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Entry version 132 (13 Nov 2019)
Sequence version 1 (01 Feb 1997)
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Protein
Submitted name:

65 kDa virulence protein

Gene

spvB

Organism
Salmonella typhimurium
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
65 kDa virulence proteinImported (EC:2.4.2.31Imported)
Submitted name:
Hydrophilic proteinImported
Submitted name:
SPI-2 type III secretion system effector NAD(+)--protein-arginine ADP-ribosyltransferase SpvBImported
Submitted name:
Salmonella plasmid virulence protein BImported
Submitted name:
SpvBImported
Submitted name:
Virulence plasmid DNA (spvA9::Tn5, spvB5::aph)Imported
Submitted name:
Virulence proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spvBImported
Synonyms:SpvBImported
ORF Names:AAP89_19310Imported, ABO94_23300Imported, AF488_25085Imported, AIC76_23075Imported, AXR84_19610Imported, AXU58_24455Imported, CD48_23475Imported, CE87_23390Imported, CET98_21095Imported, D7H43_23380Imported, DJ388_20845Imported, ERS450001_04956Imported, F0A03_07480Imported, F0A05_00595Imported, FKA80_18255Imported, FKA81_22970Imported, FKA82_18080Imported, FKA83_13800Imported, FKA84_11835Imported, FKA85_23095Imported, FKA86_17590Imported, FKA88_18935Imported, FKA89_08370Imported, FKA91_23260Imported, FKA92_19295Imported, FKA93_19120Imported, FKA95_19105Imported, FKA96_19175Imported, FKA97_18635Imported, FKA99_19575Imported, FKB00_19130Imported, FKB01_18205Imported, FKB02_18700Imported, FKB03_19135Imported, FKB12_21825Imported, FKB15_18955Imported, FYL57_14225Imported, FYL84_20970Imported, FYL94_03455Imported, FZ993_12385Imported, GW08_23770Imported, NCTC13348_01337Imported, NG18_23565Imported, p6919o079Imported, p8934bo079Imported, QB40_19445Imported, QD15_14490Imported, RJ78_25560Imported, SAMEA4398682_05106Imported, YI33_24955Imported, YR17_20335Imported, ZB89_17090Imported, ZC54_17375Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid 5Imported
Plasmid pSBLTImported
Plasmid pSTV-Mu1Imported
Plasmid pSal6919aImported
Plasmid pSal8934bImported
Plasmid pYT1Imported
Plasmid pYT2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimuriumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90371 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 555ADPrib_exo_ToxInterPro annotationAdd BLAST165

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000028457

KEGG Orthology (KO)

More...
KOi
K15366

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003540 ADP-ribosyltransferase
IPR003284 Sal_SpvB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03496 ADPrib_exo_Tox, 1 hit
PF03534 SpvB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01341 SALSPVBPROT

