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Entry version 214 (13 Nov 2019)
Sequence version 2 (01 Dec 2000)
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Protein

Tyrosine-protein phosphatase non-receptor type 13

Gene

PTPN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2378Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2408Phosphocysteine intermediateCurated1
Binding sitei2452SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-9008059 Interleukin-37 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12923

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 13 (EC:3.1.3.482 Publications)
Alternative name(s):
Fas-associated protein-tyrosine phosphatase 1
Short name:
FAP-1
PTP-BAS
Protein-tyrosine phosphatase 1E
Short name:
PTP-E1
Short name:
hPTPE1
Protein-tyrosine phosphatase PTPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN13
Synonyms:PNP1, PTP1E, PTPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9646 PTPN13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600267 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12923

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2154D → H: No effect on substrate affinity. 1 Publication1
Mutagenesisi2205R → W: No effect on substrate affinity. 1 Publication1
Mutagenesisi2221Q → M: Reduces substrate affinity 2 fold. 1 Publication1
Mutagenesisi2307M → T: Reduces substrate affinity 7 fold. 1 Publication1
Mutagenesisi2408C → S: Loss of catalytic activity. 1 Publication1
Mutagenesisi2444R → E: Loss of catalytic activity. 1 Publication1
Mutagenesisi2444R → K: Reduces substrate affinity 7 fold. 1 Publication1
Mutagenesisi2444R → Q: Strongly decreases catalytic activity. 1 Publication1
Mutagenesisi2448H → A: Reduces substrate affinity 2 fold. 1 Publication1
Mutagenesisi2449G → V: Loss of catalytic activity. 1 Publication1
Mutagenesisi2474E → D: No effect on substrate affinity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5783

Open Targets

More...
OpenTargetsi
ENSG00000163629

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33988

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12923

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2976

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPN13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194351 – 2485Tyrosine-protein phosphatase non-receptor type 13Add BLAST2485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1
Modified residuei301PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei890PhosphoserineCombined sources1
Modified residuei897PhosphoserineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei911PhosphoserineBy similarity1
Modified residuei914PhosphoserineBy similarity1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1085PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12923

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12923

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12923

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12923

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12923

PeptideAtlas

More...
PeptideAtlasi
Q12923

PRoteomics IDEntifications database

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PRIDEi
Q12923

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59027 [Q12923-1]
59028 [Q12923-2]
59029 [Q12923-3]
59030 [Q12923-4]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q12923

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q12923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163629 Expressed in 231 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q12923 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12923 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002213
HPA048888
HPA065290

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the first PDZ domain) with PLEKHA1 and PLEKHA2 (PubMed:14516276).

Interacts (via the second PDZ domain) with TNFRSF6 (Fas receptor) (via C-terminus) (PubMed:10704206).

Interacts (via the second PDZ domain) with TRIP6 (via the third LIM domain and C-terminus) (PubMed:10826496, PubMed:10400701).

Interacts (via the third PDZ domain) with NGFR (via C-terminal SVP motif) and PKN2 (via C-terminus) (PubMed:10544233, PubMed:11356191).

Interacts (via the second or fourth PDZ domains) with PDLIM4 (via C-terminus only or via combined C-terminus and LIM domain, but not LIM domain only).

Found in a complex with PDLIM4 and TRIP6 (By similarity).

Interacts with PDLIM4; this interaction results in dephosphorylation of SRC 'Tyr-419' by this protein leading to its inactivation (PubMed:19307596).

Interacts with BRD7 (By similarity).

Interacts with RAPGEF6 (PubMed:12095257).

Interacts with ARHGAP29 (PubMed:9305890).

Interacts with PIK3R2; dephosphorylates PIK3R2 (PubMed:23604317).

Interacts with FBXL2 (PubMed:23604317).

Interacts (via the FERM domain) with ENTR1 (PubMed:23108400).

Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400).

