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Entry version 175 (03 Jul 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Cytochrome c

Gene

CYCS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei15Heme (covalent)1
Binding sitei18Heme (covalent)1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Electron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111457 Release of apoptotic factors from the mitochondria
R-HSA-111458 Formation of apoptosome
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463 SMAC (DIABLO) binds to IAPs
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
R-HSA-9627069 Regulation of the apoptosome activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P99999

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P99999 Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYCS
Synonyms:CYC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:19986 CYCS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123970 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P99999

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thrombocytopenia 4 (THC4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04445042G → S in THC4; increases the pro-apoptotic function by triggering caspase activation more efficiently than wild-type; does not affect the redox function. 1 PublicationCorresponds to variant dbSNP:rs121918552EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54205

MalaCards human disease database

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MalaCardsi
CYCS
MIMi612004 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172115

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
168629 Autosomal thrombocytopenia with normal platelets

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134981636

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2189163

Drug and drug target database

More...
DrugBanki
DB03317 Heme C
DB01017 Minocycline
DB03977 N-Trimethyllysine
DB02110 Protoporphyrin Ix Containing Co
DB03934 Protoporphyrin Ix Containing Zn
DB04249 Zinc Substituted Heme C

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYCS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
42560196

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001082182 – 105Cytochrome cAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei49PhosphotyrosineBy similarity1
Modified residuei56N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysine; alternateBy similarity1
Modified residuei73N6-succinyllysine; alternateBy similarity1
Modified residuei98PhosphotyrosineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P99999

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P99999

MaxQB - The MaxQuant DataBase

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MaxQBi
P99999

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P99999

PeptideAtlas

More...
PeptideAtlasi
P99999

PRoteomics IDEntifications database

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PRIDEi
P99999

ProteomicsDB human proteome resource

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ProteomicsDBi
12630
57831

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P99999

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P99999

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P99999

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P99999

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172115 Expressed in 197 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P99999 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P99999 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004222
CAB005126
CAB018597

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119922, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3762 Apoptosome

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P99999

Database of interacting proteins

More...
DIPi
DIP-29683N

Protein interaction database and analysis system

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IntActi
P99999, 29 interactors

Molecular INTeraction database

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MINTi
P99999

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307786

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P99999

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P99999

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3453 Eukaryota
COG3474 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009405

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000009762

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P99999

KEGG Orthology (KO)

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KOi
K08738

Identification of Orthologs from Complete Genome Data

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OMAi
QGPNLYG

Database of Orthologous Groups

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OrthoDBi
1322508at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P99999

TreeFam database of animal gene trees

More...
TreeFami
TF300226

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B

The PANTHER Classification System

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PANTHERi
PTHR11961 PTHR11961, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00034 Cytochrom_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00604 CYTCHRMECIAB

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46626 SSF46626, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51007 CYTC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P99999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT
60 70 80 90 100
AANKNKGIIW GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK

KATNE
Length:105
Mass (Da):11,749
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EE9689E0102506B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFR7C9JFR7_HUMAN
Cytochrome c
CYCS
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18C → Y in AAH15130 (PubMed:15489334).Curated1
Sequence conflicti41T → I in AAH68464 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04445042G → S in THC4; increases the pro-apoptotic function by triggering caspase activation more efficiently than wild-type; does not affect the redox function. 1 PublicationCorresponds to variant dbSNP:rs121918552EnsemblClinVar.1
Natural variantiVAR_04885056K → R. Corresponds to variant dbSNP:rs11548795Ensembl.1
Natural variantiVAR_00220466M → L. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22877 Genomic DNA Translation: AAA35732.1
BT006946 mRNA Translation: AAP35592.1
AK311836 mRNA Translation: BAG34778.1
AL713681 mRNA Translation: CAD28485.1
AC007487 Genomic DNA Translation: AAQ96844.1
CH236948 Genomic DNA Translation: EAL24239.1
CH471073 Genomic DNA Translation: EAW93822.1
BC005299 mRNA Translation: AAH05299.1
BC008475 mRNA Translation: AAH08475.1
BC008477 mRNA Translation: AAH08477.1
BC009578 mRNA Translation: AAH09578.1
BC009579 mRNA Translation: AAH09579.1
BC009582 mRNA Translation: AAH09582.1
BC009587 mRNA Translation: AAH09587.1
BC009602 mRNA Translation: AAH09602.1
BC009607 mRNA Translation: AAH09607.1
BC014359 mRNA Translation: AAH14359.1
BC014361 mRNA Translation: AAH14361.1
BC015130 mRNA Translation: AAH15130.1
BC016006 mRNA Translation: AAH16006.1
BC021994 mRNA Translation: AAH21994.1
BC022330 mRNA Translation: AAH22330.1
BC067222 mRNA Translation: AAH67222.1
BC068464 mRNA Translation: AAH68464.1
BC070156 mRNA Translation: AAH70156.1
BC070346 mRNA Translation: AAH70346.1
BC071761 mRNA Translation: AAH71761.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5393.1

Protein sequence database of the Protein Information Resource

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PIRi
A31764 CCHU

NCBI Reference Sequences

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RefSeqi
NP_061820.1, NM_018947.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000305786; ENSP00000307786; ENSG00000172115
ENST00000409409; ENSP00000386270; ENSG00000172115
ENST00000409764; ENSP00000387279; ENSG00000172115

