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Entry version 159 (13 Nov 2019)
Sequence version 4 (19 Mar 2014)
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Protein

OTU domain-containing protein 4

Gene

OTUD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).3 Publications

Caution

When expressed in bacteria, recombinant OTUD4 specifically hydrolyzes 'Lys-48'-linked diubiquitin. The physiological relevance of this activity remains unknown (PubMed:23827681, PubMed:25944111, PubMed:29395066). In vivo deubiquitinates 'Lys-63'-linked ubiquitin chains (PubMed:29395066).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphorylation on Ser-202 and Ser-204 induces 'Lys-63'-specific deubiquitinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei42By similarity1
Active sitei45Nucleophile3 Publications1
Active sitei148By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processImmunity, Innate immunity, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
OTU domain-containing protein 4 (EC:3.4.19.123 Publications)
Alternative name(s):
HIV-1-induced protein HIN-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTUD4Imported
Synonyms:HIN-11 Publication, KIAA10461 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24949 OTUD4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611744 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01804

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45C → A: Abolishes 'Lys-48'- and 'Lys-63'-specific deubiquitinase activity. Impairs 'Lys-63'-specific deubiquitinase activity toward MYD88 substrate. 3 Publications1
Mutagenesisi45C → S: Abolishes 'Lys-48'- and 'Lys-63'-specific deubiquitinase activity. 1 Publication1
Mutagenesisi181 – 550Missing : Abolishes interaction with USP7 and USP9X deubiquitinases. 1 PublicationAdd BLAST370
Mutagenesisi202S → A: Decreases 'Lys-63'-specific deubiquitinase activity. Loss of 'Lys-63'-specific deubiquitinase activity; when associated with A-204. 1 Publication1
Mutagenesisi204S → A: Loss of 'Lys-63'-specific deubiquitinase activity; when associated with A-204. 1 Publication1
Mutagenesisi273 – 275KRD → AAA: Abolishes 'Lys-63'-specific deubiquitinase activity by impairing the affinity for 'Lys-63'-linked ubiquitin chain substrate. 1 Publication3
Mutagenesisi279A → R: Abolishes 'Lys-63'-specific deubiquitinase activity by impairing the affinity for 'Lys-63'-linked ubiquitin chain substrate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54726

Open Targets

More...
OpenTargetsi
ENSG00000164164

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671216

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q01804

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OTUD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
302393819

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839791 – 1114OTU domain-containing protein 4Add BLAST1114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei120Phosphotyrosine1 Publication1
Modified residuei126Phosphoserine1 Publication1
Modified residuei128Phosphoserine1 Publication1
Modified residuei131Phosphothreonine1 Publication1
Modified residuei166Phosphoserine1 Publication1
Modified residuei199Phosphoserine1 Publication1
Modified residuei202Phosphoserine1 Publication1
Modified residuei204Phosphoserine1 Publication1
Modified residuei341PhosphoserineCombined sources1
Modified residuei439PhosphotyrosineBy similarity1
Modified residuei443PhosphoserineCombined sources1
Modified residuei460PhosphotyrosineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1011PhosphoserineBy similarity1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1049PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-202 and Ser-204 likely by CSNK2A1-CSNK2A2 serine/threonine-protein kinase complex. Activates 'Lys-63'-specific deubiquitinase activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01804

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01804

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q01804

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q01804

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01804

PeptideAtlas

More...
PeptideAtlasi
Q01804

PRoteomics IDEntifications database

More...
PRIDEi
Q01804

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57988 [Q01804-1]
57990 [Q01804-3]
57991 [Q01804-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01804

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q01804

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By HIV-1 insertion.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164164 Expressed in 241 organ(s), highest expression level in sigmoid colon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q01804 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q01804 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036623

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYD88; the interaction is direct (PubMed:29395066).

Interacts with ALKBH3; the interaction is direct (PubMed:25944111).

Interacts with USP7; the interaction is direct (PubMed:25944111).

