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Entry version 157 (08 May 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Kinetochore-associated protein 1

Gene

KNTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.Curated3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore-associated protein 1
Alternative name(s):
Rough deal homolog
Short name:
HsROD
Short name:
Rod
Short name:
hRod
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNTC1
Synonyms:KIAA0166
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17255 KNTC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607363 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50748

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9735

Open Targets

More...
OpenTargetsi
ENSG00000184445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30184

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KNTC1

Domain mapping of disease mutations (DMDM)

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DMDMi
1723117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843121 – 2209Kinetochore-associated protein 1Add BLAST2209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1035PhosphothreonineCombined sources1
Modified residuei1045PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P50748

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P50748

MaxQB - The MaxQuant DataBase

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MaxQBi
P50748

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50748

PeptideAtlas

More...
PeptideAtlasi
P50748

PRoteomics IDEntifications database

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PRIDEi
P50748

ProteomicsDB human proteome resource

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ProteomicsDBi
56261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50748

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P50748

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184445 Expressed in 180 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P50748 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P50748 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA025241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZW10; the interaction is required for stable association with the kinetochore. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with ZWILCH.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ZWILCHQ9H9002EBI-1001245,EBI-1001239

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115084, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P50748

Database of interacting proteins

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DIPi
DIP-36479N

Protein interaction database and analysis system

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IntActi
P50748, 8 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328236

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4256 Eukaryota
ENOG410YKFS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001565

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P50748

KEGG Orthology (KO)

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KOi
K11577

Identification of Orthologs from Complete Genome Data

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OMAi
ANFNCCY

Database of Orthologous Groups

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OrthoDBi
122381at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P50748

