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Entry version 199 (03 Jul 2019)
Sequence version 2 (01 Nov 1995)
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Protein

Neutrophil gelatinase-associated lipocalin

Gene

LCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).By similarity5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei126Catecholate-type ferric siderophoreCombined sources1
Binding sitei145Catecholate-type ferric siderophoreCombined sources2 Publications1
Binding sitei154Catecholate-type ferric siderophoreCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Immunity, Innate immunity, Ion transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-6799990 Metal sequestration by antimicrobial proteins
R-HSA-917937 Iron uptake and transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P80188

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P80188 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutrophil gelatinase-associated lipocalin1 Publication
Short name:
NGAL
Alternative name(s):
25 kDa alpha-2-microglobulin-related subunit of MMP-91 Publication
Lipocalin-2
Oncogene 24p3
Siderocalin2 Publications
p25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCN2
Synonyms:HNL, NGAL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6526 LCN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600181 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P80188

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi145K → A: Strongly reduced affinity for catecholate-type ferric siderophores; when associated with A-154. 1 Publication1
Mutagenesisi154K → A: Strongly reduced affinity for catecholate-type ferric siderophores; when associated with A-145. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3934

Open Targets

More...
OpenTargetsi
ENSG00000148346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30309

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01926 Carboxymycobactin S
DB04043 Carboxymycobactin T
DB01631 Methyl Nonanoate (Ester)

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LCN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1171700

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001793321 – 198Neutrophil gelatinase-associated lipocalinAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi85N-linked (GlcNAc...) asparagineCombined sources6 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi96 ↔ 195Combined sources3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P80188

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P80188

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P80188

PeptideAtlas

More...
PeptideAtlasi
P80188

PRoteomics IDEntifications database

More...
PRIDEi
P80188

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57669
57670 [P80188-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1565

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P80188

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P80188

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148346 Expressed in 152 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P80188 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P80188 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016549
CAB016550
HPA002695

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:7683678, PubMed:1281792). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TXNDC5Q86UY04EBI-11911016,EBI-2825190

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110126, 26 interactors

Database of interacting proteins

More...
DIPi
DIP-29952N

Protein interaction database and analysis system

More...
IntActi
P80188, 67 interactors

Molecular INTeraction database

More...
MINTi
P80188

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362108

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P80188

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P80188

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P80188

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JAXJ Eukaryota
ENOG4111A75 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P80188

KEGG Orthology (KO)

More...
KOi
K21129

Database of Orthologous Groups

More...
OrthoDBi
1341030at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P80188

TreeFam database of animal gene trees

More...
TreeFami
TF336103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012674 Calycin
IPR003087 LCN2/LCN12
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11430 PTHR11430, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01275 NGELATINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50814 SSF50814, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00213 LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P80188-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK
60 70 80 90 100
WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI
110 120 130 140 150
RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR
160 170 180 190
EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG
Length:198
Mass (Da):22,588
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD761805723FEF1E
GO
Isoform 2 (identifier: P80188-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-198: DQCIDG → GNGQSG

Show »
Length:198
Mass (Da):22,457
Checksum:iCD691E83A0AD3F1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8F3X6R8F3_HUMAN
Neutrophil gelatinase-associated li...
LCN2
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9G → R in BAG63166 (PubMed:14702039).Curated1
Sequence conflicti13L → S in CAG46889 (Ref. 4) Curated1
Sequence conflicti82K → N AA sequence (PubMed:1281792).Curated1
Sequence conflicti155I → V AA sequence (PubMed:1281792).Curated1
Sequence conflicti178S → Y in CAA67574 (PubMed:9339356).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039780193 – 198DQCIDG → GNGQSG in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X83006 mRNA Translation: CAA58127.1
X99133 Genomic DNA Translation: CAA67574.1
AK301694 mRNA Translation: BAG63166.1
AK316217 mRNA Translation: BAH14588.1
CR542092 mRNA Translation: CAG46889.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87750.1
BC033089 mRNA Translation: AAH33089.1
S75256 mRNA Translation: AAD14168.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6892.1 [P80188-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC2339

NCBI Reference Sequences

More...
RefSeqi
NP_005555.2, NM_005564.4 [P80188-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000277480; ENSP00000277480; ENSG00000148346 [P80188-1]
ENST00000373017; ENSP00000362108; ENSG00000148346 [P80188-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3934

