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Entry version 184 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Interleukin-24

Gene

IL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854691 Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
Melanoma differentiation-associated gene 7 protein
Short name:
MDA-7
Suppression of tumorigenicity 16 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL24
Synonyms:MDA7, ST16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11346 IL24

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604136 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13007

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11009

Open Targets

More...
OpenTargetsi
ENSG00000162892

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29825

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL24

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2497340

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 511 PublicationAdd BLAST51
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001538652 – 206Interleukin-24Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitination at Lys-122 promotes proteasomal degradation.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13007

PeptideAtlas

More...
PeptideAtlasi
Q13007

PRoteomics IDEntifications database

More...
PRIDEi
Q13007

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59095
59096 [Q13007-2]
59097 [Q13007-3]
59098 [Q13007-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Up-regulated in melanoma cells induced to terminally differentiate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162892 Expressed in 87 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13007 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13007 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116199, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q13007, 25 interactors

Molecular INTeraction database

More...
MINTi
Q13007

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375795

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13007

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZYS Eukaryota
ENOG41119SI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183124

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13007

KEGG Orthology (KO)

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KOi
K22668

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESCYLVH

Database of Orthologous Groups

More...
OrthoDBi
1434107at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13007

TreeFam database of animal gene trees

More...
TreeFami
TF333253

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020423 IL-10_CS
IPR020444 IL-24

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01937 INTRLEUKIN24

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ
60 70 80 90 100
GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV
110 120 130 140 150
SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ
160 170 180 190 200
LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM

QKFYKL
Length:206
Mass (Da):23,825
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB8135083EAB8DDD
GO
Isoform 2 (identifier: Q13007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS

Show »
Length:207
Mass (Da):23,912
Checksum:i17687A467B9CB551
GO
Isoform 3 (identifier: Q13007-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
     101-153: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,751
Checksum:i1AAAE1B2FD252B4E
GO
Isoform 4 (identifier: Q13007-4) [UniParc]FASTAAdd to basket
Also known as: mda-7s

The sequence of this isoform differs from the canonical sequence as follows:
     15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

Show »
Length:63
Mass (Da):7,347
Checksum:iBEC50016AB595409
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER64E7ER64_HUMAN
Interleukin-24
IL24
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETP6E7ETP6_HUMAN
Interleukin-24
IL24
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011974124Y → H2 PublicationsCorresponds to variant dbSNP:rs1150258Ensembl.1
Natural variantiVAR_013097125H → R1 PublicationCorresponds to variant dbSNP:rs3093431Ensembl.1
Natural variantiVAR_013098131V → L1 PublicationCorresponds to variant dbSNP:rs3093446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04267314A → AS in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_04391515 – 206RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_042674101 – 153Missing in isoform 3. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16261 mRNA Translation: AAA91780.1
AF276916 Genomic DNA Translation: AAG41401.1
AF235005 Genomic DNA Translation: AAK52589.1
AY237723 mRNA Translation: AAO67513.1
AY062931 Genomic DNA Translation: AAL34146.1
AY641441 mRNA Translation: AAV52801.1
BT007156 mRNA Translation: AAP35820.1
AC098935 Genomic DNA No translation available.
BC009681 mRNA Translation: AAH09681.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1471.1 [Q13007-1]
CCDS53465.1 [Q13007-2]
CCDS53466.1 [Q13007-3]
CCDS73021.1 [Q13007-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001172085.1, NM_001185156.1 [Q13007-2]
NP_001172086.1, NM_001185157.1 [Q13007-3]
NP_001172087.1, NM_001185158.1 [Q13007-4]
NP_006841.1, NM_006850.3 [Q13007-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294984; ENSP00000294984; ENSG00000162892 [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892 [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892 [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892 [Q13007-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11009

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11009

UCSC genome browser

More...
UCSCi
uc001hes.3 human [Q13007-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-24 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16261 mRNA Translation: AAA91780.1
AF276916 Genomic DNA Translation: AAG41401.1
AF235005 Genomic DNA Translation: AAK52589.1
AY237723 mRNA Translation: AAO67513.1
AY062931 Genomic DNA Translation: AAL34146.1
AY641441 mRNA Translation: AAV52801.1
BT007156 mRNA Translation: AAP35820.1
AC098935 Genomic DNA No translation available.
BC009681 mRNA Translation: AAH09681.1
CCDSiCCDS1471.1 [Q13007-1]
CCDS53465.1 [Q13007-2]
CCDS53466.1 [Q13007-3]
CCDS73021.1 [Q13007-4]
RefSeqiNP_001172085.1, NM_001185156.1 [Q13007-2]
NP_001172086.1, NM_001185157.1 [Q13007-3]
NP_001172087.1, NM_001185158.1 [Q13007-4]
NP_006841.1, NM_006850.3 [Q13007-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DF3X-ray2.15C52-206[»]
6GG1X-ray1.30A54-206[»]
SMRiQ13007
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116199, 27 interactors
IntActiQ13007, 25 interactors
MINTiQ13007
STRINGi9606.ENSP00000375795

PTM databases

iPTMnetiQ13007
PhosphoSitePlusiQ13007

Polymorphism and mutation databases

BioMutaiIL24
DMDMi2497340

Proteomic databases

PaxDbiQ13007
PeptideAtlasiQ13007
PRIDEiQ13007
ProteomicsDBi59095
59096 [Q13007-2]
59097 [Q13007-3]
59098 [Q13007-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11009
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294984; ENSP00000294984; ENSG00000162892 [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892 [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892 [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892 [Q13007-4]
GeneIDi11009
KEGGihsa:11009
UCSCiuc001hes.3 human [Q13007-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11009
DisGeNETi11009

GeneCards: human genes, protein and diseases

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GeneCardsi
IL24
HGNCiHGNC:11346 IL24
HPAiCAB025972
MIMi604136 gene
neXtProtiNX_Q13007
OpenTargetsiENSG00000162892
PharmGKBiPA29825

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IZYS Eukaryota
ENOG41119SI LUCA
GeneTreeiENSGT00950000183124
HOGENOMiHOG000113033
InParanoidiQ13007
KOiK22668
OMAiESCYLVH
OrthoDBi1434107at2759
PhylomeDBiQ13007
TreeFamiTF333253

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ13007

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_24

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11009

Protein Ontology

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PROi
PR:Q13007

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162892 Expressed in 87 organ(s), highest expression level in adrenal gland
ExpressionAtlasiQ13007 baseline and differential
GenevisibleiQ13007 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020423 IL-10_CS
IPR020444 IL-24
PRINTSiPR01937 INTRLEUKIN24
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL24_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13007
Secondary accession number(s): Q2YHE5
, Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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