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Entry version 180 (31 Jul 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Actin, cytoplasmic 2

Gene

ACTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.1 Publication

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-418990 Adherens junctions interactions
R-HSA-437239 Recycling pathway of L1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P63261

SIGNOR Signaling Network Open Resource

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SIGNORi
P63261

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin, cytoplasmic 2
Alternative name(s):
Gamma-actin
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACTG1
Synonyms:ACTG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:144 ACTG1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
102560 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P63261

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 20 (DFNA20)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03243489T → I in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs28999111EnsemblClinVar.1
Natural variantiVAR_032435118K → M in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894544EnsemblClinVar.1
Natural variantiVAR_067824118K → N in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs267606630EnsemblClinVar.1
Natural variantiVAR_067825122I → V in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs281875330EnsemblClinVar.1
Natural variantiVAR_079878187D → H in DFNA20. 1 Publication1
Natural variantiVAR_067826241E → K in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs267606631EnsemblClinVar.1
Natural variantiVAR_032436264P → L in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894546EnsemblClinVar.1
Natural variantiVAR_032437278T → I in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs28999112EnsemblClinVar.1
Natural variantiVAR_079879316E → K in DFNA20; unknown pathological significance. 1 Publication1
Natural variantiVAR_032438332P → A in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894545EnsemblClinVar.1
Natural variantiVAR_032439370V → A in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894547EnsemblClinVar.1
Baraitser-Winter syndrome 2 (BRWS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067814120T → I in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875325EnsemblClinVar.1
Natural variantiVAR_067815135A → V in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs11549190EnsemblClinVar.1
Natural variantiVAR_067816155S → F in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875326EnsemblClinVar.1
Natural variantiVAR_067817203T → K in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875327EnsemblClinVar.1
Natural variantiVAR_067818254R → W in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875328EnsemblClinVar.1
Natural variantiVAR_067819256R → W in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875329EnsemblClinVar.1
Defects in ACTG1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Keywords - Diseasei

Deafness, Disease mutation, Mental retardation, Non-syndromic deafness

Organism-specific databases

DisGeNET

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DisGeNETi
71

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ACTG1

MalaCards human disease database

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MalaCardsi
ACTG1
MIMi604717 phenotype
614583 phenotype

Open Targets

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OpenTargetsi
ENSG00000184009

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
2995 Baraitser-Winter cerebrofrontofacial syndrome
98942 Coloboma of choroid and retina
98944 Coloboma of iris

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24468

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ACTG1

Domain mapping of disease mutations (DMDM)

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DMDMi
54036678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003671001 – 375Actin, cytoplasmic 2Add BLAST375
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources3 Publications
ChainiPRO_00000008312 – 375Actin, cytoplasmic 2, N-terminally processed1 PublicationAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed; partialCombined sources4 Publications1
Modified residuei44Methionine (R)-sulfoxideBy similarity1
Modified residuei47Methionine (R)-sulfoxideBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki50(Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG11 Publication
Modified residuei73Tele-methylhistidine2 Publications1
Modified residuei84N6-methyllysine1 Publication1
Cross-linki270(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG11 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.By similarity
Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.1 Publication
Actin, cytoplasmic 2, N-terminally processed: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins (PubMed:29581253). In contrast, filament nucleation by the Arp2/3 complex is not affected (PubMed:29581253).1 Publication
Methylated at His-73 by SETD3.1 Publication
(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Oxidation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P63261

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P63261

MaxQB - The MaxQuant DataBase

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MaxQBi
P63261

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P63261

PeptideAtlas

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PeptideAtlasi
P63261

PRoteomics IDEntifications database

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PRIDEi
P63261

ProteomicsDB human proteome resource

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ProteomicsDBi
57514

Consortium for Top Down Proteomics

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TopDownProteomicsi
P63261

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P63261

USC-OGP 2-DE database

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OGPi
P63261

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
P63261

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P63261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P63261

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P63261

SwissPalm database of S-palmitoylation events

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SwissPalmi
P63261

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P63261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184009 Expressed in 89 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63261 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63261 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041264
HPA041271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Interacts with TWF1, CAPZB, cofilin and profilin (PubMed:28493397).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106586, 175 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P63261

Protein interaction database and analysis system

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IntActi
P63261, 87 interactors

