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Entry version 177 (13 Nov 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Methylosome subunit pICln

Gene

CLNS1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-191859 snRNP Assembly

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.47.1.1 the nucleotide-sensitive anion-selective channel, icln (icln) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylosome subunit pICln
Alternative name(s):
Chloride channel, nucleotide sensitive 1A
Chloride conductance regulatory protein ICln
Short name:
I(Cln)
Chloride ion current inducer protein
Short name:
ClCI
Reticulocyte pICln
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLNS1A
Synonyms:CLCI, ICLN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2080 CLNS1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602158 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1207

Open Targets

More...
OpenTargetsi
ENSG00000074201

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26607

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54105

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLNS1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851552 – 237Methylosome subunit pIClnAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei102PhosphoserineCombined sources2 Publications1
Modified residuei144PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei223PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P54105

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P54105

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P54105

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54105

PeptideAtlas

More...
PeptideAtlasi
P54105

PRoteomics IDEntifications database

More...
PRIDEi
P54105

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56643

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074201 Expressed in 236 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P54105 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P54105 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017840
HPA031707
HPA031708
HPA032045

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the methylosome, a 20S complex containing at least PRMT5/SKB1, WDR77/MEP50 and CLNS1A/pICln (PubMed:21081503, PubMed:11747828, PubMed:18984161). May mediate SNRPD1 and SNRPD3 methylation.

Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (PubMed:18984161).

Interacts with LSM10 and LSM11 (PubMed:16087681).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107617, 112 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-696 Methylosome

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P54105

Database of interacting proteins

More...
DIPi
DIP-44185N

Protein interaction database and analysis system

More...
IntActi
P54105, 44 interactors

Molecular INTeraction database

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MINTi
P54105

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000433919

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54105

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3238 Eukaryota
ENOG4111R94 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006913

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54105

KEGG Orthology (KO)

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KOi
K05019

Identification of Orthologs from Complete Genome Data

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OMAi
DFEDGME

Database of Orthologous Groups

More...
OrthoDBi
1508796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54105

TreeFam database of animal gene trees

More...
TreeFami
TF315155

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003521 ICln
IPR039924 ICln/Lot5

The PANTHER Classification System

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PANTHERi
PTHR21399 PTHR21399, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03517 Voldacs, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01348 ICLNCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P54105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLKSFPPP GPAEGLLRQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS
60 70 80 90 100
GLGFSLEYPT ISLHALSRDR SDCLGEHLYV MVNAKFEEES KEPVADEEEE
110 120 130 140 150
DSDDDVEPIT EFRFVPSDKS ALEAMFTAMC ECQALHPDPE DEDSDDYDGE
160 170 180 190 200
EYDVEAHEQG QGDIPTFYTY EEGLSHLTAE GQATLERLEG MLSQSVSSQY
210 220 230
NMAGVRTEDS IRDYEDGMEV DTTPTVAGQF EDADVDH
Length:237
Mass (Da):26,215
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE9C09884A6FF158
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJF4E9PJF4_HUMAN
Methylosome subunit pICln
CLNS1A
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMI6E9PMI6_HUMAN
Methylosome subunit pICln
CLNS1A
167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN38J3KN38_HUMAN
Methylosome subunit pICln
CLNS1A
203Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ83E9PQ83_HUMAN
Methylosome subunit pICln
CLNS1A
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN9H0YEN9_HUMAN
Methylosome subunit pICln
CLNS1A
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPU0U3KPU0_HUMAN
Methylosome subunit pICln
CLNS1A
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01573620Q → H1 Publication1
Natural variantiVAR_015737218M → T1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X91788 mRNA Translation: CAA62902.1
U17899 mRNA Translation: AAC50111.1
U53454 mRNA Translation: AAB03316.1
AF005422 mRNA Translation: AAB61444.1
AF026003 mRNA Translation: AAB88806.1
AF232708 Genomic DNA Translation: AAF76861.1
AF232224 Genomic DNA Translation: AAF76858.1
AF232225 Genomic DNA Translation: AAF76859.1
AK315259 mRNA Translation: BAG37676.1
BT019907 mRNA Translation: AAV38710.1
BC119634 mRNA Translation: AAI19635.1
BC119635 mRNA Translation: AAI19636.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8252.1

