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Entry version 203 (13 Nov 2019)
Sequence version 2 (01 Jan 1998)
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Protein

Glutathione S-transferase omega-1

Gene

GSTO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 8.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32Nucleophile1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei59Glutathione2 Publications1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygen2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07564-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.20.4.2 2681
1.8.5.1 2681
2.5.1.18 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156581 Methylation
R-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione S-transferase omega-1 (EC:2.5.1.185 Publications)
Short name:
GSTO-1
Alternative name(s):
Glutathione S-transferase omega 1-1
Short name:
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.12 Publications)
Monomethylarsonic acid reductase (EC:1.20.4.21 Publication)
Short name:
MMA(V) reductase
S-(Phenacyl)glutathione reductase
Short name:
SPG-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSTO1
Synonyms:GSTTLP28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13312 GSTO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605482 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78417

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32C → A: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9446

Open Targets

More...
OpenTargetsi
ENSG00000148834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA133787054

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P78417

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3174

Drug and drug target database

More...
DrugBanki
DB14001 alpha-Tocopherol succinate
DB14002 D-alpha-Tocopherol acetate
DB00143 Glutathione
DB00163 Vitamin E

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSTO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6016173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001858842 – 241Glutathione S-transferase omega-1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei143N6-acetyllysineCombined sources1
Modified residuei148N6-acetyllysineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-381
CPTAC-382

Encyclopedia of Proteome Dynamics

More...
EPDi
P78417

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P78417

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P78417

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78417

PeptideAtlas

More...
PeptideAtlasi
P78417

PRoteomics IDEntifications database

More...
PRIDEi
P78417

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12755
27484
57621 [P78417-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P78417-1 [P78417-1]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P78417

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P78417

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78417

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78417

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P78417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148834 Expressed in 226 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P78417 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78417 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037603
HPA037604

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P047922EBI-712083,EBI-352682

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114836, 38 interactors

Protein interaction database and analysis system

More...
IntActi
P78417, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358727

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P78417

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P78417

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P78417

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 230GST C-terminalAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 86Glutathione binding2 Publications2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0406 Eukaryota
ENOG410XSIX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155351

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006560

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P78417

KEGG Orthology (KO)

More...
KOi
K00799

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHPLKLY

Database of Orthologous Groups

More...
OrthoDBi
1225872at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78417

TreeFam database of animal gene trees

More...
TreeFami
TF105325

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14497 GST_C_3, 1 hit
PF13417 GST_N_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01625 GSTRNSFRASEO

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGESARSLG KGSAPPGPVP EGSIRIYSMR FCPFAERTRL VLKAKGIRHE
60 70 80 90 100
VININLKNKP EWFFKKNPFG LVPVLENSQG QLIYESAITC EYLDEAYPGK
110 120 130 140 150
KLLPDDPYEK ACQKMILELF SKVPSLVGSF IRSQNKEDYA GLKEEFRKEF
160 170 180 190 200
TKLEEVLTNK KTTFFGGNSI SMIDYLIWPW FERLEAMKLN ECVDHTPKLK
210 220 230 240
LWMAAMKEDP TVSALLTSEK DWQGFLELYL QNSPEACDYG L
Length:241
Mass (Da):27,566
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9134ABA265F5C87E
GO
Isoform 2 (identifier: P78417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-155: Missing.

Show »
Length:208
Mass (Da):23,709
Checksum:iF00CDE200E2A1738
GO
Isoform 3 (identifier: P78417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:213
Mass (Da):24,796
Checksum:iC3F8EBA348399628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TA01Q5TA01_HUMAN
Glutathione S-transferase omega-1
GSTO1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TA02Q5TA02_HUMAN
Glutathione S-transferase omega-1
GSTO1
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD97673 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06123132C → Y. Corresponds to variant dbSNP:rs45529437Ensembl.1
Natural variantiVAR_02926986S → C. Corresponds to variant dbSNP:rs11509436Ensembl.1
Natural variantiVAR_016811140A → D in allele GSTO1*C; no effect on protein stability. 3 PublicationsCorresponds to variant dbSNP:rs4925Ensembl.1
Natural variantiVAR_016813155Missing in allele GSTO1*B; decreased protein stability. 3 Publications1
Natural variantiVAR_024484208E → K1 PublicationCorresponds to variant dbSNP:rs11509438Ensembl.1
Natural variantiVAR_026583236A → V1 PublicationCorresponds to variant dbSNP:rs11509439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0458191 – 28Missing in isoform 3. CuratedAdd BLAST28
Alternative sequenceiVSP_045820123 – 155Missing in isoform 2. CuratedAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U90313 mRNA Translation: AAB70109.1
AF212303 mRNA Translation: AAF73376.1
AY817669 Genomic DNA Translation: AAV68046.1
BX537431 mRNA Translation: CAD97673.1 Different initiation.
AL139341 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49601.1
CH471066 Genomic DNA Translation: EAW49602.1
CH471066 Genomic DNA Translation: EAW49603.1
BC000127 mRNA Translation: AAH00127.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53572.1 [P78417-2]
CCDS53573.1 [P78417-3]
CCDS7555.1 [P78417-1]

