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Entry version 139 (13 Nov 2019)
Sequence version 1 (03 Oct 2006)
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Protein

Serine/threonine-protein kinase Tao

Gene

Tao

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein (PubMed:22075147, PubMed:22075148). In imaginal cells, phosphorylates and activates hpo and leads to repression of yki (PubMed:22075147, PubMed:22075148). In the midgut, negatively regulates the proliferation of intestinal stem cells through the Hippo/SWH pathway (PubMed:25160975). Independent of the hippo/SWH pathway, regulates epithelial morphogenesis in follicle cells by promoting the endocytosis of Fas2 and reducing lateral adhesion between epithelial cells which, in turn, permits shrinking of the lateral membrane and initiates morphogenesis of the squamous epithelium (PubMed:23266957). Required for the development of both the mushroom body and the ellipsoid body in the brain and may act as a negative regulator of the par-1 kinase (PubMed:21248138). Negatively regulates the JNK pathway which increases sensitivity to ethanol exposure (PubMed:23227189). Plays a role in the control of cell shape by negatively regulating the growth of microtubule plus-ends as they contact the actin-rich cell cortex (PubMed:20647372). Required for the induction of apoptosis in pole cells by promoting expression of skl which enhances activity of the apoptosis activator hid (PubMed:17449640).8 Publications
Isoform D: Induces in vitro expression of large, highly dynamic, microtubule-dependent lamellopodia-like cytoplasmic expansions which constantly probe the environment.1 Publication
Isoform A: Induces in vitro expression of actin-dependent filopodia-like cytoplasmic protrusions which firmly attach to the substrate. Antagonizes the activity of isoform D.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33 – 41ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q0KHQ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase TaoCurated (EC:2.7.11.12 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TaoImported
Synonyms:Tao-1Imported
ORF Names:CG14217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031030 Tao

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morphological defects in the follicular epithelium where cells in the anterior part of the epithelium stay cuboidal and fail to stretch (PubMed:23266957). RNAi-mediated knockdown in eye and wing imaginal disks results in tissue overgrowth (PubMed:22075147, PubMed:22075148). It also gives rise to transcriptional up-regulation of a number of targets of the Hippo/SWH pathway (PubMed:22075147). RNAi-mediated knockdown in wing imaginal disks results in strong elevation of yki activity (PubMed:22075148). RNAi-mediated knockdown in the adult posterior midgut results in an increased number of intestinal stem cells (PubMed:25160975). RNAi-mediated knockdown in the embryo results in disordered migration of primordial germ cells out of the gut epithelium, their dispersal within the embryo and embryonic death (PubMed:25589578).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56K → A: Induces the formation of microtubule-rich protrusions. Abolishes repression of Yki. Causes an isoform A-like cellular phenotype with development of filopodia-like structures. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004365421 – 1039Serine/threonine-protein kinase TaoCuratedAdd BLAST1039

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.2 Publications

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0KHQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q0KHQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the posterior midgut, expressed in almost all intestinal cell types including intestinal stem cells and enterocytes (at protein level). Maternally expressed, ubiquitously distributed in the egg and early embryo and enriched in the germ plasm at the posterior pole of the early embryo including the pole cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform A: Enriched in germ plasm but is degraded in pole cells immediately after pole cell formation. Isoform D: Enriched in germ plasm, partitions into pole cells and remains detectable in pole cells until they migrate through the midgut epithelium toward the overlying mesoderm.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031030 Expressed in 40 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0KHQ5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Schip1; the interaction enhances Tao kinase activity.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q0KHQ5, 4 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0292968

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0KHQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 280Protein kinasePROSITE-ProRule annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili631 – 765Sequence analysisAdd BLAST135
Coiled coili835 – 993Sequence analysisAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi341 – 370Ser-richPROSITE-ProRule annotationAdd BLAST30
Compositional biasi378 – 405His-richPROSITE-ProRule annotationAdd BLAST28
Compositional biasi406 – 476Pro-richPROSITE-ProRule annotationAdd BLAST71
Compositional biasi482 – 503Gly-richPROSITE-ProRule annotationAdd BLAST22
Compositional biasi691 – 937Gln-richPROSITE-ProRule annotationAdd BLAST247

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0577 Eukaryota
ENOG410Y259 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168060

