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UniProtKB - P48960 (CD97_HUMAN)

Entry version 198 (16 Oct 2019)
Sequence version 4 (21 Mar 2006)
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Protein

CD97 antigen

Gene

CD97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P48960

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.002

Transport Classification Database

More...TCDBi		9.A.14.6.2 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD97 antigen
Alternative name(s):
Leukocyte antigen CD97
CD_antigen: CD97
Cleaved into the following 2 chains:
CD97 antigen subunit alpha
CD97 antigen subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD97
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1711 CD97

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601211 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P48960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 552ExtracellularSequence analysisAdd BLAST532
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei553 – 572Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini573 – 581CytoplasmicSequence analysis9
Transmembranei582 – 601Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini602 – 620ExtracellularSequence analysisAdd BLAST19
Transmembranei621 – 642Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini643 – 653CytoplasmicSequence analysisAdd BLAST11
Transmembranei654 – 674Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini675 – 691ExtracellularSequence analysisAdd BLAST17
Transmembranei692 – 712Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini713 – 739CytoplasmicSequence analysisAdd BLAST27
Transmembranei740 – 760Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini761 – 766ExtracellularSequence analysis6
Transmembranei767 – 789Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini790 – 835CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		976

Open Targets

More...OpenTargetsi		ENSG00000123146

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26248

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P48960

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRE5

Domain mapping of disease mutations (DMDM)

More...DMDMi		90110013

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001286821 – 835CD97 antigenAdd BLAST815
ChainiPRO_000029623521 – 530CD97 antigen subunit alphaBy similarityAdd BLAST510
ChainiPRO_0000296236531 – 835CD97 antigen subunit betaBy similarityAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 36PROSITE-ProRule annotation
Disulfide bondi30 ↔ 42PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi68 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 91PROSITE-ProRule annotation
Disulfide bondi93 ↔ 114PROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Disulfide bondi127 ↔ 142PROSITE-ProRule annotation
Disulfide bondi144 ↔ 158PROSITE-ProRule annotation
Disulfide bondi164 ↔ 177PROSITE-ProRule annotation
Disulfide bondi171 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 207PROSITE-ProRule annotation
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi213 ↔ 226PROSITE-ProRule annotation
Disulfide bondi220 ↔ 235PROSITE-ProRule annotation
Disulfide bondi237 ↔ 256PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei815PhosphoserineCombined sources1
Modified residuei816PhosphothreonineCombined sources1
Modified residuei818PhosphoserineCombined sources1
Modified residuei825PhosphothreonineCombined sources1
Modified residuei831PhosphoserineCombined sources1
Modified residuei833PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei530 – 531CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P48960

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P48960

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P48960

MaxQB - The MaxQuant DataBase

More...MaxQBi		P48960

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48960

PeptideAtlas

More...PeptideAtlasi		P48960

PRoteomics IDEntifications database

More...PRIDEi		P48960

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55949 [P48960-1]
55950 [P48960-2]
55951 [P48960-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P48960-2 [P48960-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1090

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48960

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P48960

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P48960

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Rapid up-regulation during lymphocyte activation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123146 Expressed in 172 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P48960 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P48960 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA013707

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).

Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107414, 61 interactors

Database of interacting proteins

More...DIPi		DIP-52292N

Protein interaction database and analysis system

More...IntActi		P48960, 56 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000242786

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48960

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 63EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini64 – 115EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST52
Domaini116 – 159EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini160 – 208EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini209 – 257EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini492 – 542GPSPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
Binding to chondroitin sulfate is mediated by the fourth EGF domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160578

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48960

KEGG Orthology (KO)

More...KOi		K08446

Identification of Orthologs from Complete Genome Data

More...OMAi		ARMLLNW

Database of Orthologous Groups

More...OrthoDBi		210309at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48960

TreeFam database of animal gene trees

More...TreeFami		TF316380

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 4 hits
PF01825 GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01278 CD97PROTEIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00303 GPS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 4 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48960-1) [UniParc]FASTAAdd to basket
Also known as: EGF(1,2,3,4,5)

