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Entry version 160 (13 Nov 2019)
Sequence version 1 (27 Apr 2001)
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Protein

Sestrin-2

Gene

SESN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Cysteine sulfenic acid (-SOH) intermediate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei386Leucine; via carbonyl oxygenCombined sources1 Publication1
Binding sitei451LeucineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-9639288 Amino acids regulate mTORC1

SIGNOR Signaling Network Open Resource

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SIGNORi
P58004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sestrin-2Curated (EC:1.11.1.151 Publication)
Alternative name(s):
Hypoxia-induced gene1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SESN2Imported
Synonyms:Hi951 Publication, SEST21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20746 SESN2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607767 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P58004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86H → A: Loss of leucine-binding. 1 Publication1
Mutagenesisi87P → S: No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi113H → E: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with C-128. 1 Publication1
Mutagenesisi125C → S: Decreased alkylhydroperoxide reductase activity and loss of the ability to decrease intracellular reactive oxygen species. No effect on interaction with the GATOR2 complex. No effect on inhibition of TOR signaling. 3 Publications1
Mutagenesisi127Y → F: Decreased alkylhydroperoxide reductase activity. No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi128L → C: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with E-113. 1 Publication1
Mutagenesisi132H → A: Decreased alkylhydroperoxide reductase activity. No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi190S → W: Loss of interaction with GATOR2. No effect on leucine-binding. Unable to mediate leucine-induced inhibition of the TORC1 signaling pathway. 1 Publication1
Mutagenesisi204C → S: No effect on alkylhydroperoxide reductase activity. No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi214C → S: No effect on alkylhydroperoxide reductase activity. 1 Publication1
Mutagenesisi258V → R: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with L-259 and R-261. 1 Publication1
Mutagenesisi259E → L: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with R-258 and R-261. 1 Publication1
Mutagenesisi261L → A: Decreased leucine-binding. 1 Publication1
Mutagenesisi261L → R: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with R-258 and L-259. 1 Publication1
Mutagenesisi262 – 264MER → LMM: No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication3
Mutagenesisi264R → P: No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi314C → S: No effect on ability to decrease intracellular reactive oxygen species. 1 Publication1
Mutagenesisi336 – 337TF → AA: No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication2
Mutagenesisi340 – 341QD → AA: No effect on the ability to inhibit the TORC1 signaling pathway. 1 Publication2
Mutagenesisi373L → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-376. 1 Publication1
Mutagenesisi374T → A: Loss of leucine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi375Y → A: Loss of leucine-binding. 1 Publication1
Mutagenesisi376N → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-373. 1 Publication1
Mutagenesisi385D → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-387. 1 Publication1
Mutagenesisi386T → A: Loss of leucine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi387S → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-385. 1 Publication1
Mutagenesisi390R → A: Loss of leucine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi399C → S: No effect on alkylhydroperoxide reductase activity. Altered ability to decrease intracellular reactive oxygen species. No effect on the ability to inhibit the TORC1 signaling pathway. 2 Publications1
Mutagenesisi406 – 407DD → AA: Loss of interaction with the GATOR2 complex. No effect on leucine-binding. 1 Publication2
Mutagenesisi406D → A: No effect on alkylhydroperoxide reductase activity. Loss of interaction with the GATOR2 complex. Unable to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi407D → A: No effect on alkylhydroperoxide reductase activity. Loss of interaction with the GATOR2 complex. Unable to inhibit the TORC1 signaling pathway. 1 Publication1
Mutagenesisi409D → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-411 and A-415. 1 Publication1
Mutagenesisi411G → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-409 and A-415. 1 Publication1
Mutagenesisi415Q → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-409 and A-411. 1 Publication1
Mutagenesisi419R → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-422 and A-426. 1 Publication1
Mutagenesisi422K → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-419 and A-426. 1 Publication1
Mutagenesisi426K → A: No effect on the ability to inhibit the TORC1 signaling pathway; when associated with A-419 and A-422. 1 Publication1
Mutagenesisi430C → S: No effect on alkylhydroperoxide reductase activity. Altered ability to decrease intracellular reactive oxygen species. No effect on the ability to inhibit the TORC1 signaling pathway. 2 Publications1
Mutagenesisi444W → E: Loss of leucine-binding. 1 Publication1
Mutagenesisi444W → L: Decreased affinity for leucine. Requires increased leucine concentration to dissociate from GATOR2 and activate TORC1 signaling. 1 Publication1
Mutagenesisi451E → A: Decreased leucine-binding. 1 Publication1
Mutagenesisi451E → Q: Loss of leucine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
83667

Open Targets

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OpenTargetsi
ENSG00000130766

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134882791

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P58004

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SESN2

Domain mapping of disease mutations (DMDM)

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DMDMi
13633882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211811 – 480Sestrin-2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei249PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ULK1 at multiple sites.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P58004

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P58004

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P58004

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P58004

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P58004

PeptideAtlas

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PeptideAtlasi
P58004

PRoteomics IDEntifications database

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PRIDEi
P58004

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57043

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P58004

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58004

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by hypoxia and DNA damage (PubMed:12203114). Up-regulated by treatments inducing endoplasmic reticulum stress (PubMed:24947615).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130766 Expressed in 187 organ(s), highest expression level in kidney epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P58004 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA018191

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (PubMed:25263562, PubMed:25457612, PubMed:26449471).

Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). May interact with the TORC2 complex (By similarity).

