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Entry version 146 (08 May 2019)
Sequence version 1 (01 May 1997)
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Protein

Disks large-associated protein 1

Gene

Dlgap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the postsynaptic scaffold in neuronal cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large-associated protein 1Curated
Short name:
DAP-1
Alternative name(s):
Guanylate kinase-associated protein
Short name:
rGKAP1 Publication
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name:
SAPAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlgap1Imported
Synonyms:Gkap1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
620223 Dlgap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi990T → A: Abolishes interaction with SHANK1. 1 Publication1
Mutagenesisi991R → D: Abolishes interaction with SHANK1. 1 Publication1
Mutagenesisi992L → A: Abolishes interaction with SHANK1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001742901 – 992Disks large-associated protein 1Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineBy similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei516PhosphoserineBy similarity1
Modified residuei578PhosphoserineBy similarity1
Modified residuei579PhosphothreonineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei605PhosphoserineCombined sources1
Modified residuei606PhosphothreonineBy similarity1
Modified residuei608PhosphoserineCombined sources1
Modified residuei611PhosphoserineCombined sources1
Modified residuei947PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P97836

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97836

PRoteomics IDEntifications database

More...
PRIDEi
P97836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and testis.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016196 Expressed in 9 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97836 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1.

Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3.

Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3.

Found in a complex with DLG4 and BEGAIN.

Interacts with DYL2 and LRFN1.

Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (PubMed:27756895).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249233, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P97836

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P97836

Protein interaction database and analysis system

More...
IntActi
P97836, 15 interactors

Molecular INTeraction database

More...
MINTi
P97836

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000022351

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1992
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni665 – 676Interaction with DYL21 PublicationAdd BLAST12
Regioni687 – 698Interaction with DYL21 PublicationAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi990 – 992PDZ-binding3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3971 Eukaryota
ENOG4111JKV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015346

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97836

KEGG Orthology (KO)

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KOi
K15008

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030524 DLGAP1
IPR005026 SAPAP

The PANTHER Classification System

More...
PANTHERi
PTHR12353 PTHR12353, 1 hit
PTHR12353:SF7 PTHR12353:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03359 GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P97836-1) [UniParc]FASTAAdd to basket
Also known as: SAPAP1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGLSGSRSH HHGITCESAC DSLSHHSDHK PYLLSPVDHH PADHPYYTQR
60 70 80 90 100
NSFQAECVGP FSDPLASSTF PRRHYTSQQE LKDESALVPR TLATKANRLP
110 120 130 140 150
TNLLDQFERQ LPLSRDGYHT LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT
160 170 180 190 200
KSHSLEGASK GGVNGGKASP DGSQTVRYGK RSKSKERRSE PKARSNASNA
210 220 230 240 250
SPTSPSWWSS DDNLDGDMCL YHTPSGVMTM GRCPDRSVSQ YFMGAYNTIS
260 270 280 290 300
EQAVKASRSN NDVKCSTCAN LPVTLDAPLL KKSAWSSTLT VSRAREVYQK
310 320 330 340 350
ASVNMDQAVV KSEACQQERS CQYLQVPQDE WTGYTPRGKD DEIPCRRMRS
360 370 380 390 400
GSYIKAMGDE DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN
410 420 430 440 450
EHSPKLQIRS HSYLRAVSEV SINRSLDSLD PAGLLTSPKF RSRNESYMRA
460 470 480 490 500
MSTISQVSEM EVNGQFESVC ESVFSELESQ AVEALDLPMP GCFRMRSHSY
510 520 530 540 550
VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK LSSAVEVSSC
560 570 580 590 600
ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS
610 620 630 640 650
GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV
660 670 680 690 700
TTEDRKKDFK KNRCLSIGIQ VDDAEESEKM AESKTSSKFQ SVGVQVEEEK
710 720 730 740 750
CFRRFTRSNS VTTAVQADLD FHDNLENSLE SIEDNSCPGP MARQFSRDAS
760 770 780 790 800
TSTVSIQGSG NHYHACAADD DFDTDFDPSI LPPPDPWIDS ITEDPLEAVQ
810 820 830 840 850
RSVCHRDGHW FLKLLQAERD RMEGWCKQME REERENNLPE DILGKIRTAV
860 870 880 890 900
GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS
910 920 930 940 950
MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES
960 970 980 990
SQRQEARKRL MAAKRAASVR QNSATESAES IEIYIPEAQT RL
Length:992
Mass (Da):110,178
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44BAF9BC0C14C099
GO
Isoform 2 (identifier: P97836-4) [UniParc]FASTAAdd to basket
Also known as: GKAP C, 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW

Show »
Length:694
Mass (Da):77,263
Checksum:i2263D659AD1F6627
GO
Isoform 3 (identifier: P97836-5) [UniParc]FASTAAdd to basket
Also known as: GKAP A, GKAP1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW
     547-574: Missing.

