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Entry version 227 (31 Jul 2019)
Sequence version 2 (15 Jul 1998)
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Protein

Peroxisome proliferator-activated receptor alpha

Gene

PPARA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei280Synthetic agonist5 Publications1
Binding sitei314Synthetic agonist5 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei433Essential for heterodimerization with RXRA1
Binding sitei440Synthetic agonist5 Publications1
Binding sitei464Synthetic agonist5 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi99 – 173Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-4090294 SUMOylation of intracellular receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q07869

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q07869

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001644

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPARA
Synonyms:NR1C1, PPAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9232 PPARA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170998 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07869

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi122C → G: Prevents DNA binding but no effect on heterodimerization with RXRA. 1 Publication1
Mutagenesisi304D → A: Reduced heterodimerization with RXRA. Reduced DNA binding. 1 Publication1
Mutagenesisi370L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication1
Mutagenesisi391L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication1
Mutagenesisi422L → R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity. 1 Publication1
Mutagenesisi431A → T: No effect on heterodimerization with RXRA nor on DNA binding. 1 Publication1
Mutagenesisi433L → R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5465
MIMi170998 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA280

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL239

Drug and drug target database

More...
DrugBanki
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01393 Bezafibrate
DB00636 Clofibrate
DB01039 Fenofibrate
DB01241 Gemfibrozil
DB05187 GFT505
DB00328 Indomethacin
DB01708 Prasterone
DB04971 Reglixane

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
593

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPARA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3041727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000534811 – 468Peroxisome proliferator-activated receptor alphaAdd BLAST468

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07869

PeptideAtlas

More...
PeptideAtlasi
Q07869

PRoteomics IDEntifications database

More...
PRIDEi
Q07869

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58553 [Q07869-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07869

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by aging.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186951 Expressed in 211 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q07869 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07869 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB075701
HPA058901
HPA067049

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity.

Interacts with NCOA3 coactivator.

Interacts with CITED2; the interaction stimulates its transcriptional activity.

Also interacts with PPARBP in vitro.

Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6.

Interacts with ASXL1 and ASXL2.

Interacts with PER2.

Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (PubMed:24043310).

Interacts with CRY1 and CRY2 (By similarity).

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111461, 46 interactors

Database of interacting proteins

More...
DIPi
DIP-241N

Protein interaction database and analysis system

More...
IntActi
Q07869, 18 interactors

Molecular INTeraction database

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MINTi
Q07869

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385523

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q07869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07869

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07869

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini239 – 466NR LBDPROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni304 – 433Required for heterodimerization with RXRAAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000261626

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07869

KEGG Orthology (KO)

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KOi
K07294

Identification of Orthologs from Complete Genome Data

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OMAi
FSFTEYQ

Database of Orthologous Groups

More...
OrthoDBi
623111at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07869

TreeFam database of animal gene trees

More...
TreeFami
TF316304

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.565.10, 1 hit
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003076 PPAR-alpha
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

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Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01288 PROXISOMEPAR
PR01289 PROXISOMPAAR
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG
60 70 80 90 100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET
210 220 230 240 250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM
410 420 430 440 450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT
460
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,225
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i850846FD51ADA883
GO
Isoform 2 (identifier: Q07869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-174: IRFG → FCHT
     175-468: Missing.

Show »
Length:174
Mass (Da):18,942
Checksum:i8587321146D06A03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYX1B0QYX1_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-003
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYX2B0QYX2_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-009
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86SF0Q86SF0_HUMAN
Peroxisome proliferator-activated r...
PPARA SC22CB-5E3.5-002
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71T → M in CAA68898 (PubMed:8993548).Curated1
Sequence conflicti123K → M in CAA68898 (PubMed:8993548).Curated1
Sequence conflicti296G → A in AAA36468 (PubMed:7684926).Curated1
Sequence conflicti444V → A in CAA68898 (PubMed:8993548).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016110127R → Q. Corresponds to variant dbSNP:rs1800204Ensembl.1
Natural variantiVAR_016111162L → V1 PublicationCorresponds to variant dbSNP:rs1800206EnsemblClinVar.1
Natural variantiVAR_016112227V → A. Corresponds to variant dbSNP:rs1800234Ensembl.1
Natural variantiVAR_016113268A → V1 PublicationCorresponds to variant dbSNP:rs1042311Ensembl.1
Natural variantiVAR_016114304D → N. Corresponds to variant dbSNP:rs1800242Ensembl.1
Natural variantiVAR_050578395G → R. Corresponds to variant dbSNP:rs2229245Ensembl.1
Natural variantiVAR_016115409R → T. Corresponds to variant dbSNP:rs1800243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047571171 – 174IRFG → FCHT in isoform 2. 1 Publication4
Alternative sequenceiVSP_047572175 – 468Missing in isoform 2. 1 PublicationAdd BLAST294

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L02932 mRNA Translation: AAA36468.1
S74349 mRNA Translation: AAB32649.1
Y07619 mRNA Translation: CAA68898.1
AB307690 mRNA Translation: BAH02281.1
EU650667 mRNA Translation: ACD12656.1
EU395809 mRNA Translation: ABY73535.1
CR456547 mRNA Translation: CAG30433.1
AK289821 mRNA Translation: BAF82510.1
CR457435 mRNA Translation: CAG33716.1
AY206718 Genomic DNA Translation: AAO13489.1
AL049856, AL078611 Genomic DNA Translation: CAI22450.1
Z94161 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73402.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33669.1 [Q07869-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49289
I56603

