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Entry version 181 (18 Sep 2019)
Sequence version 3 (24 Jan 2006)
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Protein

CD151 antigen

Gene

CD151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.1 Publication
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-446107 Type I hemidesmosome assembly

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P48509

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.40.1.15 the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
Tetraspanin-24
Short name:
Tspan-24
CD_antigen: CD151
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD151
Synonyms:TSPAN24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1630 CD151

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602243 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 57ExtracellularSequence analysisAdd BLAST18
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 91CytoplasmicSequence analysisAdd BLAST13
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 221ExtracellularSequence analysisAdd BLAST109
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 253CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
Related information in OMIM

Keywords - Diseasei

Deafness, Epidermolysis bullosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
977

MalaCards human disease database

More...
MalaCardsi
CD151
MIMi179620 phenotype
609057 phenotype

Open Targets

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OpenTargetsi
ENSG00000177697

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
300333 Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26189

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD151

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85687560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192301 – 253CD151 antigenAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi11S-palmitoyl cysteine1 Publication1
Lipidationi15S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi242S-palmitoyl cysteine1 Publication1
Lipidationi243S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P48509

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48509

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P48509

MaxQB - The MaxQuant DataBase

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MaxQBi
P48509

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48509

PeptideAtlas

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PeptideAtlasi
P48509

PRoteomics IDEntifications database

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PRIDEi
P48509

ProteomicsDB human proteome resource

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ProteomicsDBi
55898

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48509

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48509

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P48509

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By HTLV-1.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177697 Expressed in 218 organ(s), highest expression level in descending thoracic aorta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48509 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48509 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002428
HPA011906

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1 and ITGA6:ITGB4 and with CD9 and CD181 (PubMed:11907260).

Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:27993971).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107415, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P48509

Protein interaction database and analysis system

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IntActi
P48509, 19 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380565

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230651

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48509

KEGG Orthology (KO)

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KOi
K06537

Identification of Orthologs from Complete Genome Data

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OMAi
CKTVVAG

Database of Orthologous Groups

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OrthoDBi
1051357at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P48509

TreeFam database of animal gene trees

More...
TreeFami
TF352892

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P48509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASGTYLAT AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYAYYQQLNT ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ
160 170 180 190 200
QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV PDSCCKTVVA LCGQRDHASN
210 220 230 240 250
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,295
Last modified:January 24, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C8FE4CF2C3C286D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRJ3E9PRJ3_HUMAN
Tetraspanin
CD151
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLZ6E9PLZ6_HUMAN
Tetraspanin
CD151
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DIB7K4DIB7_HUMAN
Tetraspanin
CD151
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJC8E9PJC8_HUMAN
Tetraspanin
CD151
170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DIA7K4DIA7_HUMAN
Tetraspanin
CD151
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMR4E9PMR4_HUMAN
Tetraspanin
CD151
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJE8E9PJE8_HUMAN
CD151 antigen
CD151
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSA1E9PSA1_HUMAN
CD151 antigen
CD151
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK37E9PK37_HUMAN
CD151 antigen
CD151
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP93E9PP93_HUMAN
CD151 antigen
CD151
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025098120T → M1 PublicationCorresponds to variant dbSNP:rs34215390Ensembl.1
Natural variantiVAR_012490132K → R2 Publications1
Natural variantiVAR_012491137P → S2 PublicationsCorresponds to variant dbSNP:rs1431926999Ensembl.1
Natural variantiVAR_021153178R → H1 PublicationCorresponds to variant dbSNP:rs779114765Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U14650 mRNA Translation: AAA87064.1
D29963 mRNA Translation: BAA06229.1
AF315942 Genomic DNA Translation: AAK14179.1
BT007397 mRNA Translation: AAP36061.1
BT020132 mRNA Translation: AAV38934.1
CR456826 mRNA Translation: CAG33107.1
CR542098 mRNA Translation: CAG46895.1
AK293073 mRNA Translation: BAF85762.1
DQ074789 Genomic DNA Translation: AAY68211.1
AP006621 Genomic DNA No translation available.
AP006623 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02400.1
BC001374 mRNA Translation: AAH01374.1
BC013302 mRNA Translation: AAH13302.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7719.1

NCBI Reference Sequences

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RefSeqi
NP_001034579.1, NM_001039490.1
NP_004348.2, NM_004357.4
NP_620598.1, NM_139029.1
NP_620599.1, NM_139030.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322008; ENSP00000324101; ENSG00000177697
ENST00000397420; ENSP00000380565; ENSG00000177697
ENST00000397421; ENSP00000380566; ENSG00000177697
ENST00000530726; ENSP00000432385; ENSG00000177697

Database of genes from NCBI RefSeq genomes

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GeneIDi
977

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:977

UCSC genome browser

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UCSCi
uc001lry.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14650 mRNA Translation: AAA87064.1
D29963 mRNA Translation: BAA06229.1
AF315942 Genomic DNA Translation: AAK14179.1
BT007397 mRNA Translation: AAP36061.1
BT020132 mRNA Translation: AAV38934.1
CR456826 mRNA Translation: CAG33107.1
CR542098 mRNA Translation: CAG46895.1
AK293073 mRNA Translation: BAF85762.1
DQ074789 Genomic DNA Translation: AAY68211.1
AP006621 Genomic DNA No translation available.
AP006623 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02400.1
BC001374 mRNA Translation: AAH01374.1
BC013302 mRNA Translation: AAH13302.1
CCDSiCCDS7719.1
RefSeqiNP_001034579.1, NM_001039490.1
NP_004348.2, NM_004357.4
NP_620598.1, NM_139029.1
NP_620599.1, NM_139030.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi107415, 17 interactors
CORUMiP48509
IntActiP48509, 19 interactors
STRINGi9606.ENSP00000380565

Protein family/group databases

TCDBi8.A.40.1.15 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiP48509
PhosphoSitePlusiP48509
SwissPalmiP48509

Polymorphism and mutation databases

BioMutaiCD151
DMDMi85687560

Proteomic databases

EPDiP48509
jPOSTiP48509
MassIVEiP48509
MaxQBiP48509
PaxDbiP48509
PeptideAtlasiP48509
PRIDEiP48509
ProteomicsDBi55898

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
977
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697
ENST00000397420; ENSP00000380565; ENSG00000177697
ENST00000397421; ENSP00000380566; ENSG00000177697
ENST00000530726; ENSP00000432385; ENSG00000177697
GeneIDi977
KEGGihsa:977
UCSCiuc001lry.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
977
DisGeNETi977

GeneCards: human genes, protein and diseases

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GeneCardsi
CD151
HGNCiHGNC:1630 CD151
HPAiCAB002428
HPA011906
MalaCardsiCD151
MIMi179620 phenotype
602243 gene
609057 phenotype
neXtProtiNX_P48509
OpenTargetsiENSG00000177697
Orphaneti300333 Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome
PharmGKBiPA26189

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000157760
HOGENOMiHOG000230651
InParanoidiP48509
KOiK06537
OMAiCKTVVAG
OrthoDBi1051357at2759
PhylomeDBiP48509
TreeFamiTF352892

Enzyme and pathway databases

ReactomeiR-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-446107 Type I hemidesmosome assembly
SIGNORiP48509

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD151

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
977

Pharos

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Pharosi
P48509

Protein Ontology

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PROi
PR:P48509

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177697 Expressed in 218 organ(s), highest expression level in descending thoracic aorta
ExpressionAtlasiP48509 baseline and differential
GenevisibleiP48509 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD151_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48509
Secondary accession number(s): A8KAK8
, E9PI15, Q14826, Q86U54, Q96TE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: September 18, 2019
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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