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Entry version 181 (18 Sep 2019)
Sequence version 1 (01 May 1997)
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Protein

Protein pangolin, isoforms A/H/I/S

Gene

pan

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi273 – 341HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor, Segmentation polarity protein
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209421 Transcription activation by ARM
R-DME-209441 WG ligand not bound to FZ receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P91943

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein pangolin, isoforms A/H/I/S
Alternative name(s):
dTCF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pan
Synonyms:TCF
ORF Names:CG34403
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0085432 pan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit a segment polarity phenotype and altered expression of the wg target genes en and Ubx.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000486011 – 751Protein pangolin, isoforms A/H/I/SAdd BLAST751

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P91943

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0085432 Expressed in 36 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P91943 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P91943 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the beta-catenin homolog arm or to gro.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
68607, 61 interactors

Database of interacting proteins

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DIPi
DIP-19970N

Protein interaction database and analysis system

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IntActi
P91943, 29 interactors

Molecular INTeraction database

More...
MINTi
P91943

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P91943

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53Beta-catenin binding siteBy similarityAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi351 – 357Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi351 – 357Poly-Lys7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3248 Eukaryota
ENOG41109RU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168653

KEGG Orthology (KO)

More...
KOi
K04491

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNKLEPH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF

The PANTHER Classification System

More...
PANTHERi
PTHR10373 PTHR10373, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P91943-3) [UniParc]FASTAAdd to basket
Also known as: C, D, E, F, G

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHTHSRHGS SGDDLCSTDE VKIFKDEGDR EDEKISSENL LVEEKSSLID
60 70 80 90 100
LTESEEKGHK ISRPDHSPVF NKLDTHAPSF NMGYLVSPYS YANGSPSGLP
110 120 130 140 150
VTMANKIGLP PFFCHNADPL STPPPAHCGI PPYQLDPKMG LTRPALYPFA
160 170 180 190 200
GGQYPYPMLS SDMSQVASWH TPSVYSASSF RTPYPSSLPI NTTLASDFPF
210 220 230 240 250
RFSPSLLPSV HATSHHVINA HSAIVGVSSK QECGVQDPTT NNRYPRNLEA
260 270 280 290 300
KHTSNAQSNE SKETTNDKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES
310 320 330 340 350
AAINQILGRR WHELSREEQS KYYEKARQER QLHMELYPGW SARDNYGYVS
360 370 380 390 400
KKKKRKKDRS TTDSGGNNMK KCRARFGLDQ QSQWCKPCRR KKKCIRYMEA
410 420 430 440 450
LNGNGPAEDG SCFDEHGSQL SDDDEDDYDD DKLGGSCGSA DETNKIEDED
460 470 480 490 500
SESLNQSMPS PGCLSGLSSL QSPSTTMSLA SPLNMNANSA TNVIFPASSN
510 520 530 540 550
ALLIVGADQP TAQQRPTLVS TSGSSSGSTS SISTTPNTSS TVSPVTCMTG
560 570 580 590 600
PCLGSSQERA MMLGNRFSHL GMGLSPPVVS TSTSKSEPFF KPHPTVCNNP
610 620 630 640 650
IFALPSIGNC SLNISSMPNT SRNPIGANPR DINNPLSINQ LTKRREYKNV
660 670 680 690 700
ELIEASESKT IVAHAATSII QHVAVNGYHA NHSLLNSNLG HLHHQLNNRT
710 720 730 740 750
ENPNRSEQTM LSVSNHSVNS SECHKESDSQ AIVSSNPPNA GSSDNGVISV

S
Length:751
Mass (Da):81,892
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C6E5A0B36017143
GO
Isoform H (identifier: P91943-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-364: ELSREEQSKY...RKKDRSTTDS → ALGREEQAKY...KRKRKQDTND

Note: No experimental confirmation available.
Show »
Length:747
Mass (Da):81,391
Checksum:i227A1983477B38C8
GO
Isoform S (identifier: P91943-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-730: Missing.