By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111747, 66 interactors

Database of interacting proteins

More...
DIPi
DIP-40449N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q12923

Protein interaction database and analysis system

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IntActi
Q12923, 29 interactors

Molecular INTeraction database

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MINTi
Q12923

STRING: functional protein association networks

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STRINGi
9606.ENSP00000394794

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q12923

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12923

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12923

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 190KINDPROSITE-ProRule annotationAdd BLAST188
Domaini572 – 872FERMPROSITE-ProRule annotationAdd BLAST301
Domaini1093 – 1178PDZ 1PROSITE-ProRule annotationAdd BLAST86
Domaini1368 – 1452PDZ 2PROSITE-ProRule annotationAdd BLAST85
Domaini1501 – 1588PDZ 3PROSITE-ProRule annotationAdd BLAST88
Domaini1788 – 1868PDZ 4PROSITE-ProRule annotationAdd BLAST81
Domaini1882 – 1965PDZ 5PROSITE-ProRule annotationAdd BLAST84
Domaini2213 – 2467Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2408 – 2414Substrate7
Regioni2408 – 2414Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili469 – 504Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 59Poly-Leu4
Compositional biasi1742 – 1749Poly-Ser8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0792 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155133

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12923

KEGG Orthology (KO)

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KOi
K02374

Identification of Orthologs from Complete Genome Data

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OMAi
HQVIYIS

Database of Orthologous Groups

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OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12923