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P74846-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLILNGFSSA TLALITPPFL PKGGKALSQS GPDGLASITL PLPISAERGF
60 70 80 90 100
APALALHYSS GGGNGPFGVG WSCATMSIAR RTSHGVPQYN DSDEFLGPDG
110 120 130 140 150
EVLVQTLSTG DAPNPVTCFA YGDVSFPQSY TVTRYQPRTE SSFYRLEYWV
160 170 180 190 200
GNSNGDDFWL LHDSNGILHL LGKTAAARLS DPQAASHTAQ WLVEESVTPA
210 220 230 240 250
GEHIYYSYLA ENGDNVDLNG NEAGRDRSAM RYLSKVQYGN ATPAADLYLW
260 270 280 290 300
TSATPAVQWL FTLVFDYGER GVDPQVPPAF TAQNSWLARQ DPFSLYNYGF
310 320 330 340 350
EIRLHRLCRQ VLMFHHFPDE LGEADTLVSR LLLEYDENPI LTQLCAARTL
360 370 380 390 400
AYEGDGYRRA PVNNMMPPPP PPPMMGGNSS RPKSKWAIVE ESKQIQALRY
410 420 430 440 450
YSAQGYSVIN KYLRGDDYPE TQAKETLLSR DYLSTNEPSD EEFKNAMSVY
460 470 480 490 500
INDIAEGLSS LPETDHRVVY RGLKLDKPAL SDVLKEYTTI GNIIIDKAFM
510 520 530 540 550
STSPDKAWIN DTILNIYLEK GHKGRILGDV AHFKGEAEML FPPNTKLKIE
560 570 580 590
SIVNCGSQDF ASQLSKLRLS DDATADTNRI KRIINMRVLN S
Length:591
Mass (Da):65,420
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA38F33E02915D5F4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JF274991 Genomic DNA Translation: AEX00767.1
JF274992 Genomic DNA Translation: AEX00908.1
KX777254 Genomic DNA Translation: AOZ60928.1
AB576781 Genomic DNA Translation: BAJ15338.1
AB605179 Genomic DNA Translation: BAL48696.1
Z11557 Genomic DNA Translation: CAA77649.1
LN794247 Genomic DNA Translation: CEO37095.1
LN829405 Genomic DNA Translation: CKI21811.1
AAAALU010000042 Genomic DNA Translation: EAA1161345.1
AAABXQ010000029 Genomic DNA Translation: EAA5770938.1
AAACDS010000018 Genomic DNA Translation: EAA6486603.1
AAACKB010000018 Genomic DNA Translation: EAA7216777.1
AAACKA010000037 Genomic DNA Translation: EAA7298047.1
AAACMS010000029 Genomic DNA Translation: EAA7667971.1
AAACOB010000028 Genomic DNA Translation: EAA7813693.1
AAACPZ010000035 Genomic DNA Translation: EAA8003216.1
AAACUH010000030 Genomic DNA Translation: EAA8508599.1
AAACTG010000044 Genomic DNA Translation: EAA8550792.1
AAACXJ010000024 Genomic DNA Translation: EAA8929144.1
AAADEE010000028 Genomic DNA Translation: EAA9727652.1
AAAFEY010000015 Genomic DNA Translation: EAB6023173.1
AAAFRV010000053 Genomic DNA Translation: EAB7515118.1
AAAFZS010000052 Genomic DNA Translation: EAB8562727.1
AAAGPP010000026 Genomic DNA Translation: EAC0511088.1
AAAGQC010000018 Genomic DNA Translation: EAC0528970.1
AAAGUK010000027 Genomic DNA Translation: EAC1019593.1
AAAGVF010000013 Genomic DNA Translation: EAC1146566.1
AAAHBU010000024 Genomic DNA Translation: EAC1708853.1
VHLU01000015 Genomic DNA Translation: KAA0287929.1
VHLX01000025 Genomic DNA Translation: KAA0322611.1
VHMG01000014 Genomic DNA Translation: KAA0336670.1
VHMK01000014 Genomic DNA Translation: KAA0353827.1
VHMM01000015 Genomic DNA Translation: KAA0362775.1
VHMJ01000015 Genomic DNA Translation: KAA0364830.1
VHMI01000014 Genomic DNA Translation: KAA0366506.1
VHMH01000014 Genomic DNA Translation: KAA0376380.1
VHMO01000014 Genomic DNA Translation: KAA0377868.1
VHMQ01000015 Genomic DNA Translation: KAA0390781.1
VHMN01000014 Genomic DNA Translation: KAA0391152.1
VHMR01000015 Genomic DNA Translation: KAA0393175.1
VHMS01000053 Genomic DNA Translation: KAA0404821.1
VHMV01000014 Genomic DNA Translation: KAA0404950.1
VHMX01000017 Genomic DNA Translation: KAA0405740.1
VHMY01000057 Genomic DNA Translation: KAA0424584.1
VHMU01000020 Genomic DNA Translation: KAA0424907.1
VHNA01000016 Genomic DNA Translation: KAA0433522.1
VHMZ01000013 Genomic DNA Translation: KAA0438723.1
VHNB01000014 Genomic DNA Translation: KAA0451493.1
VHND01000015 Genomic DNA Translation: KAA0459897.1
VHNC01000049 Genomic DNA Translation: KAA0475248.1
VSXC01000013 Genomic DNA Translation: TYM89483.1
VSXL01000139 Genomic DNA Translation: TYN18134.1
VSXJ01000065 Genomic DNA Translation: TYN30327.1
VTSA01000032 Genomic DNA Translation: TZF39302.1
VTRZ01000048 Genomic DNA Translation: TZF44375.1
VTSM01000002 Genomic DNA Translation: TZG39692.1
CAADIU010000007 Genomic DNA Translation: VFS15456.1
CABIII010000003 Genomic DNA Translation: VUZ13048.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S22664

NCBI Reference Sequences

More...
RefSeqi
WP_001676648.1, NZ_VKKR01000017.1
YP_003264392.1, NC_013437.1
YP_003864189.1, NC_014476.2
YP_006955266.1, NC_019108.1
YP_006955406.1, NC_019109.1
YP_006955575.1, NC_019001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
KKE06701; KKE06701; TJ44_23860

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13909717
13910344
13910555
40104961
8541860
9715242