Interacts with KEAP1, RBX1, SQSTM and ULK1; to regulate the degradation of KEAP1 (PubMed:23274085, PubMed:25040165). May also associate with the complex composed of TSC1, TSC2 and the AMP-responsive protein kinase/AMPK to regulate TORC1 signaling (PubMed:18692468). May interact with PRDX1 (PubMed:15105503).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123724, 20 interactors

Database of interacting proteins

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DIPi
DIP-62044N

Protein interaction database and analysis system

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IntActi
P58004, 20 interactors

Molecular INTeraction database

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MINTi
P58004

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253063

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P58004

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 239N-terminal domain; mediates the alkylhydroperoxide reductase activity1 PublicationAdd BLAST174
Regioni308 – 480C-terminal domain; mediates TORC1 regulation1 PublicationAdd BLAST173
Regioni374 – 377Leucine-bindingCombined sources1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of an N-terminal domain that has an alkylhydroperoxide reductase activity and a C-terminal domain that mediates interaction with GATOR2 through which it regulates TORC1 signaling.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sestrin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3746 Eukaryota
ENOG410XP7Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232949

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P58004

KEGG Orthology (KO)

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KOi
K20394

Identification of Orthologs from Complete Genome Data

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OMAi
TRRMYNH

Database of Orthologous Groups

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OrthoDBi
588598at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P58004

TreeFam database of animal gene trees

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TreeFami
TF314230

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1290.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029032 AhpD-like
IPR006730 Sestrin

The PANTHER Classification System

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PANTHERi
PTHR12474 PTHR12474, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04636 PA26, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69118 SSF69118, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P58004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVADSECRA ELKDYLRFAP GGVGDSGPGE EQRESRARRG PRGPSAFIPV
60 70 80 90 100
EEVLREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYF TSFWRLHYLL
110 120 130 140 150
LHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMAEFLQTG GDPEWLLGLH
160 170 180 190 200
RAPEKLRKLS EINKLLAHRP WLITKEHIQA LLKTGEHTWS LAELIQALVL
210 220 230 240 250
LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG
260 270 280 290 300
GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS
310 320 330 340 350
ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS
360 370 380 390 400
LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV
410 420 430 440 450
FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS
460 470 480
EKVHVNLLLL EARMQAALLY ALRAITRYMT
Length:480
Mass (Da):54,494
Last modified:April 27, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C13371316D84060
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55438 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022101320T → A. Corresponds to variant dbSNP:rs2274848Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY123223 mRNA Translation: AAM92261.1
AL136551 mRNA Translation: CAB66486.1
AK027896 mRNA Translation: BAB55438.1 Different initiation.
AK025640 mRNA No translation available.
AK315710 mRNA Translation: BAG38070.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07703.1
BC013304 mRNA Translation: AAH13304.1
BC033719 mRNA Translation: AAH33719.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS321.1

NCBI Reference Sequences

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RefSeqi
NP_113647.1, NM_031459.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000253063; ENSP00000253063; ENSG00000130766
ENST00000645231; ENSP00000496365; ENSG00000285069

Database of genes from NCBI RefSeq genomes

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GeneIDi
83667

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83667

UCSC genome browser

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UCSCi
uc001bps.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY123223 mRNA Translation: AAM92261.1
AL136551 mRNA Translation: CAB66486.1
AK027896 mRNA Translation: BAB55438.1 Different initiation.
AK025640 mRNA No translation available.
AK315710 mRNA Translation: BAG38070.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07703.1
BC013304 mRNA Translation: AAH13304.1
BC033719 mRNA Translation: AAH33719.1
CCDSiCCDS321.1
RefSeqiNP_113647.1, NM_031459.4

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CUFX-ray3.50A/B/C/D/E1-480[»]
5DJ4X-ray2.70A/B/C/D/E1-480[»]
5T0NX-ray3.00A/B/C/D/E1-480[»]
6N0MX-ray3.30A/B/C/D/E66-480[»]
SMRiP58004
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123724, 20 interactors
DIPiDIP-62044N
IntActiP58004, 20 interactors
MINTiP58004
STRINGi9606.ENSP00000253063

PTM databases

iPTMnetiP58004
PhosphoSitePlusiP58004

Polymorphism and mutation databases

BioMutaiSESN2
DMDMi13633882

Proteomic databases

EPDiP58004
jPOSTiP58004
MassIVEiP58004
MaxQBiP58004
PaxDbiP58004
PeptideAtlasiP58004
PRIDEiP58004
ProteomicsDBi57043

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
83667

Genome annotation databases

EnsembliENST00000253063; ENSP00000253063; ENSG00000130766
ENST00000645231; ENSP00000496365; ENSG00000285069
GeneIDi83667
KEGGihsa:83667
UCSCiuc001bps.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83667
DisGeNETi83667

GeneCards: human genes, protein and diseases

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GeneCardsi
SESN2
HGNCiHGNC:20746 SESN2
HPAiHPA018191
MIMi607767 gene
neXtProtiNX_P58004
OpenTargetsiENSG00000130766
PharmGKBiPA134882791

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3746 Eukaryota
ENOG410XP7Z LUCA
GeneTreeiENSGT00950000183168
HOGENOMiHOG000232949
InParanoidiP58004
KOiK20394
OMAiTRRMYNH
OrthoDBi588598at2759
PhylomeDBiP58004
TreeFamiTF314230

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-9639288 Amino acids regulate mTORC1
SIGNORiP58004

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SESN2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SESN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83667
PharosiP58004

Protein Ontology

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PROi
PR:P58004

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130766 Expressed in 187 organ(s), highest expression level in kidney epithelium
GenevisibleiP58004 HS

Family and domain databases

Gene3Di1.20.1290.10, 1 hit
InterProiView protein in InterPro
IPR029032 AhpD-like
IPR006730 Sestrin
PANTHERiPTHR12474 PTHR12474, 1 hit
PfamiView protein in Pfam
PF04636 PA26, 1 hit
SUPFAMiSSF69118 SSF69118, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSESN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58004
Secondary accession number(s): Q5T7D0, Q96SI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 13, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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