Meiotic recombination protein REC8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes."
    Sommermeyer V., Beneut C., Chaplais E., Serrentino M.E., Borde V.
    Mol. Cell 49:43-54(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• double-strand break repair Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• meiotic sister chromatid cohesion Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.5

    "A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis."
    Klein F., Mahr P., Galova M., Buonomo S.B.C., Michaelis C., Nairz K., Nasmyth K.
    Cell 98:91-103(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.
• protein localization to chromosome, centromeric region Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I."
    Kiburz B.M., Reynolds D.B., Megee P.C., Marston A.L., Lee B.H., Lee T.I., Levine S.S., Young R.A., Amon A.
    Genes Dev. 19:3017-3030(2005) [PubMed] [Europe PMC] [Abstract]
• reciprocal meiotic recombination Source: SGDInferred from mutant phenotypeⁱ
  • Ref.5

    "A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis."
    Klein F., Mahr P., Galova M., Buonomo S.B.C., Michaelis C., Nairz K., Nasmyth K.
    Cell 98:91-103(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.
• sister chromatid cohesion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• synaptonemal complex assembly Source: SGDInferred from mutant phenotypeⁱ
  • Ref.5

    "A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis."
    Klein F., Mahr P., Galova M., Buonomo S.B.C., Michaelis C., Nairz K., Nasmyth K.
    Cell 98:91-103(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPLSLNFKD DKKYKGLTTV WLLSALGNSI VKESNNYYSN KSNSTGNISS 
        60         70         80         90        100
STVKKKDIVN ISIPKTCDEI QNFENDFSLR YISNLLYGVT ICYNKKTEYV 
       110        120        130        140        150
LNDLNHLLVQ LQKNDVYAFK AKNKSTRING LNSNNSIIGN KNNNYTWEEC 
       160        170        180        190        200
VFFDDDPLYD ITKVPALEFL NTTLQDNVSF IEEAKSIRRQ DYINELSNSN 
       210        220        230        240        250
RFELHGDMTN SDAQSNLGSN VRNSFPLDEI PVDVDFNLDL DDIVSHQGTP 
       260        270        280        290        300
LGSHSSSQKD GNDFKFNYQG DELVLNFEND NENNSNGGED TSVENEGPVA 
       310        320        330        340        350
NLKDYELGLE AQASEEENDL QQKLNTRMQR GHRADVGGQF SKVQFDAKTS 
       360        370        380        390        400
YPNEVLKFNH GNYSHLMEKN RIRKLTGQNF LTSNISSLVR SCGEEEFFST 
       410        420        430        440        450
NWLSIFNDFS NIKTSEWDLY PQGFSSVERG RKRAHSLVST QSSSSTRSHE 
       460        470        480        490        500
YGRKSFRNNK NDNYSSDMEN DNLLLNLEQI NEDLEDGHYI EENSQGNILD 
       510        520        530        540        550
FNLNLPPSSF GRSHTRNSTR SSGFNEDIVG ALRRRVGPSE QNFAEEDDSS 
       560        570        580        590        600
NSCFSDGSQQ NLQQDKTNFQ DVILDYQTKK FYDYIKERSI VVGRTTRSNP 
       610        620        630        640        650
PFKRKMLLVD IIPSRMGEAQ TGANFDDVER GVSRQIAASA FLSLLNLATK 
       660        670        680
GMVKLNEYPV ADAVTKDLKL RREDEIIVYA                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. SIMILARITY comments
   Index of protein domains and families
3. Yeast chromosome XVI
   Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names