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Entry version 156 (08 May 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Drosomycin

Gene

Drs

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi (PubMed:8808632, PubMed:12872120). It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology (PubMed:7806546). Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway (PubMed:8808632). Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system (PubMed:18854145).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Fungicide

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.B.1.1.9 the long (4c-c) scorpion toxin (l-st) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Drosomycin
Alternative name(s):
Cysteine-rich peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Drs
Synonyms:CRP
ORF Names:CG10810
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283461 Drs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000703821 – 261 Publication6
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000703927 – 70DrosomycinAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 70
Disulfide bondi37 ↔ 59
Disulfide bondi45 ↔ 65
Disulfide bondi49 ↔ 67

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41964

PRoteomics IDEntifications database

More...
PRIDEi
P41964

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized in the fat body and is secreted into the blood (PubMed:9736738). In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following three weeks (PubMed:9736738). In larvae, expressed in the visceral branches and posterior spiracles of the trachea (PubMed:22022271).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by septic injury caused by the Gram-positive bacteria M.luteus and the fungus C.albicans, and by M.luteus or E.faecalis-derived peptidoglycans and by B.subtilis or A.oryzae proteases (PubMed:19590012). Up-regulated by Gram-negative bacteria in the respiratory epithelium (PubMed:22022271). Up-regulated in the trachea and fat body in response to tracheal melanization, either by spontaneous melanization or melanization resulting from infection by bacteria (E.coli and M.luteus) or the fungus B.bassiana (PubMed:18854145).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010381 Expressed in 26 organ(s), highest expression level in spermathecum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41964 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41964 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-18879N

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072935

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41964

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P41964

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176294

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41964

KEGG Orthology (KO)

More...
KOi
K20670

Database of Orthologous Groups

More...
OrthoDBi
1570019at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41964

Family and domain databases

Conserved Domains Database

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CDDi
cd00107 Knot1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00505 Knot1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57095 SSF57095, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P41964-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQIKYLFAL FAVLMLVVLG ANEADADCLS GRYKGPCAVW DNETCRRVCK
60 70
EEGRSSGHCS PSLKCWCEGC
Length:70
Mass (Da):7,752
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A702E959ECEF181
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 4889.5 Da from positions 27 - 70. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75595 mRNA Translation: CAA53267.1
AJ885056 Genomic DNA Translation: CAI76995.1
AJ885057 Genomic DNA Translation: CAI77002.1
AJ885058 Genomic DNA Translation: CAI77009.1
AJ885059 Genomic DNA Translation: CAI77016.1
AJ885060 Genomic DNA Translation: CAI77023.1
AJ885061 Genomic DNA Translation: CAI77030.1
AJ885062 Genomic DNA Translation: CAI77037.1
AJ885063 Genomic DNA Translation: CAI77044.1
AJ885064 Genomic DNA Translation: CAI77051.1
AJ885065 Genomic DNA Translation: CAI77058.1
AJ885066 Genomic DNA Translation: CAI77065.1
AJ885067 Genomic DNA Translation: CAI77072.1
AJ885068 Genomic DNA Translation: CAI77079.1
AJ885069 Genomic DNA Translation: CAI77086.1
AJ885070 Genomic DNA Translation: CAI77093.1
AJ885071 Genomic DNA Translation: CAI77100.1
AJ885072 Genomic DNA Translation: CAI77107.1
AJ885073 Genomic DNA Translation: CAI77114.1
AJ885074 Genomic DNA Translation: CAI77121.1
AJ885075 Genomic DNA Translation: CAI77128.1
AJ885086 Genomic DNA Translation: CAI77205.1
AE014296 Genomic DNA Translation: AAF47767.2
AY119009 mRNA Translation: AAM50869.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55824

NCBI Reference Sequences

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RefSeqi
NP_523901.1, NM_079177.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073073; FBpp0072935; FBgn0283461

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75595 mRNA Translation: CAA53267.1
AJ885056 Genomic DNA Translation: CAI76995.1
AJ885057 Genomic DNA Translation: CAI77002.1
AJ885058 Genomic DNA Translation: CAI77009.1
AJ885059 Genomic DNA Translation: CAI77016.1
AJ885060 Genomic DNA Translation: CAI77023.1
AJ885061 Genomic DNA Translation: CAI77030.1
AJ885062 Genomic DNA Translation: CAI77037.1
AJ885063 Genomic DNA Translation: CAI77044.1
AJ885064 Genomic DNA Translation: CAI77051.1
AJ885065 Genomic DNA Translation: CAI77058.1
AJ885066 Genomic DNA Translation: CAI77065.1
AJ885067 Genomic DNA Translation: CAI77072.1
AJ885068 Genomic DNA Translation: CAI77079.1
AJ885069 Genomic DNA Translation: CAI77086.1
AJ885070 Genomic DNA Translation: CAI77093.1
AJ885071 Genomic DNA Translation: CAI77100.1
AJ885072 Genomic DNA Translation: CAI77107.1
AJ885073 Genomic DNA Translation: CAI77114.1
AJ885074 Genomic DNA Translation: CAI77121.1
AJ885075 Genomic DNA Translation: CAI77128.1
AJ885086 Genomic DNA Translation: CAI77205.1
AE014296 Genomic DNA Translation: AAF47767.2
AY119009 mRNA Translation: AAM50869.1
PIRiA55824
RefSeqiNP_523901.1, NM_079177.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MYNNMR-A27-70[»]
SMRiP41964
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-18879N
STRINGi7227.FBpp0072935

Protein family/group databases

TCDBi8.B.1.1.9 the long (4c-c) scorpion toxin (l-st) superfamily

Proteomic databases

PaxDbiP41964
PRIDEiP41964

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073073; FBpp0072935; FBgn0283461
GeneIDi38419
KEGGidme:Dmel_CG10810

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38419
FlyBaseiFBgn0283461 Drs

Phylogenomic databases

GeneTreeiENSGT00940000176294
InParanoidiP41964
KOiK20670
OrthoDBi1570019at2759
PhylomeDBiP41964

Miscellaneous databases

EvolutionaryTraceiP41964

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38419

Protein Ontology

More...
PROi
PR:P41964

Gene expression databases

BgeeiFBgn0010381 Expressed in 26 organ(s), highest expression level in spermathecum
ExpressionAtlasiP41964 differential
GenevisibleiP41964 DM

Family and domain databases

CDDicd00107 Knot1, 1 hit
Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMYC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41964
Secondary accession number(s): Q2UYN5, Q9VZQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 8, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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