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Entry version 142 (03 Jul 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H4

Gene

His4

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 215

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-212300 PRC2 methylates histones and DNA
R-DME-2299718 Condensation of Prophase Chromosomes
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214841 PKMTs methylate histone lysines
R-DME-3214842 HDMs demethylate histones
R-DME-3214847 HATs acetylate histones
R-DME-3214858 RMTs methylate histone arginines
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:His4
Synonyms:H4
AND
Name:His4r
Synonyms:H4r
ORF Names:CG3379
AND
ORF Names:CG31611
AND
ORF Names:CG33869
AND
ORF Names:CG33871
AND
ORF Names:CG33873
AND
ORF Names:CG33875
AND
ORF Names:CG33877
AND
ORF Names:CG33879
AND
ORF Names:CG33881
AND
ORF Names:CG33883
AND
ORF Names:CG33885
AND
ORF Names:CG33887
AND
ORF Names:CG33889
AND
ORF Names:CG33891
AND
ORF Names:CG33893
AND
ORF Names:CG33895
AND
ORF Names:CG33897
AND
ORF Names:CG33899
AND
ORF Names:CG33901
AND
ORF Names:CG33903
AND
ORF Names:CG33905
AND
ORF Names:CG33907
AND
ORF Names:CG33909
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2L, Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001200 His4
FBgn0051611 His4:CG31611
FBgn0053869 His4:CG33869
FBgn0053871 His4:CG33871
FBgn0053873 His4:CG33873
FBgn0053875 His4:CG33875
FBgn0053877 His4:CG33877
FBgn0053879 His4:CG33879
FBgn0053881 His4:CG33881
FBgn0053883 His4:CG33883
FBgn0053885 His4:CG33885
FBgn0053887 His4:CG33887
FBgn0053889 His4:CG33889
FBgn0053891 His4:CG33891
FBgn0053893 His4:CG33893
FBgn0053895 His4:CG33895
FBgn0053897 His4:CG33897
FBgn0053899 His4:CG33899
FBgn0053901 His4:CG33901
FBgn0053903 His4:CG33903
FBgn0053905 His4:CG33905
FBgn0053907 His4:CG33907
FBgn0053909 His4:CG33909
FBgn0013981 His4r

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001583052 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6N6-acetyllysine1 Publication1
Modified residuei13N6-acetyllysine1 Publication1
Modified residuei32N6-succinyllysine1 Publication1
Modified residuei78N6-succinyllysine1 Publication1
Modified residuei80N6-succinyllysine1 Publication1
Modified residuei81Phosphothreonine1 Publication1
Modified residuei83Phosphothreonine1 Publication1
Modified residuei92N6-succinyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P84040

PRoteomics IDEntifications database

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PRIDEi
P84040

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P84040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0013981 Expressed in 31 organ(s), highest expression level in eye disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P84040 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P84040 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
534263, 1 interactor
66847, 11 interactors
77139, 45 interactors

Database of interacting proteins

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DIPi
DIP-29505N

Protein interaction database and analysis system

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IntActi
P84040, 32 interactors

Molecular INTeraction database

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MINTi
P84040

STRING: functional protein association networks

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STRINGi
7227.FBpp0091154

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P84040

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P84040

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3467 Eukaryota
COG2036 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182673

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P84040

KEGG Orthology (KO)

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KOi
K11254

Identification of Orthologs from Complete Genome Data

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OMAi
QKEHING

Database of Orthologous Groups

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OrthoDBi
1594208at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P84040

Family and domain databases

Conserved Domains Database

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CDDi
cd00076 H4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd

Pfam protein domain database

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Pfami
View protein in Pfam
PF15511 CENP-T_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00623 HISTONEH4

