gene

IFI27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Apoptosis, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-909733 Interferon alpha/beta signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha-inducible protein 27, mitochondrialCurated
Short name:
p27
Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein1 Publication
Short name:
ISG12(a)1 Publication
Short name:
ISG12A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFI27Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5397 IFI27

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600009 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P40305

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 57HelicalSequence analysisAdd BLAST24
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56F → D: Increased pro-apoptotic activity; when associated with D-96. 1 Publication1
Mutagenesisi96A → D: Increased pro-apoptotic activity; when associated with D-56. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3429

Open Targets

More...
OpenTargetsi
ENSG00000165949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29643

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFI27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242590

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 33Mitochondrion1 PublicationAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000014737234 – 122Interferon alpha-inducible protein 27, mitochondrialAdd BLAST89

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P40305

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40305

PeptideAtlas

More...
PeptideAtlasi
P40305

PRoteomics IDEntifications database

More...
PRIDEi
P40305

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55359
69349

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40305

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P40305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by type-I and type-II interferons.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165949 Expressed in 227 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P40305 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028875

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:27673746).

Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766).

Interacts with SKP2; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766).

Interacts with NR4A1 (PubMed:22427340). May interact with BCL2 (PubMed:27673746).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109655, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P40305, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483430

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 122Mediates interaction with SKP2 and hepatitis C virus non-structural protein NS5A1 PublicationAdd BLAST47
Regioni103 – 112Required for hepatitis C virus non-structural protein NS5A degradation1 Publication10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JFVP Eukaryota
ENOG410Z2RX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112988

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40305

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFLSSTR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P40305

TreeFam database of animal gene trees

More...
TreeFami
TF340510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.246.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16932 PTHR16932, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06140 Ifi-6-16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40305-2) [UniParc]FASTAAdd to basket
Also known as: ISG121 Publication, ISG12A1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAMAAVPMV
60 70 80 90 100
LSAMGFTAAG IASSSIAAKM MSAAAIANGG GVASGSLVAT LQSLGATGLS
110 120
GLTKFILGSI GSAIAAVIAR FY
Length:122
Mass (Da):11,542
Last modified:October 10, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA424B2EDEAA678A3
GO
Isoform 2 (identifier: P40305-1) [UniParc]FASTAAdd to basket
Also known as: ISG12delta1 Publication, ISG12Adelta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     43-45: Missing.

Show »
Length:119
Mass (Da):11,268
Checksum:i242C9388FEF8FF9C
GO
Isoform 3 (identifier: P40305-3) [UniParc]FASTAAdd to basket
Also known as: ISG12-S1 Publication, ISG12A-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Major isoform in blood and cervix.1 Publication
Show »
Length:79
Mass (Da):7,451
Checksum:iA0E4077F6BFA7E56
GO
Isoform 4 (identifier: P40305-4) [UniParc]FASTAAdd to basket
Also known as: ISG12-Sdelta1 Publication, ISG12A-Sdelta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:74
Mass (Da):6,981
Checksum:i568D8A99D73466B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUJ8A0A087WUJ8_HUMAN
Interferon alpha-inducible protein ...
IFI27
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZR1A0A087WZR1_HUMAN
Interferon alpha-inducible protein ...
IFI27
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X174A0A087X174_HUMAN
Interferon alpha-inducible protein ...
IFI27
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV79A0A087WV79_HUMAN
Interferon alpha-inducible protein ...
IFI27
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4U3G3V4U3_HUMAN
Interferon alpha-inducible protein ...
IFI27
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X035A0A087X035_HUMAN
Interferon alpha-inducible protein ...
IFI27
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89A → G in CAA47739 (PubMed:8358738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028066109S → F. Corresponds to variant dbSNP:rs2227974Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0599071 – 48Missing in isoform 4. Add BLAST48
Alternative sequenceiVSP_0599081 – 43Missing in isoform 3. Add BLAST43
Alternative sequenceiVSP_05990943 – 45Missing in isoform 2. 3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67325 mRNA Translation: CAA47739.1
BT006781 mRNA Translation: AAP35427.1
AK289535 mRNA Translation: BAF82224.1
AK312089 mRNA Translation: BAG35025.1
AM393107 mRNA Translation: CAL37985.1
AL079302 Genomic DNA No translation available.
AL121838 Genomic DNA No translation available.
KF573698 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81556.1
CH471061 Genomic DNA Translation: EAW81557.1
CH471061 Genomic DNA Translation: EAW81558.1
BC015492 mRNA Translation: AAH15492.1
AJ294851 mRNA Translation: CAC10503.2
AY126456 mRNA Translation: AAM95743.1
AY126457 mRNA Translation: AAM95744.1
AY126458 mRNA Translation: AAM95745.1
BN000227 mRNA Translation: CAE00394.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32148.1 [P40305-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38081