Protein sequence database of the Protein Information Resource

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PIRi
JC4135

NCBI Reference Sequences

More...
RefSeqi
NP_001284.1, NM_001293.2
NP_001298128.1, NM_001311199.1
NP_001298129.1, NM_001311200.1
NP_001298130.1, NM_001311201.1
NP_001298131.1, NM_001311202.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000525428; ENSP00000433919; ENSG00000074201
ENST00000528364; ENSP00000434311; ENSG00000074201

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1207

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1207

UCSC genome browser

More...
UCSCi
uc001oyk.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91788 mRNA Translation: CAA62902.1
U17899 mRNA Translation: AAC50111.1
U53454 mRNA Translation: AAB03316.1
AF005422 mRNA Translation: AAB61444.1
AF026003 mRNA Translation: AAB88806.1
AF232708 Genomic DNA Translation: AAF76861.1
AF232224 Genomic DNA Translation: AAF76858.1
AF232225 Genomic DNA Translation: AAF76859.1
AK315259 mRNA Translation: BAG37676.1
BT019907 mRNA Translation: AAV38710.1
BC119634 mRNA Translation: AAI19635.1
BC119635 mRNA Translation: AAI19636.1
CCDSiCCDS8252.1
PIRiJC4135
RefSeqiNP_001284.1, NM_001293.2
NP_001298128.1, NM_001311199.1
NP_001298129.1, NM_001311200.1
NP_001298130.1, NM_001311201.1
NP_001298131.1, NM_001311202.1

3D structure databases

SMRiP54105
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107617, 112 interactors
ComplexPortaliCPX-696 Methylosome
CORUMiP54105
DIPiDIP-44185N
IntActiP54105, 44 interactors
MINTiP54105
STRINGi9606.ENSP00000433919

Protein family/group databases

TCDBi1.A.47.1.1 the nucleotide-sensitive anion-selective channel, icln (icln) family

PTM databases

iPTMnetiP54105
PhosphoSitePlusiP54105

Polymorphism and mutation databases

BioMutaiCLNS1A

Proteomic databases

EPDiP54105
jPOSTiP54105
MassIVEiP54105
MaxQBiP54105
PaxDbiP54105
PeptideAtlasiP54105
PRIDEiP54105
ProteomicsDBi56643

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1207

Genome annotation databases

EnsembliENST00000525428; ENSP00000433919; ENSG00000074201
ENST00000528364; ENSP00000434311; ENSG00000074201
GeneIDi1207
KEGGihsa:1207
UCSCiuc001oyk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1207
DisGeNETi1207

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLNS1A
HGNCiHGNC:2080 CLNS1A
HPAiCAB017840
HPA031707
HPA031708
HPA032045
MIMi602158 gene
neXtProtiNX_P54105
OpenTargetsiENSG00000074201
PharmGKBiPA26607

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3238 Eukaryota
ENOG4111R94 LUCA
GeneTreeiENSGT00390000010063
HOGENOMiHOG000006913
InParanoidiP54105
KOiK05019
OMAiDFEDGME
OrthoDBi1508796at2759
PhylomeDBiP54105
TreeFamiTF315155

Enzyme and pathway databases

ReactomeiR-HSA-191859 snRNP Assembly

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLNS1A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLNS1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1207
PharosiP54105

Protein Ontology

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PROi
PR:P54105

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000074201 Expressed in 236 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP54105 baseline and differential
GenevisibleiP54105 HS

Family and domain databases

InterProiView protein in InterPro
IPR003521 ICln
IPR039924 ICln/Lot5
PANTHERiPTHR21399 PTHR21399, 1 hit
PfamiView protein in Pfam
PF03517 Voldacs, 1 hit
PRINTSiPR01348 ICLNCHANNEL

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICLN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54105
Secondary accession number(s): B2RCS9
, Q0VDK6, Q9NRD2, Q9NRD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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