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00047 HISTONE_H4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P84040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,381
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF3EB26393BD208C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KFZ9A0A0B4KFZ9_DROME
Histone H4
His4r BcDNA:RH52884, CG3379, Dmel\CG3379, FBtr0082962, H4r
103Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32435.1
X97437 Genomic DNA Translation: CAA66067.1
X97438 mRNA Translation: CAA66068.1
AE014297 Genomic DNA Translation: AAF55080.1
AE014134 Genomic DNA Translation: AAN11126.1
AE014297 Genomic DNA Translation: AAN13612.1
AE014297 Genomic DNA Translation: AAN13613.1
AE014134 Genomic DNA Translation: AAZ66480.1
AE014134 Genomic DNA Translation: AAZ66484.1
AE014134 Genomic DNA Translation: AAZ66489.1
AE014134 Genomic DNA Translation: AAZ66493.1
AE014134 Genomic DNA Translation: AAZ66498.1
AE014134 Genomic DNA Translation: AAZ66503.1
AE014134 Genomic DNA Translation: AAZ66508.1
AE014134 Genomic DNA Translation: AAZ66513.1
AE014134 Genomic DNA Translation: AAZ66518.1
AE014134 Genomic DNA Translation: AAZ66523.1
AE014134 Genomic DNA Translation: AAZ66528.1
AE014134 Genomic DNA Translation: AAZ66533.1
AE014134 Genomic DNA Translation: AAZ66538.1
AE014134 Genomic DNA Translation: AAZ66543.1
AE014134 Genomic DNA Translation: AAZ66548.1
AE014134 Genomic DNA Translation: AAZ66553.1
AE014134 Genomic DNA Translation: AAZ66558.1
AE014134 Genomic DNA Translation: AAZ66563.1
AE014134 Genomic DNA Translation: AAZ66568.1
AE014134 Genomic DNA Translation: AAZ66573.1
AE014134 Genomic DNA Translation: AAZ66578.1
BT001842 mRNA Translation: AAN71603.1
BT015217 mRNA Translation: AAT94446.1

Protein sequence database of the Protein Information Resource

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PIRi
S10098 HSFF4

NCBI Reference Sequences

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RefSeqi
NP_001027284.1, NM_001032113.2
NP_001027288.1, NM_001032117.2
NP_001027293.1, NM_001032122.2
NP_001027297.1, NM_001032126.2
NP_001027302.1, NM_001032131.2
NP_001027307.1, NM_001032136.2
NP_001027312.1, NM_001032141.2
NP_001027317.1, NM_001032146.2
NP_001027322.1, NM_001032151.2
NP_001027327.1, NM_001032156.2
NP_001027332.1, NM_001032161.2
NP_001027337.1, NM_001032166.2
NP_001027342.1, NM_001032171.2
NP_001027347.1, NM_001032176.2
NP_001027352.1, NM_001032181.2
NP_001027357.1, NM_001032186.2
NP_001027362.1, NM_001032191.2
NP_001027367.1, NM_001032196.1
NP_001027372.1, NM_001032201.1
NP_001027377.1, NM_001032206.1
NP_001027382.1, NM_001032211.1
NP_001262576.1, NM_001275647.1
NP_524352.1, NM_079628.4
NP_724344.1, NM_165383.3
NP_731927.1, NM_169592.3
NP_731928.1, NM_169593.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082962; FBpp0082421; FBgn0013981
FBtr0082963; FBpp0082422; FBgn0013981
FBtr0082964; FBpp0082423; FBgn0013981
FBtr0085926; FBpp0085280; FBgn0051611
FBtr0091875; FBpp0091116; FBgn0053871
FBtr0091877; FBpp0091118; FBgn0053873
FBtr0091879; FBpp0091120; FBgn0053875
FBtr0091887; FBpp0091128; FBgn0053883
FBtr0091889; FBpp0091130; FBgn0053885
FBtr0091891; FBpp0091132; FBgn0053887
FBtr0091893; FBpp0091134; FBgn0053889
FBtr0091895; FBpp0091136; FBgn0053891
FBtr0091897; FBpp0091138; FBgn0053893
FBtr0091899; FBpp0091140; FBgn0053895
FBtr0091901; FBpp0091142; FBgn0053897
FBtr0091903; FBpp0091144; FBgn0053899
FBtr0091905; FBpp0091146; FBgn0053901
FBtr0091907; FBpp0091148; FBgn0053903
FBtr0091909; FBpp0091150; FBgn0053905
FBtr0091911; FBpp0091152; FBgn0053907
FBtr0091913; FBpp0091154; FBgn0053909
FBtr0334029; FBpp0306146; FBgn0013981

Database of genes from NCBI RefSeq genomes

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GeneIDi
318846
3771854
3771893
3771908
3771935
3771938
3771941
3771947
3772096
3772113
3772129
3772172
3772211
3772254
3772314
3772317
3772319
3772325
3772509
3772519
3772666
3772708
41773

