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Entry version 169 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Probable E3 ubiquitin-protein ligase makorin-3

Gene

MKRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.By similarity1 Publication

Miscellaneous

Imprinted, expressed from the paternal chromosome only. A deficiency of MKRN3 is not sufficient to cause Prader-Willi syndrome (PWS).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri95 – 122C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri238 – 265C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri311 – 365RING-typePROSITE-ProRule annotationAdd BLAST55
Zinc fingeri394 – 423C3H1-type 3PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q13064 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase makorin-3 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 63
RING-type E3 ubiquitin transferase makorin-3Curated
Zinc finger protein 127
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MKRN3
Synonyms:D15S9, RNF63, ZNF127
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7114 MKRN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603856 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13064

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Precocious puberty, central 2 (CPPB2)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073023340C → G in CPPB2. 1 Publication1
Natural variantiVAR_070103365R → S in CPPB2. 1 PublicationCorresponds to variant dbSNP:rs879255240EnsemblClinVar.1
Natural variantiVAR_073024417F → I in CPPB2. 1 Publication1
Natural variantiVAR_073025420H → Q in CPPB2. 1 PublicationCorresponds to variant dbSNP:rs755791221Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7681

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MKRN3

MalaCards human disease database

More...
MalaCardsi
MKRN3
MIMi615346 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179455

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
169615 Idiopathic central precocious puberty

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30833

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13064

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MKRN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17368438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559591 – 507Probable E3 ubiquitin-protein ligase makorin-3Add BLAST507

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13064

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13064

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13064

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13064

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13064

PeptideAtlas

More...
PeptideAtlasi
Q13064

PRoteomics IDEntifications database

More...
PRIDEi
Q13064

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59127

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13064

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13064

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179455 Expressed in 88 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13064 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13064 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029494

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113479, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q13064, 181 interactors

Molecular INTeraction database

More...
MINTi
Q13064

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313881

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 293Makorin-type Cys-HisAdd BLAST28

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri95 – 122C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri238 – 265C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri311 – 365RING-typePROSITE-ProRule annotationAdd BLAST55
Zinc fingeri394 – 423C3H1-type 3PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1039 Eukaryota
ENOG410XRM0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252976

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13064

KEGG Orthology (KO)

More...
KOi
K15687

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEYPEGW

Database of Orthologous Groups

More...
OrthoDBi
1388677at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13064

TreeFam database of animal gene trees

More...
TreeFami
TF315108

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026294 Makorin_3
IPR031644 MKRN1_C
IPR041367 Znf-CCCH_4
IPR018957 Znf_C3HC4_RING-type
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11224:SF38 PTHR11224:SF38, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15815 MKRN1_C, 1 hit
PF00097 zf-C3HC4, 1 hit
PF18044 zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit
SM00356 ZnF_C3H1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 3 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q13064-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPAAPSEA HEAAGAQAGA EAAREGVSGP DLPVCEPSGE SAAPDSALPH
60 70 80 90 100
AARGWAPFPV APVPAHLRRG GLRPAPASGG GAWPSPLPSR SSGIWTKQII
110 120 130 140 150
CRYYIHGQCK EGENCRYSHD LSGRKMATEG GVSPPGASAG GGPSTAAHIE
160 170 180 190 200
PPTQEVAEAP PAASSLSLPV IGSAAERGFF EAERDNADRG AAGGAGVESW
210 220 230 240 250
ADAIEFVPGQ PYRGRWVASA PEAPLQSSET ERKQMAVGSG LRFCYYASRG
260 270 280 290 300
VCFRGESCMY LHGDICDMCG LQTLHPMDAA QREEHMRACI EAHEKDMELS
310 320 330 340 350
FAVQRGMDKV CGICMEVVYE KANPNDRRFG ILSNCNHSFC IRCIRRWRSA
360 370 380 390 400
RQFENRIVKS CPQCRVTSEL VIPSEFWVEE EEEKQKLIQQ YKEAMSNKAC
410 420 430 440 450
RYFAEGRGNC PFGDTCFYKH EYPEGWGDEP PGPGGGSFSA YWHQLVEPVR
460 470 480 490 500
MGEGNMLYKS IKKELVVLRL ASLLFKRFLS LRDELPFSED QWDLLHYELE

