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Entry version 179 (18 Sep 2019)
Sequence version 2 (04 Jan 2005)
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Protein

3-ketoacyl-CoA thiolase, mitochondrial

Gene

ACAA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312).1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 14.8 sec(-1) for the degradation of acetoacetyl-CoA (3-oxoacyl-CoA thiolase) (PubMed:25478839). kcat is 1.4 sec(-1) for the synthesis of acetoacetyl-CoA (PubMed:25478839). kcat is 0.02 sec(-1) for octanoyl-CoA hydrolysis (PubMed:25478839).1 Publication
  1. KM=9.2 µM for acetoacetyl-CoA1 Publication
  2. KM=250 µM for acetyl-CoA1 Publication
  3. KM=35 µM for octanoyl-CoA1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

    This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei92Acyl-thioester intermediate1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei224Coenzyme ACombined sources1 Publication1
    Binding sitei227Coenzyme ACombined sources1 Publication1
    Binding sitei251Coenzyme A; via carbonyl oxygenCombined sources1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei352Increases nucleophilicity of active site Cys1 Publication1
    Active sitei382Proton donor/acceptor1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Hydrolase, Transferase
    Biological processFatty acid metabolism, Lipid metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS09539-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00659

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001273

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    3-ketoacyl-CoA thiolase, mitochondrialCurated (EC:2.3.1.161 Publication)
    Alternative name(s):
    Acetyl-CoA acetyltransferaseCurated (EC:2.3.1.91 Publication)
    Acetyl-CoA acyltransferase
    Acyl-CoA hydrolase, mitochondrialCurated (EC:3.1.2.-1 Publication, EC:3.1.2.11 Publication, EC:3.1.2.2By similarity)
    Beta-ketothiolase
    Mitochondrial 3-oxoacyl-CoA thiolase
    T1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ACAA2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:83 ACAA2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604770 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P42765

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92C → A: Decreased acyl-CoA hydrolase activity. 1 Publication1
    Mutagenesisi92C → S: Decreased acyl-CoA hydrolase activity; when associated with A-382. 1 Publication1
    Mutagenesisi382C → S: Decreased acyl-CoA hydrolase activity; when associated with S-92. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10449

    Open Targets

    More...
    OpenTargetsi
    ENSG00000167315

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24420

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ACAA2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    57015371

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002232991 – 3973-ketoacyl-CoA thiolase, mitochondrialAdd BLAST397
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 16Mitochondrion; not cleavedAdd BLAST16

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25N6-acetyllysine; alternateBy similarity1
    Modified residuei25N6-succinyllysine; alternateBy similarity1
    Modified residuei45N6-succinyllysineBy similarity1
    Modified residuei119PhosphothreonineCombined sources1
    Modified residuei121PhosphoserineCombined sources1
    Modified residuei127PhosphotyrosineCombined sources1
    Modified residuei136PhosphothreonineBy similarity1
    Modified residuei137N6-acetyllysine; alternateBy similarity1
    Modified residuei137N6-succinyllysine; alternateBy similarity1
    Modified residuei140PhosphoserineCombined sources1
    Modified residuei143N6-acetyllysine; alternateBy similarity1
    Modified residuei143N6-succinyllysine; alternateBy similarity1
    Modified residuei171N6-acetyllysine; alternateBy similarity1
    Modified residuei171N6-succinyllysine; alternateBy similarity1
    Modified residuei191N6-acetyllysine; alternateBy similarity1
    Modified residuei191N6-succinyllysine; alternateBy similarity1
    Modified residuei209N6-acetyllysine; alternateBy similarity1
    Modified residuei209N6-succinyllysine; alternateBy similarity1
    Modified residuei211N6-succinyllysineBy similarity1
    Modified residuei212N6-succinyllysineBy similarity1
    Modified residuei214N6-succinyllysineBy similarity1
    Modified residuei234N6-acetyllysine; alternateBy similarity1
    Modified residuei234N6-succinyllysine; alternateBy similarity1
    Modified residuei240N6-succinyllysineBy similarity1
    Modified residuei241N6-acetyllysineBy similarity1
    Modified residuei269N6-acetyllysineBy similarity1
    Modified residuei270N6-acetyllysineBy similarity1
    Modified residuei305N6-acetyllysine; alternateBy similarity1
    Modified residuei305N6-succinyllysine; alternateBy similarity1
    Modified residuei310PhosphoserineBy similarity1
    Modified residuei312N6-acetyllysine; alternateBy similarity1
    Modified residuei312N6-succinyllysine; alternateBy similarity1
    Modified residuei333PhosphoserineCombined sources1
    Modified residuei340N6-acetyllysineBy similarity1
    Modified residuei375N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-158
    CPTAC-159

