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Entry version 156 (16 Oct 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

SLC6A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-71288 Creatine metabolism
R-HSA-888593 Reuptake of GABA

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P48066

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.3.9 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 3
Short name:
GAT-3
Alternative name(s):
Solute carrier family 6 member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A11
Synonyms:GABT3, GAT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11044 SLC6A11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607952 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 79Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei87 – 106Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei131 – 151Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini152 – 225ExtracellularSequence analysisAdd BLAST74
Transmembranei226 – 244Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei253 – 270Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei306 – 323Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei335 – 356Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei389 – 408Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei438 – 456Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei473 – 493Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei514 – 533Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei553 – 571Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini572 – 632CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6538

Open Targets

More...
OpenTargetsi
ENSG00000132164

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35907

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P48066

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5208

Drug and drug target database

More...
DrugBanki
DB00349 Clobazam
DB08848 Guvacine

DrugCentral

More...
DrugCentrali
P48066

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC6A11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147841 – 632Sodium- and chloride-dependent GABA transporter 3Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P48066

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P48066

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48066

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48066

PeptideAtlas

More...
PeptideAtlasi
P48066

PRoteomics IDEntifications database

More...
PRIDEi
P48066

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55860 [P48066-1]
71155

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widespread distribution in the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132164 Expressed in 134 organ(s), highest expression level in medial globus pallidus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48066 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037981

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254488

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P48066

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157569

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116406

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48066

KEGG Orthology (KO)

More...
KOi
K05044

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRWELAM

Database of Orthologous Groups

More...
OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48066

TreeFam database of animal gene trees

More...
TreeFami
TF343812

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11508 SLC6sbd_GAT3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR002982 Na/ntran_symport_GABA_GAT3
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01197 GAT3TRNSPORT
PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P48066-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER
60 70 80 90 100
GHWNNKVEFV LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG
110 120 130 140 150
IPVFFLETAL GQFTSEGGIT CWRKVCPLFE GIGYATQVIE AHLNVYYIII
160 170 180 190 200
LAWAIFYLSN CFTTELPWAT CGHEWNTENC VEFQKLNVSN YSHVSLQNAT
210 220 230 240 250
SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY FCIWKGTKST
260 270 280 290 300
GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV
310 320 330 340 350
DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF
360 370 380 390 400
AIFSVLGFMA YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF
410 420 430 440 450
MMLIFLGLDS QFVCVESLVT AVVDMYPKVF RRGYRRELLI LALSVISYFL
460 470 480 490 500
GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA IFECICIGWV YGSNRFYDNI
510 520 530 540 550
EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY NNIYTYPAWG
560 570 580 590 600
YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL
610 620 630
GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF
Length:632
Mass (Da):70,606
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD75C5B988E983278
GO
Isoform 2 (identifier: P48066-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-632: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,036
Checksum:i993E85CD5C8E2ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284F → L in BAG35593 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056539209 – 632Missing in isoform 2. 1 PublicationAdd BLAST424

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S75989 mRNA Translation: AAB33570.1
AK312719 mRNA Translation: BAG35593.1
AC018495 Genomic DNA No translation available.
AC027128 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64086.1
BC036083 mRNA Translation: AAH36083.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2602.1 [P48066-1]
CCDS82734.1 [P48066-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001304335.1, NM_001317406.1 [P48066-2]
NP_055044.1, NM_014229.2 [P48066-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254488; ENSP00000254488; ENSG00000132164 [P48066-1]
ENST00000454147; ENSP00000404120; ENSG00000132164 [P48066-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6538

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6538

UCSC genome browser

More...
UCSCi
uc003bvy.2 human [P48066-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75989 mRNA Translation: AAB33570.1
AK312719 mRNA Translation: BAG35593.1
AC018495 Genomic DNA No translation available.
AC027128 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64086.1
BC036083 mRNA Translation: AAH36083.1
CCDSiCCDS2602.1 [P48066-1]
CCDS82734.1 [P48066-2]
RefSeqiNP_001304335.1, NM_001317406.1 [P48066-2]
NP_055044.1, NM_014229.2 [P48066-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000254488

Chemistry databases

BindingDBiP48066
ChEMBLiCHEMBL5208
DrugBankiDB00349 Clobazam
DB08848 Guvacine
DrugCentraliP48066

Protein family/group databases

TCDBi2.A.22.3.9 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiP48066
PhosphoSitePlusiP48066

Polymorphism and mutation databases

BioMutaiSLC6A11
DMDMi1352531

Proteomic databases

EPDiP48066
MassIVEiP48066
MaxQBiP48066
PaxDbiP48066
PeptideAtlasiP48066
PRIDEiP48066
ProteomicsDBi55860 [P48066-1]
71155

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6538

Genome annotation databases

EnsembliENST00000254488; ENSP00000254488; ENSG00000132164 [P48066-1]
ENST00000454147; ENSP00000404120; ENSG00000132164 [P48066-2]
GeneIDi6538
KEGGihsa:6538
UCSCiuc003bvy.2 human [P48066-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6538
DisGeNETi6538

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC6A11
HGNCiHGNC:11044 SLC6A11
HPAiHPA037981
MIMi607952 gene
neXtProtiNX_P48066
OpenTargetsiENSG00000132164
PharmGKBiPA35907

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000157569
HOGENOMiHOG000116406
InParanoidiP48066
KOiK05044
OMAiMRWELAM
OrthoDBi250396at2759
PhylomeDBiP48066
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-71288 Creatine metabolism
R-HSA-888593 Reuptake of GABA
SIGNORiP48066

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC6A11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6538
PharosiP48066

Protein Ontology

More...
PROi
PR:P48066

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132164 Expressed in 134 organ(s), highest expression level in medial globus pallidus
GenevisibleiP48066 HS

Family and domain databases

CDDicd11508 SLC6sbd_GAT3, 1 hit
InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002982 Na/ntran_symport_GABA_GAT3
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01197 GAT3TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS6A11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48066
Secondary accession number(s): B2R6U6, Q8IYC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 16, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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