Note: No experimental confirmation available.
Show »
Length:733
Mass (Da):79,936
Checksum:i2B90BC91E37D8FB1
GO
Isoform I (identifier: P91943-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-364: ELSREEQSKY...RKKDRSTTDS → ALGREEQAKY...KRKRKQDTND
     390-414: RKKKCIRYMEALNGNGPAEDGSCFD → YVLPLFLFTMLYILLQMDLQDSRKN
     415-751: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):46,291
Checksum:iD80032389302FA84
GO
Isoform J (identifier: Q8IMA8-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8IMA8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:1,192
Mass (Da):132,080
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IMA8PANG2_DROME
Protein pangolin, isoform J
pan TCF, CG34403
1,192Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021967313 – 364ELSRE…STTDS → ALGREEQAKYYELARRERQL HMQMYPDWSSRTNASRGKKR KRKQDTND in isoform H and isoform I. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_021968390 – 414RKKKC…GSCFD → YVLPLFLFTMLYILLQMDLQ DSRKN in isoform I. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_021969415 – 751Missing in isoform I. 1 PublicationAdd BLAST337
Alternative sequenceiVSP_047713713 – 730Missing in isoform S. CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y09125 mRNA Translation: CAA70343.1
U88538 mRNA Translation: AAC47464.1
AE014135 Genomic DNA Translation: AAF59371.2
AE014135 Genomic DNA Translation: AAN06545.1
AE014135 Genomic DNA Translation: AAN06548.2
AE014135 Genomic DNA Translation: AFH06766.1
AE014135 Genomic DNA Translation: AAX52517.1
AE014135 Genomic DNA Translation: ABC65830.1
BT021431 mRNA Translation: AAX33579.1
BT029282 mRNA Translation: ABK30919.1
BT044547 mRNA Translation: ACI03583.1
BT053747 mRNA Translation: ACK77665.1
AY312729 Genomic DNA Translation: AAQ67543.1
AY312730 Genomic DNA Translation: AAQ67544.1
AY312731 Genomic DNA Translation: AAQ67545.1
AY312732 Genomic DNA Translation: AAQ67546.1
AY312733 Genomic DNA Translation: AAQ67547.1
AY312734 Genomic DNA Translation: AAQ67548.1
AY312735 Genomic DNA Translation: AAQ67549.1
AY312736 Genomic DNA Translation: AAQ67550.1
AY312737 Genomic DNA Translation: AAQ67551.1
AY312738 Genomic DNA Translation: AAQ67552.1
AY312739 Genomic DNA Translation: AAQ67553.1
AY312740 Genomic DNA Translation: AAQ67554.1
AY312741 Genomic DNA Translation: AAQ67555.1
AY312742 Genomic DNA Translation: AAQ67556.1
AY312743 Genomic DNA Translation: AAQ67557.1
AY312744 Genomic DNA Translation: AAQ67558.1
AY312745 Genomic DNA Translation: AAQ67559.1
AY312746 Genomic DNA Translation: AAQ67560.1
AY312747 Genomic DNA Translation: AAQ67561.1
AY312748 Genomic DNA Translation: AAQ67562.1
AY312749 Genomic DNA Translation: AAQ67563.1
AY312750 Genomic DNA Translation: AAQ67564.1
AY312751 Genomic DNA Translation: AAQ67565.1
AY312752 Genomic DNA Translation: AAQ67566.1

NCBI Reference Sequences

More...
RefSeqi
NP_001014685.1, NM_001014685.3 [P91943-4]
NP_001033798.1, NM_001038709.3 [P91943-5]
NP_001245406.1, NM_001258477.2 [P91943-3]
NP_524619.3, NM_079880.6 [P91943-3]
NP_726522.1, NM_166718.3 [P91943-3]
NP_726524.1, NM_166720.3 [P91943-3]
NP_726527.2, NM_166723.3 [P91943-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089159; FBpp0088226; FBgn0085432 [P91943-3]
FBtr0089161; FBpp0088228; FBgn0085432 [P91943-3]
FBtr0089162; FBpp0088229; FBgn0085432 [P91943-3]
FBtr0100245; FBpp0099631; FBgn0085432 [P91943-4]
FBtr0100246; FBpp0099632; FBgn0085432 [P91943-5]
FBtr0309803; FBpp0301556; FBgn0085432 [P91943-3]
FBtr0334301; FBpp0306416; FBgn0085432 [P91943-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG34403

