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  1. 6
    "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C."
    Kato Y., Kravchenko V.V., Tapping R.I., Han J., Ulevitch R.J., Lee J.-D.
    EMBO J. 16:7054-7066(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-293; THR-300 AND SER-419, FUNCTION, MUTAGENESIS OF THR-293; THR-300 AND SER-419.
    Category: Function, Pathology & Biotech, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  2. 7
    "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation."
    Han J., Jiang Y., Li Z., Kravchenko V.V., Ulevitch R.J.
    Nature 386:296-299(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-293; THR-300 AND SER-419, FUNCTION, MUTAGENESIS OF THR-293; THR-300 AND SER-419.
    Category: Function, Pathology & Biotech, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

  3. 12
    "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis."
    Okamoto S., Li Z., Ju C., Scholzke M.N., Mathews E., Cui J., Salvesen G.S., Bossy-Wetzel E., Lipton S.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:3974-3979(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING AT ASP-432, FUNCTION, MUTAGENESIS OF ASP-432.
    Category: Function, Pathology & Biotech, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  4. 13
    "Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity."
    Zhu B., Gulick T.
    Mol. Cell. Biol. 24:8264-8275(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-396, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF SER-396, FUNCTION OF ISOFORMS.
    Category: Function, Pathology & Biotech, PTM / Processing, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 4 other entries.

  5. 16
    "Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."
    Zhu B., Ramachandran B., Gulick T.
    J. Biol. Chem. 280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF BETA DOMAIN, MUTAGENESIS OF SER-271; GLU-272; ASP-273; ASP-275; SER-387 AND SER-396.
    Category: Function, Pathology & Biotech, Family & Domains.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 5 and mapped to 22 other entries.

  6. 18
    "Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation."
    Ma K., Chan J.K., Zhu G., Wu Z.
    Mol. Cell. Biol. 25:3575-3582(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT LYS-116; LYS-119; LYS-234; LYS-239; LYS-252 AND LYS-264, INTERACTION WITH EP300, FUNCTION, DNA-BINDING, MUTAGENESIS OF LYS-116; LYS-119; LYS-234; LYS-239; LYS-252 AND LYS-264.
    Category: Function, Pathology & Biotech, PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 5 other entries.

  7. 24
    "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors."
    Yang S.-H., Galanis A., Sharrocks A.D.
    Mol. Cell. Biol. 19:4028-4038(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938, Reactome:R-HSA-448838.

    This publication is cited by 2 and mapped to 3 other entries.

  8. 25
    "Cloning and mRNA tissue distribution of human PPARgamma coactivator-1."
    Larrouy D., Vidal H., Andreelli F., Laville M., Langin D.
    Int. J. Obes. Relat. Metab. Disord. 23:1327-1332(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938.

    This publication is mapped to 9 other entries.

  9. 26
    "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen."
    Knutti D., Kaul A., Kralli A.
    Mol. Cell. Biol. 20:2411-2422(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938.

    This publication is mapped to 9 other entries.

  10. 28
    "p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps."
    Wu Z., Woodring P.J., Bhakta K.S., Tamura K., Wen F., Feramisco J.R., Karin M., Wang J.Y., Puri P.L.
    Mol. Cell. Biol. 20:3951-3964(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: Pathway. [Reactome:R-HSA-199938, Reactome:R-HSA-448838]. Phosphorylation. [iPTMnet:Q06413].
    Source: Reactome:R-HSA-199938, Reactome:R-HSA-448838, iPTMnet:Q06413.

    This publication is mapped to 6 other entries.

  11. 32
    "The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression."
    Rogerson P.J., Jamali M., Skerjanc I.S.
    FEBS Lett. 524:134-138(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: upregulation of expression by C-terminus of myogenin.
    Source: GeneRIF:4208.

    This publication is mapped to 8 other entries.

  12. 34
    "Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle."
    Pilegaard H., Saltin B., Neufer P.D.
    J. Physiol. (Lond.) 546:851-858(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938.

    This publication is mapped to 12 other entries.

  13. 35
    "ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons."
    Liu L., Cavanaugh J.E., Wang Y., Sakagami H., Mao Z., Xia Z.
    Proc. Natl. Acad. Sci. U.S.A. 100:8532-8537(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938, Reactome:R-HSA-199942.

    This publication is mapped to 2 other entries.

