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Entry version 200 (18 Sep 2019)
Sequence version 2 (05 Apr 2011)
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Protein

Tyrosine-protein phosphatase non-receptor type substrate 1

Gene

SIRPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P78324

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P78324

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type substrate 1
Short name:
SHP substrate 1
Short name:
SHPS-1
Alternative name(s):
Brain Ig-like molecule with tyrosine-based activation motifs
Short name:
Bit
CD172 antigen-like family member A
Inhibitory receptor SHPS-1
Macrophage fusion receptor
MyD-1 antigen
Signal-regulatory protein alpha-1
Short name:
Sirp-alpha-1
Signal-regulatory protein alpha-2
Short name:
Sirp-alpha-2
Signal-regulatory protein alpha-3
Short name:
Sirp-alpha-3
p84
CD_antigen: CD172a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIRPA
Synonyms:BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9662 SIRPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602461 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78324

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 373ExtracellularSequence analysisAdd BLAST343
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 504CytoplasmicSequence analysisAdd BLAST110

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140885

Open Targets

More...
OpenTargetsi
ENSG00000198053

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34006

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIRPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478534

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001494131 – 504Tyrosine-protein phosphatase non-receptor type substrate 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 121PROSITE-ProRule annotation2 Publications
Disulfide bondi170 ↔ 228PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi245N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi270N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi273 ↔ 331PROSITE-ProRule annotation
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei429Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei453Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei470Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei496PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.3 Publications
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P78324

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P78324

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P78324

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P78324

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78324

PeptideAtlas

More...
PeptideAtlasi
P78324

PRoteomics IDEntifications database

More...
PRIDEi
P78324

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57564 [P78324-1]
57565 [P78324-2]
57566 [P78324-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
650

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78324

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78324

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P78324

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198053 Expressed in 217 organ(s), highest expression level in anterior cingulate cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P78324 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002776
CAB015122
HPA054437
HPA058511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126752, 72 interactors

Protein interaction database and analysis system

More...
IntActi
P78324, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78324

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P78324

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 137Ig-like V-typeAdd BLAST106
Domaini148 – 247Ig-like C1-type 1Add BLAST100
Domaini254 – 348Ig-like C1-type 2Add BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi429 – 432SH2-bindingSequence analysis4
Motifi439 – 444SH3-bindingSequence analysis6
Motifi453 – 456SH2-bindingSequence analysis4
Motifi470 – 473SH2-bindingSequence analysis4
Motifi496 – 499SH2-bindingSequence analysis4

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKYM Eukaryota
ENOG410YKK2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186656

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P78324

KEGG Orthology (KO)

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KOi
K06551

Identification of Orthologs from Complete Genome Data

More...
OMAi
RAAEPNN

Database of Orthologous Groups

More...
OrthoDBi
962484at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78324

TreeFam database of animal gene trees

More...
TreeFami
TF341862

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P78324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET
60 70 80 90 100
ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN
110 120 130 140 150
NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA
160 170 180 190 200
PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP
210 220 230 240 250
VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI
260 270 280 290 300
RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS
310 320 330 340 350
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS
360 370 380 390 400
AHPKEQGSNT AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK
410 420 430 440 450
AQGSTSSTRL HEPEKNAREI TQDTNDITYA DLNLPKGKKP APQAAEPNNH
460 470 480 490 500
TEYASIQTSP QPASEDTLTY ADLDMVHLNR TPKQPAPKPE PSFSEYASVQ

VPRK
Length:504
Mass (Da):54,967
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18D2FD04F6182AD0
GO
Isoform 2 (identifier: P78324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     422-422: Q → QVQSL

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,394
Checksum:i098D9B24276FA4E1
GO
Isoform 4 (identifier: P78324-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Missing.