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09125 mRNA Translation: CAA70343.1
U88538 mRNA Translation: AAC47464.1
AE014135 Genomic DNA Translation: AAF59371.2
AE014135 Genomic DNA Translation: AAN06545.1
AE014135 Genomic DNA Translation: AAN06548.2
AE014135 Genomic DNA Translation: AFH06766.1
AE014135 Genomic DNA Translation: AAX52517.1
AE014135 Genomic DNA Translation: ABC65830.1
BT021431 mRNA Translation: AAX33579.1
BT029282 mRNA Translation: ABK30919.1
BT044547 mRNA Translation: ACI03583.1
BT053747 mRNA Translation: ACK77665.1
AY312729 Genomic DNA Translation: AAQ67543.1
AY312730 Genomic DNA Translation: AAQ67544.1
AY312731 Genomic DNA Translation: AAQ67545.1
AY312732 Genomic DNA Translation: AAQ67546.1
AY312733 Genomic DNA Translation: AAQ67547.1
AY312734 Genomic DNA Translation: AAQ67548.1
AY312735 Genomic DNA Translation: AAQ67549.1
AY312736 Genomic DNA Translation: AAQ67550.1
AY312737 Genomic DNA Translation: AAQ67551.1
AY312738 Genomic DNA Translation: AAQ67552.1
AY312739 Genomic DNA Translation: AAQ67553.1
AY312740 Genomic DNA Translation: AAQ67554.1
AY312741 Genomic DNA Translation: AAQ67555.1
AY312742 Genomic DNA Translation: AAQ67556.1
AY312743 Genomic DNA Translation: AAQ67557.1
AY312744 Genomic DNA Translation: AAQ67558.1
AY312745 Genomic DNA Translation: AAQ67559.1
AY312746 Genomic DNA Translation: AAQ67560.1
AY312747 Genomic DNA Translation: AAQ67561.1
AY312748 Genomic DNA Translation: AAQ67562.1
AY312749 Genomic DNA Translation: AAQ67563.1
AY312750 Genomic DNA Translation: AAQ67564.1
AY312751 Genomic DNA Translation: AAQ67565.1
AY312752 Genomic DNA Translation: AAQ67566.1
RefSeqiNP_001014685.1, NM_001014685.3 [P91943-4]
NP_001033798.1, NM_001038709.3 [P91943-5]
NP_001245406.1, NM_001258477.2 [P91943-3]
NP_524619.3, NM_079880.6 [P91943-3]
NP_726522.1, NM_166718.3 [P91943-3]
NP_726524.1, NM_166720.3 [P91943-3]
NP_726527.2, NM_166723.3 [P91943-6]

3D structure databases

SMRiP91943
ModBaseiSearch...

Protein-protein interaction databases

BioGridi68607, 61 interactors
DIPiDIP-19970N
IntActiP91943, 29 interactors
MINTiP91943

Proteomic databases

PRIDEiP91943

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089159; FBpp0088226; FBgn0085432 [P91943-3]
FBtr0089161; FBpp0088228; FBgn0085432 [P91943-3]
FBtr0089162; FBpp0088229; FBgn0085432 [P91943-3]
FBtr0100245; FBpp0099631; FBgn0085432 [P91943-4]
FBtr0100246; FBpp0099632; FBgn0085432 [P91943-5]
FBtr0309803; FBpp0301556; FBgn0085432 [P91943-3]
FBtr0334301; FBpp0306416; FBgn0085432 [P91943-6]
GeneIDi43769
KEGGidme:Dmel_CG34403

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43769
FlyBaseiFBgn0085432 pan

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00940000168653
KOiK04491
OMAiFNKLEPH

Enzyme and pathway databases

ReactomeiR-DME-209421 Transcription activation by ARM
R-DME-209441 WG ligand not bound to FZ receptors
SignaLinkiP91943

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
pan fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43769

Gene expression databases

BgeeiFBgn0085432 Expressed in 36 organ(s), highest expression level in head
ExpressionAtlasiP91943 baseline and differential
GenevisibleiP91943 DM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
PANTHERiPTHR10373 PTHR10373, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANG1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91943
Secondary accession number(s): A0AVW4
, A4V148, B5RJS3, O02548, Q0KIE9, Q59DP5, Q5BHZ3, Q6W492, Q6W493, Q6W494, Q6W495, Q6W4A6, Q6W4B4, Q9V4B0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: September 18, 2019
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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