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Entry version 151 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Ornithine decarboxylase antizyme 1

Gene

OAZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPolyamine biosynthesis, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 1
Short name:
AZ1
Short name:
ODC-Az
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OAZ1
Synonyms:OAZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8095 OAZ1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601579 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54368

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4946

Open Targets

More...
OpenTargetsi
ENSG00000104904

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31884

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P54368

Chemistry databases

Drug and drug target database

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DrugBanki
DB00129 Ornithine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
OAZ1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1709427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002208491 – 228Ornithine decarboxylase antizyme 1Add BLAST228

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P54368

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P54368

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P54368

PeptideAtlas

More...
PeptideAtlasi
P54368

PRoteomics IDEntifications database

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PRIDEi
P54368

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56685 [P54368-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P54368

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P54368

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by a ribosomal frameshifting mechanism in response to increased levels of intracellular polyamines.By similarity

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104904 Expressed in 251 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P54368 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54368 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009291

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (PubMed:26305948, PubMed:26443277).

Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (PubMed:12097147).

Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240).

Interacts with FAM171A1 (PubMed:30312582).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P305562EBI-948441,EBI-6623016

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111000, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P54368

Protein interaction database and analysis system

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IntActi
P54368, 21 interactors

Molecular INTeraction database

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MINTi
P54368

STRING: functional protein association networks

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STRINGi
9606.ENSP00000473381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54368

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4387 Eukaryota
ENOG4112791 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54368

KEGG Orthology (KO)

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KOi
K16548

Identification of Orthologs from Complete Genome Data

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OMAi
GPRWCDA

Database of Orthologous Groups

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OrthoDBi
1403675at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P54368

TreeFam database of animal gene trees

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TreeFami
TF314741

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.630.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029914 ODC-AZ_1
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf

The PANTHER Classification System

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PANTHERi
PTHR10279 PTHR10279, 1 hit
PTHR10279:SF8 PTHR10279:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02100 ODC_AZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55729 SSF55729, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01337 ODC_AZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by ribosomal frameshifting. AlignAdd to basket
Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.By similarity

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54368-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS
60 70 80 90 100
RVSLHCCSNP GPGPRWCSDA PHPPLKIPGG RGNSQRDHNL SANLFYSDDR
110 120 130 140 150
LNVTEELTSN DKTRILNVQS RLTDAKRINW RTVLSGGSLY IEIPGGALPE
160 170 180 190 200
GSKDSFAVLL EFAEEQLRAD HVFICFHKNR EDRAALLRTF SFLGFEIVRP
210 220
GHPLVPKRPD ACFMAYTFER ESSGEEEE
Length:228
Mass (Da):25,406
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA43B74DF030BD9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPM6K7EPM6_HUMAN
Ornithine decarboxylase antizyme 1
OAZ1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERW1K7ERW1_HUMAN
Ornithine decarboxylase antizyme 1
OAZ1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQY4J3QQY4_HUMAN
Ornithine decarboxylase antizyme 1
OAZ1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11374 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69D → C in BAA13497 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02221532R → L1 PublicationCorresponds to variant dbSNP:rs4667Ensembl.1
Natural variantiVAR_02221644G → D1 PublicationCorresponds to variant dbSNP:rs28359762Ensembl.1
Natural variantiVAR_02221750S → F1 PublicationCorresponds to variant dbSNP:rs28384673Ensembl.1
Natural variantiVAR_02221853S → F1 PublicationCorresponds to variant dbSNP:rs2230749Ensembl.1
Natural variantiVAR_022219147A → V1 PublicationCorresponds to variant dbSNP:rs28384677Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09202 mRNA Translation: AAA82155.1 Sequence problems.
U09202 mRNA Translation: AAA82154.1 Sequence problems.
D87914 mRNA Translation: BAA13497.1
D78361 mRNA Translation: BAA11373.1
D78361 mRNA Translation: BAA11374.1 Different initiation.
D89870 Genomic DNA Translation: BAA23101.1
AY865622 Genomic DNA Translation: AAW56074.1
AC004152 Genomic DNA Translation: AAC02802.1
AC004152 Genomic DNA Translation: AAC02803.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS58639.1 [P54368-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38591

NCBI Reference Sequences

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RefSeqi
NP_004143.1, NM_004152.3 [P54368-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000602676; ENSP00000473381; ENSG00000104904 [P54368-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4946

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4946

UCSC genome browser

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UCSCi
uc002lvk.4 human [P54368-1]

Keywords - Coding sequence diversityi

Polymorphism, Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09202 mRNA Translation: AAA82155.1 Sequence problems.
U09202 mRNA Translation: AAA82154.1 Sequence problems.
D87914 mRNA Translation: BAA13497.1
D78361 mRNA Translation: BAA11373.1
D78361 mRNA Translation: BAA11374.1 Different initiation.
D89870 Genomic DNA Translation: BAA23101.1
AY865622 Genomic DNA Translation: AAW56074.1
AC004152 Genomic DNA Translation: AAC02802.1
AC004152 Genomic DNA Translation: AAC02803.1
CCDSiCCDS58639.1 [P54368-1]
PIRiI38591
RefSeqiNP_004143.1, NM_004152.3 [P54368-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZGYX-ray2.63B95-219[»]
4ZGZX-ray5.81B/D110-228[»]
5BWAX-ray3.20B69-228[»]
SMRiP54368
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111000, 28 interactors
CORUMiP54368
IntActiP54368, 21 interactors
MINTiP54368
STRINGi9606.ENSP00000473381

Chemistry databases

DrugBankiDB00129 Ornithine

PTM databases

iPTMnetiP54368
PhosphoSitePlusiP54368

Polymorphism and mutation databases

BioMutaiOAZ1
DMDMi1709427

Proteomic databases

jPOSTiP54368
MassIVEiP54368
PaxDbiP54368
PeptideAtlasiP54368
PRIDEiP54368
ProteomicsDBi56685 [P54368-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4946

Genome annotation databases

EnsembliENST00000602676; ENSP00000473381; ENSG00000104904 [P54368-1]
GeneIDi4946
KEGGihsa:4946
UCSCiuc002lvk.4 human [P54368-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4946
DisGeNETi4946

GeneCards: human genes, protein and diseases

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GeneCardsi
OAZ1
HGNCiHGNC:8095 OAZ1
HPAiHPA009291
MIMi601579 gene
neXtProtiNX_P54368
OpenTargetsiENSG00000104904
PharmGKBiPA31884

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00940000159808
HOGENOMiHOG000115253
InParanoidiP54368
KOiK16548
OMAiGPRWCDA
OrthoDBi1403675at2759
PhylomeDBiP54368
TreeFamiTF314741

Enzyme and pathway databases

ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OAZ1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OAZ1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4946
PharosiP54368

Protein Ontology

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PROi
PR:P54368

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104904 Expressed in 251 organ(s), highest expression level in blood
ExpressionAtlasiP54368 baseline and differential
GenevisibleiP54368 HS

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029914 ODC-AZ_1
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF8 PTHR10279:SF8, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOAZ1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54368
Secondary accession number(s): O43382
, Q14989, Q92595, Q9UPL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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