TreeFam database of animal gene trees

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TreeFami
TF101176

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019527 RZZ-complex_KNTC1/ROD_C
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10493 Rod_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50748-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWNDIELLTN DDTGSGYLSV GSRKEHGTAL YQVDLLVKIS SEKASLNPKI
60 70 80 90 100
QACSLSDGFI IVADQSVILL DSICRSLQLH LVFDTEVDVV GLCQEGKFLL
110 120 130 140 150
VGERSGNLHL IHVTSKQTLL TNAFVQKAND ENRRTYQNLV IEKDGSNEGT
160 170 180 190 200
YYMLLLTYSG FFCITNLQLL KIQQAIENVD FSTAKKLQGQ IKSSFISTEN
210 220 230 240 250
YHTLGCLSLV AGDLASEVPV IIGGTGNCAF SKWEPDSSKK GMTVKNLIDA
260 270 280 290 300
EIIKGAKKFQ LIDNLLFVLD TDNVLSLWDI YTLTPVWNWP SLHVEEFLLT
310 320 330 340 350
TEADSPSSVT WQGITNLKLI ALTASANKKM KNLMVYSLPT MEILYSLEVS
360 370 380 390 400
SVSSLVQTGI STDTIYLLEG VCKNDPKLSE DSVSVLVLRC LTEALPENRL
410 420 430 440 450
SRLLHKHRFA EAESFAIQFG LDVELVYKVK SNHILEKLAL SSVDASEQTE
460 470 480 490 500
WQQLVDDAKE NLHKIQDDEF VVNYCLKAQW ITYETTQEML NYAKTRLLKK
510 520 530 540 550
EDKTALIYSD GLKEVLRAHA KLTTFYGAFG PEKFSGSSWI EFLNNEDDLK
560 570 580 590 600
DIFLQLKEGN LVCAQYLWLR HRANFESRFD VKMLESLLNS MSASVSLQKL
610 620 630 640 650
CPWFKNDVIP FVRRTVPEGQ IILAKWLEQA ARNLELTDKA NWPENGLQLA
660 670 680 690 700
EIFFTAEKTD ELGLASSWHW ISLKDYQNTE EVCQLRTLVN NLRELITLHR
710 720 730 740 750
KYNCKLALSD FEKENTTTIV FRMFDKVLAP ELIPSILEKF IRVYMREHDL
760 770 780 790 800
QEEELLLLYI EDLLNRCSSK STSLFETAWE AKAMAVIACL SDTDLIFDAV
810 820 830 840 850
LKIMYAAVVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM EMKKLLRGYG
860 870 880 890 900
IREVNLLNKE IMRVVRYILK QDVPSSLEDA LKVAQAFMLS DDEIYSLRII
910 920 930 940 950
DLIDREQGED CLLLLKSLPP AEAEKTAERV IIWARLALQE EPDHSKEGKA
960 970 980 990 1000
WRMSVAKTSV DILKILCDIQ KDNLQKKDEC EEMLKLFKEV ASLQENFEVF
1010 1020 1030 1040 1050
LSFEDYSNSS LVADLREQHI KAHEVAQAKH KPGSTPEPIA AEVRSPSMES
1060 1070 1080 1090 1100
KLHRQALALQ MSKQELEAEL TLRALKDGNI KTALKKCSDL FKYHCNADTG
1110 1120 1130 1140 1150
KLLFLTCQKL CQMLADNVPV TVPVGLNLPS MIHDLASQAA TICSPDFLLD
1160 1170 1180 1190 1200
ALELCKHTLM AVELSRQCQM DDCGILMKAS FGTHKDPYEE WSYSDFFSED
1210 1220 1230 1240 1250
GIVLESQMVL PVIYELISSL VPLAESKRYP LESTSLPYCS LNEGDGLVLP
1260 1270 1280 1290 1300
VINSISALLQ NLQESSQWEL ALRFVVGSFG TCLQHSVSNF MNATLSEKLF
1310 1320 1330 1340 1350
GETTLVKSRH VVMELKEKAV IFIRENATTL LHKVFNCRLV DLDLALGYCT
1360 1370 1380 1390 1400
LLPQKDVFEN LWKLIDKAWQ NYDKILAISL VGSELASLYQ EIEMGLKFRE
1410 1420 1430 1440 1450
LSTDAQWGIR LGKLGISFQP VFRQHFLTKK DLIKALVENI DMDTSLILEY
1460 1470 1480 1490 1500
CSTFQLDCDA VLQLFIETLL HNTNAGQGQG DASMDSAKRR HPKLLAKALE
1510 1520 1530 1540 1550
MVPLLTSTKD LVISLSGILH KLDPYDYEMI EVVLKVIERA DEKITNININ
1560 1570 1580 1590 1600
QALSILKHLK SYRRISPPVD LEYQYMLEHV ITLPSAAQTR LPFHLIFFGT
1610 1620 1630 1640 1650
AQNFWKILST ELSEESFPTL LLISKLMKFS LDTLYVSTAK HVFEKKLKPK
1660 1670 1680 1690 1700
LLKLTQAKSS TLINKEITKI TQTIESCLLS IVNPEWAVAI AISLAQDIPE
1710 1720 1730 1740 1750
GSFKISALKF CLYLAERWLQ NIPSQDEKRE KAEALLKKLH IQYRRSGTEA
1760 1770 1780 1790 1800
VLIAHKLNTE EYLRVIGKPA HLIVSLYEHP SINQRIQNSS GTDYPDIHAA
1810 1820 1830 1840 1850
AKEIAEVNEI NLEKVWDMLL EKWLCPSTKP GEKPSELFEL QEDEALRRVQ
1860 1870 1880 1890 1900
YLLLSRPIDY SSRMLFVFAT STTTTLGMHQ LTFAHRTRAL QCLFYLADKE
1910 1920 1930 1940 1950
TIESLFKKPI EEVKSYLRCI TFLASFETLN IPITYELFCS SPKEGMIKGL
1960 1970 1980 1990 2000
WKNHSHESMA VRLVTELCLE YKIYDLQLWN GLLQKLLGFN MIPYLRKVLK
2010 2020 2030 2040 2050
AISSIHSLWQ VPYFSKAWQR VIQIPLLSAS CPLSPDQLSD CSESLIAVLE
2060 2070 2080 2090 2100
CPVSGDLDLI GVARQYIQLE LPAFALACLM LMPHSEKRHQ QIKNFLGSCD
2110 2120 2130 2140 2150
PQVILKQLEE HMNTGQLAGF SHQIRSLILN NIINKKEFGI LAKTKYFQML
2160 2170 2180 2190 2200
KMHAMNTNNI TELVNYLAND LSLDEASVLI TEYSKHCGKP VPPDTAPCEI