UCSC genome browser

More...
UCSCi
uc004bto.1 human [P80188-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83006 mRNA Translation: CAA58127.1
X99133 Genomic DNA Translation: CAA67574.1
AK301694 mRNA Translation: BAG63166.1
AK316217 mRNA Translation: BAH14588.1
CR542092 mRNA Translation: CAG46889.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87750.1
BC033089 mRNA Translation: AAH33089.1
S75256 mRNA Translation: AAD14168.1
CCDSiCCDS6892.1 [P80188-1]
PIRiJC2339
RefSeqiNP_005555.2, NM_005564.4 [P80188-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFVX-ray2.60A/B21-197[»]
1L6MX-ray2.40A/B/C21-198[»]
1NGLNMR-A21-198[»]
1QQSX-ray2.40A24-197[»]
1X71X-ray2.10A/B/C21-198[»]
1X89X-ray2.10A/B/C21-198[»]
1X8UX-ray2.20A/B/C21-198[»]
3BY0X-ray2.57A/B/C1-198[»]
3CBCX-ray2.17A/B/C1-198[»]
3CMPX-ray2.80A/B/C1-198[»]
3DSZX-ray2.00A/B21-198[»]
3DTQX-ray2.50A/B/C21-198[»]
3FW4X-ray2.30A/B/C21-198[»]
3FW5X-ray2.30A/B/C21-198[»]
3HWDX-ray2.95A/B/C1-198[»]
3HWEX-ray2.80A/B/C1-198[»]
3HWFX-ray3.20A/B/C1-198[»]
3HWGX-ray2.19A/B/C1-198[»]
3I0AX-ray2.60A/B/C1-198[»]
3K3LX-ray2.62A/B/C21-198[»]
3PECX-ray2.19A/B/C21-198[»]
3PEDX-ray2.30A/B/C21-198[»]
3T1DX-ray2.30A/B/C1-198[»]
3TF6X-ray2.35A/B/C21-198[»]
3TZSX-ray2.45A/B/C21-198[»]
3U03X-ray2.40A/C1-198[»]
3U0DX-ray2.51A/B/C/D1-198[»]
4GH7X-ray2.60A/C21-198[»]
4IAWX-ray2.40A/B/C21-198[»]
4IAXX-ray1.90A21-198[»]
4K19X-ray2.74A/B/C21-198[»]
4MVIX-ray1.70A21-198[»]
4MVKX-ray1.50A21-198[»]
4MVLX-ray2.30A/B/C/D21-198[»]
4QAEX-ray2.10A/B/C/D/E/F21-198[»]
4ZFXX-ray2.55A/B/C21-198[»]
4ZHCX-ray2.04A/B/C21-198[»]
4ZHDX-ray2.05A/B/C21-198[»]
4ZHFX-ray2.45A/B/C/D/E/F21-198[»]
4ZHGX-ray2.05A/B/C/D/E/F21-198[»]
4ZHHX-ray2.04A/B/C/D/E/F21-198[»]
5JR8X-ray2.65A/B21-198[»]
5KHPX-ray2.65A/B/C21-198[»]
5KICX-ray2.70A/B/C21-198[»]
5KIDX-ray2.15A/B/C21-198[»]
5MHHX-ray2.00A21-198[»]
5N47X-ray3.00A/C/E21-198[»]
5N48X-ray1.60A/C21-198[»]
5NKNX-ray2.20A25-198[»]
6GQZX-ray1.40A/B25-198[»]
6GR0X-ray2.50A/B/C25-198[»]
SMRiP80188
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110126, 26 interactors
DIPiDIP-29952N
IntActiP80188, 67 interactors
MINTiP80188
STRINGi9606.ENSP00000362108

Chemistry databases

BindingDBiP80188
DrugBankiDB01926 Carboxymycobactin S
DB04043 Carboxymycobactin T
DB01631 Methyl Nonanoate (Ester)

Protein family/group databases

MoonDBiP80188 Predicted

PTM databases

GlyConnecti1565
iPTMnetiP80188
PhosphoSitePlusiP80188

Polymorphism and mutation databases

BioMutaiLCN2
DMDMi1171700

Proteomic databases

jPOSTiP80188
MaxQBiP80188
PaxDbiP80188
PeptideAtlasiP80188
PRIDEiP80188
ProteomicsDBi57669
57670 [P80188-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P80188

The DNASU plasmid repository

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DNASUi
3934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277480; ENSP00000277480; ENSG00000148346 [P80188-1]
ENST00000373017; ENSP00000362108; ENSG00000148346 [P80188-1]
GeneIDi3934
KEGGihsa:3934
UCSCiuc004bto.1 human [P80188-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3934
DisGeNETi3934

GeneCards: human genes, protein and diseases

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GeneCardsi
LCN2
HGNCiHGNC:6526 LCN2
HPAiCAB016549
CAB016550
HPA002695
MIMi600181 gene
neXtProtiNX_P80188
OpenTargetsiENSG00000148346
PharmGKBiPA30309

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JAXJ Eukaryota
ENOG4111A75 LUCA
GeneTreeiENSGT00960000186615
InParanoidiP80188
KOiK21129
OrthoDBi1341030at2759
PhylomeDBiP80188
TreeFamiTF336103

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-6799990 Metal sequestration by antimicrobial proteins
R-HSA-917937 Iron uptake and transport
SIGNORiP80188

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LCN2 human
EvolutionaryTraceiP80188

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LCN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3934

Protein Ontology

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PROi
PR:P80188

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148346 Expressed in 152 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiP80188 baseline and differential
GenevisibleiP80188 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR003087 LCN2/LCN12
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01275 NGELATINASE
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNGAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P80188
Secondary accession number(s): A6NII8
, B4DWV4, B7ZAA2, P30150, Q5SYV9, Q5SYW0, Q6FGL5, Q92683
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: July 3, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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