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Entry version 182 (16 Oct 2019)
Sequence version 2 (23 Mar 2010)
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Protein

All-trans-retinol dehydrogenase [NAD(+)] ADH7

Gene

ADH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387).3 Publications

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Retinol oxidation is inhibited by the detergent Tween 80 (PubMed:15369820). Ethanol inhibits both all-trans-retinol and 9-cis-retinol oxidation (PubMed:9600267). 13-cis-retinol is an effective competitive inhibitor of the 9-cis-retinol oxidation (PubMed:9600267). All-trans-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). 13-cis-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). Cimetidine competitively inhibited ethanol oxidation (PubMed:9600267).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=23 µM for all-trans-retinol1 Publication
  2. KM=15 µM for all-trans-4-hydroxyretinol1 Publication
  3. KM=28 µM for all-trans-3,4-didehydroretinol1 Publication
  4. KM=34 µM for all-trans-retinal2 Publications
  5. KM=17 µM for all-trans-4-oxoretinal1 Publication
  6. KM=26 µM for all-trans-3,4-didehydroretinal1 Publication
  7. KM=0.3 µM for all-trans-retinol1 Publication
  8. KM=0.8 µM for all-trans-retinal1 Publication
  9. KM=0.1 mM for 10-OH-decanoic acid (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  10. KM=0.17 mM for 12-OH-dodecanoic acid (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  11. KM=0.07 mM for 12-OH-dodecanoic acid (with 0.1 M glycine/NaOH at pH 10)1 Publication
  12. KM=0.035 mM for 16-OH-hexadecanoic acid (with 0.1 M glycine/NaOH at pH 10)1 Publication
  13. KM=0.14 mM for hexanol (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  14. KM=0.02 mM for hexanal (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  15. KM=0.017 mM for 2-hexenol (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  16. KM=0.025 mM for 2-hexenal (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  17. KM=0.038 mM for 4-hydroxynonenal (with 0.1 M sodium phosphate at pH 7.5)1 Publication
  18. KM=15 µM for all-trans-retinol1 Publication
  19. KM=36 µM for 9-cis-retinol1 Publication
  20. KM=21 µM for 9-cis-retinal1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi59Zinc 1; catalyticCombined sources1 Publication1
    Metal bindingi80Zinc 1; catalyticCombined sources1 Publication1
    Metal bindingi110Zinc 2Combined sources1 Publication1
    Metal bindingi113Zinc 2Combined sources1 Publication1
    Metal bindingi116Zinc 2Combined sources1 Publication1
    Metal bindingi124Zinc 2Combined sources1 Publication1
    Metal bindingi186Zinc 1; catalyticCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei235NADCombined sources1 Publication1
    Binding sitei240NADCombined sources1 Publication1
    Binding sitei381NADCombined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi60 – 64NADCombined sources1 Publication5
    Nucleotide bindingi211 – 216NADCombined sources1 Publication6
    Nucleotide bindingi281 – 283NADCombined sources1 Publication3
    Nucleotide bindingi304 – 306NADCombined sources1 Publication3
    Nucleotide bindingi329 – 331NADCombined sources1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandMetal-binding, NAD, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-71384 Ethanol oxidation

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001879

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    All-trans-retinol dehydrogenase [NAD(+)] ADH7Curated (EC:1.1.1.1052 Publications)
    Alternative name(s):
    Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.11 Publication)
    Alcohol dehydrogenase class IV mu/sigma chain
    Gastric alcohol dehydrogenase
    Omega-hydroxydecanoate dehydrogenase ADH7Curated (EC:1.1.1.661 Publication)
    Retinol dehydrogenase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ADH7Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:256 ADH7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600086 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P40394

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    131

    Open Targets

    More...
    OpenTargetsi
    ENSG00000196344

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24577

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P40394

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3867

    Drug and drug target database

    More...
    DrugBanki
    DB00898 Ethanol
    DB00157 NADH

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ADH7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    292495000

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001606911 – 386All-trans-retinol dehydrogenase [NAD(+)] ADH7Add BLAST386

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P40394

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P40394

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P40394

    PeptideAtlas

    More...
    PeptideAtlasi
    P40394

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P40394

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    55365 [P40394-1]
    55366 [P40394-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P40394

