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Entry version 158 (16 Oct 2019)
Sequence version 3 (26 Feb 2008)
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Protein

Selenoprotein P

Gene

SELENOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • selenium binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandSelenium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Selenoprotein P1 Publication
Short name:
SeP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SELENOP1 PublicationImported
Synonyms:SELPImported, SEPP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10751 SELENOP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601484 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49908

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6414

Open Targets

More...
OpenTargetsi
ENSG00000250722

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49908

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11127 Selenious acid
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SELENOP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046864

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002231320 – 381Selenoprotein PAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi119N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi128N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi174N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266PhosphoserineCombined sources1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49908

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49908

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49908

PeptideAtlas

More...
PeptideAtlasi
P49908

PRoteomics IDEntifications database

More...
PRIDEi
P49908

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56176

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1729

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000250722 Expressed in 251 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49908 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49908 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036287

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112313, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P49908, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420939

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 249Poly-His6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the selenoprotein P family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXIQ Eukaryota
ENOG4111JK7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049326

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49908

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASXYLCI

Database of Orthologous Groups

More...
OrthoDBi
1197628at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49908

TreeFam database of animal gene trees

More...
TreeFami
TF333425

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007671 Selenoprotein-P_N
IPR007672 SelP_C
IPR037941 SeP

The PANTHER Classification System

More...
PANTHERi
PTHR10105 PTHR10105, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04593 SelP_C, 1 hit
PF04592 SelP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P49908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT
60 70 80 90 100
VVALLQASUY LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY
110 120 130 140 150
THLKNKVSEH IPVYQQEENQ TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP
160 170 180 190 200
FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL KDEDFCKRVS LATVDKTVET
210 220 230 240 250
PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP PGLHHHHKHK
260 270 280 290 300
GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRSU
310 320 330 340 350
CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA
360 370 380
AUQISQQLIP TEASASURUK NQAKKUEUPS N
Length:381
Mass (Da):43,174
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00872B8030840B02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMT5R4GMT5_HUMAN
Selenoprotein P
SELENOP
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A182DWH7A0A182DWH7_HUMAN
Selenoprotein P
SELENOP
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A182DWH8A0A182DWH8_HUMAN
Selenoprotein P
SELENOP
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64 – 65LQ → IE in CAA77836 (PubMed:8421687).Curated2
Sequence conflicti187K → E in AAH15875 (PubMed:15489334).Curated1
Sequence conflicti347L → F in AAH46152 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023256112P → S1 PublicationCorresponds to variant dbSNP:rs28919895Ensembl.1
Natural variantiVAR_023257234A → T2 PublicationsCorresponds to variant dbSNP:rs3877899Ensembl.1
Natural variantiVAR_023258278R → Q1 PublicationCorresponds to variant dbSNP:rs28919923Ensembl.1
Natural variantiVAR_023259314S → P1 PublicationCorresponds to variant dbSNP:rs28919925Ensembl.1
Natural variantiVAR_023260368R → C1 PublicationCorresponds to variant dbSNP:rs28919926Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei59Selenocysteine1
Non-standard residuei300Selenocysteine1
Non-standard residuei318Selenocysteine1
Non-standard residuei330Selenocysteine1
Non-standard residuei345Selenocysteine1
Non-standard residuei352Selenocysteine1
Non-standard residuei367Selenocysteine1
Non-standard residuei369Selenocysteine1
Non-standard residuei376Selenocysteine1
Non-standard residuei378Selenocysteine1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z11793 mRNA Translation: CAA77836.2
DQ022288 Genomic DNA Translation: AAY26400.1
AC008945 Genomic DNA No translation available.
BC005244 mRNA No translation available.
BC015875 mRNA Translation: AAH15875.1
BC040075 mRNA Translation: AAH40075.1
BC046152 mRNA Translation: AAH46152.1
BC058919 mRNA Translation: AAH58919.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43311.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47327

NCBI Reference Sequences

More...
RefSeqi
NP_001078955.1, NM_001085486.2
NP_001087195.1, NM_001093726.2
NP_005401.3, NM_005410.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000506577; ENSP00000425915; ENSG00000250722
ENST00000511224; ENSP00000427671; ENSG00000250722
ENST00000514985; ENSP00000420939; ENSG00000250722

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6414

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6414

UCSC genome browser

More...
UCSCi
uc011cpt.3 human

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11793 mRNA Translation: CAA77836.2
DQ022288 Genomic DNA Translation: AAY26400.1
AC008945 Genomic DNA No translation available.
BC005244 mRNA No translation available.
BC015875 mRNA Translation: AAH15875.1
BC040075 mRNA Translation: AAH40075.1
BC046152 mRNA Translation: AAH46152.1
BC058919 mRNA Translation: AAH58919.1
CCDSiCCDS43311.1
PIRiA47327
RefSeqiNP_001078955.1, NM_001085486.2
NP_001087195.1, NM_001093726.2
NP_005401.3, NM_005410.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112313, 4 interactors
IntActiP49908, 15 interactors
STRINGi9606.ENSP00000420939

Chemistry databases

DrugBankiDB11127 Selenious acid
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

PTM databases

GlyConnecti1729
iPTMnetiP49908
PhosphoSitePlusiP49908

Polymorphism and mutation databases

BioMutaiSELENOP
DMDMi172046864

Proteomic databases

jPOSTiP49908
MassIVEiP49908
PaxDbiP49908
PeptideAtlasiP49908
PRIDEiP49908
ProteomicsDBi56176

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6414

Genome annotation databases

EnsembliENST00000506577; ENSP00000425915; ENSG00000250722
ENST00000511224; ENSP00000427671; ENSG00000250722
ENST00000514985; ENSP00000420939; ENSG00000250722
GeneIDi6414
KEGGihsa:6414
UCSCiuc011cpt.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6414
DisGeNETi6414

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SELENOP
HGNCiHGNC:10751 SELENOP
HPAiHPA036287
MIMi601484 gene
neXtProtiNX_P49908
OpenTargetsiENSG00000250722
PharmGKBiPA35672

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXIQ Eukaryota
ENOG4111JK7 LUCA
GeneTreeiENSGT00510000049326
InParanoidiP49908
OMAiASXYLCI
OrthoDBi1197628at2759
PhylomeDBiP49908
TreeFamiTF333425

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SELENOP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEPP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6414
PharosiP49908

Protein Ontology

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PROi
PR:P49908

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000250722 Expressed in 251 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiP49908 baseline and differential
GenevisibleiP49908 HS

Family and domain databases

InterProiView protein in InterPro
IPR007671 Selenoprotein-P_N
IPR007672 SelP_C
IPR037941 SeP
PANTHERiPTHR10105 PTHR10105, 1 hit
PfamiView protein in Pfam
PF04593 SelP_C, 1 hit
PF04592 SelP_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEPP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49908
Secondary accession number(s): Q6PD59
, Q6PI43, Q6PI87, Q6PJF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 26, 2008
Last modified: October 16, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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