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Entry version 158 (13 Feb 2019)
Sequence version 1 (01 Apr 1993)
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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q01362

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q01362

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.37.3.2 the cd20 ca(2+) channel (cd20) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A2
Synonyms:APY, FCER1B, IGER
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149534.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7316 MS4A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147138 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 79HelicalSequence analysisAdd BLAST20
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 117HelicalSequence analysisAdd BLAST20
Topological domaini118 – 130CytoplasmicSequence analysisAdd BLAST13
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Topological domaini151 – 180ExtracellularSequence analysisAdd BLAST30
Transmembranei181 – 200HelicalSequence analysisAdd BLAST20
Topological domaini201 – 244CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2206

MalaCards human disease database

More...
MalaCardsi
MS4A2

Open Targets

More...
OpenTargetsi
ENSG00000149534

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31109

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00043 Omalizumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MS4A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
232084

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586291 – 244High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219PhosphotyrosineBy similarity1
Modified residuei225PhosphotyrosineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei229PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01362

PeptideAtlas

More...
PeptideAtlasi
Q01362

PRoteomics IDEntifications database

More...
PRIDEi
Q01362

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57942

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01362

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01362

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found on the surface of mast cells and basophils.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149534 Expressed in 100 organ(s), highest expression level in fundus of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01362 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01362 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059967

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108500, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q01362

Protein interaction database and analysis system

More...
IntActi
Q01362, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q01362

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J28C Eukaryota
ENOG4111DU9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161985

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060211

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01362

KEGG Orthology (KO)

More...
KOi
K08090

Identification of Orthologs from Complete Genome Data

More...
OMAi
NKVPDDR

Database of Orthologous Groups

More...
OrthoDBi
1048914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01362

TreeFam database of animal gene trees

More...
TreeFami
TF335157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2

The PANTHER Classification System

More...
PANTHERi
PTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW
60 70 80 90 100
LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY
110 120 130 140 150
PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII
160 170 180 190 200
NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT
210 220 230 240
ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL
Length:244
Mass (Da):26,534
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE523102D5F567AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2E9A0A0B4J2E9_HUMAN
High affinity immunoglobulin epsilo...
MS4A2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLJ1E9PLJ1_HUMAN
High affinity immunoglobulin epsilo...
MS4A2
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia (PubMed:8817330).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053515143T → M. Corresponds to variant dbSNP:rs35033981Ensembl.1
Natural variantiVAR_053516211N → K. Corresponds to variant dbSNP:rs535630Ensembl.1
Natural variantiVAR_003965237E → G Polymorphism; risk factor for atopic dermatitis and asthma. 2 PublicationsCorresponds to variant dbSNP:rs569108EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D10583 mRNA Translation: BAA01440.1
M89796 Genomic DNA Translation: AAA60269.1
AB080913 Genomic DNA Translation: BAC66486.1
BC074800 mRNA Translation: AAH74800.1
BC074843 mRNA Translation: AAH74843.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7980.1

Protein sequence database of the Protein Information Resource

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PIRi
A42806

NCBI Reference Sequences

More...
RefSeqi
NP_000130.1, NM_000139.4
XP_011543152.1, XM_011544850.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.386748

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278888; ENSP00000278888; ENSG00000149534

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2206

UCSC genome browser

More...
UCSCi
uc001nop.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA Translation: BAA01440.1
M89796 Genomic DNA Translation: AAA60269.1
AB080913 Genomic DNA Translation: BAC66486.1
BC074800 mRNA Translation: AAH74800.1
BC074843 mRNA Translation: AAH74843.1
CCDSiCCDS7980.1
PIRiA42806
RefSeqiNP_000130.1, NM_000139.4
XP_011543152.1, XM_011544850.2
UniGeneiHs.386748

3D structure databases

ProteinModelPortaliQ01362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108500, 4 interactors
CORUMiQ01362
IntActiQ01362, 1 interactor
STRINGi9606.ENSP00000278888

Chemistry databases

DrugBankiDB00043 Omalizumab

Protein family/group databases

TCDBi1.A.37.3.2 the cd20 ca(2+) channel (cd20) family

PTM databases

iPTMnetiQ01362
PhosphoSitePlusiQ01362

Polymorphism and mutation databases

BioMutaiMS4A2
DMDMi232084

Proteomic databases

PaxDbiQ01362
PeptideAtlasiQ01362
PRIDEiQ01362
ProteomicsDBi57942

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534
GeneIDi2206
KEGGihsa:2206
UCSCiuc001nop.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2206
DisGeNETi2206
EuPathDBiHostDB:ENSG00000149534.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MS4A2
HGNCiHGNC:7316 MS4A2
HPAiHPA059967
MalaCardsiMS4A2
MIMi147138 gene
neXtProtiNX_Q01362
OpenTargetsiENSG00000149534
PharmGKBiPA31109

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J28C Eukaryota
ENOG4111DU9 LUCA
GeneTreeiENSGT00940000161985
HOGENOMiHOG000060211
HOVERGENiHBG051600
InParanoidiQ01362
KOiK08090
OMAiNKVPDDR
OrthoDBi1048914at2759
PhylomeDBiQ01362
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
SignaLinkiQ01362
SIGNORiQ01362

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MS4A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2206

Protein Ontology

More...
PROi
PR:Q01362

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149534 Expressed in 100 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiQ01362 baseline and differential
GenevisibleiQ01362 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCERB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 13, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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