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS 
        60         70         80         90        100
FSEIITTPTE TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV 
       110        120        130        140        150
SGAKTFKNES ENTCQDVDEC QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF 
       160        170        180        190        200
IPEDPKVCTD VNECTSGQNP CHSSTHCLNN VGSYQCRCRP GWQPIPGSPN 
       210        220        230        240        250
GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG WKPRHGIPNN 
       260        270        280        290        300
QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN 
       310        320        330        340        350
VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF 
       360        370        380        390        400
TYISPSNTEL TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG 
       410        420        430        440        450
ILSIQNMTTL LANASLNLHS KKQAELEEIY ESSIRGVQLR RLSAVNSIFL 
       460        470        480        490        500
SHNNTKELNS PILFAFSHLE SSDGEAGRDP PAKDVMPGPR QELLCAFWKS 
       510        520        530        540        550
DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY DVEDWKLTLI 
       560        570        580        590        600
TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG 
       610        620        630        640        650
IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL 
       660        670        680        690        700
STRWLCLIGY GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV 
       710        720        730        740        750
TFIILCNAVI FVTTVWKLTQ KFSEINPDMK KLKKARALTI TAIAQLFLLG 
       760        770        780        790        800
CTWVFGLFIF DDRSLVLTYV FTILNCLQGA FLYLLHCLLN KKVREEYRKW 
       810        820        830 
ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI
Length:835
Mass (Da):91,869
Last modified:March 21, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06DDDE9178BC494B
GO
Isoform 2 (identifier: P48960-2) [UniParc]FASTAAdd to basket
Also known as: EGF(1,2,5)

The sequence of this isoform differs from the canonical sequence as follows:
     116-208: Missing.

Show »
Length:742
Mass (Da):81,743
Checksum:iC98F20493CA3E482
GO
Isoform 3 (identifier: P48960-3) [UniParc]FASTAAdd to basket
Also known as: EGF(1,2,3,5)

The sequence of this isoform differs from the canonical sequence as follows:
     160-208: Missing.

Show »
Length:786
Mass (Da):86,628
Checksum:i03982263B73EFA2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKV5K7EKV5_HUMAN
Adhesion G protein-coupled receptor...
ADGRE5
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPP8K7EPP8_HUMAN
Adhesion G protein-coupled receptor...
ADGRE5
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPE8K7EPE8_HUMAN
Adhesion G protein-coupled receptor...
ADGRE5
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC27673 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC06178 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103A → T in AAB36682 (PubMed:8955192).Curated1
Sequence conflicti512G → V (PubMed:7636245).Curated1
Sequence conflicti512G → V (PubMed:8786105).Curated1
Sequence conflicti534A → T (PubMed:7636245).Curated1
Sequence conflicti534A → T (PubMed:8786105).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017760367R → Q. Corresponds to variant dbSNP:rs2230748Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009411116 – 208Missing in isoform 2. 4 PublicationsAdd BLAST93
Alternative sequenceiVSP_009412160 – 208Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X84700 mRNA Translation: CAA59173.1
X94630
, X94631, X94632, X94633, Z99830, Z99831, X94634, X94635, X94636, X94637, X94638, X94639, X94640, X94641, X94642, X94643, X94644, X94645, X94646, X94647 Genomic DNA Translation: CAA64333.1
U76764 mRNA Translation: AAB36682.1
AB065966 Genomic DNA Translation: BAC06178.1 Sequence problems.
AC005327 Genomic DNA Translation: AAC27673.1 Sequence problems.
AK292159 mRNA Translation: BAF84848.1
AK314697 mRNA Translation: BAG37246.1
CH471106 Genomic DNA Translation: EAW84412.1
CH471106 Genomic DNA Translation: EAW84413.1
BC026690 mRNA Translation: AAH26690.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32929.1 [P48960-1]
CCDS32930.1 [P48960-3]
CCDS32931.1 [P48960-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I37225