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0KHQ5

KEGG Orthology (KO)

More...
KOi
K04429

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0KHQ5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform DImported (identifier: Q0KHQ5-1) [UniParc]FASTAAdd to basket
Also known as: EImported, FImported, Tao-L1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSARPGSLK DPEIADLFNK HDPEKIFEDL REIGHGSFGA VYYARCNLTR
60 70 80 90 100
EIVAIKKMSY TGKQSQEKWQ DILKEIRFLR QLNHPNTIEY KGCYLRESTA
110 120 130 140 150
WLVMEYCVGS ASDIIEVHKK PLHEDEIAAI CLGVLSGLSY LHSLGRIHRD
160 170 180 190 200
IKAGNILLTD NGVVKLADFG SAAIKCPANS FVGTPYWMAP EVILAMDEGQ
210 220 230 240 250
YDGKVDVWSL GITCIELAER KPPYFNMNAM SALYHIAQNE SPTLPKNDWS
260 270 280 290 300
DAFCSFVELC LKKMPAERPS SAKLLTHAYV TRPRSDTVLL ELIARTKSAV
310 320 330 340 350
RELDNLNYRK MKKILMVDTC ETESAVGDTD DQQDDHAGGD SSKSNSITSE
360 370 380 390 400
HSIHSVGVSA ASSQSSSSNS IPAAAQNHHH IAAHHHQQAA SAAVAAAMHH
410 420 430 440 450
HHHPHQQPPP SWPSGQQGQP VPPGAVSRNS SRHRNRPPLP NIMHSMNNNV
460 470 480 490 500
TPTNSASVVP APAPAPVLPP PISVLPHLSA MGHVGGGGTG TGGSGGGSPA
510 520 530 540 550
SGGPLADRIQ PVQPRYLTTP AAQAAVYAAS SASSQQAISN AVNDHGPNNF
560 570 580 590 600
ATIRTTSIVT KQQKEHMQEE MHEQMSGYKR MRREHQAHLV KLEEKCKVDM
610 620 630 640 650
EAHKTALDKE YDTLLHNFTR DLDRLETKHQ QDVERRAKQT SAAEKKLHKE
660 670 680 690 700
ITLKQENDRK VYDLNRKKEY KANKERWKRE LSMDESTPKR QRDLTLQSQK
710 720 730 740 750
DNLKQHEAQE EQRMLQAQKQ YIELEMRKFK RKRMIMQHEH EDQQLRDELG
760 770 780 790 800
KKEQQLQQAH AMLLKHHEKT QELEYRQQKS VHQLREEQIN KQHDTELHNQ
810 820 830 840 850
KDYMDRIKKE LVRKHAVELR QQPKSLKQKE LQIRKQFRET CKTQTKQYKR
860 870 880 890 900
YKAQVLQTTP KEQQKEVIKQ LKEEKHRKLT LLGEQYEQSI ADMFQSQSYK
910 920 930 940 950
LDESQVIECQ RTHEQLEYEL EMLTAYQNKN KKQAQEQRDR ERRELENRVS
960 970 980 990 1000
VRRGLLENKM DAELQQFNQE RAERLRMKHE KHTKELEAFD NESIALGFST
1010 1020 1030
LSLIEVSREA YADEEGSLSG SMISLAHSNS STSFPAGSL
Length:1,039
Mass (Da):118,298
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i391D15216D295F3A
GO
Isoform AImported (identifier: Q0KHQ5-2) [UniParc]FASTAAdd to basket
Also known as: GImported, Tao-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-568: MPSARPGSLK...VTKQQKEHMQ → MFWPRFAPVEVMVELEFGSGF

Show »
Length:492
Mass (Da):59,429
Checksum:i2B56E2EC8BEC2EE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PHK2M9PHK2_DROME
Tao, isoform I
Tao AAF48973, Dmel\CG14217, dTao-1, MARKK, tao
1,038Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NE33M9NE33_DROME
Tao, isoform H
Tao AAF48973, Dmel\CG14217, dTao-1, MARKK, tao
611Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PI11M9PI11_DROME
Tao, isoform J
Tao AAF48973, Dmel\CG14217, dTao-1, MARKK, tao
615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IQW6Q8IQW6_DROME
Tao, isoform B
Tao AAF48973, Dmel\CG14217, dTao-1, MARKK, tao
469Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0583861 – 568MPSAR…KEHMQ → MFWPRFAPVEVMVELEFGSG F in isoform A. Add BLAST568

