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Entry version 215 (03 Jul 2019)
Sequence version 3 (22 Feb 2003)
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Protein

Caspase-9

Gene

CASP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei237By similarity1
Active sitei287By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.22.62 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-111458 Formation of apoptosome
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463 SMAC (DIABLO) binds to IAPs
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-9627069 Regulation of the apoptosome activity

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P55211

SIGNOR Signaling Network Open Resource

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SIGNORi
P55211

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C14.010

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-9 (EC:3.4.22.621 Publication)
Short name:
CASP-9
Alternative name(s):
Apoptotic protease Mch-6
Apoptotic protease-activating factor 3
Short name:
APAF-3
ICE-like apoptotic protease 6
Short name:
ICE-LAP6
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP9
Synonyms:MCH6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1511 CASP9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602234 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55211

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi153Y → F: Inhibits tyrosine phosphorylation. Reduces caspase-9 subunit p35 formation in response to genotoxic stress. Attenuates ABL1/c-Abl-mediated caspase-3 activation, DNA fragmentation and UV irradiation-induced apoptosis. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
842

Open Targets

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OpenTargetsi
ENSG00000132906

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26094

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2273

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1625

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASP9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
28558771

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000046401 – ?Sequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004641? – 315Caspase-9 subunit p35
PropeptideiPRO_0000004642316 – 330Add BLAST15
ChainiPRO_0000004643331 – 416Caspase-9 subunit p10Add BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125Phosphothreonine; by MAPK1Combined sources1 Publication1
Modified residuei153Phosphotyrosine; by ABL11 Publication1
Modified residuei302PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.2 Publications

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55211

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55211

MaxQB - The MaxQuant DataBase

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MaxQBi
P55211

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55211

PeptideAtlas

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PeptideAtlasi
P55211

PRoteomics IDEntifications database

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PRIDEi
P55211

ProteomicsDB human proteome resource

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ProteomicsDBi
56814
56815 [P55211-2]
56816 [P55211-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55211

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55211

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P55211

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low levels in fetal heart, at moderate levels in neonate heart, and at high levels in adult heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132906 Expressed in 232 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55211 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55211 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004348
HPA001473
HPA046488

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP.

Interacts (inactive form) with EFHD2.

Interacts with HAX1.

Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin.

Interacts with ABL1 (via SH3 domain); the interaction is direct and increases in the response of cells to genotoxic stress and ABL1/c-Abl activation.

Interacts with NleF from pathogenic E.coli.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107292, 38 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3762 Apoptosome
CPX-991 Caspase-9 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P55211

Database of interacting proteins

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DIPi
DIP-27625N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P55211

Protein interaction database and analysis system

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IntActi
P55211, 18 interactors

Molecular INTeraction database

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MINTi
P55211

STRING: functional protein association networks

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STRINGi
9606.ENSP00000330237

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P55211

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55211

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P55211

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3573 Eukaryota
ENOG410ZQIE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159698

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55211

KEGG Orthology (KO)

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KOi
K04399

Database of Orthologous Groups

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OrthoDBi
1092723at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P55211

TreeFam database of animal gene trees

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TreeFami
TF102023

Family and domain databases

Conserved Domains Database

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CDDi
cd08326 CARD_CASP9, 1 hit
cd00032 CASc, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001315 CARD
IPR042147 CARD_CASP9
IPR033171 Caspase-9
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A

The PANTHER Classification System

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PANTHERi
PTHR10454 PTHR10454, 1 hit
PTHR10454:SF157 PTHR10454:SF157, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00376 IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55211-1) [UniParc]FASTAAdd to basket
Also known as: 9L, Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS
60 70 80 90 100
RRDQARQLII DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK
110 120 130 140 150
PTLENLTPVV LRPEIRKPEV LRPETPRPVD IGSGGFGDVG ALESLRGNAD
160 170 180 190 200
LAYILSMEPC GHCLIINNVN FCRESGLRTR TGSNIDCEKL RRRFSSLHFM
210 220 230 240 250
VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ ASHLQFPGAV
260 270 280 290 300
YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS
310 320 330 340 350
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG
360 370 380 390 400
FVSWRDPKSG SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM
410
PGCFNFLRKK LFFKTS
Length:416
Mass (Da):46,281
Last modified:February 22, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78E0180DF2A3BDD2
GO
Isoform 2 (identifier: P55211-2) [UniParc]FASTAAdd to basket
Also known as: 9S, Beta

The sequence of this isoform differs from the canonical sequence as follows:
     140-289: Missing.