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P42765

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P42765

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P42765

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P42765

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P42765

    PeptideAtlas

    More...
    PeptideAtlasi
    P42765

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P42765

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    55548

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P42765

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00001539

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    P42765

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P42765

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P42765

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P42765

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000167315 Expressed in 205 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P42765 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P42765 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA042303

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer (PubMed:25478839).

    Interacts with BNIP3.

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    115713, 64 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P42765, 17 interactors

    Molecular INTeraction database

    More...
    MINTi
    P42765

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000285093

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1397
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P42765

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1391 Eukaryota
    COG0183 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182771

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000012238

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P42765

    KEGG Orthology (KO)

    More...
    KOi
    K07508

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DYYWGMG

    Database of Orthologous Groups

    More...
    OrthoDBi
    1129049at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P42765

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105696

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00751 thiolase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.47.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002155 Thiolase
    IPR016039 Thiolase-like
    IPR020615 Thiolase_acyl_enz_int_AS
    IPR020610 Thiolase_AS
    IPR020617 Thiolase_C
    IPR020613 Thiolase_CS
    IPR020616 Thiolase_N

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02803 Thiolase_C, 1 hit
    PF00108 Thiolase_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000429 Ac-CoA_Ac_transf, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53901 SSF53901, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01930 AcCoA-C-Actrans, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00098 THIOLASE_1, 1 hit
    PS00737 THIOLASE_2, 1 hit
    PS00099 THIOLASE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

    P42765-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALLRGVFVV AAKRTPFGAY GGLLKDFTAT DLSEFAAKAA LSAGKVSPET
    60 70 80 90 100
    VDSVIMGNVL QSSSDAIYLA RHVGLRVGIP KETPALTINR LCGSGFQSIV
    110 120 130 140 150
    NGCQEICVKE AEVVLCGGTE SMSQAPYCVR NVRFGTKLGS DIKLEDSLWV
    160 170 180 190 200
    SLTDQHVQLP MAMTAENLAV KHKISREECD KYALQSQQRW KAANDAGYFN
    210 220 230 240 250
    DEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPPVFK KDGTVTAGNA
    260 270 280 290 300
    SGVADGAGAV IIASEDAVKK HNFTPLARIV GYFVSGCDPS IMGIGPVPAI
    310 320 330 340 350
    SGALKKAGLS LKDMDLVEVN EAFAPQYLAV ERSLDLDISK TNVNGGAIAL
    360 370 380 390
    GHPLGGSGSR ITAHLVHELR RRGGKYAVGS ACIGGGQGIA VIIQSTA
    Length:397
    Mass (Da):41,924
    Last modified:January 4, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i380CC8262ACF6D01
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0B4J2A4A0A0B4J2A4_HUMAN
    3-ketoacyl-CoA thiolase, mitochondr...
    ACAA2
    394Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EME0K7EME0_HUMAN
    3-ketoacyl-CoA thiolase, mitochondr...
    ACAA2
    342Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ER88K7ER88_HUMAN
    3-ketoacyl-CoA thiolase, mitochondr...
    ACAA2
    72Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EJB1K7EJB1_HUMAN
    3-ketoacyl-CoA thiolase, mitochondr...
    ACAA2
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EJ68K7EJ68_HUMAN
    3-ketoacyl-CoA thiolase, mitochondr...
    ACAA2
    124Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → R in BAA03800 (PubMed:8241273).Curated1
    Sequence conflicti169A → T in BAA03800 (PubMed:8241273).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052577217M → V. Corresponds to variant dbSNP:rs11549285Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D16294 mRNA Translation: BAA03800.1
    BC001918 mRNA Translation: AAH01918.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11939.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S43440

