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Entry version 157 (03 Jul 2019)
Sequence version 2 (11 Feb 2002)
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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Gene

WDR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic component of a methyltransferase complex required for the formation of N7-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N7-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, tRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315 tRNA modification in the nucleus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P57081

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00989

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4UniRule annotation
Alternative name(s):
Protein Wuho homolog1 Publication
Short name:
hWH1 Publication
WD repeat-containing protein 4UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR4UniRule annotationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12756 WDR4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605924 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57081

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Galloway-Mowat syndrome 6 (GAMOS6)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood. GAMOS6 is an autosomal recessive form with onset in infancy or early childhood. Affected individuals manifest microcephaly, global developmental delay, variable degrees of intellectual disability, and growth deficiency. Renal impairment may be age-dependent or may not be present.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081828164D → A in GAMOS6; unknown pathological significance. 1 Publication1
Natural variantiVAR_081830170R → Q in GAMOS6. 1 Publication1
Microcephaly, growth deficiency, seizures, and brain malformations (MIGSB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by intrauterine growth retardation, postnatal growth deficiency, microcephaly, facial dysmorphism, early-onset seizures, brain malformations such as partial agenesis of the corpus callosum and simplified gyration, and poor or absent psychomotor development.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081829170R → L in MIGSB. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10785
MIMi618346 phenotype
618347 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160193

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2065 Galloway-Mowat syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37360

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR4

Domain mapping of disease mutations (DMDM)

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DMDMi
20141943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513482 – 412tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei391PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P57081

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P57081

MaxQB - The MaxQuant DataBase

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MaxQBi
P57081

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P57081

PeptideAtlas

More...
PeptideAtlasi
P57081

PRoteomics IDEntifications database

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PRIDEi
P57081

ProteomicsDB human proteome resource

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ProteomicsDBi
56991
56992 [P57081-2]
56993 [P57081-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P57081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P57081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160193 Expressed in 154 organ(s), highest expression level in vagina

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P57081 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA017381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1 (PubMed:12403464, PubMed:26751069).

Interacts with FEN1; the interaction is direct (PubMed:26751069).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116001, 57 interactors

Database of interacting proteins

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DIPi
DIP-61919N

Protein interaction database and analysis system

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IntActi
P57081, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381266

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P57081

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3 – 40WD 1Add BLAST38
Repeati50 – 90WD 2Add BLAST41
Repeati94 – 131WD 3Add BLAST38
Repeati137 – 174WD 4Add BLAST38
Repeati180 – 218WD 5Add BLAST39
Repeati230 – 273WD 6Add BLAST44
Repeati319 – 373WD 7Add BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3914 Eukaryota
ENOG4111WRP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012174

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P57081

KEGG Orthology (KO)

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KOi
K15443

Identification of Orthologs from Complete Genome Data

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OMAi
CQENCVA

Database of Orthologous Groups

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OrthoDBi
937275at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P57081

TreeFam database of animal gene trees

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TreeFami
TF105877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_03056 TRM82, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028884 Trm82
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR16288 PTHR16288, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P57081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN
60 70 80 90 100
KGEDAPLDQG SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT
110 120 130 140 150
VARRCTALTF IASEEKVLVA DKSGDVYSFS VLEPHGCGRL ELGHLSMLLD
160 170 180 190 200
VAVSPDDRFI LTADRDEKIR VSWAAAPHSI ESFCLGHTEF VSRISVVPTQ
210 220 230 240 250
PGLLLSSSGD GTLRLWEYRS GRQLHCCHLA SLQELVDPQA PQKFAASRIA
260 270 280 290 300
FWCQENCVAL LCDGTPVVYI FQLDARRQQL VYRQQLAFQH QVWDVAFEET
310 320 330 340 350
QGLWVLQDCQ EAPLVLYRPV GDQWQSVPES TVLKKVSGVL RGNWAMLEGS
360 370 380 390 400
AGADASFSSL YKATFDNVTS YLKKKEERLQ QQLEKKQRRR SPPPGPDGHA
410
KKMRPGEATL SC
Length:412
Mass (Da):45,490
Last modified:February 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i394B11A2AFB1CADB
GO
Isoform 2 (identifier: P57081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):45,362
Checksum:iA32E06F66CE6574F
GO
Isoform 3 (identifier: P57081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:266
Mass (Da):29,946
Checksum:i121DF7AE95363BD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141E → K in CAB93144 (PubMed:10950928).Curated1
Sequence conflicti141E → K in CAB93145 (PubMed:10950928).Curated1
Sequence conflicti149L → V in CAB93144 (PubMed:10950928).Curated1
Sequence conflicti149L → V in CAB93145 (PubMed:10950928).Curated1
Sequence conflicti236V → A in BAG37500 (PubMed:14702039).Curated1
Sequence conflicti318R → K in BAG60319 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02012071K → N2 PublicationsCorresponds to variant dbSNP:rs2248490Ensembl.1
Natural variantiVAR_081828164D → A in GAMOS6; unknown pathological significance. 1 Publication1
Natural variantiVAR_081829170R → L in MIGSB. 1 Publication1
Natural variantiVAR_081830170R → Q in GAMOS6. 1 Publication1
Natural variantiVAR_033121266P → S2 PublicationsCorresponds to variant dbSNP:rs15736Ensembl.1
Natural variantiVAR_033122390R → Q. Corresponds to variant dbSNP:rs6586250Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369351 – 146Missing in isoform 3. 2 PublicationsAdd BLAST146
Alternative sequenceiVSP_036936243Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ243912 mRNA Translation: CAB93144.1
AJ243913 mRNA Translation: CAB93145.1
AK056343 mRNA Translation: BAG51684.1
AK292923 mRNA Translation: BAF85612.1
AK298015 mRNA Translation: BAG60319.1
AK315008 mRNA Translation: BAG37500.1
AB039887 Genomic DNA Translation: BAB13726.1
AP001629 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09528.1
CH471079 Genomic DNA Translation: EAX09529.1
BC001074 mRNA Translation: AAH01074.1
BC006341 mRNA Translation: AAH06341.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13691.1 [P57081-1]