Show »
Length:266
Mass (Da):30,184
Checksum:iA12848BEBDC35A64
GO
Isoform 3 (identifier: P55211-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     152-154: AYI → TVL
     155-416: Missing.

Note: May function as an endogenous apoptotic inhibitor, inhibits the BAX-mediated cleavage of procaspase-3.
Show »
Length:154
Mass (Da):17,397
Checksum:iB23A46C92AC6AA11
GO
Isoform 4 (identifier: P55211-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:333
Mass (Da):36,564
Checksum:i2B62F8CFD1FF3145
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VVS7F8VVS7_HUMAN
Caspase-9
CASP9
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JRU8Q5JRU8_HUMAN
Caspase-9
CASP9
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JRU2Q5JRU2_HUMAN
Caspase-9
CASP9
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Y2H0Y6Y2_HUMAN
Caspase-9
CASP9
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3S8H0Y3S8_HUMAN
Caspase-9
CASP9
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWA5F8VWA5_HUMAN
Caspase-9
CASP9
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX72A0A087WX72_HUMAN
Caspase-9
CASP9
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32R → S in AAC50776 (PubMed:8900201).Curated1
Sequence conflicti32R → S in BAA82697 (PubMed:10384055).Curated1
Sequence conflicti32R → S in BAA87905 (Ref. 6) Curated1
Sequence conflicti96A → G in AAC50640 (PubMed:8663294).Curated1
Sequence conflicti197L → P in AAC50776 (PubMed:8900201).Curated1
Sequence conflicti197L → P in BAA82697 (PubMed:10384055).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01541528A → V4 PublicationsCorresponds to variant dbSNP:rs1052571Ensembl.1
Natural variantiVAR_01541699S → L1 PublicationCorresponds to variant dbSNP:rs4646008Ensembl.1
Natural variantiVAR_015417102T → I1 PublicationCorresponds to variant dbSNP:rs2308941Ensembl.1
Natural variantiVAR_015418106L → V1 PublicationCorresponds to variant dbSNP:rs2308938Ensembl.1
Natural variantiVAR_015419114E → D1 PublicationCorresponds to variant dbSNP:rs2020897Ensembl.1
Natural variantiVAR_059198136F → L. Corresponds to variant dbSNP:rs1132312Ensembl.1
Natural variantiVAR_015420173R → H1 PublicationCorresponds to variant dbSNP:rs2308950Ensembl.1
Natural variantiVAR_016131176G → R. Corresponds to variant dbSNP:rs2308949Ensembl.1
Natural variantiVAR_022053185I → M. Corresponds to variant dbSNP:rs9282624Ensembl.1
Natural variantiVAR_016132192R → C. Corresponds to variant dbSNP:rs2308939Ensembl.1
Natural variantiVAR_015421221Q → R2 PublicationsCorresponds to variant dbSNP:rs1052576Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442561 – 83Missing in isoform 4. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_000818140 – 289Missing in isoform 2. 4 PublicationsAdd BLAST150
Alternative sequenceiVSP_043910152 – 154AYI → TVL in isoform 3. 1 Publication3
Alternative sequenceiVSP_043911155 – 416Missing in isoform 3. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U56390 mRNA Translation: AAC50640.1
U60521 mRNA Translation: AAC50776.1
AB019205 Genomic DNA Translation: BAA82697.1
AF093130 mRNA Translation: AAD12248.1
AB015653 mRNA Translation: BAA78780.1
AB020979 mRNA Translation: BAA87905.1
AF110376 mRNA Translation: AAD13615.1
AY732490 mRNA Translation: AAV33129.1
AY214168 Genomic DNA Translation: AAO21133.1
BT006911 mRNA Translation: AAP35557.1
AK303743 mRNA Translation: BAG64715.1
AL512883 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51730.1
CH471167 Genomic DNA Translation: EAW51731.1
BC002452 mRNA Translation: AAH02452.1
BC006463 mRNA Translation: AAH06463.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS158.1 [P55211-1]
CCDS159.2 [P55211-4]
CCDS59995.1 [P55211-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02635

NCBI Reference Sequences

More...
RefSeqi
NP_001220.2, NM_001229.4 [P55211-1]
NP_001264983.1, NM_001278054.1 [P55211-2]
NP_127463.2, NM_032996.3 [P55211-4]
XP_005246071.1, XM_005246014.2 [P55211-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333868; ENSP00000330237; ENSG00000132906 [P55211-1]
ENST00000348549; ENSP00000255256; ENSG00000132906 [P55211-2]
ENST00000375890; ENSP00000365051; ENSG00000132906 [P55211-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
842

