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Entry version 188 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

TNF receptor-associated factor 1

Gene

TRAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.6 Publications

Caution

Lacks a RING domain and has therefore no E3 ubiquitin-protein ligase activity by itself.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q13077

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13077

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TNF receptor-associated factor 1
Alternative name(s):
Epstein-Barr virus-induced protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAF1
Synonyms:EBI6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12031 TRAF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601711 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13077

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163D → A: Abolishes CASP8-mediated cleavage. 2 Publications1
Mutagenesisi185K → R: Nearly abolished ubiquitination; when associated with R-193. 1 Publication1
Mutagenesisi193K → R: Nearly abolished ubiquitination; when associated with R-185. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7185

Open Targets

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OpenTargetsi
ENSG00000056558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36708

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6707734

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563971 – 416TNF receptor-associated factor 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei163 – 164Cleavage; by CASP82

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13077

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13077

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13077

PeptideAtlas

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PeptideAtlasi
Q13077

PRoteomics IDEntifications database

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PRIDEi
Q13077

ProteomicsDB human proteome resource

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ProteomicsDBi
59136
59137 [Q13077-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13077

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13077

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q13077

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000056558 Expressed in 117 organ(s), highest expression level in right coronary artery

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13077 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB009593
HPA001852

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:15383523, PubMed:20385093). Heterotrimer with TRAF2 (PubMed:8069916, PubMed:19287455, PubMed:20385093).

Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:10037686, PubMed:10809768, PubMed:10903733, PubMed:11035039, PubMed:11313261, PubMed:16323247, PubMed:19287455, PubMed:19698991, PubMed:8069916, PubMed:8627180, PubMed:8710854, PubMed:9418902, PubMed:9607925, PubMed:9642260, PubMed:9705938, PubMed:9718306, PubMed:9774460).

Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2 (PubMed:11907583, PubMed:20447407, PubMed:20385093).

Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity).

Interacts with MAP3K14.

Interacts with GPS2 (By similarity).