LKMFLSGLS
Length:2,209
Mass (Da):250,749
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i514C948733CBFDAC
GO
Isoform 2 (identifier: P50748-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1575: Missing.
     2011-2018: VPYFSKAW → RWRSCYVA
     2019-2209: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):51,102
Checksum:i5BE89E57935B68AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ES84E7ES84_HUMAN
Kinetochore-associated protein 1
KNTC1
1,134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFL5H0YFL5_HUMAN
Kinetochore-associated protein 1
KNTC1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQF2J3KQF2_HUMAN
Kinetochore-associated protein 1
KNTC1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5V0F5H5V0_HUMAN
Kinetochore-associated protein 1
KNTC1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11483 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051082245K → N. Corresponds to variant dbSNP:rs7968222Ensembl.1
Natural variantiVAR_051083738E → D. Corresponds to variant dbSNP:rs17883249Ensembl.1
Natural variantiVAR_0510841506T → M. Corresponds to variant dbSNP:rs35315099Ensembl.1
Natural variantiVAR_0510851830P → L. Corresponds to variant dbSNP:rs7310898Ensembl.1
Natural variantiVAR_0510862021V → G. Corresponds to variant dbSNP:rs11837038Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570131 – 1575Missing in isoform 2. 1 PublicationAdd BLAST1575
Alternative sequenceiVSP_0570142011 – 2018VPYFSKAW → RWRSCYVA in isoform 2. 1 Publication8
Alternative sequenceiVSP_0570152019 – 2209Missing in isoform 2. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D79988 mRNA Translation: BAA11483.2 Different initiation.
AK093470 mRNA Translation: BAG52724.1
AC026333 Genomic DNA No translation available.
AC127002 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98334.1
BC150278 mRNA Translation: AAI50279.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45002.1 [P50748-1]

NCBI Reference Sequences

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RefSeqi
NP_055523.1, NM_014708.4 [P50748-1]
XP_006719769.1, XM_006719706.2 [P50748-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000333479; ENSP00000328236; ENSG00000184445 [P50748-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9735

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9735

UCSC genome browser

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UCSCi
uc001ucv.4 human [P50748-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79988 mRNA Translation: BAA11483.2 Different initiation.
AK093470 mRNA Translation: BAG52724.1
AC026333 Genomic DNA No translation available.
AC127002 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98334.1
BC150278 mRNA Translation: AAI50279.1
CCDSiCCDS45002.1 [P50748-1]
RefSeqiNP_055523.1, NM_014708.4 [P50748-1]
XP_006719769.1, XM_006719706.2 [P50748-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115084, 33 interactors
CORUMiP50748
DIPiDIP-36479N
IntActiP50748, 8 interactors
STRINGi9606.ENSP00000328236

PTM databases

iPTMnetiP50748
PhosphoSitePlusiP50748

Polymorphism and mutation databases

BioMutaiKNTC1
DMDMi1723117

Proteomic databases

EPDiP50748
jPOSTiP50748
MaxQBiP50748
PaxDbiP50748
PeptideAtlasiP50748
PRIDEiP50748
ProteomicsDBi56261

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333479; ENSP00000328236; ENSG00000184445 [P50748-1]
GeneIDi9735
KEGGihsa:9735
UCSCiuc001ucv.4 human [P50748-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9735
DisGeNETi9735

GeneCards: human genes, protein and diseases

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GeneCardsi
KNTC1
HGNCiHGNC:17255 KNTC1
HPAiHPA025241
MIMi607363 gene
neXtProtiNX_P50748
OpenTargetsiENSG00000184445
PharmGKBiPA30184

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4256 Eukaryota
ENOG410YKFS LUCA
GeneTreeiENSGT00390000007883
HOGENOMiHOG000001565
InParanoidiP50748
KOiK11577
OMAiANFNCCY
OrthoDBi122381at2759
PhylomeDBiP50748
TreeFamiTF101176

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KNTC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9735

Protein Ontology

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PROi
PR:P50748

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184445 Expressed in 180 organ(s), highest expression level in lung
ExpressionAtlasiP50748 baseline and differential
GenevisibleiP50748 HS

Family and domain databases

InterProiView protein in InterPro
IPR019527 RZZ-complex_KNTC1/ROD_C
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF10493 Rod_C, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKNTC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50748
Secondary accession number(s): A7E2C4, B3KSG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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