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P40394

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Preferentially expressed in stomach.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000196344 Expressed in 92 organ(s), highest expression level in esophagus mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P40394 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P40394 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA039695

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    106643, 4 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P40394, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000420269

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P40394

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1386
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P40394

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P40394

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0022 Eukaryota
    COG1062 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000162708

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000294674

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P40394

    KEGG Orthology (KO)

    More...
    KOi
    K13951

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SNETYNE

    Database of Orthologous Groups

    More...
    OrthoDBi
    664798at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P40394

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300429

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR028635 Zinc_ADH_IV

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43880:SF2 PTHR43880:SF2, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P40394-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR
    60 70 80 90 100
    IKILATGICR TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD
    110 120 130 140 150
    KVIPLFLPQC RECNACRNPD GNLCIRSDIT GRGVLADGTT RFTCKGKPVH
    160 170 180 190 200
    HFMNTSTFTE YTVVDESSVA KIDDAAPPEK VCLIGCGFST GYGAAVKTGK
    210 220 230 240 250
    VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK FEKAMAVGAT
    260 270 280 290 300
    ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT
    310 320 330 340 350
    SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK
    360 370 380
    KFDLDQLITH VLPFKKISEG FELLNSGQSI RTVLTF
    Length:386
    Mass (Da):41,481
    Last modified:March 23, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE34C959778ED6817
    GO
    Isoform 2 (identifier: P40394-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MFAEIQIQDKDRMGTAGK → MKCLVSRHTVRETLDMVFQRMSVEAG

    Note: No experimental confirmation available.
    Show »
    Length:394
    Mass (Da):42,467
    Checksum:i2EBC96FC412B6729
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PFG0E9PFG0_HUMAN
    All-trans-retinol dehydrogenase [NA...
    ADH7
    317Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DG85A0A0C4DG85_HUMAN
    All-trans-retinol dehydrogenase [NA...
    ADH7
    374Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JP14C9JP14_HUMAN
    All-trans-retinol dehydrogenase [NA...
    ADH7
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA19002 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence AAC51351 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence BAG35707 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAA53960 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAA53961 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9D → E in AAA19002 (PubMed:8195208).Curated1
    Sequence conflicti32Q → R AA sequence (PubMed:1592118).Curated1
    Sequence conflicti83T → R AA sequence (PubMed:1592118).Curated1
    Sequence conflicti110C → V in AAB38424 (PubMed:8824810).Curated1
    Sequence conflicti150 – 151HH → GR AA sequence (PubMed:1592118).Curated2
    Sequence conflicti160 – 161EY → VI in AAB38424 (PubMed:8824810).Curated2
    Sequence conflicti169V → E in AAB38424 (PubMed:8824810).Curated1
    Sequence conflicti175A → T in BAG35707 (PubMed:14702039).Curated1
    Sequence conflicti217L → V in AAB38424 (PubMed:8824810).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02436492G → A. Corresponds to variant dbSNP:rs1573496Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430931 – 18MFAEI…GTAGK → MKCLVSRHTVRETLDMVFQR MSVEAG in isoform 2. 1 PublicationAdd BLAST18

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X76342 mRNA Translation: CAA53961.1 Different initiation.
    X76342 mRNA Translation: CAA53960.1 Different initiation.
    U07821 mRNA Translation: AAA19002.1 Different initiation.
    U16293
    , U16286, U16287, U16288, U16289, U16290, U16291, U16292 Genomic DNA Translation: AAC51351.1 Different initiation.
    AK301696 mRNA Translation: BAG63168.1
    AK312854 mRNA Translation: BAG35707.1 Different initiation.
    AP001960 Genomic DNA No translation available.
    CH471057 Genomic DNA Translation: EAX06101.1
    BC131512 mRNA Translation: AAI31513.1
    L33179 mRNA Translation: AAA59211.1
    U09623 mRNA Translation: AAA82165.1
    L47166 Genomic DNA Translation: AAB38424.1
    S77168 mRNA Translation: AAB34478.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS34034.1 [P40394-1]
    CCDS54781.1 [P40394-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A55878 DEHUAS