Molecular INTeraction database

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MINTi
P63261

STRING: functional protein association networks

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STRINGi
9606.ENSP00000458162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P63261

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0676 Eukaryota
COG5277 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182960

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P63261

KEGG Orthology (KO)

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KOi
K05692

Identification of Orthologs from Complete Genome Data

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OMAi
FHTTAER

Database of Orthologous Groups

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OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P63261

TreeFam database of animal gene trees

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TreeFami
TF354237

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS

The PANTHER Classification System

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PANTHERi
PTHR11937 PTHR11937, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00022 Actin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00190 ACTIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00268 ACTIN, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P63261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):41,793
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54D08F986964EFD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT65J3KT65_HUMAN
Actin, cytoplasmic 2
ACTG1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4N8I3L4N8_HUMAN
Actin, cytoplasmic 2
ACTG1
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3R2I3L3R2_HUMAN
Actin, cytoplasmic 2
ACTG1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3I0I3L3I0_HUMAN
Actin, cytoplasmic 2
ACTG1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM38K7EM38_HUMAN
Actin, cytoplasmic 2
ACTG1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1U9I3L1U9_HUMAN
Actin, cytoplasmic 2
ACTG1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti316E → K in AAA51580 (PubMed:3472224).Curated1
Sequence conflicti344S → F in AAA51580 (PubMed:3472224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07984970P → L Found in a patient with isolated coloboma; decreased incorporation into F-actin; decreased interaction with cofilin; loss of interaction with TWF1, CAPZB and profilin. 1 Publication1
Natural variantiVAR_03243489T → I in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs28999111EnsemblClinVar.1
Natural variantiVAR_032435118K → M in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894544EnsemblClinVar.1
Natural variantiVAR_067824118K → N in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs267606630EnsemblClinVar.1
Natural variantiVAR_067814120T → I in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875325EnsemblClinVar.1
Natural variantiVAR_067825122I → V in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs281875330EnsemblClinVar.1
Natural variantiVAR_067815135A → V in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs11549190EnsemblClinVar.1
Natural variantiVAR_067816155S → F in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875326EnsemblClinVar.1
Natural variantiVAR_048186160T → I. Corresponds to variant dbSNP:rs11549206Ensembl.1
Natural variantiVAR_079878187D → H in DFNA20. 1 Publication1
Natural variantiVAR_067817203T → K in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875327EnsemblClinVar.1
Natural variantiVAR_067826241E → K in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs267606631EnsemblClinVar.1
Natural variantiVAR_067818254R → W in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875328EnsemblClinVar.1
Natural variantiVAR_067819256R → W in BRWS2. 1 PublicationCorresponds to variant dbSNP:rs281875329EnsemblClinVar.1
Natural variantiVAR_032436264P → L in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894546EnsemblClinVar.1
Natural variantiVAR_032437278T → I in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs28999112EnsemblClinVar.1
Natural variantiVAR_079879316E → K in DFNA20; unknown pathological significance. 1 Publication1
Natural variantiVAR_032438332P → A in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894545EnsemblClinVar.1
Natural variantiVAR_032439370V → A in DFNA20. 1 PublicationCorresponds to variant dbSNP:rs104894547EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04098 mRNA Translation: CAA27723.1
M19283 Genomic DNA Translation: AAA51579.1
AK291937 mRNA Translation: BAF84626.1
BT019856 mRNA Translation: AAV38659.1
BC000292 mRNA Translation: AAH00292.1
BC001920 mRNA Translation: AAH01920.1
BC007442 mRNA Translation: AAH07442.1
BC009848 mRNA Translation: AAH09848.1
BC010999 mRNA Translation: AAH10999.1
BC012050 mRNA Translation: AAH12050.1
BC015005 mRNA Translation: AAH15005.1
BC015695 mRNA Translation: AAH15695.1
BC015779 mRNA Translation: AAH15779.1
BC018774 mRNA Translation: AAH18774.1
BC053572 mRNA Translation: AAH53572.1
M16247 mRNA Translation: AAA51580.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11782.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28098 ATHUG
JC5818

NCBI Reference Sequences

More...
RefSeqi
NP_001186883.1, NM_001199954.1
NP_001605.1, NM_001614.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331925; ENSP00000331514; ENSG00000184009
ENST00000573283; ENSP00000458435; ENSG00000184009
ENST00000575087; ENSP00000459124; ENSG00000184009
ENST00000575842; ENSP00000458162; ENSG00000184009
ENST00000576544; ENSP00000461672; ENSG00000184009
ENST00000615544; ENSP00000477968; ENSG00000184009
ENST00000644774; ENSP00000493648; ENSG00000184009