Interacts with USP9X; the interaction is direct (PubMed:25944111).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120112, 73 interactors

Protein interaction database and analysis system

More...
IntActi
Q01804, 48 interactors

Molecular INTeraction database

More...
MINTi
Q01804

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000409279

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01804

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 155OTUPROSITE-ProRule annotation1 PublicationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 45Cys-loopBy similarity7
Regioni94 – 104Variable-loopBy similarityAdd BLAST11
Regioni143 – 148His-loopBy similarity6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2605 Eukaryota
ENOG410XNYW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160512

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01804

KEGG Orthology (KO)

More...
KOi
K13718

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYQDPLY

Database of Orthologous Groups

More...
OrthoDBi
222767at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01804

TreeFam database of animal gene trees

More...
TreeFami
TF326812

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02338 OTU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50802 OTU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q01804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV
60 70 80 90 100
AEQVLHSQSR HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW
110 120 130 140 150
VGQVEISALS LMYRKDFIIY REPNVSPSQV TENNFPEKVL LCFSNGNHYD
160 170 180 190 200
IVYPIKYKES SAMCQSLLYE LLYEKVFKTD VSKIVMELDT LEVADEDNSE
210 220 230 240 250
ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS LPLSRKVLKS
260 270 280 290 300
LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF
310 320 330 340 350
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST
360 370 380 390 400
SGQNFHSDVD YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ
410 420 430 440 450
SQKFSSEHKN LSRTPSQIIR KPDRERVEDF DHTSRESNYF GLSPEERREK
460 470 480 490 500
QAIEESRLLY EIQNRDEQAF PALSSSSVNQ SASQSSNPCV QRKSSHVGDR
510 520 530 540 550
KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK YATVSSPSKS
560 570 580 590 600
KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE
610 620 630 640 650
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP
660 670 680 690 700
LMPLPQTLSL YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR
710 720 730 740 750
FFFNLGVKAY SCPMWAPHSY LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ
760 770 780 790 800
EAPAAQNESD CTCTDAHFPM QTEASVNGQM PQPEIGPPTF SSPLVIPPSQ
810 820 830 840 850
VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP SFGPNPFLGP
860 870 880 890 900
VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS
910 920 930 940 950
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL
960 970 980 990 1000
ASIPPVAEGK AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT
1010 1020 1030 1040 1050
AADVVSPGAN SVDSRVQRPK EESSEDENEV SNILRSGRSK QFYNQTYGSR
1060 1070 1080 1090 1100
KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS RDEGYQYHRN VRGRPFRGDR
1110
RRSGMGDGHR GQHT
Note: Gene prediction based on similarity to orthologs and partial EST data.
Length:1,114
Mass (Da):124,045
Last modified:March 19, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD8DF5FEAB8CBE32
GO
Isoform 2 (identifier: Q01804-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     231-231: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,048
Mass (Da):116,953
Checksum:i5266BAE77822228E
GO
Isoform 3 (identifier: Q01804-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:1,049
Mass (Da):117,082
Checksum:i1DCACF002992C917
GO
Isoform 4 (identifier: Q01804-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     211-1114: Missing.

Note: Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention.
Show »
Length:145
Mass (Da):17,036
Checksum:iBEF79BFC3DB34EF1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RI06D6RI06_HUMAN
OTU domain-containing protein 4
OTUD4
372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA27D6RA27_HUMAN
OTU domain-containing protein 4
OTUD4
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57242 differs from that shown. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAA82998 differs from that shown. Intron retention.Curated
The sequence BAB71229 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti809S → P in BAB71229 (PubMed:14702039).Curated1
Sequence conflicti915A → S in CAB70748 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029377194A → G1 PublicationCorresponds to variant dbSNP:rs36225458EnsemblClinVar.1
Natural variantiVAR_038848216A → T1 PublicationCorresponds to variant dbSNP:rs36225838Ensembl.1
Natural variantiVAR_070050398G → V Could be associated with cerebellar ataxia and hypogonadotropic hypogonadism. 1 PublicationCorresponds to variant dbSNP:rs148857745EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0388301 – 65Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST65
Alternative sequenceiVSP_021671211 – 1114Missing in isoform 4. 1 PublicationAdd BLAST904
Alternative sequenceiVSP_053825231Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK056597 mRNA Translation: BAB71229.1 Different initiation.
AK302581 mRNA Translation: BAG63836.1
AC096757 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05045.1
CH471056 Genomic DNA Translation: EAX05046.1
X68242 mRNA Translation: CAA48313.1
DQ427109 Genomic DNA Translation: ABD72605.1
BC057242 mRNA Translation: AAH57242.2 Sequence problems.
BC118572 mRNA Translation: AAI18573.1
BC118653 mRNA Translation: AAI18654.1
AB028969 mRNA Translation: BAA82998.2 Sequence problems.
AL137460 mRNA Translation: CAB70748.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3764.1 [Q01804-4]
CCDS47139.1 [Q01804-3]

