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Entry version 163 (31 Jul 2019)
Sequence version 2 (08 Nov 2005)
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Protein

Cadherin-4

Gene

CDH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418990 Adherens junctions interactions
R-HSA-525793 Myogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P55283

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDH4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1763 CDH4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603006 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini170 – 734ExtracellularSequence analysisAdd BLAST565
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei735 – 756HelicalSequence analysisAdd BLAST22
Topological domaini757 – 916CytoplasmicSequence analysisAdd BLAST160

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1002

Open Targets

More...
OpenTargetsi
ENSG00000179242

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26300

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDH4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
81175161

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000374921 – 169Sequence analysisAdd BLAST149
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000003750170 – 916Cadherin-4Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi661N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55283

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P55283

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P55283

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55283

PeptideAtlas

More...
PeptideAtlasi
P55283

PRoteomics IDEntifications database

More...
PRIDEi
P55283

ProteomicsDB human proteome resource

More...
ProteomicsDBi
32401
56833 [P55283-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in brain but also found in other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179242 Expressed in 103 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P55283 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55283 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015613

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107437, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P55283, 2 interactors

Molecular INTeraction database

More...
MINTi
P55283

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484928

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55283

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 277Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini278 – 392Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini393 – 507Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini508 – 613Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini614 – 724Cadherin 5PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi873 – 888Ser-richAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158073

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231254

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55283

KEGG Orthology (KO)

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KOi
K06797

Identification of Orthologs from Complete Genome Data

More...
OMAi
NWLHINT

Database of Orthologous Groups

More...
OrthoDBi
191117at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55283

TreeFam database of animal gene trees

More...
TreeFami
TF316817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24027 PTHR24027, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE
60 70 80 90 100
GEKLLQVKFS SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF
110 120 130 140 150
TVTAWDSQTA EKWDAVVRLL VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD
160 170 180 190 200
TLLPWPQHQN ANGLRRRKRD WVIPPINVPE NSRGPFPQQL VRIRSDKDND
210 220 230 240 250
IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH ASYHLRAHAV
260 270 280 290 300
DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT
310 320 330 340 350
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE
360 370 380 390 400
KVQQYTVIVQ ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE
410 420 430 440 450
VPENRVETVV ANLTVMDRDQ PHSPNWNAVY RIISGDPSGH FSVRTDPVTN
460 470 480 490 500
EGMVTVVKAV DYELNRAFML TVMVSNQAPL ASGIQMSFQS TAGVTISIMD
510 520 530 540 550
INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ AVRYSKLSDP
560 570 580 590 600
ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT
610 620 630 640 650
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE
660 670 680 690 700
LPFVPAAVRK NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL
710 720 730 740 750
SNTSIIKVKV CPCDDNGDCT TIGAVAAAGL GTGAIVAILI CILILLTMVL
760 770 780 790 800
LFVMWMKRRE KERHTKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL
810 820 830 840 850
QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG DIGDFINEGL
860 870 880 890 900
RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG
910
PRFKKLADMY GGGEED
Length:916
Mass (Da):100,281
Last modified:November 8, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4512F94E58046D7
GO
Isoform 2 (identifier: P55283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):92,388
Checksum:iDD1D6C1B9EF29D32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX99A0A087WX99_HUMAN
Cadherin-4
CDH4
822Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRA4A0A0G2JRA4_HUMAN
Cadherin-4
CDH4
566Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88T → A in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti223D → N in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti274R → H in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti284G → C in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti299V → I in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti347L → W in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti390P → S in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti405R → S in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti405R → S no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti502N → S in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti540Q → R in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti566A → V in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti566A → V no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti641D → H in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti641D → H no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti778 – 779DN → EK in AAA35627 (PubMed:7982033).Curated2
Sequence conflicti778 – 779DN → EK no nucleotide entry (PubMed:2059658).Curated2
Sequence conflicti826A → P in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti826A → P no nucleotide entry (PubMed:2059658).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048504141A → V. Corresponds to variant dbSNP:rs34937312Ensembl.1
Natural variantiVAR_033699625K → R2 PublicationsCorresponds to variant dbSNP:rs6142884Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0455481 – 74Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L34059 mRNA Translation: AAA35627.1
AK124724 mRNA Translation: BAG54080.1
AL365401 Genomic DNA No translation available.
AL162457 Genomic DNA No translation available.
AL109911 Genomic DNA No translation available.
AL365229 Genomic DNA No translation available.
AL079336 Genomic DNA No translation available.
AL160412 Genomic DNA No translation available.
AL391316 Genomic DNA No translation available.
AL450463 Genomic DNA No translation available.
BX640515 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75409.1
BC101651 mRNA Translation: AAI01652.1
BC112150 mRNA Translation: AAI12151.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13488.1 [P55283-1]
CCDS58784.1 [P55283-2]