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:71

UCSC genome browser

More...
UCSCi
uc002kak.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mendelian genes actin, gamma 1 (ACTG1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04098 mRNA Translation: CAA27723.1
M19283 Genomic DNA Translation: AAA51579.1
AK291937 mRNA Translation: BAF84626.1
BT019856 mRNA Translation: AAV38659.1
BC000292 mRNA Translation: AAH00292.1
BC001920 mRNA Translation: AAH01920.1
BC007442 mRNA Translation: AAH07442.1
BC009848 mRNA Translation: AAH09848.1
BC010999 mRNA Translation: AAH10999.1
BC012050 mRNA Translation: AAH12050.1
BC015005 mRNA Translation: AAH15005.1
BC015695 mRNA Translation: AAH15695.1
BC015779 mRNA Translation: AAH15779.1
BC018774 mRNA Translation: AAH18774.1
BC053572 mRNA Translation: AAH53572.1
M16247 mRNA Translation: AAA51580.1
CCDSiCCDS11782.1
PIRiA28098 ATHUG
JC5818
RefSeqiNP_001186883.1, NM_001199954.1
NP_001605.1, NM_001614.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JLHelectron microscopy3.90A/B/C/D/E2-375[»]
6CXIelectron microscopy11.00A/B/C/D/E1-375[»]
6CXJelectron microscopy11.00A/B/C/D/E1-375[»]
6G2Telectron microscopy9.00A/B/C/D/E/F1-375[»]
SMRiP63261
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106586, 175 interactors
CORUMiP63261
IntActiP63261, 87 interactors
MINTiP63261
STRINGi9606.ENSP00000458162

PTM databases

iPTMnetiP63261
PhosphoSitePlusiP63261
SwissPalmiP63261

Polymorphism and mutation databases

BioMutaiACTG1
DMDMi54036678

2D gel databases

DOSAC-COBS-2DPAGEiP63261
OGPiP63261
REPRODUCTION-2DPAGEiP63261
SWISS-2DPAGEiP63261

Proteomic databases

EPDiP63261
jPOSTiP63261
MaxQBiP63261
PaxDbiP63261
PeptideAtlasiP63261
PRIDEiP63261
ProteomicsDBi57514
TopDownProteomicsiP63261

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
71
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331925; ENSP00000331514; ENSG00000184009
ENST00000573283; ENSP00000458435; ENSG00000184009
ENST00000575087; ENSP00000459124; ENSG00000184009
ENST00000575842; ENSP00000458162; ENSG00000184009
ENST00000576544; ENSP00000461672; ENSG00000184009
ENST00000615544; ENSP00000477968; ENSG00000184009
ENST00000644774; ENSP00000493648; ENSG00000184009
GeneIDi71
KEGGihsa:71
UCSCiuc002kak.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
71
DisGeNETi71

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACTG1
GeneReviewsiACTG1
HGNCiHGNC:144 ACTG1
HPAiHPA041264
HPA041271
MalaCardsiACTG1
MIMi102560 gene
604717 phenotype
614583 phenotype
neXtProtiNX_P63261
OpenTargetsiENSG00000184009
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
2995 Baraitser-Winter cerebrofrontofacial syndrome
98942 Coloboma of choroid and retina
98944 Coloboma of iris
PharmGKBiPA24468

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00950000182960
InParanoidiP63261
KOiK05692
OMAiFHTTAER
OrthoDBi649708at2759
PhylomeDBiP63261
TreeFamiTF354237

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190873 Gap junction degradation
R-HSA-196025 Formation of annular gap junctions
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-418990 Adherens junctions interactions
R-HSA-437239 Recycling pathway of L1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP63261
SIGNORiP63261

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACTG1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ACTG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
71
PMAP-CutDBiP63261

Protein Ontology

More...
PROi
PR:P63261

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184009 Expressed in 89 organ(s), highest expression level in ectocervix
ExpressionAtlasiP63261 baseline and differential
GenevisibleiP63261 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACTG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63261
Secondary accession number(s): A8K7C2
, P02571, P14104, P99022, Q5U032, Q96E67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 31, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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