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG31611
dme:Dmel_CG3379
dme:Dmel_CG33869
dme:Dmel_CG33871
dme:Dmel_CG33873
dme:Dmel_CG33875
dme:Dmel_CG33877
dme:Dmel_CG33879
dme:Dmel_CG33881
dme:Dmel_CG33883
dme:Dmel_CG33885
dme:Dmel_CG33887
dme:Dmel_CG33889
dme:Dmel_CG33891
dme:Dmel_CG33893
dme:Dmel_CG33895
dme:Dmel_CG33897
dme:Dmel_CG33899
dme:Dmel_CG33901
dme:Dmel_CG33903
dme:Dmel_CG33905
dme:Dmel_CG33907
dme:Dmel_CG33909

UCSC genome browser

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UCSCi
CG31611-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32435.1
X97437 Genomic DNA Translation: CAA66067.1
X97438 mRNA Translation: CAA66068.1
AE014297 Genomic DNA Translation: AAF55080.1
AE014134 Genomic DNA Translation: AAN11126.1
AE014297 Genomic DNA Translation: AAN13612.1
AE014297 Genomic DNA Translation: AAN13613.1
AE014134 Genomic DNA Translation: AAZ66480.1
AE014134 Genomic DNA Translation: AAZ66484.1
AE014134 Genomic DNA Translation: AAZ66489.1
AE014134 Genomic DNA Translation: AAZ66493.1
AE014134 Genomic DNA Translation: AAZ66498.1
AE014134 Genomic DNA Translation: AAZ66503.1
AE014134 Genomic DNA Translation: AAZ66508.1
AE014134 Genomic DNA Translation: AAZ66513.1
AE014134 Genomic DNA Translation: AAZ66518.1
AE014134 Genomic DNA Translation: AAZ66523.1
AE014134 Genomic DNA Translation: AAZ66528.1
AE014134 Genomic DNA Translation: AAZ66533.1
AE014134 Genomic DNA Translation: AAZ66538.1
AE014134 Genomic DNA Translation: AAZ66543.1
AE014134 Genomic DNA Translation: AAZ66548.1
AE014134 Genomic DNA Translation: AAZ66553.1
AE014134 Genomic DNA Translation: AAZ66558.1
AE014134 Genomic DNA Translation: AAZ66563.1
AE014134 Genomic DNA Translation: AAZ66568.1
AE014134 Genomic DNA Translation: AAZ66573.1
AE014134 Genomic DNA Translation: AAZ66578.1
BT001842 mRNA Translation: AAN71603.1
BT015217 mRNA Translation: AAT94446.1
PIRiS10098 HSFF4
RefSeqiNP_001027284.1, NM_001032113.2
NP_001027288.1, NM_001032117.2
NP_001027293.1, NM_001032122.2
NP_001027297.1, NM_001032126.2
NP_001027302.1, NM_001032131.2
NP_001027307.1, NM_001032136.2
NP_001027312.1, NM_001032141.2
NP_001027317.1, NM_001032146.2
NP_001027322.1, NM_001032151.2
NP_001027327.1, NM_001032156.2
NP_001027332.1, NM_001032161.2
NP_001027337.1, NM_001032166.2
NP_001027342.1, NM_001032171.2
NP_001027347.1, NM_001032176.2
NP_001027352.1, NM_001032181.2
NP_001027357.1, NM_001032186.2
NP_001027362.1, NM_001032191.2
NP_001027367.1, NM_001032196.1
NP_001027372.1, NM_001032201.1
NP_001027377.1, NM_001032206.1
NP_001027382.1, NM_001032211.1
NP_001262576.1, NM_001275647.1
NP_524352.1, NM_079628.4
NP_724344.1, NM_165383.3
NP_731927.1, NM_169592.3
NP_731928.1, NM_169593.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30B/F2-103[»]
2PYOX-ray2.43B/F2-103[»]
2XYIX-ray1.75B27-46[»]
3C9CX-ray3.20B16-42[»]
4QLCX-ray3.50B/F2-103[»]
4UUZX-ray2.90B1-103[»]
4X23X-ray3.50B/F/L/P25-103[»]
5WCUX-ray5.53B/F/L/P22-103[»]
6DZTelectron microscopy2.99B/F2-103[»]
SMRiP84040
ModBaseiSearch...