EYFNLIL
Length:507
Mass (Da):55,645
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EDBA91190F3A292
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6NSB6Q6NSB6_HUMAN
MKRN3 protein
MKRN3
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPL3H3BPL3_HUMAN
Probable E3 ubiquitin-protein ligas...
MKRN3
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISD8A0A3B3ISD8_HUMAN
Probable E3 ubiquitin-protein ligas...
MKRN3
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRU9A0A3B3IRU9_HUMAN
Probable E3 ubiquitin-protein ligas...
MKRN3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRN4A0A3B3IRN4_HUMAN
Probable E3 ubiquitin-protein ligas...
MKRN3
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035955145T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371642799Ensembl.1
Natural variantiVAR_035956239S → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_073023340C → G in CPPB2. 1 Publication1
Natural variantiVAR_070103365R → S in CPPB2. 1 PublicationCorresponds to variant dbSNP:rs879255240EnsemblClinVar.1
Natural variantiVAR_073024417F → I in CPPB2. 1 Publication1
Natural variantiVAR_073025420H → Q in CPPB2. 1 PublicationCorresponds to variant dbSNP:rs755791221Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19107 Genomic DNA Translation: AAC13989.1
BC044639 mRNA Translation: AAH44639.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10013.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G01614

NCBI Reference Sequences

More...
RefSeqi
NP_005655.1, NM_005664.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314520; ENSP00000313881; ENSG00000179455

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7681

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7681

UCSC genome browser

More...
UCSCi
uc001ywh.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19107 Genomic DNA Translation: AAC13989.1
BC044639 mRNA Translation: AAH44639.1
CCDSiCCDS10013.1
PIRiG01614
RefSeqiNP_005655.1, NM_005664.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi113479, 62 interactors
IntActiQ13064, 181 interactors
MINTiQ13064
STRINGi9606.ENSP00000313881

Protein family/group databases

MoonDBiQ13064 Predicted

PTM databases

iPTMnetiQ13064
PhosphoSitePlusiQ13064

Polymorphism and mutation databases

BioMutaiMKRN3
DMDMi17368438

Proteomic databases

EPDiQ13064
jPOSTiQ13064
MassIVEiQ13064
MaxQBiQ13064
PaxDbiQ13064
PeptideAtlasiQ13064
PRIDEiQ13064
ProteomicsDBi59127

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7681

Genome annotation databases

EnsembliENST00000314520; ENSP00000313881; ENSG00000179455
GeneIDi7681
KEGGihsa:7681
UCSCiuc001ywh.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7681
DisGeNETi7681

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MKRN3
GeneReviewsiMKRN3
HGNCiHGNC:7114 MKRN3
HPAiHPA029494
MalaCardsiMKRN3
MIMi603856 gene
615346 phenotype
neXtProtiNX_Q13064
OpenTargetsiENSG00000179455
Orphaneti169615 Idiopathic central precocious puberty
PharmGKBiPA30833

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1039 Eukaryota
ENOG410XRM0 LUCA
GeneTreeiENSGT00950000183077
HOGENOMiHOG000252976
InParanoidiQ13064
KOiK15687
OMAiHEYPEGW
OrthoDBi1388677at2759
PhylomeDBiQ13064
TreeFamiTF315108

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MKRN3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7681
PharosiQ13064

Protein Ontology

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PROi
PR:Q13064

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000179455 Expressed in 88 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ13064 baseline and differential
GenevisibleiQ13064 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR026294 Makorin_3
IPR031644 MKRN1_C
IPR041367 Znf-CCCH_4
IPR018957 Znf_C3HC4_RING-type
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR11224:SF38 PTHR11224:SF38, 1 hit
PfamiView protein in Pfam
PF15815 MKRN1_C, 1 hit
PF00097 zf-C3HC4, 1 hit
PF18044 zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMKRN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13064
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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