TreeFam database of animal gene trees

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TreeFami
TF315388

Family and domain databases

Conserved Domains Database

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CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011019 KIND_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012153 PTPN13
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 5 hits
PF00102 Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000933 Tyr-Ptase_nr13, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00935 BAND41
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00750 KIND, 1 hit
SM00228 PDZ, 5 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 5 hits
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS51377 KIND, 1 hit
PS50106 PDZ, 5 hits
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12923-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI
60 70 80 90 100
ISPWSLLLLP SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH
110 120 130 140 150
IYSLGMTLYW GADYEVPQSQ PIKLGDHLNS ILLGMCEDVI YARVSVRTVL
160 170 180 190 200
DACSAHIRNS NCAPSFSYVK HLVKLVLGNL SGTDQLSCNS EQKPDRSQAI
210 220 230 240 250
RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS MGFLSIKDTQ
260 270 280 290 300
DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA
310 320 330 340 350
SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA
360 370 380 390 400
LDIFGPQKMD PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP
410 420 430 440 450
VRRYKTYHGD VFSTSSESPS IISSESDFRQ VRRSEASKRF ESSSGLPGVD
460 470 480 490 500
ETLSQGQSQR PSRQYETPFE GNLINQEIML KRQEEELMQL QAKMALRQSR
510 520 530 540 550
LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG PEFVKMTIEP
560 570 580 590 600
FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM
610 620 630 640 650
VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA
660 670 680 690 700
TVNFTLFFRI KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL
710 720 730 740 750
LLASLALQAE YGDYQPEVHG VSYFRMEHYL PARVMEKLDL SYIKEELPKL
760 770 780 790 800
HNTYVGASEK ETELEFLKVC QRLTEYGVHF HRVHPEKKSQ TGILLGVCSK
810 820 830 840 850
GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD GIKHGFQTDN
860 870 880 890 900
SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG
910 920 930 940 950
FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS
960 970 980 990 1000
KEKNDKASWE EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV
1010 1020 1030 1040 1050
GKPSHQMSRS DAESLAGVTK LNNSKSVASL NRSPERRKHE SDSSSIEDPG
1060 1070 1080 1090 1100
QAYVLGMTMH SSGNSSSQVP LKENDVLHKR WSIVSSPERE ITLVNLKKDA
1110 1120 1130 1140 1150
KYGLGFQIIG GEKMGRLDLG IFISSVAPGG PADLDGCLKP GDRLISVNSV
1160 1170 1180 1190 1200
SLEGVSHHAA IEILQNAPED VTLVISQPKE KISKVPSTPV HLTNEMKNYM
1210 1220 1230 1240 1250
KKSSYMQDSA IDSSSKDHHW SRGTLRHISE NSFGPSGGLR EGSLSSQDSR
1260 1270 1280 1290 1300
TESASLSQSQ VNGFFASHLG DQTWQESQHG SPSPSVISKA TEKETFTDSN
1310 1320 1330 1340 1350
QSKTKKPGIS DVTDYSDRGD SDMDEATYSS SQDHQTPKQE SSSSVNTSNK
1360 1370 1380 1390 1400
MNFKTFSSSP PKPGDIFEVE LAKNDNSLGI SVTGGVNTSV RHGGIYVKAV
1410 1420 1430 1440 1450
IPQGAAESDG RIHKGDRVLA VNGVSLEGAT HKQAVETLRN TGQVVHLLLE
1460 1470 1480 1490 1500
KGQSPTSKEH VPVTPQCTLS DQNAQGQGPE KVKKTTQVKD YSFVTEENTF
1510 1520 1530 1540 1550
EVKLFKNSSG LGFSFSREDN LIPEQINASI VRVKKLFPGQ PAAESGKIDV
1560 1570 1580 1590 1600
GDVILKVNGA SLKGLSQQEV ISALRGTAPE VFLLLCRPPP GVLPEIDTAL
1610 1620 1630 1640 1650
LTPLQSPAQV LPNSSKDSSQ PSCVEQSTSS DENEMSDKSK KQCKSPSRRD
1660 1670 1680 1690 1700
SYSDSSGSGE DDLVTAPANI SNSTWSSALH QTLSNMVSQA QSHHEAPKSQ
1710 1720 1730 1740 1750
EDTICTMFYY PQKIPNKPEF EDSNPSPLPP DMAPGQSYQP QSESASSSSM
1760 1770 1780 1790 1800
DKYHIHHISE PTRQENWTPL KNDLENHLED FELEVELLIT LIKSEKGSLG
1810 1820 1830 1840 1850
FTVTKGNQRI GCYVHDVIQD PAKSDGRLKP GDRLIKVNDT DVTNMTHTDA
1860 1870 1880 1890 1900
VNLLRAASKT VRLVIGRVLE LPRIPMLPHL LPDITLTCNK EELGFSLCGG
1910 1920 1930 1940 1950
HDSLYQVVYI SDINPRSVAA IEGNLQLLDV IHYVNGVSTQ GMTLEEVNRA
1960 1970 1980 1990 2000
LDMSLPSLVL KATRNDLPVV PSSKRSAVSA PKSTKGNGSY SVGSCSQPAL
2010 2020 2030 2040 2050
TPNDSFSTVA GEEINEISYP KGKCSTYQIK GSPNLTLPKE SYIQEDDIYD
2060 2070 2080 2090 2100
DSQEAEVIQS LLDVVDEEAQ NLLNENNAAG YSCGPGTLKM NGKLSEERTE
2110 2120 2130 2140 2150
DTDCDGSPLP EYFTEATKMN GCEEYCEEKV KSESLIQKPQ EKKTDDDEIT
2160 2170 2180 2190 2200
WGNDELPIER TNHEDSDKDH SFLTNDELAV LPVVKVLPSG KYTGANLKSV
2210 2220 2230 2240 2250
IRVLRGLLDQ GIPSKELENL QELKPLDQCL IGQTKENRRK NRYKNILPYD
2260 2270 2280 2290 2300
ATRVPLGDEG GYINASFIKI PVGKEEFVYI ACQGPLPTTV GDFWQMIWEQ
2310 2320 2330 2340 2350
KSTVIAMMTQ EVEGEKIKCQ RYWPNILGKT TMVSNRLRLA LVRMQQLKGF
2360 2370 2380 2390 2400
VVRAMTLEDI QTREVRHISH LNFTAWPDHD TPSQPDDLLT FISYMRHIHR
2410 2420 2430 2440 2450
SGPIITHCSA GIGRSGTLIC IDVVLGLISQ DLDFDISDLV RCMRLQRHGM
2460 2470 2480
VQTEDQYIFC YQVILYVLTR LQAEEEQKQQ PQLLK
Length:2,485
Mass (Da):276,906
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D1B31597C66962B
GO
Isoform 2 (identifier: Q12923-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-1074: Missing.

Show »
Length:2,294
Mass (Da):255,926
Checksum:iABBFA4BCD60FF56F
GO
Isoform 3 (identifier: Q12923-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1056-1074: Missing.