Show »
Length:503
Mass (Da):54,852
Checksum:iAB4F162B7FF8D97A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti259T → I in CAA71944 (PubMed:9485180).Curated1
Sequence conflicti503R → K in CAA71944 (PubMed:9485180).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0154626 – 7PA → RS. 2
Natural variantiVAR_01546320A → P. 1
Natural variantiVAR_01546440D → E. Corresponds to variant dbSNP:rs1349896458Ensembl.1
Natural variantiVAR_01546544L → S4 PublicationsCorresponds to variant dbSNP:rs143735290Ensembl.1
Natural variantiVAR_01546650T → S4 PublicationsCorresponds to variant dbSNP:rs17855609Ensembl.1
Natural variantiVAR_01546852T → I4 PublicationsCorresponds to variant dbSNP:rs17855610Ensembl.1
Natural variantiVAR_01547054R → H4 PublicationsCorresponds to variant dbSNP:rs17855611Ensembl.1
Natural variantiVAR_01547157A → V4 PublicationsCorresponds to variant dbSNP:rs17855612Ensembl.1
Natural variantiVAR_01547261I → N. Corresponds to variant dbSNP:rs1371837011Ensembl.1
Natural variantiVAR_01547368W → R. 1
Natural variantiVAR_01547475G → A4 PublicationsCorresponds to variant dbSNP:rs1057114Ensembl.1
Natural variantiVAR_01547577E → K. Corresponds to variant dbSNP:rs1182420620Ensembl.1
Natural variantiVAR_01547781N → H. 1
Natural variantiVAR_01547895D → E4 PublicationsCorresponds to variant dbSNP:rs138283486Ensembl.1
Natural variantiVAR_01547996L → S4 Publications1
Natural variantiVAR_015480100N → E Requires 2 nucleotide substitutions. 4 PublicationsCorresponds to variant dbSNP:rs386811662Ensembl.1
Natural variantiVAR_015483107R → S4 PublicationsCorresponds to variant dbSNP:rs17855615Ensembl.1
Natural variantiVAR_015484109G → S4 PublicationsCorresponds to variant dbSNP:rs17855616Ensembl.1
Natural variantiVAR_015485125R → Q. Corresponds to variant dbSNP:rs767136065Ensembl.1
Natural variantiVAR_015486132V → T Requires 2 nucleotide substitutions. 4 PublicationsCorresponds to variant dbSNP:rs386811663Ensembl.1
Natural variantiVAR_015487134F → L. 1
Natural variantiVAR_015488163Q → D Requires 2 nucleotide substitutions. 1
Natural variantiVAR_015489181T → S. 1
Natural variantiVAR_015490190E → Q. 1
Natural variantiVAR_015491201 – 202VG → AR. 2
Natural variantiVAR_015492214K → N. 1
Natural variantiVAR_015493220E → G. 1
Natural variantiVAR_015494222V → I. Corresponds to variant dbSNP:rs143385810Ensembl.1
Natural variantiVAR_015495236Q → R. 1
Natural variantiVAR_015496239 – 240PL → SF. 2
Natural variantiVAR_015497251R → Q. Corresponds to variant dbSNP:rs377448893Ensembl.1
Natural variantiVAR_015498261Q → L. 1
Natural variantiVAR_015499263V → M. Corresponds to variant dbSNP:rs754806675Ensembl.1
Natural variantiVAR_015500271V → I. 1
Natural variantiVAR_015501276R → T. 1
Natural variantiVAR_015502302V → L. Corresponds to variant dbSNP:rs2422666Ensembl.1
Natural variantiVAR_015503339P → S. 1
Natural variantiVAR_015504353P → L. Corresponds to variant dbSNP:rs138876160Ensembl.1
Natural variantiVAR_015505357G → S. Corresponds to variant dbSNP:rs1200233096Ensembl.1
Natural variantiVAR_015506367S → P. 1
Natural variantiVAR_015507370R → Q. Corresponds to variant dbSNP:rs778218860Ensembl.1
Natural variantiVAR_015508389A → E. 1
Natural variantiVAR_015509443Q → R. 1
Natural variantiVAR_015510460P → L. Corresponds to variant dbSNP:rs1168490568Ensembl.1
Natural variantiVAR_015511486A → L Requires 2 nucleotide substitutions. 1
Natural variantiVAR_015512491P → L. Corresponds to variant dbSNP:rs367629199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040799130Missing in isoform 4. Curated1
Alternative sequenceiVSP_007030422Q → QVQSL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86043 mRNA Translation: BAA12974.1
Y10375 mRNA Translation: CAA71403.1
AB023430 mRNA Translation: BAA87929.1
AK290776 mRNA Translation: BAF83465.1
AK312521 mRNA Translation: BAG35420.1
AL034562 Genomic DNA No translation available.
AL117335 Genomic DNA No translation available.
BC026692 mRNA Translation: AAH26692.1
BC033092 mRNA Translation: AAH33092.1
BC038510 mRNA Translation: AAH38510.1
BC075849 mRNA Translation: AAH75849.1
Y11047 mRNA Translation: CAA71944.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13022.1 [P78324-1]
CCDS82593.1 [P78324-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5287