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:842

UCSC genome browser

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UCSCi
uc001awn.5 human [P55211-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
Wikipedia

Caspase-9 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56390 mRNA Translation: AAC50640.1
U60521 mRNA Translation: AAC50776.1
AB019205 Genomic DNA Translation: BAA82697.1
AF093130 mRNA Translation: AAD12248.1
AB015653 mRNA Translation: BAA78780.1
AB020979 mRNA Translation: BAA87905.1
AF110376 mRNA Translation: AAD13615.1
AY732490 mRNA Translation: AAV33129.1
AY214168 Genomic DNA Translation: AAO21133.1
BT006911 mRNA Translation: AAP35557.1
AK303743 mRNA Translation: BAG64715.1
AL512883 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51730.1
CH471167 Genomic DNA Translation: EAW51731.1
BC002452 mRNA Translation: AAH02452.1
BC006463 mRNA Translation: AAH06463.1
CCDSiCCDS158.1 [P55211-1]
CCDS159.2 [P55211-4]
CCDS59995.1 [P55211-2]
PIRiG02635
RefSeqiNP_001220.2, NM_001229.4 [P55211-1]
NP_001264983.1, NM_001278054.1 [P55211-2]
NP_127463.2, NM_032996.3 [P55211-4]
XP_005246071.1, XM_005246014.2 [P55211-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JXQX-ray2.80A/B/C/D140-416[»]
1NW9X-ray2.40B140-416[»]
2AR9X-ray2.80A/B/C/D139-416[»]
3D9TX-ray1.50C/D316-321[»]
3V3KX-ray3.49A/C/E/G/I/K/M/O141-416[»]
3YGSX-ray2.50P1-95[»]
4RHWX-ray2.10E/F1-100[»]
5JUYelectron microscopy4.10O/P/Q/R1-95[»]
5WVCX-ray2.99B/D/F1-128[»]
5WVEelectron microscopy4.40S/T/U/V/Y1-100[»]
SMRiP55211
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107292, 38 interactors
ComplexPortaliCPX-3762 Apoptosome
CPX-991 Caspase-9 complex
CORUMiP55211
DIPiDIP-27625N
ELMiP55211
IntActiP55211, 18 interactors
MINTiP55211
STRINGi9606.ENSP00000330237

Chemistry databases

BindingDBiP55211
ChEMBLiCHEMBL2273
GuidetoPHARMACOLOGYi1625

Protein family/group databases

MEROPSiC14.010

PTM databases

iPTMnetiP55211
PhosphoSitePlusiP55211

Polymorphism and mutation databases

BioMutaiCASP9
DMDMi28558771

Proteomic databases

EPDiP55211
jPOSTiP55211
MaxQBiP55211
PaxDbiP55211
PeptideAtlasiP55211
PRIDEiP55211
ProteomicsDBi56814
56815 [P55211-2]
56816 [P55211-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
842
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333868; ENSP00000330237; ENSG00000132906 [P55211-1]
ENST00000348549; ENSP00000255256; ENSG00000132906 [P55211-2]
ENST00000375890; ENSP00000365051; ENSG00000132906 [P55211-4]
GeneIDi842
KEGGihsa:842
UCSCiuc001awn.5 human [P55211-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
842
DisGeNETi842

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASP9
HGNCiHGNC:1511 CASP9
HPAiCAB004348
HPA001473
HPA046488
MIMi602234 gene
neXtProtiNX_P55211
OpenTargetsiENSG00000132906
PharmGKBiPA26094

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00940000159698
InParanoidiP55211
KOiK04399
OrthoDBi1092723at2759
PhylomeDBiP55211
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.62 2681
ReactomeiR-HSA-111458 Formation of apoptosome
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463 SMAC (DIABLO) binds to IAPs
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-9627069 Regulation of the apoptosome activity
SABIO-RKiP55211
SIGNORiP55211

Miscellaneous databases

EvolutionaryTraceiP55211

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Caspase-9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
842
PMAP-CutDBiP55211

Protein Ontology

More...
PROi
PR:P55211

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132906 Expressed in 232 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiP55211 baseline and differential
GenevisibleiP55211 HS

Family and domain databases

CDDicd08326 CARD_CASP9, 1 hit
cd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR042147 CARD_CASP9
IPR033171 Caspase-9
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454 PTHR10454, 1 hit
PTHR10454:SF157 PTHR10454:SF157, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55211
Secondary accession number(s): B4E1A3
, O95348, Q53Y70, Q5JRU9, Q5UGI1, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 22, 2003
Last modified: July 3, 2019
This is version 215 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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