  14. 36
    "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation."
    Konig S., Hinard V., Arnaudeau S., Holzer N., Potter G., Bader C.R., Bernheim L.
    J. Biol. Chem. 279:28187-28196(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation.
    Source: GeneRIF:4208.

    This publication is mapped to 19 other entries.

  15. 37
    "Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice."
    Xu J., Gong N.L., Bodi I., Aronow B.J., Backx P.H., Molkentin J.D.
    J. Biol. Chem. 281:9152-9162(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: data show a dosage-dependent cardiomyopathic phenotype and a progressive reduction in ventricular performance associated with MEF2A or MEF2C overexpression.
    Source: GeneRIF:4208.

    This publication is mapped to 13 other entries.

  16. 38
    "Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression."
    Gong X., Tsai S.W., Yan B., Rubin L.P.
    BMC Mol. Biol. 7:7-7(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: Study demonstrates that human intestinal cell BCMO1 expression is dependent on the functional cooperation between peroxisome proliferator-activated receptor-gamma and myocyte enhancer factor 2 isoforms.
    Source: GeneRIF:4208.

    This publication is mapped to 30 other entries.

  17. 39
    "Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma."
    Bai X., Wu L., Liang T., Liu Z., Li J., Li D., Xie H., Yin S., Yu J., Lin Q., Zheng S.
    J. Cancer Res. Clin. Oncol. 134:83-91(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: Overexpression of MEF2C is associated with hepatocellular carcinoma.
    Source: GeneRIF:4208.

    This publication is mapped to 13 other entries.

  18. 41
    "Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness."
    Levy D., Larson M.G., Benjamin E.J., Newton-Cheh C., Wang T.J., Hwang S.J., Vasan R.S., Mitchell G.F.
    BMC Med. Genet. 8 Suppl 1:S3-S3(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Associated with OTHER: tonometry. [GAD:598777]. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator). [GeneRIF:4208].
    Source: GeneRIF:4208, GAD:598777.

    This publication is mapped to 86 other entries.

  19. 44
    "MeCP2, a key contributor to neurological disease, activates and represses transcription."
    Chahrour M., Jung S.Y., Shaw C., Zhou X., Wong S.T., Qin J., Zoghbi H.Y.
    Science 320:1224-1229(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-199938.

    This publication is mapped to 18 other entries.

  20. 45
    "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations."
    Lu Y., Dolle M.E., Imholz S., van 't Slot R., Verschuren W.M., Wijmenga C., Feskens E.J., Boer J.M.
    J. Lipid Res. 49:2582-2589(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator). [GeneRIF:4208]. Not Associated with METABOLIC: plasma HDL cholesterol (HDL-C) levels. [GAD:590352].
    Source: GeneRIF:4208, GAD:590352.

    This publication is mapped to 1555 other entries.

  21. 47
    "Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells."
    Zhao Z., Geng J., Ge Z., Wang W., Zhang Y., Kang W.
    Mol. Cell. Biochem. 322:171-178(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Thus ERK5 phosphorylation contributes to MEF2C activation and subsequent HASMC hypertrophy induced by Ang II.
    Source: GeneRIF:4208.

    This publication is mapped to 23 other entries.

  22. 49
    "Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis."
    Liu G., Han J., Profirovic J., Strekalova E., Voyno-Yasenetskaya T.A.
    Angiogenesis 12:1-15(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: MEF2 proteins are an important component in Galpha13-mediated angiogenesis.
    Source: GeneRIF:4208.

    This publication is mapped to 21 other entries.

  23. 55
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:4208.

    This publication is mapped to 18812 other entries.

  24. 64
    Category: Function.
    Annotation: NKX2-1 NKX2-2 and MEF2C define oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL).
    Source: GeneRIF:4208.

    This publication is mapped to 11 other entries.

  25. 66
    "Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization."
    Stephens A.S., Stephens S.R., Hobbs C., Hutmacher D.W., Bacic-Welsh D., Woodruff M.A., Morrison N.A.
    J. Biol. Chem. 286:30071-30086(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: knockdown of bone-specific transcription factors Runx2 and osterix by shRNAi knockdown of Mef2c suggests that Mef2c lies upstream of these two important factors in the cascade of gene expression in osteoblasts.
    Source: GeneRIF:4208.

    This publication is mapped to 30 other entries.

1 to 25 of 51  Show
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