Show »
Length:2,466
Mass (Da):274,932
Checksum:i5BDCC226F2DEC19D
GO
Isoform 4 (identifier: Q12923-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1383-1383: T → TVLFDK

Note: May be due to a competing donor splice site.
Show »
Length:2,490
Mass (Da):277,508
Checksum:i8D1FE03D9738A247
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9M4D6R9M4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN13
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9X4D6R9X4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN13
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39610 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1134 – 1135LD → FH in CAA56563 (PubMed:7929060).Curated2
Sequence conflicti1216 – 1229KDHHW…LRHIS → DLSRSHCHVYLAHL (Ref. 5) CuratedAdd BLAST14
Sequence conflicti1238 – 1239GL → A in CAA56124 (Ref. 5) Curated2
Sequence conflicti1357S → P in CAA56124 (Ref. 5) Curated1
Sequence conflicti1362 – 1363KP → RS in CAA56124 (Ref. 5) Curated2
Sequence conflicti1538P → A in CAA56563 (PubMed:7929060).Curated1
Sequence conflicti1649R → K in CAA56124 (Ref. 5) Curated1
Sequence conflicti1698 – 1714KSQED…YPQKI → RVKKIPFVPCFTILRKR in CAA56124 (Ref. 5) CuratedAdd BLAST17
Sequence conflicti1797G → A in CAA56563 (PubMed:7929060).Curated1
Sequence conflicti1856 – 1857AA → G in CAA56124 (Ref. 5) Curated2
Sequence conflicti2069A → S in CAA56124 (Ref. 5) Curated1
Sequence conflicti2206 – 2210GLLDQ → VARS in CAA56124 (Ref. 5) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0483591356F → L. Corresponds to variant dbSNP:rs10033029Ensembl.1
Natural variantiVAR_0162001419L → P1 PublicationCorresponds to variant dbSNP:rs749353184Ensembl.1
Natural variantiVAR_0162011522I → M1 PublicationCorresponds to variant dbSNP:rs2230600Ensembl.1
Natural variantiVAR_0243731625E → K. Corresponds to variant dbSNP:rs12500797Ensembl.1
Natural variantiVAR_0483601744S → P. Corresponds to variant dbSNP:rs17012064Ensembl.1
Natural variantiVAR_0243742081Y → D. Corresponds to variant dbSNP:rs989902Ensembl.1
Natural variantiVAR_0483612458I → V No effect on substrate affinity. 1 PublicationCorresponds to variant dbSNP:rs34226837Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000496884 – 1074Missing in isoform 2. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_0004971056 – 1074Missing in isoform 3. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_0079211383T → TVLFDK in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12128 mRNA Translation: AAB60339.1
D21209 mRNA Translation: BAA04750.1
D21210 mRNA Translation: BAA04751.1
D21211 mRNA Translation: BAA04752.1
X80289 mRNA Translation: CAA56563.1
BC039610 mRNA Translation: AAH39610.1 Sequence problems.
BC140777 mRNA Translation: AAI40778.1
X79676 mRNA Translation: CAA56124.1
L34583 mRNA Translation: AAC41755.1
AF233323 mRNA Translation: AAF63474.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47093.1 [Q12923-4]
CCDS47094.1 [Q12923-1]
CCDS47095.1 [Q12923-3]
CCDS47096.1 [Q12923-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54971
I67629
I67630

NCBI Reference Sequences

More...
RefSeqi
NP_006255.1, NM_006264.2 [Q12923-3]
NP_542414.1, NM_080683.2 [Q12923-1]
NP_542415.1, NM_080684.2 [Q12923-2]
NP_542416.1, NM_080685.2 [Q12923-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316707; ENSP00000322675; ENSG00000163629 [Q12923-2]
ENST00000411767; ENSP00000407249; ENSG00000163629 [Q12923-1]
ENST00000427191; ENSP00000408368; ENSG00000163629 [Q12923-3]
ENST00000436978; ENSP00000394794; ENSG00000163629 [Q12923-4]
ENST00000511467; ENSP00000426626; ENSG00000163629 [Q12923-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5783