Protein-protein interaction databases

BioGridi534263, 1 interactor
66847, 11 interactors
77139, 45 interactors
DIPiDIP-29505N
IntActiP84040, 32 interactors
MINTiP84040
STRINGi7227.FBpp0091154

PTM databases

iPTMnetiP84040

Proteomic databases

PaxDbiP84040
PRIDEiP84040

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082962; FBpp0082421; FBgn0013981
FBtr0082963; FBpp0082422; FBgn0013981
FBtr0082964; FBpp0082423; FBgn0013981
FBtr0085926; FBpp0085280; FBgn0051611
FBtr0091875; FBpp0091116; FBgn0053871
FBtr0091877; FBpp0091118; FBgn0053873
FBtr0091879; FBpp0091120; FBgn0053875
FBtr0091887; FBpp0091128; FBgn0053883
FBtr0091889; FBpp0091130; FBgn0053885
FBtr0091891; FBpp0091132; FBgn0053887
FBtr0091893; FBpp0091134; FBgn0053889
FBtr0091895; FBpp0091136; FBgn0053891
FBtr0091897; FBpp0091138; FBgn0053893
FBtr0091899; FBpp0091140; FBgn0053895
FBtr0091901; FBpp0091142; FBgn0053897
FBtr0091903; FBpp0091144; FBgn0053899
FBtr0091905; FBpp0091146; FBgn0053901
FBtr0091907; FBpp0091148; FBgn0053903
FBtr0091909; FBpp0091150; FBgn0053905
FBtr0091911; FBpp0091152; FBgn0053907
FBtr0091913; FBpp0091154; FBgn0053909
FBtr0334029; FBpp0306146; FBgn0013981
GeneIDi318846
3771854
3771893
3771908
3771935
3771938
3771941
3771947
3772096
3772113
3772129
3772172
3772211
3772254
3772314
3772317
3772319
3772325
3772509
3772519
3772666
3772708
41773
KEGGidme:Dmel_CG31611
dme:Dmel_CG3379
dme:Dmel_CG33869
dme:Dmel_CG33871
dme:Dmel_CG33873
dme:Dmel_CG33875
dme:Dmel_CG33877
dme:Dmel_CG33879
dme:Dmel_CG33881
dme:Dmel_CG33883
dme:Dmel_CG33885
dme:Dmel_CG33887
dme:Dmel_CG33889
dme:Dmel_CG33891
dme:Dmel_CG33893
dme:Dmel_CG33895
dme:Dmel_CG33897
dme:Dmel_CG33899
dme:Dmel_CG33901
dme:Dmel_CG33903
dme:Dmel_CG33905
dme:Dmel_CG33907
dme:Dmel_CG33909
UCSCiCG31611-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
318846
3771854
3771893
3771908
3771935
3771938
3771941
3771947
3772096
3772113
3772129
3772172
3772211
3772254
3772314
3772317
3772319
3772325
3772509
3772519
3772666
3772708
41773
FlyBaseiFBgn0001200 His4
FBgn0051611 His4:CG31611
FBgn0053869 His4:CG33869
FBgn0053871 His4:CG33871
FBgn0053873 His4:CG33873
FBgn0053875 His4:CG33875
FBgn0053877 His4:CG33877
FBgn0053879 His4:CG33879
FBgn0053881 His4:CG33881
FBgn0053883 His4:CG33883
FBgn0053885 His4:CG33885
FBgn0053887 His4:CG33887
FBgn0053889 His4:CG33889
FBgn0053891 His4:CG33891
FBgn0053893 His4:CG33893
FBgn0053895 His4:CG33895
FBgn0053897 His4:CG33897
FBgn0053899 His4:CG33899
FBgn0053901 His4:CG33901
FBgn0053903 His4:CG33903
FBgn0053905 His4:CG33905
FBgn0053907 His4:CG33907
FBgn0053909 His4:CG33909
FBgn0013981 His4r

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00950000182673
InParanoidiP84040
KOiK11254
OMAiQKEHING
OrthoDBi1594208at2759
PhylomeDBiP84040

Enzyme and pathway databases

ReactomeiR-DME-212300 PRC2 methylates histones and DNA
R-DME-2299718 Condensation of Prophase Chromosomes
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214841 PKMTs methylate histone lysines
R-DME-3214842 HDMs demethylate histones
R-DME-3214847 HATs acetylate histones
R-DME-3214858 RMTs methylate histone arginines
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
His4r fly
EvolutionaryTraceiP84040

Protein Ontology

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PROi
PR:P84040

Gene expression databases

BgeeiFBgn0013981 Expressed in 31 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiP84040 baseline and differential
GenevisibleiP84040 DM

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P84040
Secondary accession number(s): A4V2W8
, P02307, Q4AB71, Q4ABE0, Q6AWN1, Q9VFH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 3, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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