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Entry version 189 (05 Jun 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Interferon alpha/beta receptor 2

Gene

IFNAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine receptor activity Source: GO_Central
  • protein kinase binding Source: UniProtKB
  • type I interferon binding Source: UniProtKB
  • type I interferon receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P48551

SIGNOR Signaling Network Open Resource

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SIGNORi
P48551

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha/beta receptor 2
Short name:
IFN-R-2
Short name:
IFN-alpha binding protein
Short name:
IFN-alpha/beta receptor 2
Alternative name(s):
Interferon alpha binding protein
Type I interferon receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNAR2
Synonyms:IFNABR, IFNARB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5433 IFNAR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602376 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48551

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 243ExtracellularSequence analysisAdd BLAST217
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 515CytoplasmicSequence analysisAdd BLAST251

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 45 (IMD45)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi269Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi306Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi316Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337. 2 Publications1
Mutagenesisi318Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337. 2 Publications1
Mutagenesisi337Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318. 2 Publications1
Mutagenesisi411Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. 2 Publications1
Mutagenesisi512Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3455

MalaCards human disease database

More...
MalaCardsi
IFNAR2
MIMi610424 phenotype
616669 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000159110

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
431166 Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29671

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2364170

Drug and drug target database

More...
DrugBanki
DB00011 Interferon alfa-n1
DB00018 Interferon alfa-n3
DB00069 Interferon alfacon-1
DB00060 Interferon beta-1a
DB00068 Interferon beta-1b
DB05472 omega interferon
DB00008 Peginterferon alfa-2a
DB00022 Peginterferon alfa-2b

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFNAR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Add BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001100627 – 515Interferon alpha/beta receptor 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 122Combined sources4 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 93Combined sources4 Publications
Glycosylationi87N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi207 ↔ 227Combined sources4 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337Phosphotyrosine2 Publications1
Modified residuei400PhosphoserineCombined sources1
Modified residuei467PhosphoserineBy similarity1
Modified residuei512Phosphotyrosine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.3 Publications
Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48551

MaxQB - The MaxQuant DataBase

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MaxQBi
P48551

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48551

PeptideAtlas

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PeptideAtlasi
P48551

PRoteomics IDEntifications database

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PRIDEi
P48551

ProteomicsDB human proteome resource

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ProteomicsDBi
55905
55906 [P48551-2]
55907 [P48551-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
2051

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48551

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P48551

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000159110 Expressed in 227 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48551 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48551 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453).

Interacts with JAK1 (PubMed:8181059, PubMed:7759950).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • type I interferon binding Source: UniProtKB

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109677, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P48551

Database of interacting proteins

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DIPi
DIP-945N

Protein interaction database and analysis system

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IntActi
P48551, 14 interactors

Molecular INTeraction database

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MINTi
P48551

STRING: functional protein association networks

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STRINGi
9606.ENSP00000343957

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48551

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P48551

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHB9 Eukaryota
ENOG410YTXY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000049322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000013219

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48551

KEGG Orthology (KO)

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KOi
K05131

Identification of Orthologs from Complete Genome Data

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OMAi
HPEEMVD

Database of Orthologous Groups

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OrthoDBi
680035at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P48551

TreeFam database of animal gene trees

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TreeFami
TF335897

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48551-1) [UniParc]FASTAAdd to basket
Also known as: Long form beta1 Publication, IFNaR2-2, IFNaR2-1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS
60 70 80 90 100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR
110 120 130 140 150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV
160 170 180 190 200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL
210 220 230 240 250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV
260 270 280 290 300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD
310 320 330 340 350
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA
360 370 380 390 400
SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS
410 420 430 440 450
PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS
460 470 480 490 500
SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD
510
TSESDVDLGD GYIMR
Length:515
Mass (Da):57,759
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D7730D93AA739F4
GO
Isoform 2 (identifier: P48551-2) [UniParc]FASTAAdd to basket
Also known as: Short form beta1 Publication, IFNaR2-1, IFNaR2-1a

The sequence of this isoform differs from the canonical sequence as follows:
     281-331: NFHNFLAWPF...SDSDTEAAPR → RQGLAKGWNA...YKRASLCPSD
     332-515: Missing.

Show »
Length:331
Mass (Da):37,393
Checksum:i6F6A2FD6E7A7449B
GO
Isoform 3 (identifier: P48551-3) [UniParc]FASTAAdd to basket
Also known as: IFNaR2-3, IFNaR2-2a, P401 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: SA → FS
     240-515: Missing.

Note: Soluble receptor.
Show »
Length:239
Mass (Da):27,384
Checksum:i705E887E728A4FB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCU0C9JCU0_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JM33C9JM33_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDE1F8WDE1_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K067C9K067_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C176H7C176_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151M → V in AAC50202 (PubMed:7665574).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0205218F → S Associated with susceptibility to HVB infection; lower cell surface levels; lower induction of MHC class 1 expression by INF-alpha. 2 PublicationsCorresponds to variant dbSNP:rs2229207EnsemblClinVar.1
Natural variantiVAR_02052210F → V5 PublicationsCorresponds to variant dbSNP:rs1051393Ensembl.1
Natural variantiVAR_020523196I → V1 PublicationCorresponds to variant dbSNP:rs17860223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001736238 – 239SA → FS in isoform 3. 2 Publications2
Alternative sequenceiVSP_001737240 – 515Missing in isoform 3. 2 PublicationsAdd BLAST276
Alternative sequenceiVSP_001738281 – 331NFHNF…EAAPR → RQGLAKGWNAVAIHRCSHNA LQSETPELKQSSCLSFPSSW DYKRASLCPSD in isoform 2. 3 PublicationsAdd BLAST51
Alternative sequenceiVSP_001739332 – 515Missing in isoform 2. 3 PublicationsAdd BLAST184

