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Entry version 161 (16 Oct 2019)
Sequence version 3 (20 Feb 2007)
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Protein

Phosphatidylinositol-glycan-specific phospholipase D

Gene

GPLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.50 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P80108

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol-glycan-specific phospholipase D (EC:3.1.4.50)
Short name:
PI-G PLD
Alternative name(s):
Glycoprotein phospholipase D
Glycosyl-phosphatidylinositol-specific phospholipase D
Short name:
GPI-PLD
Short name:
GPI-specific phospholipase D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPLD1
Synonyms:PIGPLD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4459 GPLD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602515 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P80108

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2822

Open Targets

More...
OpenTargetsi
ENSG00000112293

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28842

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P80108

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPLD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002204724 – 840Phosphatidylinositol-glycan-specific phospholipase DAdd BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi659N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-2231

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P80108

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P80108

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P80108

PeptideAtlas

More...
PeptideAtlasi
P80108

PRoteomics IDEntifications database

More...
PRIDEi
P80108

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57666 [P80108-1]
57667 [P80108-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1601

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P80108

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P80108

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112293 Expressed in 165 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P80108 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008625
HPA012500

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109083, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P80108, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati367 – 428FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati436 – 497FG-GAP 2PROSITE-ProRule annotationAdd BLAST62
Repeati499 – 559FG-GAP 3PROSITE-ProRule annotationAdd BLAST61
Repeati563 – 623FG-GAP 4PROSITE-ProRule annotationAdd BLAST61
Repeati633 – 693FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati704 – 770FG-GAP 6PROSITE-ProRule annotationAdd BLAST67
Repeati788 – 840FG-GAP 7PROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPLD1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPB3 Eukaryota
ENOG4111ZDA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013522

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P80108

KEGG Orthology (KO)

More...
KOi
K01127

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADISWHS

Database of Orthologous Groups

More...
OrthoDBi
743479at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P80108

TreeFam database of animal gene trees

More...
TreeFami
TF335726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR001028 Gprt_PLipase_D
IPR013519 Int_alpha_beta-p
IPR028994 Integrin_alpha_N
IPR029002 PLPC/GPLD1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 3 hits
PF00882 Zn_dep_PLPC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00718 PHPHLIPASED

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P80108-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR
60 70 80 90 100
ELLLEHQDAY QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI
110 120 130 140 150
RENYPLPWEK DTEKLVAFLF GITSHMAADV SWHSLGLEQG FLRTMGAIDF
160 170 180 190 200
HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR RWYVPVKDLL GIYEKLYGRK
210 220 230 240 250
VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV EQFQEYFLGG
260 270 280 290 300
LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ
310 320 330 340 350
KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI
360 370 380 390 400
RTMFIGGSQL SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV
410 420 430 440 450
GAPGYSRPGH IHIGRVYLIY GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF
460 470 480 490 500
GSALAVLDFN VDGVPDLAVG APSVGSEQLT YKGAVYVYFG SKQGGMSSSP
510 520 530 540 550
NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG GKQKGIVAAF
560 570 580 590 600
YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP
610 620 630 640 650
TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS
660 670 680 690 700
LSSGHVLMNG TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD
710 720 730 740 750
AQPLLLSTFS GDRRFSRFGG VLHLSDLDDD GLDEIIMAAP LRIADVTSGL
760 770 780 790 800
IGGEDGRVYV YNGKETTLGD MTGKCKSWIT PCPEEKAQYV LISPEASSRF
810 820 830 840
GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD
Length:840
Mass (Da):92,336
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11369BAFEC3D6D38
GO
Isoform 2 (identifier: P80108-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-176: GDVLSQFEFNFN → TVYLHLLNFLVV
     177-840: Missing.

Show »
Length:176
Mass (Da):19,865
Checksum:iB71070D7DD58234B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36444 differs from that shown. This sequence has numerous of conflicts with the human genome.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti531 – 534VIGS → MLGT AA sequence (PubMed:1606959).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03074317L → V1 PublicationCorresponds to variant dbSNP:rs2235501Ensembl.1
Natural variantiVAR_03074430V → I3 PublicationsCorresponds to variant dbSNP:rs1126617Ensembl.1
Natural variantiVAR_030745275D → E. Corresponds to variant dbSNP:rs17300770Ensembl.1
Natural variantiVAR_051278350I → V1 PublicationCorresponds to variant dbSNP:rs1062496Ensembl.1
Natural variantiVAR_030746396G → S. Corresponds to variant dbSNP:rs6924628Ensembl.1
Natural variantiVAR_030747461V → M1 PublicationCorresponds to variant dbSNP:rs1062505Ensembl.1
Natural variantiVAR_030748694M → V1 PublicationCorresponds to variant dbSNP:rs1042303Ensembl.1
Natural variantiVAR_030749698T → I4 PublicationsCorresponds to variant dbSNP:rs1772256Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023261165 – 176GDVLS…EFNFN → TVYLHLLNFLVV in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_023262177 – 840Missing in isoform 2. 1 PublicationAdd BLAST664

