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Entry version 153 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Exocyst complex component SEC10

Gene

SEC10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Miscellaneous

Present with 2340 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32296-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-SCE-264876 Insulin processing

Protein family/group databases

Transport Classification Database

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TCDBi
1.F.2.1.1 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component SEC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC10
Ordered Locus Names:YLR166C
ORF Names:L9362.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YLR166C

Saccharomyces Genome Database

More...
SGDi
S000004156 SEC10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189501 – 871Exocyst complex component SEC10Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q06245

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06245

PRoteomics IDEntifications database

More...
PRIDEi
Q06245

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31439, 206 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1890 Exocyst

Database of interacting proteins

More...
DIPi
DIP-1724N

Protein interaction database and analysis system

More...
IntActi
Q06245, 16 interactors

Molecular INTeraction database

More...
MINTi
Q06245

STRING: functional protein association networks

More...
STRINGi
4932.YLR166C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06245

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 101Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000012837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000248789

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06245

KEGG Orthology (KO)

More...
KOi
K19984

Identification of Orthologs from Complete Genome Data

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OMAi
AMCAICD

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like

The PANTHER Classification System

More...
PANTHERi
PTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07393 Sec10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLYELDPK WKKLLKTDNF LGGLTVNEFV QELSKDHRND VLIDANTKNL
60 70 80 90 100
PTNEKDQDAI REAIWKQLDP KPYIRTFEST LKELKNLNEE TLNKRQYFSE
110 120 130 140 150
QVATQEVIHS ENVIKLSKDL HTTLLTFDKL DDRLTNVTQV VSPLGDKLET
160 170 180 190 200
AIKKKQNYIQ SVELIRRYND FYSMGKSDIV EQLRLSKNWK LNLKSVKLMK
210 220 230 240 250
NLLILSSKLE TSSIPKTINT KLVIEKYSEM MENELLENFN SAYRENNFTK
260 270 280 290 300
LNEIAIILNN FNGGVNVIQS FINQHDYFID TKQIDLENEF ENVFIKNVKF
310 320 330 340 350
KEQLIDFENH SVIIETSMQN LINDVETVIK NESKIVKRVF EEKATHVIQL
360 370 380 390 400
FIQRVFAQKI EPRFEVLLRN SLSISNLAYV RILHGLFTLF GKFTKSLIDY
410 420 430 440 450
FQLLEIDDSN QILSTTLEQC FADLFSHYLY DRSKYFGIEK RSLEAILVDM
460 470 480 490 500
TSKFTVNYDK EINKRVLLDK YKEKLSTNVD AFMHSPRGNT HSRQDSTSRS
510 520 530 540 550
KLSQFNSFLK THLDKDHLSL NRTNTLSDSF NNSSSSTQYD VANNSSSLVN
560 570 580 590 600
SSFTASDIDN SPNSPANYSL NDVDSMLKCV VESTARVMEL IPNKAHLYIL
610 620 630 640 650
EILKIMFLGI VDSYMEIALE VAYWKICKVD INKTAGVVNL NFLKFISMST
660 670 680 690 700
EILDLLSISI KSIFLPLLNN SPEIKAQIIE MTNSQIQKME ILINIILQET
710 720 730 740 750
ITVISTKFSA ILCKQKKKDF VPKSQELLDQ DTLPAIEIVN ILNLIFEQSS
760 770 780 790 800
KFLKGKNLQT FLTLIGEELY GLLLSHYSHF QVNSIGGVVV TKDIIGYQTA
810 820 830 840 850
IEDWGVASLI DKFATLRELA NLFTVQPELL ESLTKEGHLA DIGRDIIQSY
860 870
ISNREDFNHD NFINSVKLNF R
Length:871
Mass (Da):100,342
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA32073099815388D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y08789 Genomic DNA Translation: CAA70041.1
U51921 Genomic DNA Translation: AAB67490.1
U17246 Genomic DNA Translation: AAB67476.2
BK006945 Genomic DNA Translation: DAA09488.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S68482

NCBI Reference Sequences

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RefSeqi
NP_013267.1, NM_001182053.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR166C_mRNA; YLR166C_mRNA; YLR166C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR166C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08789 Genomic DNA Translation: CAA70041.1
U51921 Genomic DNA Translation: AAB67490.1
U17246 Genomic DNA Translation: AAB67476.2
BK006945 Genomic DNA Translation: DAA09488.1
PIRiS68482
RefSeqiNP_013267.1, NM_001182053.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YFPelectron microscopy4.40E1-871[»]
SMRiQ06245
ModBaseiSearch...

Protein-protein interaction databases

BioGridi31439, 206 interactors
ComplexPortaliCPX-1890 Exocyst
DIPiDIP-1724N
IntActiQ06245, 16 interactors
MINTiQ06245
STRINGi4932.YLR166C

Protein family/group databases

TCDBi1.F.2.1.1 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ06245

Proteomic databases

MaxQBiQ06245
PaxDbiQ06245
PRIDEiQ06245

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR166C_mRNA; YLR166C_mRNA; YLR166C
GeneIDi850863
KEGGisce:YLR166C

Organism-specific databases

EuPathDBiFungiDB:YLR166C
SGDiS000004156 SEC10

Phylogenomic databases

GeneTreeiENSGT00390000012837
HOGENOMiHOG000248789
InParanoidiQ06245
KOiK19984
OMAiAMCAICD

Enzyme and pathway databases

BioCyciYEAST:G3O-32296-MONOMER
ReactomeiR-SCE-264876 Insulin processing

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06245

Family and domain databases

InterProiView protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like
PANTHERiPTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit
PfamiView protein in Pfam
PF07393 Sec10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC10_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06245
Secondary accession number(s): D6VYH2, P87329
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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