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Entry version 168 (13 Nov 2019)
Sequence version 3 (22 Aug 2003)
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Protein

Lysophosphatidic acid receptor 6

Gene

LPAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.1 Publication

Miscellaneous

This is a nested gene within intron 17 of the retinoblastoma gene.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43657

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001579

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
RB intron encoded G-protein coupled receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPAR6
Synonyms:P2RY5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15520 LPAR6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609239 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43657

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 46Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini47 – 55CytoplasmicSequence analysis9
Transmembranei56 – 79Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini80 – 92ExtracellularSequence analysisAdd BLAST13
Transmembranei93 – 112Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini113 – 133CytoplasmicSequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 181ExtracellularSequence analysisAdd BLAST27
Transmembranei182 – 209Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini210 – 227CytoplasmicSequence analysisAdd BLAST18
Transmembranei228 – 253Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini254 – 272ExtracellularSequence analysisAdd BLAST19
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 344CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04432663D → V in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs879255262EnsemblClinVar.1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434307EnsemblClinVar.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434309EnsemblClinVar.1
Hypotrichosis 8 (HYPT8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.
Related information in OMIM

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
10161

MalaCards human disease database

More...
MalaCardsi
LPAR6
MIMi278150 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000139679

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
55654 Hypotrichosis simplex
170 Woolly hair

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165505129

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43657

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2331058

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
163

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPAR6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34223726

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700251 – 344Lysophosphatidic acid receptor 6Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi284S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43657

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43657

PeptideAtlas

More...
PeptideAtlasi
P43657

PRoteomics IDEntifications database

More...
PRIDEi
P43657

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55648

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43657

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43657

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139679 Expressed in 208 organ(s), highest expression level in squamous epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43657 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43657 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028934
HPA076273

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115463, 60 interactors

Protein interaction database and analysis system

More...
IntActi
P43657, 35 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367691

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43657

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFM0 Eukaryota
ENOG41115C6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182689

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43657

KEGG Orthology (KO)

More...
KOi
K04273

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFATRNW

Database of Orthologous Groups

More...
OrthoDBi
323029at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43657

TreeFam database of animal gene trees

More...
TreeFami
TF350009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP
160 170 180 190 200
AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA
Length:344
Mass (Da):39,392
Last modified:August 22, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i699212F3C1249433
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence L11910 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242F → I in BAD97109 (Ref. 6) Curated1
Sequence conflicti303K → I in CAD97680 (PubMed:17974005).Curated1
Sequence conflicti344A → G in CAD97687 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02263633I → V. Corresponds to variant dbSNP:rs1060585Ensembl.1
Natural variantiVAR_04432663D → V in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs879255262EnsemblClinVar.1
Natural variantiVAR_016253137C → W1 PublicationCorresponds to variant dbSNP:rs4151553Ensembl.1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434307EnsemblClinVar.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434309EnsemblClinVar.1
Natural variantiVAR_049430307W → C. Corresponds to variant dbSNP:rs17071686Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11910 Genomic DNA No translation available.
L78805 Genomic DNA Translation: AAL40065.1
AF000546 mRNA Translation: AAB62190.1
BX537392 mRNA Translation: CAD97634.1
BX537438 mRNA Translation: CAD97680.1
BX537445 mRNA Translation: CAD97687.1
AK122856 mRNA Translation: BAG53764.1
AK223389 mRNA Translation: BAD97109.1
HQ995530 mRNA Translation: ADZ31975.1
JF810890 mRNA Translation: AEP43757.1
AF551763 Genomic DNA Translation: AAN64134.1
AL392048 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08796.1
BC040850 mRNA Translation: AAH40850.1
BC045651 mRNA Translation: AAH45651.1
BC070295 mRNA Translation: AAH70295.1
BC106756 mRNA Translation: AAI06757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9410.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T09508

NCBI Reference Sequences

More...
RefSeqi
NP_001155969.1, NM_001162497.1
NP_001155970.1, NM_001162498.1
NP_005758.2, NM_005767.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345941; ENSP00000344353; ENSG00000139679
ENST00000378434; ENSP00000367691; ENSG00000139679
ENST00000620633; ENSP00000482660; ENSG00000139679

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10161

UCSC genome browser

More...
UCSCi
uc001vce.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA No translation available.
L78805 Genomic DNA Translation: AAL40065.1
AF000546 mRNA Translation: AAB62190.1
BX537392 mRNA Translation: CAD97634.1
BX537438 mRNA Translation: CAD97680.1
BX537445 mRNA Translation: CAD97687.1
AK122856 mRNA Translation: BAG53764.1
AK223389 mRNA Translation: BAD97109.1
HQ995530 mRNA Translation: ADZ31975.1
JF810890 mRNA Translation: AEP43757.1
AF551763 Genomic DNA Translation: AAN64134.1
AL392048 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08796.1
BC040850 mRNA Translation: AAH40850.1
BC045651 mRNA Translation: AAH45651.1
BC070295 mRNA Translation: AAH70295.1
BC106756 mRNA Translation: AAI06757.1
CCDSiCCDS9410.1
PIRiT09508
RefSeqiNP_001155969.1, NM_001162497.1
NP_001155970.1, NM_001162498.1
NP_005758.2, NM_005767.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115463, 60 interactors
IntActiP43657, 35 interactors
STRINGi9606.ENSP00000367691

Chemistry databases

BindingDBiP43657
ChEMBLiCHEMBL2331058
GuidetoPHARMACOLOGYi163
SwissLipidsiSLP:000001579

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP43657
PhosphoSitePlusiP43657

Polymorphism and mutation databases

BioMutaiLPAR6
DMDMi34223726

Proteomic databases

MassIVEiP43657
PaxDbiP43657
PeptideAtlasiP43657
PRIDEiP43657
ProteomicsDBi55648

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10161

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679
ENST00000378434; ENSP00000367691; ENSG00000139679
ENST00000620633; ENSP00000482660; ENSG00000139679
GeneIDi10161
KEGGihsa:10161
UCSCiuc001vce.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10161
DisGeNETi10161

GeneCards: human genes, protein and diseases

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GeneCardsi
LPAR6
HGNCiHGNC:15520 LPAR6
HPAiHPA028934
HPA076273
MalaCardsiLPAR6
MIMi278150 phenotype
609239 gene
neXtProtiNX_P43657
OpenTargetsiENSG00000139679
Orphaneti55654 Hypotrichosis simplex
170 Woolly hair
PharmGKBiPA165505129

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00950000182689
InParanoidiP43657
KOiK04273
OMAiYFATRNW
OrthoDBi323029at2759
PhylomeDBiP43657
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
SIGNORiP43657

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPAR6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10161
PharosiP43657

Protein Ontology

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PROi
PR:P43657

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139679 Expressed in 208 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP43657 baseline and differential
GenevisibleiP43657 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPAR6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43657
Secondary accession number(s): A4FTW9
, B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 22, 2003
Last modified: November 13, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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