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Entry version 176 (16 Oct 2019)
Sequence version 2 (21 Jun 2005)
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Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

TNFAIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hyaluronic acid binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P98066

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
Hyaluronate-binding protein
TNF-stimulated gene 6 protein
Short name:
TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name:
TNF alpha-induced protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFAIP6
Synonyms:TSG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11898 TNFAIP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P98066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7130

Open Targets

More...
OpenTargetsi
ENSG00000123610

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36595

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P98066

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00945 Acetylsalicylic acid
DB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFAIP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68067717

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002669218 – 277Tumor necrosis factor-inducible gene 6 proteinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 127
Disulfide bondi82 ↔ 103
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 161By similarity
Disulfide bondi188 ↔ 210By similarity
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P98066

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98066

PeptideAtlas

More...
PeptideAtlasi
P98066

PRoteomics IDEntifications database

More...
PRIDEi
P98066

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57783

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P98066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the synovial fluid of patients with rheumatoid arthritis.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123610 Expressed in 178 organ(s), highest expression level in layer of synovial tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98066 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032719
HPA050884

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112984, 22 interactors

Protein interaction database and analysis system

More...
IntActi
P98066, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000243347

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98066

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P98066

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 129LinkPROSITE-ProRule annotationAdd BLAST94
Domaini135 – 247CUBPROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
KOG3714 Eukaryota
ENOG410ZI1H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043074

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98066

KEGG Orthology (KO)

More...
KOi
K19018

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGRFCGD

Database of Orthologous Groups

More...
OrthoDBi
934805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98066

TreeFam database of animal gene trees

More...
TreeFami
TF334173

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR000538 Link_dom
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF00193 Xlink, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265 LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 1 hit
SM00445 LINK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 1 hit
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P98066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT
60 70 80 90 100
YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG
110 120 130 140 150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG
160 170 180 190 200
FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD
210 220 230 240 250
DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV
260 270
SKSSQGKNTS TTSTGNKNFL AGRFSHL
Length:277
Mass (Da):31,203
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2B3AEB76353A782
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013005144Q → R2 PublicationsCorresponds to variant dbSNP:rs1046668Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31165 mRNA Translation: AAB00792.1
AJ421518 mRNA Translation: CAD13434.1
AJ419936 mRNA Translation: CAD12353.1
AC009311 Genomic DNA Translation: AAY15067.1
CH471058 Genomic DNA Translation: EAX11511.1
BC030205 mRNA Translation: AAH30205.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2193.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41735

NCBI Reference Sequences

More...
RefSeqi
NP_009046.2, NM_007115.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000243347; ENSP00000243347; ENSG00000123610

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7130

UCSC genome browser

More...
UCSCi
uc002txk.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA Translation: AAB00792.1
AJ421518 mRNA Translation: CAD13434.1
AJ419936 mRNA Translation: CAD12353.1
AC009311 Genomic DNA Translation: AAY15067.1
CH471058 Genomic DNA Translation: EAX11511.1
BC030205 mRNA Translation: AAH30205.1
CCDSiCCDS2193.1
PIRiA41735
RefSeqiNP_009046.2, NM_007115.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2N40NMR-A36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
SMRiP98066
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112984, 22 interactors
IntActiP98066, 25 interactors
STRINGi9606.ENSP00000243347

Chemistry databases

DrugBankiDB00945 Acetylsalicylic acid
DB08818 Hyaluronic acid

PTM databases

iPTMnetiP98066
PhosphoSitePlusiP98066

Polymorphism and mutation databases

BioMutaiTNFAIP6
DMDMi68067717

Proteomic databases

MassIVEiP98066
PaxDbiP98066
PeptideAtlasiP98066
PRIDEiP98066
ProteomicsDBi57783

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7130

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610
GeneIDi7130
KEGGihsa:7130
UCSCiuc002txk.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7130
DisGeNETi7130

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFAIP6
HGNCiHGNC:11898 TNFAIP6
HPAiCAB032719
HPA050884
MIMi600410 gene
neXtProtiNX_P98066
OpenTargetsiENSG00000123610
PharmGKBiPA36595

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
KOG3714 Eukaryota
ENOG410ZI1H LUCA
GeneTreeiENSGT00940000157201
HOGENOMiHOG000043074
InParanoidiP98066
KOiK19018
OMAiAGRFCGD
OrthoDBi934805at2759
PhylomeDBiP98066
TreeFamiTF334173

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SIGNORiP98066

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNFAIP6 human
EvolutionaryTraceiP98066

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TSG-6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7130
PharosiP98066

Protein Ontology

More...
PROi
PR:P98066

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123610 Expressed in 178 organ(s), highest expression level in layer of synovial tissue
GenevisibleiP98066 HS

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR000538 Link_dom
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00193 Xlink, 1 hit
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00445 LINK, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSG6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98066
Secondary accession number(s): Q53TI7, Q8WWI9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 21, 2005
Last modified: October 16, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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