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Entry version 171 (11 Dec 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Transcription initiation factor TFIID subunit 5

Gene

Taf5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P49846

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
TAFII-80
Transcription initiation factor TFIID 85 kDa subunit
Short name:
p85
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Taf5
Synonyms:TAF80
ORF Names:CG7704
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010356 Taf5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512561 – 704Transcription initiation factor TFIID subunit 5Add BLAST704

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49846

PRoteomics IDEntifications database

More...
PRIDEi
P49846

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010356 Expressed in 31 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49846 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs).

Interacts with Tbp and Taf4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9VWF25EBI-15595394,EBI-131186

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
71045, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-48906N

Protein interaction database and analysis system

More...
IntActi
P49846, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087335

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49846

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati376 – 405WD 1Add BLAST30
Repeati448 – 478WD 2Add BLAST31
Repeati490 – 520WD 3Add BLAST31
Repeati532 – 562WD 4Add BLAST31
Repeati574 – 604WD 5Add BLAST31
Repeati616 – 646WD 6Add BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0263 Eukaryota
ENOG410XPM5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49846

KEGG Orthology (KO)

More...
KOi
K03130

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMTGHKG

Database of Orthologous Groups

More...
OrthoDBi
620721at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08044 TAF5_NTD2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.500, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037783 Taf5
IPR007582 TFIID_NTD2
IPR037264 TFIID_NTD2_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR19879:SF4 PTHR19879:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04494 TFIID_NTD2, 1 hit
PF00400 WD40, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160897 SSF160897, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49846-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLEVSNING GNGTQLSHDK RELLCLLKLI KKYQLKSTEE LLCQEANVSS
60 70 80 90 100
VELSEISESD VQQVLGAVLG AGDANRERKH VQSPAQGHKQ SAVTEANAAE
110 120 130 140 150
ELAKFIDDDS FDAQHYEQAY KELRTFVEDS LDIYKHELSM VLYPILVQIY
160 170 180 190 200
FKILASGLRE KAKEFIEKYK CDLDGYYIEG LFNLLLLSKP EELLENDLVV
210 220 230 240 250
AMEQDKFVIR MSRDSHSLFK RHIQDRRQEV VADIVSKYLH FDTYEGMARN
260 270 280 290 300
KLQCVATAGS HLGEAKRQDN KMRVYYGLLK EVDFQTLTTP APAPEEEDDD
310 320 330 340 350
PDAPDRPKKK KPKKDPLLSK KSKSDPNAPS IDRIPLPELK DSDKLLKLKA
360 370 380 390 400
LREASKRLAL SKDQLPSAVF YTVLNSHQGV TCAEISDDST MLACGFGDSS
410 420 430 440 450
VRIWSLTPAK LRTLKDADSL RELDKESADI NVRMLDDRSG EVTRSLMGHT
460 470 480 490 500
GPVYRCAFAP EMNLLLSCSE DSTIRLWSLL TWSCVVTYRG HVYPVWDVRF
510 520 530 540 550
APHGYYFVSC SYDKTARLWA TDSNQALRVF VGHLSDVDCV QFHPNSNYVA
560 570 580 590 600
TGSSDRTVRL WDNMTGQSVR LMTGHKGSVS SLAFSACGRY LASGSVDHNI
610 620 630 640 650
IIWDLSNGSL VTTLLRHTST VTTITFSRDG TVLAAAGLDN NLTLWDFHKV
660 670 680 690 700
TEDYISNHIT VSHHQDENDE DVYLMRTFPS KNSPFVSLHF TRRNLLMCVG

LFKS
Length:704
Mass (Da):79,325
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4E2F12534501EF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti410 – 411KL → NV AA sequence (PubMed:8483503).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U06460 mRNA Translation: AAC46481.1
AE013599 Genomic DNA Translation: AAF58737.1
AY051960 mRNA Translation: AAK93384.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S33263

NCBI Reference Sequences

More...
RefSeqi
NP_476957.1, NM_057609.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088240; FBpp0087335; FBgn0010356

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7704

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06460 mRNA Translation: AAC46481.1
AE013599 Genomic DNA Translation: AAF58737.1
AY051960 mRNA Translation: AAK93384.1
PIRiS33263
RefSeqiNP_476957.1, NM_057609.6

3D structure databases

SMRiP49846
ModBaseiSearch...

Protein-protein interaction databases

BioGridi71045, 25 interactors
DIPiDIP-48906N
IntActiP49846, 8 interactors
STRINGi7227.FBpp0087335

Proteomic databases

PaxDbiP49846
PRIDEiP49846

Genome annotation databases

EnsemblMetazoaiFBtr0088240; FBpp0087335; FBgn0010356
GeneIDi47900
KEGGidme:Dmel_CG7704

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6877
FlyBaseiFBgn0010356 Taf5

Phylogenomic databases

eggNOGiKOG0263 Eukaryota
ENOG410XPM5 LUCA
GeneTreeiENSGT00940000153342
InParanoidiP49846
KOiK03130
OMAiLMTGHKG
OrthoDBi620721at2759
PhylomeDBiP49846

Enzyme and pathway databases

ReactomeiR-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SignaLinkiP49846

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47900

Protein Ontology

More...
PROi
PR:P49846

Gene expression databases

BgeeiFBgn0010356 Expressed in 31 organ(s), highest expression level in embryo
GenevisibleiP49846 DM

Family and domain databases

CDDicd08044 TAF5_NTD2, 1 hit
Gene3Di1.25.40.500, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037783 Taf5
IPR007582 TFIID_NTD2
IPR037264 TFIID_NTD2_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19879:SF4 PTHR19879:SF4, 1 hit
PfamiView protein in Pfam
PF04494 TFIID_NTD2, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF160897 SSF160897, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF5_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49846
Secondary accession number(s): Q9V5R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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