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11701 mRNA Translation: AAA36444.1 Sequence problems.
L11702 mRNA Translation: AAA36445.1
AJ308108 mRNA Translation: CAC87068.1
AJ400872
, AJ400873, AJ400874, AJ400875, AJ400876 Genomic DNA Translation: CAC14844.1
AY007546 mRNA Translation: AAG16627.2
AL359713, AL031230 Genomic DNA Translation: CAI17103.1
AL031230, AL359713 Genomic DNA Translation: CAI22602.1
AL031230 Genomic DNA Translation: CAD92520.1
BC007614 mRNA Translation: AAH07614.1
BC020748 mRNA Translation: AAH20748.1
BC093645 mRNA Translation: AAH93645.1
BC112001 mRNA Translation: AAI12002.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4553.1 [P80108-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001494.2, NM_001503.3 [P80108-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230036; ENSP00000230036; ENSG00000112293 [P80108-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2822

UCSC genome browser

More...
UCSCi
uc003ned.3 human [P80108-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11701 mRNA Translation: AAA36444.1 Sequence problems.
L11702 mRNA Translation: AAA36445.1
AJ308108 mRNA Translation: CAC87068.1
AJ400872
, AJ400873, AJ400874, AJ400875, AJ400876 Genomic DNA Translation: CAC14844.1
AY007546 mRNA Translation: AAG16627.2
AL359713, AL031230 Genomic DNA Translation: CAI17103.1
AL031230, AL359713 Genomic DNA Translation: CAI22602.1
AL031230 Genomic DNA Translation: CAD92520.1
BC007614 mRNA Translation: AAH07614.1
BC020748 mRNA Translation: AAH20748.1
BC093645 mRNA Translation: AAH93645.1
BC112001 mRNA Translation: AAI12002.1
CCDSiCCDS4553.1 [P80108-1]
RefSeqiNP_001494.2, NM_001503.3 [P80108-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi109083, 6 interactors
IntActiP80108, 1 interactor
STRINGi9606.ENSP00000230036

PTM databases

GlyConnecti1601
iPTMnetiP80108
PhosphoSitePlusiP80108

Polymorphism and mutation databases

BioMutaiGPLD1
DMDMi126302583

Proteomic databases

CPTACiCPTAC-2231
jPOSTiP80108
MassIVEiP80108
PaxDbiP80108
PeptideAtlasiP80108
PRIDEiP80108
ProteomicsDBi57666 [P80108-1]
57667 [P80108-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2822

Genome annotation databases

EnsembliENST00000230036; ENSP00000230036; ENSG00000112293 [P80108-1]
GeneIDi2822
KEGGihsa:2822
UCSCiuc003ned.3 human [P80108-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2822
DisGeNETi2822

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPLD1
HGNCiHGNC:4459 GPLD1
HPAiCAB008625
HPA012500
MIMi602515 gene
neXtProtiNX_P80108
OpenTargetsiENSG00000112293
PharmGKBiPA28842

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPB3 Eukaryota
ENOG4111ZDA LUCA
GeneTreeiENSGT00390000013522
InParanoidiP80108
KOiK01127
OMAiADISWHS
OrthoDBi743479at2759
PhylomeDBiP80108
TreeFamiTF335726

Enzyme and pathway databases

BRENDAi3.1.4.50 2681
ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SignaLinkiP80108

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GPLD1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPLD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2822
PharosiP80108

Protein Ontology

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PROi
PR:P80108

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112293 Expressed in 165 organ(s), highest expression level in secondary oocyte
GenevisibleiP80108 HS

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR001028 Gprt_PLipase_D
IPR013519 Int_alpha_beta-p
IPR028994 Integrin_alpha_N
IPR029002 PLPC/GPLD1
PfamiView protein in Pfam
PF01839 FG-GAP, 3 hits
PF00882 Zn_dep_PLPC, 1 hit
PRINTSiPR00718 PHPHLIPASED
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P80108
Secondary accession number(s): Q15127
, Q15128, Q2M2F2, Q5T3Y0, Q7Z6T8, Q8TCV0, Q8WW82, Q96ID6, Q9H167, Q9H4M1, Q9UJC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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