NCBI Reference Sequences

More...
RefSeqi
NP_001001928.1, NM_001001928.2 [Q07869-1]
NP_005027.2, NM_005036.4 [Q07869-1]
XP_005261712.1, XM_005261655.3
XP_005261713.1, XM_005261656.3 [Q07869-1]
XP_006724332.1, XM_006724269.3
XP_006724333.1, XM_006724270.3 [Q07869-1]
XP_011528541.1, XM_011530239.2 [Q07869-1]
XP_011528542.1, XM_011530240.2 [Q07869-1]
XP_011528543.1, XM_011530241.2 [Q07869-1]
XP_011528544.1, XM_011530242.2 [Q07869-1]
XP_011528545.1, XM_011530243.2 [Q07869-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1]
ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1]
ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5465

UCSC genome browser

More...
UCSCi
uc003bgx.1 human [Q07869-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02932 mRNA Translation: AAA36468.1
S74349 mRNA Translation: AAB32649.1
Y07619 mRNA Translation: CAA68898.1
AB307690 mRNA Translation: BAH02281.1
EU650667 mRNA Translation: ACD12656.1
EU395809 mRNA Translation: ABY73535.1
CR456547 mRNA Translation: CAG30433.1
AK289821 mRNA Translation: BAF82510.1
CR457435 mRNA Translation: CAG33716.1
AY206718 Genomic DNA Translation: AAO13489.1
AL049856, AL078611 Genomic DNA Translation: CAI22450.1
Z94161 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73402.1
CCDSiCCDS33669.1 [Q07869-1]
PIRiA49289
I56603
RefSeqiNP_001001928.1, NM_001001928.2 [Q07869-1]
NP_005027.2, NM_005036.4 [Q07869-1]
XP_005261712.1, XM_005261655.3
XP_005261713.1, XM_005261656.3 [Q07869-1]
XP_006724332.1, XM_006724269.3
XP_006724333.1, XM_006724270.3 [Q07869-1]
XP_011528541.1, XM_011530239.2 [Q07869-1]
XP_011528542.1, XM_011530240.2 [Q07869-1]
XP_011528543.1, XM_011530241.2 [Q07869-1]
XP_011528544.1, XM_011530242.2 [Q07869-1]
XP_011528545.1, XM_011530243.2 [Q07869-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I7GX-ray2.20A196-468[»]
1K7LX-ray2.50A/C/E/G192-468[»]
1KKQX-ray3.00A/B/C/D200-468[»]
2NPAX-ray2.30A/C199-468[»]
2P54X-ray1.79A202-468[»]
2REWX-ray2.35A196-468[»]
2ZNNX-ray2.01A200-468[»]
3ET1X-ray2.50A/B199-468[»]
3FEIX-ray2.40A202-468[»]
3G8IX-ray2.20A199-468[»]
3KDTX-ray2.70A/B196-468[»]
3KDUX-ray2.07A/B196-468[»]
3SP6X-ray2.21A196-468[»]
3VI8X-ray1.75A200-468[»]
4BCRX-ray2.50A/B195-468[»]
4CI4X-ray2.30A195-468[»]
5AZTX-ray3.45A/B201-468[»]
5HYKX-ray1.83A200-468[»]
SMRiQ07869
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111461, 46 interactors
DIPiDIP-241N
IntActiQ07869, 18 interactors
MINTiQ07869
STRINGi9606.ENSP00000385523

Chemistry databases

BindingDBiQ07869
ChEMBLiCHEMBL239
DrugBankiDB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01393 Bezafibrate
DB00636 Clofibrate
DB01039 Fenofibrate
DB01241 Gemfibrozil
DB05187 GFT505
DB00328 Indomethacin
DB01708 Prasterone
DB04971 Reglixane
GuidetoPHARMACOLOGYi593
SwissLipidsiSLP:000001644

PTM databases

iPTMnetiQ07869
PhosphoSitePlusiQ07869

Polymorphism and mutation databases

BioMutaiPPARA
DMDMi3041727

Proteomic databases

PaxDbiQ07869
PeptideAtlasiQ07869
PRIDEiQ07869
ProteomicsDBi58553 [Q07869-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262735; ENSP00000262735; ENSG00000186951 [Q07869-1]
ENST00000402126; ENSP00000385246; ENSG00000186951 [Q07869-1]
ENST00000407236; ENSP00000385523; ENSG00000186951 [Q07869-1]
GeneIDi5465
KEGGihsa:5465
UCSCiuc003bgx.1 human [Q07869-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5465
DisGeNETi5465

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPARA
HGNCiHGNC:9232 PPARA
HPAiCAB075701
HPA058901
HPA067049
MIMi170998 gene+phenotype
neXtProtiNX_Q07869
OpenTargetsiENSG00000186951
PharmGKBiPA280

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000157097
HOGENOMiHOG000261626
InParanoidiQ07869
KOiK07294
OMAiFSFTEYQ
OrthoDBi623111at2759
PhylomeDBiQ07869
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkiQ07869
SIGNORiQ07869

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPARA human
EvolutionaryTraceiQ07869

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Peroxisome_proliferator-activated_receptor_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5465

Protein Ontology

More...
PROi
PR:Q07869

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186951 Expressed in 211 organ(s), highest expression level in liver
ExpressionAtlasiQ07869 baseline and differential
GenevisibleiQ07869 HS

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003076 PPAR-alpha
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01289 PROXISOMPAAR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPARA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07869
Secondary accession number(s): B0G0X3
, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: July 31, 2019
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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