NCBI Reference Sequences

More...
RefSeqi
NP_001035111.1, NM_001040022.1 [P78324-1]
NP_001035112.1, NM_001040023.1 [P78324-1]
NP_001317657.1, NM_001330728.1 [P78324-2]
NP_542970.1, NM_080792.2 [P78324-1]
XP_005260727.1, XM_005260670.3 [P78324-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356025; ENSP00000348307; ENSG00000198053 [P78324-1]
ENST00000358771; ENSP00000351621; ENSG00000198053 [P78324-1]
ENST00000400068; ENSP00000382941; ENSG00000198053 [P78324-1]
ENST00000622179; ENSP00000478763; ENSG00000198053 [P78324-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
140885

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:140885

UCSC genome browser

More...
UCSCi
uc002wfq.3 human [P78324-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86043 mRNA Translation: BAA12974.1
Y10375 mRNA Translation: CAA71403.1
AB023430 mRNA Translation: BAA87929.1
AK290776 mRNA Translation: BAF83465.1
AK312521 mRNA Translation: BAG35420.1
AL034562 Genomic DNA No translation available.
AL117335 Genomic DNA No translation available.
BC026692 mRNA Translation: AAH26692.1
BC033092 mRNA Translation: AAH33092.1
BC038510 mRNA Translation: AAH38510.1
BC075849 mRNA Translation: AAH75849.1
Y11047 mRNA Translation: CAA71944.1
CCDSiCCDS13022.1 [P78324-1]
CCDS82593.1 [P78324-2]
PIRiJC5287
RefSeqiNP_001035111.1, NM_001040022.1 [P78324-1]
NP_001035112.1, NM_001040023.1 [P78324-1]
NP_001317657.1, NM_001330728.1 [P78324-2]
NP_542970.1, NM_080792.2 [P78324-1]
XP_005260727.1, XM_005260670.3 [P78324-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85A/B31-149[»]
2JJTX-ray2.30A/B31-149[»]
2UV3X-ray1.80A/B31-149[»]
2WNGX-ray2.49A31-350[»]
4CMMX-ray1.92A31-149[»]
6BITX-ray2.19G/H31-147[»]
SMRiP78324
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126752, 72 interactors
IntActiP78324, 8 interactors
STRINGi9606.ENSP00000382941

PTM databases

GlyConnecti650
iPTMnetiP78324
PhosphoSitePlusiP78324
UniCarbKBiP78324

Polymorphism and mutation databases

BioMutaiSIRPA
DMDMi327478534

Proteomic databases

EPDiP78324
jPOSTiP78324
MassIVEiP78324
MaxQBiP78324
PaxDbiP78324
PeptideAtlasiP78324
PRIDEiP78324
ProteomicsDBi57564 [P78324-1]
57565 [P78324-2]
57566 [P78324-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P78324

The DNASU plasmid repository

More...
DNASUi
140885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356025; ENSP00000348307; ENSG00000198053 [P78324-1]
ENST00000358771; ENSP00000351621; ENSG00000198053 [P78324-1]
ENST00000400068; ENSP00000382941; ENSG00000198053 [P78324-1]
ENST00000622179; ENSP00000478763; ENSG00000198053 [P78324-2]
GeneIDi140885
KEGGihsa:140885
UCSCiuc002wfq.3 human [P78324-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140885
DisGeNETi140885

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIRPA
HGNCiHGNC:9662 SIRPA
HPAiCAB002776
CAB015122
HPA054437
HPA058511
MIMi602461 gene
neXtProtiNX_P78324
OpenTargetsiENSG00000198053
PharmGKBiPA34006

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00960000186656
InParanoidiP78324
KOiK06551
OMAiRAAEPNN
OrthoDBi962484at2759
PhylomeDBiP78324
TreeFamiTF341862

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP78324
SIGNORiP78324

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIRPA human
EvolutionaryTraceiP78324

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Signal-regulatory_protein_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140885

Pharos

More...
Pharosi
P78324

Protein Ontology

More...
PROi
PR:P78324

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198053 Expressed in 217 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiP78324 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHPS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78324
Secondary accession number(s): A2A2E1
, A8K411, B2R6C3, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: April 5, 2011
Last modified: September 18, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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