NCBI Reference Sequences

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RefSeqi
NP_001123552.1, NM_001130080.2 [P40305-2]
NP_001275881.1, NM_001288952.1 [P40305-2]
NP_001275883.1, NM_001288954.1 [P40305-1]
NP_001275885.1, NM_001288956.1 [P40305-2]
NP_001275886.1, NM_001288957.1 [P40305-1]
NP_001275887.1, NM_001288958.1 [P40305-1]
NP_001275888.1, NM_001288959.1 [P40305-3]
NP_001275889.1, NM_001288960.1 [P40305-4]
NP_001275924.1, NM_001288995.1 [P40305-1]
NP_005523.3, NM_005532.4 [P40305-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000612813; ENSP00000483430; ENSG00000165949 [P40305-2]
ENST00000612838; ENSP00000483932; ENSG00000275214 [P40305-2]
ENST00000613997; ENSP00000484089; ENSG00000275214 [P40305-2]
ENST00000615978; ENSP00000483291; ENSG00000275214 [P40305-3]
ENST00000616764; ENSP00000477753; ENSG00000165949 [P40305-2]
ENST00000618863; ENSP00000482635; ENSG00000165949 [P40305-3]
ENST00000621160; ENSP00000483498; ENSG00000165949 [P40305-2]
ENST00000627111; ENSP00000486608; ENSG00000275214 [P40305-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3429

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3429

UCSC genome browser

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UCSCi
uc032bkg.2 human
uc032bkj.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA Translation: CAA47739.1
BT006781 mRNA Translation: AAP35427.1
AK289535 mRNA Translation: BAF82224.1
AK312089 mRNA Translation: BAG35025.1
AM393107 mRNA Translation: CAL37985.1
AL079302 Genomic DNA No translation available.
AL121838 Genomic DNA No translation available.
KF573698 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81556.1
CH471061 Genomic DNA Translation: EAW81557.1
CH471061 Genomic DNA Translation: EAW81558.1
BC015492 mRNA Translation: AAH15492.1
AJ294851 mRNA Translation: CAC10503.2
AY126456 mRNA Translation: AAM95743.1
AY126457 mRNA Translation: AAM95744.1
AY126458 mRNA Translation: AAM95745.1
BN000227 mRNA Translation: CAE00394.1
CCDSiCCDS32148.1 [P40305-1]
PIRiI38081
RefSeqiNP_001123552.1, NM_001130080.2 [P40305-2]
NP_001275881.1, NM_001288952.1 [P40305-2]
NP_001275883.1, NM_001288954.1 [P40305-1]
NP_001275885.1, NM_001288956.1 [P40305-2]
NP_001275886.1, NM_001288957.1 [P40305-1]
NP_001275887.1, NM_001288958.1 [P40305-1]
NP_001275888.1, NM_001288959.1 [P40305-3]
NP_001275889.1, NM_001288960.1 [P40305-4]
NP_001275924.1, NM_001288995.1 [P40305-1]
NP_005523.3, NM_005532.4 [P40305-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi109655, 2 interactors
IntActiP40305, 15 interactors
STRINGi9606.ENSP00000483430

PTM databases

iPTMnetiP40305
PhosphoSitePlusiP40305

Polymorphism and mutation databases

BioMutaiIFI27
DMDMi116242590

Proteomic databases

jPOSTiP40305
PaxDbiP40305
PeptideAtlasiP40305
PRIDEiP40305
ProteomicsDBi55359
69349

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612813; ENSP00000483430; ENSG00000165949 [P40305-2]
ENST00000612838; ENSP00000483932; ENSG00000275214 [P40305-2]
ENST00000613997; ENSP00000484089; ENSG00000275214 [P40305-2]
ENST00000615978; ENSP00000483291; ENSG00000275214 [P40305-3]
ENST00000616764; ENSP00000477753; ENSG00000165949 [P40305-2]
ENST00000618863; ENSP00000482635; ENSG00000165949 [P40305-3]
ENST00000621160; ENSP00000483498; ENSG00000165949 [P40305-2]
ENST00000627111; ENSP00000486608; ENSG00000275214 [P40305-2]
GeneIDi3429
KEGGihsa:3429
UCSCiuc032bkg.2 human
uc032bkj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3429
DisGeNETi3429

GeneCards: human genes, protein and diseases

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GeneCardsi
IFI27
HGNCiHGNC:5397 IFI27
HPAiHPA028875
MIMi600009 gene
neXtProtiNX_P40305
OpenTargetsiENSG00000165949
PharmGKBiPA29643

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JFVP Eukaryota
ENOG410Z2RX LUCA
GeneTreeiENSGT00940000164233
HOGENOMiHOG000112988
InParanoidiP40305
OMAiCFLSSTR
PhylomeDBiP40305
TreeFamiTF340510

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IFI27 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IFI27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3429

Protein Ontology

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PROi
PR:P40305

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165949 Expressed in 227 organ(s), highest expression level in ectocervix
ExpressionAtlasiP40305 baseline and differential

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFI27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40305
Secondary accession number(s): A0A087WZF8
, A8K0H0, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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