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Entry version 166 (18 Sep 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Prolactin-releasing peptide receptor

Gene

PRLHR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P49683

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49683

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolactin-releasing peptide receptor
Short name:
PrRP receptor
Short name:
PrRPR
Alternative name(s):
G-protein coupled receptor 10
hGR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRLHR
Synonyms:GPR10, GR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4464 PRLHR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600895 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49683

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 101CytoplasmicSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini123 – 126ExtracellularSequence analysis4
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 175CytoplasmicSequence analysisAdd BLAST28
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 225ExtracellularSequence analysisAdd BLAST29
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini247 – 276CytoplasmicSequence analysisAdd BLAST30
Transmembranei277 – 297Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini298 – 317ExtracellularSequence analysisAdd BLAST20
Transmembranei318 – 338Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini339 – 369CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi365 – 370Missing : Abolishes binding to GRIP1 and PICK1. 6
Mutagenesisi365T → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi366V → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi367S → A: Abolishes binding to GRIP1. 1 Publication1
Mutagenesisi368V → A: Abolishes binding to GRIP1. 1 Publication1
Mutagenesisi369V → A: No effect on binding to GRIP1. 1 Publication1
Mutagenesisi370I → A: Abolishes binding to GRIP1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2834

Open Targets

More...
OpenTargetsi
ENSG00000119973

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28847

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1681611

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
337

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRLHR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695241 – 370Prolactin-releasing peptide receptorAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi134 ↔ 211PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49683

PeptideAtlas

More...
PeptideAtlasi
P49683

PRoteomics IDEntifications database

More...
PRIDEi
P49683

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56050

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49683

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49683

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Only detected in the pituitary gland and in all cell types of pituitary adenomas.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by bromocriptine, a dopamine agonist.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119973 Expressed in 38 organ(s), highest expression level in pituitary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49683 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039361

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1.

Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GRIP1Q9Y3R02EBI-8009236,EBI-5349621

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109095, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P49683, 3 interactors

Molecular INTeraction database

More...
MINTi
P49683

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239032

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P49683

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49683

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni365 – 370Required for interaction with GRIP1, GRIP2 and PICK11 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000050229

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49683

KEGG Orthology (KO)

More...
KOi
K04314

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYHVELK

Database of Orthologous Groups

More...
OrthoDBi
1072979at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49683

TreeFam database of animal gene trees

More...
TreeFami
TF315303

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001402 Prolrel_pep_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24235:SF11 PTHR24235:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR01018 PRPRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSTTRGPR VSDLFSGLPP AVTTPANQSA EASAGNGSVA GADAPAVTPF
60 70 80 90 100
QSLQLVHQLK GLIVLLYSVV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG
110 120 130 140 150
NLALSDVLMC TACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF
160 170 180 190 200
TLTTIAVDRY VVLVHPLRRR ISLRLSAYAV LAIWALSAVL ALPAAVHTYH
210 220 230 240 250
VELKPHDVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV ILLSYVRVSV
260 270 280 290 300
KLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVIVVVFAVC WLPLHVFNLL
310 320 330 340 350
RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL
360 370
VAWPRKIAPH GQNMTVSVVI
Length:370
Mass (Da):41,121
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47F71490A080C81F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50504 differs from that shown. Reason: Frameshift at positions 168 and 175.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89R → P in AAC50504 (PubMed:8666380).Curated1
Sequence conflicti194A → P in AAC50504 (PubMed:8666380).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023948283I → V4 PublicationsCorresponds to variant dbSNP:rs1613448Ensembl.1
Natural variantiVAR_029746302D → G. Corresponds to variant dbSNP:rs8192523Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32672 Genomic DNA Translation: AAC50504.1 Frameshift.
AB015745 mRNA Translation: BAA31159.1
AB048946 Genomic DNA Translation: BAB83030.1
AL356865 Genomic DNA No translation available.
BC095539 mRNA Translation: AAH95539.1
BC101490 mRNA Translation: AAI01491.1
BC101492 mRNA Translation: AAI01493.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7606.1

NCBI Reference Sequences

More...
RefSeqi
NP_004239.1, NM_004248.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000239032; ENSP00000239032; ENSG00000119973
ENST00000636925; ENSP00000490073; ENSG00000119973

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2834

UCSC genome browser

More...
UCSCi
uc001ldp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32672 Genomic DNA Translation: AAC50504.1 Frameshift.
AB015745 mRNA Translation: BAA31159.1
AB048946 Genomic DNA Translation: BAB83030.1
AL356865 Genomic DNA No translation available.
BC095539 mRNA Translation: AAH95539.1
BC101490 mRNA Translation: AAI01491.1
BC101492 mRNA Translation: AAI01493.1
CCDSiCCDS7606.1
RefSeqiNP_004239.1, NM_004248.2

3D structure databases

SMRiP49683
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109095, 3 interactors
IntActiP49683, 3 interactors
MINTiP49683
STRINGi9606.ENSP00000239032

Chemistry databases

BindingDBiP49683
ChEMBLiCHEMBL1681611
GuidetoPHARMACOLOGYi337

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP49683
PhosphoSitePlusiP49683

Polymorphism and mutation databases

BioMutaiPRLHR
DMDMi311033415

Proteomic databases

PaxDbiP49683
PeptideAtlasiP49683
PRIDEiP49683
ProteomicsDBi56050

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239032; ENSP00000239032; ENSG00000119973
ENST00000636925; ENSP00000490073; ENSG00000119973
GeneIDi2834
KEGGihsa:2834
UCSCiuc001ldp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2834
DisGeNETi2834

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRLHR
HGNCiHGNC:4464 PRLHR
HPAiHPA039361
MIMi600895 gene
neXtProtiNX_P49683
OpenTargetsiENSG00000119973
PharmGKBiPA28847

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000162008
HOGENOMiHOG000050229
InParanoidiP49683
KOiK04314
OMAiTYHVELK
OrthoDBi1072979at2759
PhylomeDBiP49683
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
SignaLinkiP49683
SIGNORiP49683

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Prolactin-releasing_peptide_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2834

Pharos

More...
Pharosi
P49683

Protein Ontology

More...
PROi
PR:P49683

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119973 Expressed in 38 organ(s), highest expression level in pituitary gland
GenevisibleiP49683 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001402 Prolrel_pep_rcpt
PANTHERiPTHR24235:SF11 PTHR24235:SF11, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01018 PRPRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRLHR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49683
Secondary accession number(s): O75194, Q502U8, Q5VXR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: September 18, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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