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_006102.2, NM_006111.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000285093; ENSP00000285093; ENSG00000167315

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10449

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10449

    UCSC genome browser

    More...
    UCSCi
    uc002ldw.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D16294 mRNA Translation: BAA03800.1
    BC001918 mRNA Translation: AAH01918.1
    CCDSiCCDS11939.1
    PIRiS43440
    RefSeqiNP_006102.2, NM_006111.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4C2JX-ray2.00A/B/C/D1-397[»]
    4C2KX-ray2.00A/B/C/D1-397[»]
    SMRiP42765
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi115713, 64 interactors
    IntActiP42765, 17 interactors
    MINTiP42765
    STRINGi9606.ENSP00000285093

    Chemistry databases

    SwissLipidsiSLP:000001273

    PTM databases

    iPTMnetiP42765
    PhosphoSitePlusiP42765
    SwissPalmiP42765

    Polymorphism and mutation databases

    BioMutaiACAA2
    DMDMi57015371

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00001539
    UCD-2DPAGEiP42765

    Proteomic databases

    CPTACiCPTAC-158
    CPTAC-159
    EPDiP42765
    jPOSTiP42765
    MassIVEiP42765
    MaxQBiP42765
    PaxDbiP42765
    PeptideAtlasiP42765
    PRIDEiP42765
    ProteomicsDBi55548
    TopDownProteomicsiP42765

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    10449
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000285093; ENSP00000285093; ENSG00000167315
    GeneIDi10449
    KEGGihsa:10449
    UCSCiuc002ldw.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10449
    DisGeNETi10449

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ACAA2
    HGNCiHGNC:83 ACAA2
    HPAiHPA042303
    MIMi604770 gene
    neXtProtiNX_P42765
    OpenTargetsiENSG00000167315
    PharmGKBiPA24420

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1391 Eukaryota
    COG0183 LUCA
    GeneTreeiENSGT00950000182771
    HOGENOMiHOG000012238
    InParanoidiP42765
    KOiK07508
    OMAiDYYWGMG
    OrthoDBi1129049at2759
    PhylomeDBiP42765
    TreeFamiTF105696

    Enzyme and pathway databases

    UniPathwayiUPA00659
    BioCyciMetaCyc:HS09539-MONOMER
    ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ACAA2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ACAA2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    10449

    Pharos

    More...
    Pharosi
    P42765

    Protein Ontology

    More...
    PROi
    PR:P42765

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000167315 Expressed in 205 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiP42765 baseline and differential
    GenevisibleiP42765 HS

    Family and domain databases

    CDDicd00751 thiolase, 1 hit
    Gene3Di3.40.47.10, 2 hits
    InterProiView protein in InterPro
    IPR002155 Thiolase
    IPR016039 Thiolase-like
    IPR020615 Thiolase_acyl_enz_int_AS
    IPR020610 Thiolase_AS
    IPR020617 Thiolase_C
    IPR020613 Thiolase_CS
    IPR020616 Thiolase_N
    PfamiView protein in Pfam
    PF02803 Thiolase_C, 1 hit
    PF00108 Thiolase_N, 1 hit
    PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
    SUPFAMiSSF53901 SSF53901, 2 hits
    TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
    PROSITEiView protein in PROSITE
    PS00098 THIOLASE_1, 1 hit
    PS00737 THIOLASE_2, 1 hit
    PS00099 THIOLASE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHIM_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42765
    Secondary accession number(s): Q9BUT6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 4, 2005
    Last modified: September 18, 2019
    This is version 179 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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