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB277547 mRNA Translation: BAF51959.1
AB277548 mRNA Translation: BAF51960.1
AE014298 Genomic DNA Translation: AAF48973.1
AE014298 Genomic DNA Translation: AAN09504.1
AE014298 Genomic DNA Translation: AAN09505.1
AE014298 Genomic DNA Translation: ADV37754.1
AE014298 Genomic DNA Translation: ADV37755.1
AY069469 mRNA Translation: AAL39614.1
BT099719 mRNA Translation: ACV53083.1

NCBI Reference Sequences

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RefSeqi
NP_001188672.1, NM_001201743.3 [Q0KHQ5-1]
NP_001188673.1, NM_001201744.2 [Q0KHQ5-2]
NP_608319.1, NM_134475.4 [Q0KHQ5-2]
NP_728267.1, NM_167665.2 [Q0KHQ5-1]
NP_728268.1, NM_167666.3 [Q0KHQ5-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0074771; FBpp0074540; FBgn0031030 [Q0KHQ5-1]
FBtr0074772; FBpp0074541; FBgn0031030 [Q0KHQ5-1]
FBtr0074774; FBpp0074543; FBgn0031030 [Q0KHQ5-2]
FBtr0303999; FBpp0292968; FBgn0031030 [Q0KHQ5-1]
FBtr0304000; FBpp0292969; FBgn0031030 [Q0KHQ5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32948

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG14217

UCSC genome browser

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UCSCi
CG14217-RA d. melanogaster
CG14217-RD d. melanogaster [Q0KHQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB277547 mRNA Translation: BAF51959.1
AB277548 mRNA Translation: BAF51960.1
AE014298 Genomic DNA Translation: AAF48973.1
AE014298 Genomic DNA Translation: AAN09504.1
AE014298 Genomic DNA Translation: AAN09505.1
AE014298 Genomic DNA Translation: ADV37754.1
AE014298 Genomic DNA Translation: ADV37755.1
AY069469 mRNA Translation: AAL39614.1
BT099719 mRNA Translation: ACV53083.1
RefSeqiNP_001188672.1, NM_001201743.3 [Q0KHQ5-1]
NP_001188673.1, NM_001201744.2 [Q0KHQ5-2]
NP_608319.1, NM_134475.4 [Q0KHQ5-2]
NP_728267.1, NM_167665.2 [Q0KHQ5-1]
NP_728268.1, NM_167666.3 [Q0KHQ5-1]

3D structure databases

SMRiQ0KHQ5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ0KHQ5, 4 interactors
STRINGi7227.FBpp0292968

Proteomic databases

PaxDbiQ0KHQ5
PRIDEiQ0KHQ5

Genome annotation databases

EnsemblMetazoaiFBtr0074771; FBpp0074540; FBgn0031030 [Q0KHQ5-1]
FBtr0074772; FBpp0074541; FBgn0031030 [Q0KHQ5-1]
FBtr0074774; FBpp0074543; FBgn0031030 [Q0KHQ5-2]
FBtr0303999; FBpp0292968; FBgn0031030 [Q0KHQ5-1]
FBtr0304000; FBpp0292969; FBgn0031030 [Q0KHQ5-2]
GeneIDi32948
KEGGidme:Dmel_CG14217
UCSCiCG14217-RA d. melanogaster
CG14217-RD d. melanogaster [Q0KHQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32948
FlyBaseiFBgn0031030 Tao

Phylogenomic databases

eggNOGiKOG0577 Eukaryota
ENOG410Y259 LUCA
GeneTreeiENSGT00940000168060
InParanoidiQ0KHQ5
KOiK04429
PhylomeDBiQ0KHQ5

Enzyme and pathway databases

SignaLinkiQ0KHQ5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tao fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32948

Protein Ontology

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PROi
PR:Q0KHQ5

Gene expression databases

BgeeiFBgn0031030 Expressed in 40 organ(s), highest expression level in embryo
ExpressionAtlasiQ0KHQ5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAO_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KHQ5
Secondary accession number(s): Q8T093
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: October 3, 2006
Last modified: November 13, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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