Show »
Length:666
Mass (Da):74,220
Checksum:iF027510C20BC2290
GO
Isoform 4 (identifier: P97836-6) [UniParc]FASTAAdd to basket
Also known as: GKAP B, 2C

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW
     537-546: Missing.

Show »
Length:684
Mass (Da):76,279
Checksum:iC37FA0BA715BAF66
GO
Isoform 5 (identifier: P97836-7) [UniParc]FASTAAdd to basket
Also known as: 2B

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-324: QKASVNMDQAVVKSEACQQERSCQYL → MIDLFKAEWVSSVCVQVSRNGRTD

Show »
Length:692
Mass (Da):76,978
Checksum:i7180180258ADEF72
GO
Isoform 6 (identifier: P97836-8) [UniParc]FASTAAdd to basket
Also known as: 2D

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MNLIFHKDILFGVSATK

Show »
Length:684
Mass (Da):76,043
Checksum:i991D69B760948790
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V849G3V849_RAT
Discs, large (Drosophila) homolog-a...
Dlgap1 rCG_35671
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti636S → T in AAC53054 (PubMed:9024696).Curated1
Sequence conflicti636S → T in BAA24265 (PubMed:9428732).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0154151 – 298Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST298
Alternative sequenceiVSP_015416299 – 325QKASV…CQYLQ → MIDLFKAEWVSSVCVQVSRN GRTDQVW in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_015417299 – 325QKASV…CQYLQ → MNLIFHKDILFGVSATK in isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_015418299 – 324QKASV…SCQYL → MIDLFKAEWVSSVCVQVSRN GRTD in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015419537 – 546Missing in isoform 4. 2 Publications10
Alternative sequenceiVSP_015420547 – 574Missing in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U67987 mRNA Translation: AAC53054.1
AB003594 mRNA Translation: BAA24265.1
U67137 mRNA Translation: AAB48587.1

Protein sequence database of the Protein Information Resource

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PIRi
T00025

NCBI Reference Sequences

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RefSeqi
NP_001291216.1, NM_001304287.1 [P97836-7]
XP_008765652.1, XM_008767430.2 [P97836-4]
XP_008765654.1, XM_008767432.2 [P97836-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000087592; ENSRNOP00000072852; ENSRNOG00000016196 [P97836-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
65040

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:65040

UCSC genome browser

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UCSCi
RGD:620223 rat [P97836-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67987 mRNA Translation: AAC53054.1
AB003594 mRNA Translation: BAA24265.1
U67137 mRNA Translation: AAB48587.1
PIRiT00025
RefSeqiNP_001291216.1, NM_001304287.1 [P97836-7]
XP_008765652.1, XM_008767430.2 [P97836-4]
XP_008765654.1, XM_008767432.2 [P97836-8]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R0YX-ray2.00A/B807-916[»]
A/B946-971[»]
5OVCX-ray1.55B987-992[»]
SMRiP97836
ModBaseiSearch...

Protein-protein interaction databases

BioGridi249233, 8 interactors
CORUMiP97836
ELMiP97836
IntActiP97836, 15 interactors
MINTiP97836
STRINGi10116.ENSRNOP00000022351

PTM databases

iPTMnetiP97836
PhosphoSitePlusiP97836

Proteomic databases

jPOSTiP97836
PaxDbiP97836
PRIDEiP97836

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087592; ENSRNOP00000072852; ENSRNOG00000016196 [P97836-7]
GeneIDi65040
KEGGirno:65040
UCSCiRGD:620223 rat [P97836-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9229
RGDi620223 Dlgap1

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00940000156220
HOGENOMiHOG000015346
InParanoidiP97836
KOiK15008
PhylomeDBiP97836

Enzyme and pathway databases

ReactomeiR-RNO-6794361 Neurexins and neuroligins

Miscellaneous databases

Protein Ontology

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PROi
PR:P97836

Gene expression databases

BgeeiENSRNOG00000016196 Expressed in 9 organ(s), highest expression level in brain
ExpressionAtlasiP97836 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR030524 DLGAP1
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PTHR12353:SF7 PTHR12353:SF7, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLGP1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97836
Secondary accession number(s): O54773, P97841
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: May 8, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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