NCBI Reference Sequences

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RefSeqi
NP_001247403.1, NM_001260474.1 [P57081-2]
NP_001247404.1, NM_001260475.1 [P57081-3]
NP_001247405.1, NM_001260476.1 [P57081-3]
NP_001247406.1, NM_001260477.1 [P57081-3]
NP_061139.2, NM_018669.5 [P57081-1]
NP_387510.1, NM_033661.4 [P57081-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000330317; ENSP00000328671; ENSG00000160193 [P57081-1]
ENST00000398208; ENSP00000381266; ENSG00000160193 [P57081-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10785

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10785

UCSC genome browser

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UCSCi
uc002zci.5 human [P57081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243912 mRNA Translation: CAB93144.1
AJ243913 mRNA Translation: CAB93145.1
AK056343 mRNA Translation: BAG51684.1
AK292923 mRNA Translation: BAF85612.1
AK298015 mRNA Translation: BAG60319.1
AK315008 mRNA Translation: BAG37500.1
AB039887 Genomic DNA Translation: BAB13726.1
AP001629 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09528.1
CH471079 Genomic DNA Translation: EAX09529.1
BC001074 mRNA Translation: AAH01074.1
BC006341 mRNA Translation: AAH06341.1
CCDSiCCDS13691.1 [P57081-1]
RefSeqiNP_001247403.1, NM_001260474.1 [P57081-2]
NP_001247404.1, NM_001260475.1 [P57081-3]
NP_001247405.1, NM_001260476.1 [P57081-3]
NP_001247406.1, NM_001260477.1 [P57081-3]
NP_061139.2, NM_018669.5 [P57081-1]
NP_387510.1, NM_033661.4 [P57081-1]

3D structure databases

SMRiP57081
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116001, 57 interactors
DIPiDIP-61919N
IntActiP57081, 9 interactors
STRINGi9606.ENSP00000381266

PTM databases

iPTMnetiP57081
PhosphoSitePlusiP57081

Polymorphism and mutation databases

BioMutaiWDR4
DMDMi20141943

Proteomic databases

EPDiP57081
jPOSTiP57081
MaxQBiP57081
PaxDbiP57081
PeptideAtlasiP57081
PRIDEiP57081
ProteomicsDBi56991
56992 [P57081-2]
56993 [P57081-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10785
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330317; ENSP00000328671; ENSG00000160193 [P57081-1]
ENST00000398208; ENSP00000381266; ENSG00000160193 [P57081-1]
GeneIDi10785
KEGGihsa:10785
UCSCiuc002zci.5 human [P57081-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10785
DisGeNETi10785

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR4
HGNCiHGNC:12756 WDR4
HPAiHPA017381
MIMi605924 gene
618346 phenotype
618347 phenotype
neXtProtiNX_P57081
OpenTargetsiENSG00000160193
Orphaneti2065 Galloway-Mowat syndrome
PharmGKBiPA37360

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3914 Eukaryota
ENOG4111WRP LUCA
GeneTreeiENSGT00390000012174
InParanoidiP57081
KOiK15443
OMAiCQENCVA
OrthoDBi937275at2759
PhylomeDBiP57081
TreeFamiTF105877

Enzyme and pathway databases

UniPathwayiUPA00989
ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol
SignaLinkiP57081

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WDR4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10785

Protein Ontology

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PROi
PR:P57081

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160193 Expressed in 154 organ(s), highest expression level in vagina
GenevisibleiP57081 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03056 TRM82, 1 hit
InterProiView protein in InterPro
IPR028884 Trm82
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16288 PTHR16288, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57081
Secondary accession number(s): A8KA58
, B2RCA3, B4DNQ7, D3DSK3, Q9BVM5, Q9HCR3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 11, 2002
Last modified: July 3, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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