Database of genes from NCBI RefSeq genomes

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GeneIDi
54205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54205

UCSC genome browser

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UCSCi
uc003sxl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Protein Spotlight

An unexpected place - Issue 88 of November 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22877 Genomic DNA Translation: AAA35732.1
BT006946 mRNA Translation: AAP35592.1
AK311836 mRNA Translation: BAG34778.1
AL713681 mRNA Translation: CAD28485.1
AC007487 Genomic DNA Translation: AAQ96844.1
CH236948 Genomic DNA Translation: EAL24239.1
CH471073 Genomic DNA Translation: EAW93822.1
BC005299 mRNA Translation: AAH05299.1
BC008475 mRNA Translation: AAH08475.1
BC008477 mRNA Translation: AAH08477.1
BC009578 mRNA Translation: AAH09578.1
BC009579 mRNA Translation: AAH09579.1
BC009582 mRNA Translation: AAH09582.1
BC009587 mRNA Translation: AAH09587.1
BC009602 mRNA Translation: AAH09602.1
BC009607 mRNA Translation: AAH09607.1
BC014359 mRNA Translation: AAH14359.1
BC014361 mRNA Translation: AAH14361.1
BC015130 mRNA Translation: AAH15130.1
BC016006 mRNA Translation: AAH16006.1
BC021994 mRNA Translation: AAH21994.1
BC022330 mRNA Translation: AAH22330.1
BC067222 mRNA Translation: AAH67222.1
BC068464 mRNA Translation: AAH68464.1
BC070156 mRNA Translation: AAH70156.1
BC070346 mRNA Translation: AAH70346.1
BC071761 mRNA Translation: AAH71761.1
CCDSiCCDS5393.1
PIRiA31764 CCHU
RefSeqiNP_061820.1, NM_018947.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J3SNMR-A2-105[»]
2N3YNMR-A2-105[»]
2N9INMR-A2-105[»]
2N9JNMR-A2-105[»]
3NWVX-ray1.90A/B/C/D2-105[»]
3ZCFX-ray1.65A/B/C/D2-105[»]
3ZOOX-ray1.35A/B/C/D2-105[»]
5EXQX-ray1.60A/B2-105[»]
5O10X-ray1.36A/B2-105[»]
5TY3X-ray1.25A/B2-105[»]
SMRiP99999
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119922, 53 interactors
ComplexPortaliCPX-3762 Apoptosome
CORUMiP99999
DIPiDIP-29683N
IntActiP99999, 29 interactors
MINTiP99999
STRINGi9606.ENSP00000307786

Chemistry databases

ChEMBLiCHEMBL2189163
DrugBankiDB03317 Heme C
DB01017 Minocycline
DB03977 N-Trimethyllysine
DB02110 Protoporphyrin Ix Containing Co
DB03934 Protoporphyrin Ix Containing Zn
DB04249 Zinc Substituted Heme C

Protein family/group databases

MoonDBiP99999 Curated

PTM databases

iPTMnetiP99999
PhosphoSitePlusiP99999
SwissPalmiP99999

Polymorphism and mutation databases

BioMutaiCYCS
DMDMi42560196

Proteomic databases

EPDiP99999
jPOSTiP99999
MaxQBiP99999
PaxDbiP99999
PeptideAtlasiP99999
PRIDEiP99999
ProteomicsDBi12630
57831
TopDownProteomicsiP99999

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54205
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305786; ENSP00000307786; ENSG00000172115
ENST00000409409; ENSP00000386270; ENSG00000172115
ENST00000409764; ENSP00000387279; ENSG00000172115
GeneIDi54205
KEGGihsa:54205
UCSCiuc003sxl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54205
DisGeNETi54205

GeneCards: human genes, protein and diseases

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GeneCardsi
CYCS
HGNCiHGNC:19986 CYCS
HPAiCAB004222
CAB005126
CAB018597
MalaCardsiCYCS
MIMi123970 gene
612004 phenotype
neXtProtiNX_P99999
OpenTargetsiENSG00000172115
Orphaneti168629 Autosomal thrombocytopenia with normal platelets
PharmGKBiPA134981636

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3453 Eukaryota
COG3474 LUCA
GeneTreeiENSGT00390000009405
HOGENOMiHOG000009762
InParanoidiP99999
KOiK08738
OMAiQGPNLYG
OrthoDBi1322508at2759
PhylomeDBiP99999
TreeFamiTF300226

Enzyme and pathway databases

ReactomeiR-HSA-111457 Release of apoptotic factors from the mitochondria
R-HSA-111458 Formation of apoptosome
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage
R-HSA-111463 SMAC (DIABLO) binds to IAPs
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
R-HSA-9627069 Regulation of the apoptosome activity
SIGNORiP99999

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CYCS human
EvolutionaryTraceiP99999

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cytochrome_c

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54205

Protein Ontology

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PROi
PR:P99999

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172115 Expressed in 197 organ(s), highest expression level in heart
ExpressionAtlasiP99999 baseline and differential
GenevisibleiP99999 HS

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P99999
Secondary accession number(s): A4D166
, B2R4I1, P00001, Q6NUR2, Q6NX69, Q96BV4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 3, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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