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Entry version 166 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315 G beta:gamma signalling through BTK
R-HSA-8964616 G beta:gamma signalling through CDC42
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P59768

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P59768

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4404 GNG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606981 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P59768

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54331

Open Targets

More...
OpenTargetsi
ENSG00000186469

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P59768

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3883319

Drug and drug target database

More...
DrugBanki
DB01159 Halothane

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32699499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000126112 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001261269 – 71Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei68Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi68S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P59768

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P59768

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P59768

MaxQB - The MaxQuant DataBase

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MaxQBi
P59768

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59768

PeptideAtlas

More...
PeptideAtlasi
P59768

PRoteomics IDEntifications database

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PRIDEi
P59768

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57156

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59768

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186469 Expressed in 193 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P59768 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P59768 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018380
HPA003534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P628734EBI-602681,EBI-357130

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119933, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P59768

Database of interacting proteins

More...
DIPi
DIP-33949N

Protein interaction database and analysis system

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IntActi
P59768, 17 interactors

Molecular INTeraction database

More...
MINTi
P59768

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334448

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59768

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P59768

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4119 Eukaryota
ENOG41122JF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193333

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59768

KEGG Orthology (KO)

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KOi
K07826

Database for complete collections of gene phylogenies

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PhylomeDBi
P59768

TreeFam database of animal gene trees

More...
TreeFami
TF319909

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00068 GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma

The PANTHER Classification System

More...
PANTHERi
PTHR13809 PTHR13809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00631 G-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00321 GPROTEING

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00224 GGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48670 SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P59768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDB74E4135E7A37A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2N0G3V2N0_HUMAN
Guanine nucleotide-binding protein ...
GNG2
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3J9G3V3J9_HUMAN
Guanine nucleotide-binding protein ...
GNG2
102Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2C9G3V2C9_HUMAN
Guanine nucleotide-binding protein ...
GNG2
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V415G3V415_HUMAN
Guanine nucleotide binding protein ...
GNG2 hCG_2013367
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2W5G3V2W5_HUMAN
Guanine nucleotide-binding protein ...
GNG2
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF493870 mRNA Translation: AAM12584.1
AL832878 mRNA Translation: CAI46198.1
CH471078 Genomic DNA Translation: EAW65663.1
BC020774 mRNA Translation: AAH20774.1
BC060856 mRNA Translation: AAH60856.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32082.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7290 GNG2

NCBI Reference Sequences

More...
RefSeqi
NP_001230702.1, NM_001243773.1
NP_001230703.1, NM_001243774.1
NP_444292.1, NM_053064.4
XP_006720236.1, XM_006720173.2
XP_011535148.1, XM_011536846.2
XP_016876865.1, XM_017021376.1
XP_016876866.1, XM_017021377.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335281; ENSP00000334448; ENSG00000186469
ENST00000554736; ENSP00000452014; ENSG00000186469
ENST00000555472; ENSP00000451102; ENSG00000186469
ENST00000556752; ENSP00000451576; ENSG00000186469
ENST00000556766; ENSP00000451231; ENSG00000186469
ENST00000615906; ENSP00000484021; ENSG00000186469

Database of genes from NCBI RefSeq genomes

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GeneIDi
54331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54331

UCSC genome browser

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UCSCi
uc001wzi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493870 mRNA Translation: AAM12584.1
AL832878 mRNA Translation: CAI46198.1
CH471078 Genomic DNA Translation: EAW65663.1
BC020774 mRNA Translation: AAH20774.1
BC060856 mRNA Translation: AAH60856.1
CCDSiCCDS32082.1
PIRiJC7290 GNG2
RefSeqiNP_001230702.1, NM_001243773.1
NP_001230703.1, NM_001243774.1
NP_444292.1, NM_053064.4
XP_006720236.1, XM_006720173.2
XP_011535148.1, XM_011536846.2
XP_016876865.1, XM_017021376.1
XP_016876866.1, XM_017021377.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45G1-68[»]
5HE0X-ray2.56G1-71[»]
5HE1X-ray3.15G1-71[»]
5HE2X-ray2.79G1-71[»]
5HE3X-ray2.74G1-71[»]
5UKKX-ray2.60G8-64[»]
5UKLX-ray2.15G8-69[»]
5UKMX-ray3.03G1-71[»]
5UZ7electron microscopy4.10G1-68[»]
6B3Jelectron microscopy3.30G1-71[»]
6CRKX-ray2.00G1-71[»]
6D9Helectron microscopy3.60G1-71[»]
6DDEelectron microscopy3.50C1-71[»]
6DDFelectron microscopy3.50C1-71[»]
6E3Yelectron microscopy3.30G1-71[»]
6EG8X-ray2.80C/E/G/H1-71[»]
6G79electron microscopy3.78G1-71[»]
6GDGelectron microscopy4.11C1-71[»]
6M8SX-ray3.71E/F/I/J/L1-71[»]
6N4Belectron microscopy3.00C1-71[»]
6NIYelectron microscopy3.34G1-71[»]
6OIJelectron microscopy3.30G1-71[»]
6OIKelectron microscopy3.60G1-71[»]
6OS9electron microscopy3.00C1-71[»]
6OSAelectron microscopy3.00C1-71[»]
6OT0electron microscopy3.90G1-71[»]
SMRiP59768
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119933, 54 interactors
CORUMiP59768
DIPiDIP-33949N
IntActiP59768, 17 interactors
MINTiP59768
STRINGi9606.ENSP00000334448

Chemistry databases

ChEMBLiCHEMBL3883319
DrugBankiDB01159 Halothane

PTM databases

iPTMnetiP59768
PhosphoSitePlusiP59768

Polymorphism and mutation databases

BioMutaiGNG2
DMDMi32699499

Proteomic databases

EPDiP59768
jPOSTiP59768
MassIVEiP59768
MaxQBiP59768
PaxDbiP59768
PeptideAtlasiP59768
PRIDEiP59768
ProteomicsDBi57156

Genome annotation databases

EnsembliENST00000335281; ENSP00000334448; ENSG00000186469
ENST00000554736; ENSP00000452014; ENSG00000186469
ENST00000555472; ENSP00000451102; ENSG00000186469
ENST00000556752; ENSP00000451576; ENSG00000186469
ENST00000556766; ENSP00000451231; ENSG00000186469
ENST00000615906; ENSP00000484021; ENSG00000186469
GeneIDi54331
KEGGihsa:54331
UCSCiuc001wzi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54331
DisGeNETi54331

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GNG2
HGNCiHGNC:4404 GNG2
HPAiCAB018380
HPA003534
MIMi606981 gene
neXtProtiNX_P59768
OpenTargetsiENSG00000186469
PharmGKBiPA28784

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00970000193333
InParanoidiP59768
KOiK07826
PhylomeDBiP59768
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315 G beta:gamma signalling through BTK
R-HSA-8964616 G beta:gamma signalling through CDC42
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP59768
SIGNORiP59768

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GNG2 human
EvolutionaryTraceiP59768

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54331
PharosiP59768

Protein Ontology

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PROi
PR:P59768

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186469 Expressed in 193 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP59768 baseline and differential
GenevisibleiP59768 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59768
Secondary accession number(s): Q5JPE2, Q6P9A9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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