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
seni:CY43_24170

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|90371.1185.peg.5033

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF274991 Genomic DNA Translation: AEX00767.1
JF274992 Genomic DNA Translation: AEX00908.1
KX777254 Genomic DNA Translation: AOZ60928.1
AB576781 Genomic DNA Translation: BAJ15338.1
AB605179 Genomic DNA Translation: BAL48696.1
Z11557 Genomic DNA Translation: CAA77649.1
LN794247 Genomic DNA Translation: CEO37095.1
LN829405 Genomic DNA Translation: CKI21811.1
AAAALU010000042 Genomic DNA Translation: EAA1161345.1
AAABXQ010000029 Genomic DNA Translation: EAA5770938.1
AAACDS010000018 Genomic DNA Translation: EAA6486603.1
AAACKB010000018 Genomic DNA Translation: EAA7216777.1
AAACKA010000037 Genomic DNA Translation: EAA7298047.1
AAACMS010000029 Genomic DNA Translation: EAA7667971.1
AAACOB010000028 Genomic DNA Translation: EAA7813693.1
AAACPZ010000035 Genomic DNA Translation: EAA8003216.1
AAACUH010000030 Genomic DNA Translation: EAA8508599.1
AAACTG010000044 Genomic DNA Translation: EAA8550792.1
AAACXJ010000024 Genomic DNA Translation: EAA8929144.1
AAADEE010000028 Genomic DNA Translation: EAA9727652.1
AAAFEY010000015 Genomic DNA Translation: EAB6023173.1
AAAFRV010000053 Genomic DNA Translation: EAB7515118.1
AAAFZS010000052 Genomic DNA Translation: EAB8562727.1
AAAGPP010000026 Genomic DNA Translation: EAC0511088.1
AAAGQC010000018 Genomic DNA Translation: EAC0528970.1
AAAGUK010000027 Genomic DNA Translation: EAC1019593.1
AAAGVF010000013 Genomic DNA Translation: EAC1146566.1
AAAHBU010000024 Genomic DNA Translation: EAC1708853.1
VHLU01000015 Genomic DNA Translation: KAA0287929.1
VHLX01000025 Genomic DNA Translation: KAA0322611.1
VHMG01000014 Genomic DNA Translation: KAA0336670.1
VHMK01000014 Genomic DNA Translation: KAA0353827.1
VHMM01000015 Genomic DNA Translation: KAA0362775.1
VHMJ01000015 Genomic DNA Translation: KAA0364830.1
VHMI01000014 Genomic DNA Translation: KAA0366506.1
VHMH01000014 Genomic DNA Translation: KAA0376380.1
VHMO01000014 Genomic DNA Translation: KAA0377868.1
VHMQ01000015 Genomic DNA Translation: KAA0390781.1
VHMN01000014 Genomic DNA Translation: KAA0391152.1
VHMR01000015 Genomic DNA Translation: KAA0393175.1
VHMS01000053 Genomic DNA Translation: KAA0404821.1
VHMV01000014 Genomic DNA Translation: KAA0404950.1
VHMX01000017 Genomic DNA Translation: KAA0405740.1
VHMY01000057 Genomic DNA Translation: KAA0424584.1
VHMU01000020 Genomic DNA Translation: KAA0424907.1
VHNA01000016 Genomic DNA Translation: KAA0433522.1
VHMZ01000013 Genomic DNA Translation: KAA0438723.1
VHNB01000014 Genomic DNA Translation: KAA0451493.1
VHND01000015 Genomic DNA Translation: KAA0459897.1
VHNC01000049 Genomic DNA Translation: KAA0475248.1
VSXC01000013 Genomic DNA Translation: TYM89483.1
VSXL01000139 Genomic DNA Translation: TYN18134.1
VSXJ01000065 Genomic DNA Translation: TYN30327.1
VTSA01000032 Genomic DNA Translation: TZF39302.1
VTRZ01000048 Genomic DNA Translation: TZF44375.1
VTSM01000002 Genomic DNA Translation: TZG39692.1
CAADIU010000007 Genomic DNA Translation: VFS15456.1
CABIII010000003 Genomic DNA Translation: VUZ13048.1
PIRiS22664
RefSeqiWP_001676648.1, NZ_VKKR01000017.1
YP_003264392.1, NC_013437.1
YP_003864189.1, NC_014476.2
YP_006955266.1, NC_019108.1
YP_006955406.1, NC_019109.1
YP_006955575.1, NC_019001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiKKE06701; KKE06701; TJ44_23860
GeneIDi13909717
13910344
13910555
40104961
8541860
9715242
KEGGiseni:CY43_24170
PATRICifig|90371.1185.peg.5033

Phylogenomic databases

HOGENOMiHOG000028457
KOiK15366

Family and domain databases

InterProiView protein in InterPro
IPR003540 ADP-ribosyltransferase
IPR003284 Sal_SpvB
PfamiView protein in Pfam
PF03496 ADPrib_exo_Tox, 1 hit
PF03534 SpvB, 1 hit
PRINTSiPR01341 SALSPVBPROT

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP74846_SALTM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P74846
Secondary accession number(s): F1SVF1, Q7DAP6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported
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