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77722 mRNA Translation: CAA54785.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1
L41942 mRNA Translation: AAB46413.1
L41943 mRNA Translation: AAB46414.1
L41944 mRNA Translation: AAB46415.1
U29584 mRNA Translation: AAC50202.1
X89814 mRNA Translation: CAA61940.1
X89772 mRNA Translation: CAA61914.1
AY740397 Genomic DNA Translation: AAU21038.1
AK293059 mRNA Translation: BAF85748.1
CR541817 mRNA Translation: CAG46616.1
AP000292 Genomic DNA No translation available.
AP000293 Genomic DNA No translation available.
AP000294 Genomic DNA No translation available.
AP000295 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09842.1
CH471079 Genomic DNA Translation: EAX09843.1
CH471079 Genomic DNA Translation: EAX09844.1
CH471079 Genomic DNA Translation: EAX09846.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13621.1 [P48551-1]
CCDS13622.1 [P48551-2]
CCDS74782.1 [P48551-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I39073
S59501

NCBI Reference Sequences

More...
RefSeqi
NP_000865.2, NM_000874.4 [P48551-2]
NP_001276054.1, NM_001289125.1 [P48551-1]
NP_001276055.1, NM_001289126.1 [P48551-3]
NP_001276057.1, NM_001289128.1 [P48551-3]
NP_997467.1, NM_207584.2 [P48551-2]
NP_997468.1, NM_207585.2 [P48551-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3455

UCSC genome browser

More...
UCSCi
uc002yrb.5 human [P48551-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77722 mRNA Translation: CAA54785.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1
L41942 mRNA Translation: AAB46413.1
L41943 mRNA Translation: AAB46414.1
L41944 mRNA Translation: AAB46415.1
U29584 mRNA Translation: AAC50202.1
X89814 mRNA Translation: CAA61940.1
X89772 mRNA Translation: CAA61914.1
AY740397 Genomic DNA Translation: AAU21038.1
AK293059 mRNA Translation: BAF85748.1
CR541817 mRNA Translation: CAG46616.1
AP000292 Genomic DNA No translation available.
AP000293 Genomic DNA No translation available.
AP000294 Genomic DNA No translation available.
AP000295 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09842.1
CH471079 Genomic DNA Translation: EAX09843.1
CH471079 Genomic DNA Translation: EAX09844.1
CH471079 Genomic DNA Translation: EAX09846.1
CCDSiCCDS13621.1 [P48551-1]
CCDS13622.1 [P48551-2]
CCDS74782.1 [P48551-3]
PIRiI39073
S59501
RefSeqiNP_000865.2, NM_000874.4 [P48551-2]
NP_001276054.1, NM_001289125.1 [P48551-1]
NP_001276055.1, NM_001289126.1 [P48551-3]
NP_001276057.1, NM_001289128.1 [P48551-3]
NP_997467.1, NM_207584.2 [P48551-2]
NP_997468.1, NM_207585.2 [P48551-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6UNMR-A28-237[»]
1N6VNMR-A28-237[»]
2HYMNMR-A28-237[»]
2KZ1NMR-B28-237[»]
2LAGNMR-B28-237[»]
3S8WX-ray2.60A/B/C131-232[»]
3S9DX-ray2.00B/D37-232[»]
3SE3X-ray4.00C34-232[»]
3SE4X-ray3.50C34-232[»]
SMRiP48551
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109677, 12 interactors
CORUMiP48551
DIPiDIP-945N
IntActiP48551, 14 interactors
MINTiP48551
STRINGi9606.ENSP00000343957

Chemistry databases

ChEMBLiCHEMBL2364170
DrugBankiDB00011 Interferon alfa-n1
DB00018 Interferon alfa-n3
DB00069 Interferon alfacon-1
DB00060 Interferon beta-1a
DB00068 Interferon beta-1b
DB05472 omega interferon
DB00008 Peginterferon alfa-2a
DB00022 Peginterferon alfa-2b

PTM databases

GlyConnecti2051
iPTMnetiP48551
PhosphoSitePlusiP48551

Polymorphism and mutation databases

BioMutaiIFNAR2
DMDMi1352466

Proteomic databases

jPOSTiP48551
MaxQBiP48551
PaxDbiP48551
PeptideAtlasiP48551
PRIDEiP48551
ProteomicsDBi55905
55906 [P48551-2]
55907 [P48551-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3455
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]
GeneIDi3455
KEGGihsa:3455
UCSCiuc002yrb.5 human [P48551-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3455
DisGeNETi3455

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFNAR2
HGNCiHGNC:5433 IFNAR2
MalaCardsiIFNAR2
MIMi602376 gene
610424 phenotype
616669 phenotype
neXtProtiNX_P48551
OpenTargetsiENSG00000159110
Orphaneti431166 Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
PharmGKBiPA29671

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHB9 Eukaryota
ENOG410YTXY LUCA
GeneTreeiENSGT00510000049322
HOGENOMiHOG000013219
InParanoidiP48551
KOiK05131
OMAiHPEEMVD
OrthoDBi680035at2759
PhylomeDBiP48551
TreeFamiTF335897

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP48551
SIGNORiP48551

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IFNAR2 human
EvolutionaryTraceiP48551

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IFNAR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3455

Protein Ontology

More...
PROi
PR:P48551

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159110 Expressed in 227 organ(s), highest expression level in blood
ExpressionAtlasiP48551 baseline and differential
GenevisibleiP48551 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINAR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48551
Secondary accession number(s): A8KAJ4
, D3DSE8, D3DSE9, Q15467, Q6FHD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 5, 2019
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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