NCBI Reference Sequences

More...RefSeqi		NP_001020331.1, NM_001025160.2 [P48960-3]
NP_001775.2, NM_001784.4 [P48960-2]
NP_510966.1, NM_078481.3 [P48960-1]
XP_016883036.1, XM_017027547.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000242786; ENSP00000242786; ENSG00000123146 [P48960-1]
ENST00000357355; ENSP00000349918; ENSG00000123146 [P48960-3]
ENST00000358600; ENSP00000351413; ENSG00000123146 [P48960-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:976

UCSC genome browser

More...UCSCi		uc002myl.4 human [P48960-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84700 mRNA Translation: CAA59173.1
X94630
, X94631, X94632, X94633, Z99830, Z99831, X94634, X94635, X94636, X94637, X94638, X94639, X94640, X94641, X94642, X94643, X94644, X94645, X94646, X94647 Genomic DNA Translation: CAA64333.1
U76764 mRNA Translation: AAB36682.1
AB065966 Genomic DNA Translation: BAC06178.1 Sequence problems.
AC005327 Genomic DNA Translation: AAC27673.1 Sequence problems.
AK292159 mRNA Translation: BAF84848.1
AK314697 mRNA Translation: BAG37246.1
CH471106 Genomic DNA Translation: EAW84412.1
CH471106 Genomic DNA Translation: EAW84413.1
BC026690 mRNA Translation: AAH26690.1
CCDSiCCDS32929.1 [P48960-1]
CCDS32930.1 [P48960-3]
CCDS32931.1 [P48960-2]
PIRiI37225
RefSeqiNP_001020331.1, NM_001025160.2 [P48960-3]
NP_001775.2, NM_001784.4 [P48960-2]
NP_510966.1, NM_078481.3 [P48960-1]
XP_016883036.1, XM_017027547.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BOUX-ray1.90A22-32[»]
SMRiP48960
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107414, 61 interactors
DIPiDIP-52292N
IntActiP48960, 56 interactors
STRINGi9606.ENSP00000242786

Protein family/group databases

MEROPSiP02.002
TCDBi9.A.14.6.2 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyConnecti1090
iPTMnetiP48960
PhosphoSitePlusiP48960
SwissPalmiP48960

Polymorphism and mutation databases

BioMutaiADGRE5
DMDMi90110013

Proteomic databases

EPDiP48960
jPOSTiP48960
MassIVEiP48960
MaxQBiP48960
PaxDbiP48960
PeptideAtlasiP48960
PRIDEiP48960
ProteomicsDBi55949 [P48960-1]
55950 [P48960-2]
55951 [P48960-3]
TopDownProteomicsiP48960-2 [P48960-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		976

Genome annotation databases

EnsembliENST00000242786; ENSP00000242786; ENSG00000123146 [P48960-1]
ENST00000357355; ENSP00000349918; ENSG00000123146 [P48960-3]
ENST00000358600; ENSP00000351413; ENSG00000123146 [P48960-2]
GeneIDi976
KEGGihsa:976
UCSCiuc002myl.4 human [P48960-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		976
DisGeNETi976

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRE5
HGNCiHGNC:1711 CD97
HPAiHPA013707
MIMi601211 gene
neXtProtiNX_P48960
OpenTargetsiENSG00000123146
PharmGKBiPA26248

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000160578
InParanoidiP48960
KOiK08446
OMAiARMLLNW
OrthoDBi210309at2759
PhylomeDBiP48960
TreeFamiTF316380

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-6798695 Neutrophil degranulation
SIGNORiP48960

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRE5 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD97

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		976
PharosiP48960

Protein Ontology

More...PROi		PR:P48960

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123146 Expressed in 172 organ(s), highest expression level in blood
ExpressionAtlasiP48960 baseline and differential
GenevisibleiP48960 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 4 hits
PF01825 GPS, 1 hit
PRINTSiPR01278 CD97PROTEIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00303 GPS, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 4 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD97_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48960
Secondary accession number(s): A8K7Z4
, B2RBJ9, O00718, O76101, Q8NG72, Q8TBQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 21, 2006
Last modified: October 16, 2019
This is version 198 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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