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000664.2, NM_000673.4 [P40394-1]
    NP_001159976.1, NM_001166504.1 [P40394-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000209665; ENSP00000209665; ENSG00000196344 [P40394-1]
    ENST00000476959; ENSP00000420269; ENSG00000196344 [P40394-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    131

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:131

    UCSC genome browser

    More...
    UCSCi
    uc003huv.2 human [P40394-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X76342 mRNA Translation: CAA53961.1 Different initiation.
    X76342 mRNA Translation: CAA53960.1 Different initiation.
    U07821 mRNA Translation: AAA19002.1 Different initiation.
    U16293
    , U16286, U16287, U16288, U16289, U16290, U16291, U16292 Genomic DNA Translation: AAC51351.1 Different initiation.
    AK301696 mRNA Translation: BAG63168.1
    AK312854 mRNA Translation: BAG35707.1 Different initiation.
    AP001960 Genomic DNA No translation available.
    CH471057 Genomic DNA Translation: EAX06101.1
    BC131512 mRNA Translation: AAI31513.1
    L33179 mRNA Translation: AAA59211.1
    U09623 mRNA Translation: AAA82165.1
    L47166 Genomic DNA Translation: AAB38424.1
    S77168 mRNA Translation: AAB34478.1
    CCDSiCCDS34034.1 [P40394-1]
    CCDS54781.1 [P40394-2]
    PIRiA55878 DEHUAS
    RefSeqiNP_000664.2, NM_000673.4 [P40394-1]
    NP_001159976.1, NM_001166504.1 [P40394-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1AGNX-ray3.00A/B/C/D14-386[»]
    1D1SX-ray2.50A/B/C/D14-386[»]
    1D1TX-ray2.40A/B/C/D14-386[»]
    SMRiP40394
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi106643, 4 interactors
    IntActiP40394, 1 interactor
    STRINGi9606.ENSP00000420269

    Chemistry databases

    BindingDBiP40394
    ChEMBLiCHEMBL3867
    DrugBankiDB00898 Ethanol
    DB00157 NADH
    SwissLipidsiSLP:000001879

    PTM databases

    iPTMnetiP40394
    PhosphoSitePlusiP40394

    Polymorphism and mutation databases

    BioMutaiADH7
    DMDMi292495000

    Proteomic databases

    jPOSTiP40394
    MassIVEiP40394
    PaxDbiP40394
    PeptideAtlasiP40394
    PRIDEiP40394
    ProteomicsDBi55365 [P40394-1]
    55366 [P40394-2]

    Genome annotation databases

    EnsembliENST00000209665; ENSP00000209665; ENSG00000196344 [P40394-1]
    ENST00000476959; ENSP00000420269; ENSG00000196344 [P40394-2]
    GeneIDi131
    KEGGihsa:131
    UCSCiuc003huv.2 human [P40394-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    131
    DisGeNETi131

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ADH7
    HGNCiHGNC:256 ADH7
    HPAiHPA039695
    MIMi600086 gene
    neXtProtiNX_P40394
    OpenTargetsiENSG00000196344
    PharmGKBiPA24577

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0022 Eukaryota
    COG1062 LUCA
    GeneTreeiENSGT00940000162708
    HOGENOMiHOG000294674
    InParanoidiP40394
    KOiK13951
    OMAiSNETYNE
    OrthoDBi664798at2759
    PhylomeDBiP40394
    TreeFamiTF300429

    Enzyme and pathway databases

    ReactomeiR-HSA-71384 Ethanol oxidation

    Miscellaneous databases

    EvolutionaryTraceiP40394

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ADH7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    131
    PharosiP40394

    Protein Ontology

    More...
    PROi
    PR:P40394

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000196344 Expressed in 92 organ(s), highest expression level in esophagus mucosa
    ExpressionAtlasiP40394 baseline and differential
    GenevisibleiP40394 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR028635 Zinc_ADH_IV
    PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
    PfamiView protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit
    SUPFAMiSSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADH7_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40394
    Secondary accession number(s): A2RRB6
    , A8MVN9, B2R760, B4DWV6, Q13713
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: March 23, 2010
    Last modified: October 16, 2019
    This is version 182 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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