Protein sequence database of the Protein Information Resource

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PIRi
S30247
T46403

NCBI Reference Sequences

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RefSeqi
NP_001096123.1, NM_001102653.1 [Q01804-3]
NP_059963.1, NM_017493.6 [Q01804-4]
XP_005263136.1, XM_005263079.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000447906; ENSP00000395487; ENSG00000164164 [Q01804-1]
ENST00000454497; ENSP00000409279; ENSG00000164164 [Q01804-3]
ENST00000509620; ENSP00000424192; ENSG00000164164 [Q01804-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54726

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54726

UCSC genome browser

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UCSCi
uc003ika.5 human [Q01804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056597 mRNA Translation: BAB71229.1 Different initiation.
AK302581 mRNA Translation: BAG63836.1
AC096757 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05045.1
CH471056 Genomic DNA Translation: EAX05046.1
X68242 mRNA Translation: CAA48313.1
DQ427109 Genomic DNA Translation: ABD72605.1
BC057242 mRNA Translation: AAH57242.2 Sequence problems.
BC118572 mRNA Translation: AAI18573.1
BC118653 mRNA Translation: AAI18654.1
AB028969 mRNA Translation: BAA82998.2 Sequence problems.
AL137460 mRNA Translation: CAB70748.1
CCDSiCCDS3764.1 [Q01804-4]
CCDS47139.1 [Q01804-3]
PIRiS30247
T46403
RefSeqiNP_001096123.1, NM_001102653.1 [Q01804-3]
NP_059963.1, NM_017493.6 [Q01804-4]
XP_005263136.1, XM_005263079.4

3D structure databases

SMRiQ01804
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120112, 73 interactors
IntActiQ01804, 48 interactors
MINTiQ01804
STRINGi9606.ENSP00000409279

PTM databases

iPTMnetiQ01804
PhosphoSitePlusiQ01804

Polymorphism and mutation databases

BioMutaiOTUD4
DMDMi302393819

Proteomic databases

EPDiQ01804
jPOSTiQ01804
MassIVEiQ01804
MaxQBiQ01804
PaxDbiQ01804
PeptideAtlasiQ01804
PRIDEiQ01804
ProteomicsDBi57988 [Q01804-1]
57990 [Q01804-3]
57991 [Q01804-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54726

Genome annotation databases

EnsembliENST00000447906; ENSP00000395487; ENSG00000164164 [Q01804-1]
ENST00000454497; ENSP00000409279; ENSG00000164164 [Q01804-3]
ENST00000509620; ENSP00000424192; ENSG00000164164 [Q01804-4]
GeneIDi54726
KEGGihsa:54726
UCSCiuc003ika.5 human [Q01804-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54726
DisGeNETi54726

GeneCards: human genes, protein and diseases

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GeneCardsi
OTUD4
HGNCiHGNC:24949 OTUD4
HPAiHPA036623
MIMi611744 gene
neXtProtiNX_Q01804
OpenTargetsiENSG00000164164
PharmGKBiPA142671216

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2605 Eukaryota
ENOG410XNYW LUCA
GeneTreeiENSGT00940000160512
InParanoidiQ01804
KOiK13718
OMAiPYQDPLY
OrthoDBi222767at2759
PhylomeDBiQ01804
TreeFamiTF326812

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OTUD4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OTUD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54726
PharosiQ01804

Protein Ontology

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PROi
PR:Q01804

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164164 Expressed in 241 organ(s), highest expression level in sigmoid colon
ExpressionAtlasiQ01804 baseline and differential
GenevisibleiQ01804 HS

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF02338 OTU, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTUD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01804
Secondary accession number(s): B4DYS4
, Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 19, 2014
Last modified: November 13, 2019
This is version 159 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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