Protein sequence database of the Protein Information Resource

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PIRi
C38992

NCBI Reference Sequences

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RefSeqi
NP_001239268.1, NM_001252339.2 [P55283-2]
NP_001785.2, NM_001794.4 [P55283-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000543233; ENSP00000443301; ENSG00000179242 [P55283-2]
ENST00000614565; ENSP00000484928; ENSG00000179242 [P55283-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1002

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1002

UCSC genome browser

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UCSCi
uc032pok.1 human [P55283-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34059 mRNA Translation: AAA35627.1
AK124724 mRNA Translation: BAG54080.1
AL365401 Genomic DNA No translation available.
AL162457 Genomic DNA No translation available.
AL109911 Genomic DNA No translation available.
AL365229 Genomic DNA No translation available.
AL079336 Genomic DNA No translation available.
AL160412 Genomic DNA No translation available.
AL391316 Genomic DNA No translation available.
AL450463 Genomic DNA No translation available.
BX640515 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75409.1
BC101651 mRNA Translation: AAI01652.1
BC112150 mRNA Translation: AAI12151.1
CCDSiCCDS13488.1 [P55283-1]
CCDS58784.1 [P55283-2]
PIRiC38992
RefSeqiNP_001239268.1, NM_001252339.2 [P55283-2]
NP_001785.2, NM_001794.4 [P55283-1]

3D structure databases

SMRiP55283
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107437, 7 interactors
IntActiP55283, 2 interactors
MINTiP55283
STRINGi9606.ENSP00000484928

PTM databases

iPTMnetiP55283
PhosphoSitePlusiP55283

Polymorphism and mutation databases

BioMutaiCDH4
DMDMi81175161

Proteomic databases

EPDiP55283
jPOSTiP55283
MaxQBiP55283
PaxDbiP55283
PeptideAtlasiP55283
PRIDEiP55283
ProteomicsDBi32401
56833 [P55283-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543233; ENSP00000443301; ENSG00000179242 [P55283-2]
ENST00000614565; ENSP00000484928; ENSG00000179242 [P55283-1]
GeneIDi1002
KEGGihsa:1002
UCSCiuc032pok.1 human [P55283-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1002
DisGeNETi1002

GeneCards: human genes, protein and diseases

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GeneCardsi
CDH4
HGNCiHGNC:1763 CDH4
HPAiHPA015613
MIMi603006 gene
neXtProtiNX_P55283
OpenTargetsiENSG00000179242
PharmGKBiPA26300

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000158073
HOGENOMiHOG000231254
InParanoidiP55283
KOiK06797
OMAiNWLHINT
OrthoDBi191117at2759
PhylomeDBiP55283
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
R-HSA-525793 Myogenesis
SIGNORiP55283

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDH4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDH4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1002

Protein Ontology

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PROi
PR:P55283

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179242 Expressed in 103 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiP55283 baseline and differential
GenevisibleiP55283 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADH4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55283
Secondary accession number(s): B3KWB8
, G3V1P8, Q2M208, Q5VZ44, Q9BZ05
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: July 31, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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