NCBI Reference Sequences

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RefSeqi
NP_001177931.1, NM_001191002.1 [P78417-2]
NP_001177932.1, NM_001191003.1 [P78417-3]
NP_004823.1, NM_004832.2 [P78417-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369710; ENSP00000358724; ENSG00000148834 [P78417-2]
ENST00000369713; ENSP00000358727; ENSG00000148834 [P78417-1]
ENST00000539281; ENSP00000441488; ENSG00000148834 [P78417-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9446

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9446

UCSC genome browser

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UCSCi
uc021pxr.2 human [P78417-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90313 mRNA Translation: AAB70109.1
AF212303 mRNA Translation: AAF73376.1
AY817669 Genomic DNA Translation: AAV68046.1
BX537431 mRNA Translation: CAD97673.1 Different initiation.
AL139341 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49601.1
CH471066 Genomic DNA Translation: EAW49602.1
CH471066 Genomic DNA Translation: EAW49603.1
BC000127 mRNA Translation: AAH00127.1
CCDSiCCDS53572.1 [P78417-2]
CCDS53573.1 [P78417-3]
CCDS7555.1 [P78417-1]
RefSeqiNP_001177931.1, NM_001191002.1 [P78417-2]
NP_001177932.1, NM_001191003.1 [P78417-3]
NP_004823.1, NM_004832.2 [P78417-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EEMX-ray2.00A1-241[»]
3LFLX-ray2.10A/B/C1-241[»]
3VLNX-ray1.70A1-241[»]
4IS0X-ray1.72A1-241[»]
4YQMX-ray2.38A/B/C1-241[»]
4YQUX-ray1.94A/B1-241[»]
4YQVX-ray2.06A/B/C1-241[»]
5UEHX-ray2.00A1-241[»]
5V3QX-ray2.25A1-241[»]
5YVNX-ray1.33A1-241[»]
5YVOX-ray1.80A1-241[»]
6MHBX-ray2.75A/B/C/D/E/F1-241[»]
6MHCX-ray2.00A/B1-241[»]
6MHDX-ray2.16A/B1-241[»]
6PNMX-ray1.82A2-241[»]
6PNNX-ray2.10A2-241[»]
6PNOX-ray1.82A2-241[»]
SMRiP78417
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114836, 38 interactors
IntActiP78417, 8 interactors
STRINGi9606.ENSP00000358727

Chemistry databases

BindingDBiP78417
ChEMBLiCHEMBL3174
DrugBankiDB14001 alpha-Tocopherol succinate
DB14002 D-alpha-Tocopherol acetate
DB00143 Glutathione
DB00163 Vitamin E

PTM databases

iPTMnetiP78417
PhosphoSitePlusiP78417
SwissPalmiP78417

Polymorphism and mutation databases

BioMutaiGSTO1
DMDMi6016173

2D gel databases

OGPiP78417
UCD-2DPAGEiP78417

Proteomic databases

CPTACiCPTAC-381
CPTAC-382
EPDiP78417
jPOSTiP78417
MassIVEiP78417
PaxDbiP78417
PeptideAtlasiP78417
PRIDEiP78417
ProteomicsDBi12755
27484
57621 [P78417-1]
TopDownProteomicsiP78417-1 [P78417-1]

Genome annotation databases

EnsembliENST00000369710; ENSP00000358724; ENSG00000148834 [P78417-2]
ENST00000369713; ENSP00000358727; ENSG00000148834 [P78417-1]
ENST00000539281; ENSP00000441488; ENSG00000148834 [P78417-3]
GeneIDi9446
KEGGihsa:9446
UCSCiuc021pxr.2 human [P78417-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9446
DisGeNETi9446

GeneCards: human genes, protein and diseases

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GeneCardsi
GSTO1
HGNCiHGNC:13312 GSTO1
HPAiHPA037603
HPA037604
MIMi605482 gene
neXtProtiNX_P78417
OpenTargetsiENSG00000148834
PharmGKBiPA133787054

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00940000155351
HOGENOMiHOG000006560
InParanoidiP78417
KOiK00799
OMAiEHPLKLY
OrthoDBi1225872at2759
PhylomeDBiP78417
TreeFamiTF105325

Enzyme and pathway databases

BioCyciMetaCyc:HS07564-MONOMER
BRENDAi1.20.4.2 2681
1.8.5.1 2681
2.5.1.18 2681
ReactomeiR-HSA-156581 Methylation
R-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSTO1 human
EvolutionaryTraceiP78417

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GSTO1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9446
PharosiP78417

Protein Ontology

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PROi
PR:P78417

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148834 Expressed in 226 organ(s), highest expression level in liver
ExpressionAtlasiP78417 baseline and differential
GenevisibleiP78417 HS

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSTO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78417
Secondary accession number(s): D3DRA3
, F5H7H0, Q5TA03, Q7Z3T2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 13, 2019
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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