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Entry version 165 (13 Nov 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Nucleolar protein NET1

Gene

NET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in chromosome maintenance and is involved in mitotic exit. Inhibits the action of CDC14 by sequestering it in the nucleolus. Also binds to RNA polymerase I and stimulates rRNA synthesis. Influences RDNA chromatin by tethering SIR2 to rDNA in the nucleolus.2 Publications

Miscellaneous

Present with 1590 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-31533-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein NET1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NET1
Synonyms:CFI1, ESC5, SRM8
Ordered Locus Names:YJL076W
ORF Names:J1038
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YJL076W

Saccharomyces Genome Database

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SGDi
S000003612 NET1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967841 – 1189Nucleolar protein NET1Add BLAST1189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei676PhosphothreonineCombined sources1
Modified residuei830PhosphoserineCombined sources1
Modified residuei1042PhosphothreonineCombined sources1
Modified residuei1056PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDC5.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P47035

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P47035

PRoteomics IDEntifications database

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PRIDEi
P47035

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P47035

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P47035

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RENT complex which is composed of at least NET1, CDC14 and SIR2 (PubMed:12056824, PubMed:11511359).

Interacts with NSI1 (PubMed:22362748).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33680, 103 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1669 RENT complex

Database of interacting proteins

More...
DIPi
DIP-5153N

Protein interaction database and analysis system

More...
IntActi
P47035, 100 interactors

Molecular INTeraction database

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MINTi
P47035

STRING: functional protein association networks

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STRINGi
4932.YJL076W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi192 – 199Poly-Thr8
Compositional biasi328 – 335Poly-Ser8
Compositional biasi415 – 418Poly-Ser4
Compositional biasi982 – 988Poly-Ser7
Compositional biasi993 – 1000Poly-Ser8
Compositional biasi1171 – 1174Poly-Lys4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To yeast YKR010c.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P47035

KEGG Orthology (KO)

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KOi
K06687

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFPSVDQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018844 Dnt1-like_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10407 Cytokin_check_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47035-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKLQVVLVP PSLQATMPIQ FGYGPTIAES SQLLPNRTNM AQSAGDASLQ
60 70 80 90 100
YANLRSANVS FTPSYFNQSR FRKFLLFTKP TNTLLNLSDE IIDKCEKMYP
110 120 130 140 150
SLQEDIEILS LQDNSGCDLD PDFLVKDVFN VNNIVRVILK NEIDLDDSAP
160 170 180 190 200
VSLYKSVKRS KLNNGSPQSV QPQQQIPSSS GVLRIAKKRP PTGTTTTTTI
210 220 230 240 250
RSATNGSMRV STPLARQIYP PPSSKIVSNN SDDEDEDIGE RSFLPPPTQP
260 270 280 290 300
QSPPIRISSG IDAGKKIKSS IVEEDIVSRS ATVDPDKTKQ QRLLSGTPIM
310 320 330 340 350
STMTPNRVTL TGQRVVSEHA HKNELVFSAS ASSSSFANGG TAAVTAQDIN
360 370 380 390 400
RKPPVTTPRI TSGMLKIPEP RISEIEKELK EGPSSPASIL PAKAAKIPMK
410 420 430 440 450
KPYLENGENY ESDDSSSSEN QETPETEPHS KASLQRSQSS IADNNGSPVK
460 470 480 490 500
NSPLGDAMPH NVHLAELPKA SNTSITKSSN GESWGKQQEH QPPRKSSLET
510 520 530 540 550
IVEKKSQAEP SGIVEPKRMT NFLDDNQVRE KEDTNDKLLE KEILPTIPHN
560 570 580 590 600
DQPILASSDK SNGTLKSLAG KVSSNNNASK EDGTIINGTI EDDGNDNDEV
610 620 630 640 650
DTTVRIVPQD SDSSSFPKSD LFKMIEGDDT DLPQWFKGKN SRTSGNSKNS
660 670 680 690 700
KPYTTVLNKD IDNSKPDPRN ILPQRTPRSA AKRAAQLLAG AKKNEVPQKS
710 720 730 740 750
TEDSSSAAST DDESESGIET DFSSDDDFKR KNMSVPNNGP KDISLHSLKG
760 770 780 790 800
SVVPVKDSKI INKEVDEERN DKRDSQKKSA VSESSVTNSK ISEQMAKSFY
810 820 830 840 850
PNSNKKQNEA TKVETKPATQ ASSFPVVGGS PSVATKGTTS FNEEGNRKNV
860 870 880 890 900
KTKAKNESAQ IDRQQKETTS RVADLKSANI GGEDLNKKAE GSKEPEKASA
910 920 930 940 950
NIQDANDKNN SKEKEDSKSK QVSQKKLKMT DHLKEGNVQL PKPSANDKLK
960 970 980 990 1000
DLKAKFTNSK TLVPPGIISN EKNNSSANDD DSSSSGSSTE DESSSSSSSS
1010 1020 1030 1040 1050
DEETSTSRKA RRVVVNTPRE PVRSSSKIEA PSPSVNKKIN ATPDKIPVTQ
1060 1070 1080 1090 1100
LMDMSSPPSV KSKTTSNPSS ILHDLPRKVR PSLSSLSDLV SRGIPDVKEK
1110 1120 1130 1140 1150
TSKSNEKSQT KAPSSSDDES SSDSDSNSSS DSVSDSSSDS KSESDSDDSG
1160 1170 1180
DSSDDGKSFI SAKSASAALG KKKKPSGGFA SLIKDFKKK
Length:1,189
Mass (Da):128,531
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80EDF9A8065EB5A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49351 Genomic DNA Translation: CAA89367.1
BK006943 Genomic DNA Translation: DAA08724.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56852

NCBI Reference Sequences

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RefSeqi
NP_012459.1, NM_001181509.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJL076W_mRNA; YJL076W; YJL076W

Database of genes from NCBI RefSeq genomes

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GeneIDi
853369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJL076W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49351 Genomic DNA Translation: CAA89367.1
BK006943 Genomic DNA Translation: DAA08724.1
PIRiS56852
RefSeqiNP_012459.1, NM_001181509.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi33680, 103 interactors
ComplexPortaliCPX-1669 RENT complex
DIPiDIP-5153N
IntActiP47035, 100 interactors
MINTiP47035
STRINGi4932.YJL076W

PTM databases

CarbonylDBiP47035
iPTMnetiP47035

Proteomic databases

MaxQBiP47035
PaxDbiP47035
PRIDEiP47035

Genome annotation databases

EnsemblFungiiYJL076W_mRNA; YJL076W; YJL076W
GeneIDi853369
KEGGisce:YJL076W

Organism-specific databases

EuPathDBiFungiDB:YJL076W
SGDiS000003612 NET1

Phylogenomic databases

InParanoidiP47035
KOiK06687
OMAiRFPSVDQ

Enzyme and pathway databases

BioCyciYEAST:G3O-31533-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47035

Family and domain databases

InterProiView protein in InterPro
IPR018844 Dnt1-like_N
PfamiView protein in Pfam
PF10407 Cytokin_check_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNET1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47035
Secondary accession number(s): D6VWA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 13, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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