UCSC genome browser

More...
UCSCi
uc003hpy.4 human [Q12923-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12128 mRNA Translation: AAB60339.1
D21209 mRNA Translation: BAA04750.1
D21210 mRNA Translation: BAA04751.1
D21211 mRNA Translation: BAA04752.1
X80289 mRNA Translation: CAA56563.1
BC039610 mRNA Translation: AAH39610.1 Sequence problems.
BC140777 mRNA Translation: AAI40778.1
X79676 mRNA Translation: CAA56124.1
L34583 mRNA Translation: AAC41755.1
AF233323 mRNA Translation: AAF63474.1
CCDSiCCDS47093.1 [Q12923-4]
CCDS47094.1 [Q12923-1]
CCDS47095.1 [Q12923-3]
CCDS47096.1 [Q12923-2]
PIRiA54971
I67629
I67630
RefSeqiNP_006255.1, NM_006264.2 [Q12923-3]
NP_542414.1, NM_080683.2 [Q12923-1]
NP_542415.1, NM_080684.2 [Q12923-2]
NP_542416.1, NM_080685.2 [Q12923-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5GNMR-A1361-1456[»]
1Q7XNMR-A1358-1459[»]
1WCHX-ray1.85A2163-2477[»]
2M0ZNMR-A1361-1456[»]
2M10NMR-A1361-1456[»]
3LNXX-ray1.64A/B/C/D/E/F1361-1456[»]
3LNYX-ray1.30A1361-1456[»]
3PDZNMR-A1361-1456[»]
5GLJX-ray1.60A/B/C/D1086-1178[»]
SMRiQ12923
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111747, 66 interactors
DIPiDIP-40449N
ELMiQ12923
IntActiQ12923, 29 interactors
MINTiQ12923
STRINGi9606.ENSP00000394794

Chemistry databases

BindingDBiQ12923
ChEMBLiCHEMBL2976

PTM databases

DEPODiQ12923
iPTMnetiQ12923
PhosphoSitePlusiQ12923

Polymorphism and mutation databases

BioMutaiPTPN13
DMDMi12643716

Proteomic databases

EPDiQ12923
jPOSTiQ12923
MassIVEiQ12923
MaxQBiQ12923
PaxDbiQ12923
PeptideAtlasiQ12923
PRIDEiQ12923
ProteomicsDBi59027 [Q12923-1]
59028 [Q12923-2]
59029 [Q12923-3]
59030 [Q12923-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5783

Genome annotation databases

EnsembliENST00000316707; ENSP00000322675; ENSG00000163629 [Q12923-2]
ENST00000411767; ENSP00000407249; ENSG00000163629 [Q12923-1]
ENST00000427191; ENSP00000408368; ENSG00000163629 [Q12923-3]
ENST00000436978; ENSP00000394794; ENSG00000163629 [Q12923-4]
ENST00000511467; ENSP00000426626; ENSG00000163629 [Q12923-4]
GeneIDi5783
KEGGihsa:5783
UCSCiuc003hpy.4 human [Q12923-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5783
DisGeNETi5783

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPN13
HGNCiHGNC:9646 PTPN13
HPAiCAB002213
HPA048888
HPA065290
MIMi600267 gene
neXtProtiNX_Q12923
OpenTargetsiENSG00000163629
PharmGKBiPA33988

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0792 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000155133
InParanoidiQ12923
KOiK02374
OMAiHQVIYIS
OrthoDBi411281at2759
PhylomeDBiQ12923
TreeFamiTF315388

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-9008059 Interleukin-37 signaling
SIGNORiQ12923

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPN13 human
EvolutionaryTraceiQ12923

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPN13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5783
PharosiQ12923

Protein Ontology

More...
PROi
PR:Q12923

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163629 Expressed in 231 organ(s), highest expression level in kidney
ExpressionAtlasiQ12923 baseline and differential
GenevisibleiQ12923 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011019 KIND_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012153 PTPN13
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 5 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000933 Tyr-Ptase_nr13, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00750 KIND, 1 hit
SM00228 PDZ, 5 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 5 hits
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS51377 KIND, 1 hit
PS50106 PDZ, 5 hits
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12923
Secondary accession number(s): B2RTR0
, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9, Q9UDA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2019
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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