By similarity21 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-359224,EBI-359224
B2R8Y43EBI-359224,EBI-10175581
Q5W1503EBI-359224,EBI-10248148
Q96EJ44EBI-359224,EBI-750454
Q9NWL93EBI-359224,EBI-10315054
A1CFQ9NQ945EBI-359224,EBI-2809489
AESQ081173EBI-359224,EBI-717810
AESQ08117-25EBI-359224,EBI-11741437
AKAP17AQ02040-33EBI-359224,EBI-10222656
AQP1P299723EBI-359224,EBI-745213
ARSJQ8N5N63EBI-359224,EBI-10266832
BARD1A0AVN23EBI-359224,EBI-9977322
BCL6P411825EBI-359224,EBI-765407
BEX2Q9BXY83EBI-359224,EBI-745073
BIRC2Q134904EBI-359224,EBI-514538
BIRC3Q134892EBI-359224,EBI-517709
C1orf109Q9NX045EBI-359224,EBI-8643161
C1orf216Q8TAB55EBI-359224,EBI-747505
C2CD6Q53TS83EBI-359224,EBI-739879
C5orf30Q96GV93EBI-359224,EBI-2350695
CARHSP1Q9Y2V23EBI-359224,EBI-718719
CCDC116Q8IYX33EBI-359224,EBI-744311
CCDC120Q96HB5-43EBI-359224,EBI-10185348
CCDC146Q8IYE0-23EBI-359224,EBI-10247802
CCDC198Q9NVL83EBI-359224,EBI-10238351
CCHCR1Q8TD31-35EBI-359224,EBI-10175300
CDCA3Q996185EBI-359224,EBI-739534
CDKN1AP389363EBI-359224,EBI-375077
CDKN2BP427725EBI-359224,EBI-711280
CFLARO155195EBI-359224,EBI-514941
CHCHD3Q9NX633EBI-359224,EBI-743375
COX5BP106063EBI-359224,EBI-1053725
CRYGAQ24JT53EBI-359224,EBI-10239205
CYB5R2Q6BCY43EBI-359224,EBI-744761
DEPTORQ8TB453EBI-359224,EBI-2359040
DMRT3Q9NQL93EBI-359224,EBI-9679045
DOK3Q7L5913EBI-359224,EBI-2834978
ECH1Q130113EBI-359224,EBI-711968
EHHADHQ084263EBI-359224,EBI-2339219
EWSR1Q018443EBI-359224,EBI-739737
FAM161AQ3B8205EBI-359224,EBI-719941
FAM86C1Q9NVL13EBI-359224,EBI-751617
FBF1Q8TES7-63EBI-359224,EBI-10244131
FBXL18Q96D163EBI-359224,EBI-744419
FOSL2P154085EBI-359224,EBI-3893419
GATA1P15976-23EBI-359224,EBI-9090198
GATA2P237693EBI-359224,EBI-2806671
GATAD2BQ8WXI93EBI-359224,EBI-923440
GEMP550405EBI-359224,EBI-744104
GIT2Q141612EBI-359224,EBI-1046878
GLRX3O760035EBI-359224,EBI-374781
GMCL2Q8NEA93EBI-359224,EBI-745707
GNG5P632183EBI-359224,EBI-10220734
GORASP2Q9H8Y85EBI-359224,EBI-739467
HAUS1Q96CS23EBI-359224,EBI-2514791
HEY2Q9UBP55EBI-359224,EBI-750630
HOXA1P496393EBI-359224,EBI-740785
Hoxa1P090224EBI-359224,EBI-3957603From Mus musculus.
HOXD12P354523EBI-359224,EBI-10206752
JOSD1Q150403EBI-359224,EBI-2510602
KIAA1217Q5T5P2-63EBI-359224,EBI-10188326
KLHL38Q2WGJ63EBI-359224,EBI-6426443
LATS1Q6PJG33EBI-359224,EBI-10253976
LCORQ96JN03EBI-359224,EBI-746045
LNX1Q8TBB16EBI-359224,EBI-739832
MAPRE2Q155557EBI-359224,EBI-739717
METTL17Q9H7H06EBI-359224,EBI-749353
MORN3Q6PF187EBI-359224,EBI-9675802
MOSP005405EBI-359224,EBI-1757866
MYEF2Q9P2K5-23EBI-359224,EBI-10318831
NEBLO760413EBI-359224,EBI-2880203
NUFIP2Q7Z4173EBI-359224,EBI-1210753
NUP58Q9BVL27EBI-359224,EBI-2811583
OLIG3Q7RTU35EBI-359224,EBI-10225049
PBX3Q5JS983EBI-359224,EBI-10244393
PDE4DQ084993EBI-359224,EBI-1642831
PHF21AQ96BD53EBI-359224,EBI-745085
PIN1Q135263EBI-359224,EBI-714158
PLEKHN1Q494U13EBI-359224,EBI-10241513
POM121L1PQ3SYA95EBI-359224,EBI-10241319
POP5Q969H65EBI-359224,EBI-366525
PPP1R13BQ96KQ43EBI-359224,EBI-1105153
PRDM7Q9NQW53EBI-359224,EBI-10312471
PSMA1P257863EBI-359224,EBI-359352
PSMB1P206185EBI-359224,EBI-372273
QRICH1Q2TAL85EBI-359224,EBI-2798044
RASAL2Q9UJF23EBI-359224,EBI-359444
RASSF5Q8WWW03EBI-359224,EBI-367390
RBM41Q96IZ53EBI-359224,EBI-740773
RBM45Q8IUH33EBI-359224,EBI-2512147
RIPK1Q135465EBI-359224,EBI-358507
RTP5Q14D333EBI-359224,EBI-10217913
RYDENQ9NUL53EBI-359224,EBI-10313866
SCNM1Q9BWG67EBI-359224,EBI-748391
SIK3Q9Y2K2-73EBI-359224,EBI-17172855
SLC25A48Q6ZT893EBI-359224,EBI-10255185
SLC25A6P122363EBI-359224,EBI-356254
SNW1Q135733EBI-359224,EBI-632715
SPG21Q9NZD85EBI-359224,EBI-742688
SSC5DA1L4H13EBI-359224,EBI-10172867
STK3Q131885EBI-359224,EBI-992580
SYCE1Q8N0S23EBI-359224,EBI-6872807
TCL1AP562797EBI-359224,EBI-749995
TEAD4D3DUQ63EBI-359224,EBI-10176734
TEAD4Q155615EBI-359224,EBI-747736
TFAP4Q016643EBI-359224,EBI-2514218
TFPTA0A024R4Q54EBI-359224,EBI-11527449
THAP7Q9BT495EBI-359224,EBI-741350
TRAF2Q129336EBI-359224,EBI-355744
TRAF6Q9Y4K313EBI-359224,EBI-359276
TRIM23P364063EBI-359224,EBI-740098
TRIM42Q8IWZ53EBI-359224,EBI-5235829
TRPV6Q9Y2605EBI-359224,EBI-750052
TSSC4Q9Y5U23EBI-359224,EBI-717229
WACQ9BTA93EBI-359224,EBI-749118
yscKP699742EBI-359224,EBI-2842860From Yersinia pestis.
ZBTB16Q055164EBI-359224,EBI-711925
ZC2HC1CQ53FD03EBI-359224,EBI-740767
ZFYVE21Q9BQ243EBI-359224,EBI-2849569
ZFYVE26Q68DK2-53EBI-359224,EBI-8656416
ZNF124Q159735EBI-359224,EBI-2555767
ZNF20P170245EBI-359224,EBI-717634
ZNF417Q8TAU33EBI-359224,EBI-740727
ZNF440Q8IYI86EBI-359224,EBI-726439
ZNF502Q8TBZ55EBI-359224,EBI-10273699
ZNF512BQ96KM65EBI-359224,EBI-1049952
ZNF564Q8TBZ85EBI-359224,EBI-10273713
ZNF572Q7Z3I76EBI-359224,EBI-10172590
ZNF581Q9P0T43EBI-359224,EBI-745520
ZNF587Q96SQ55EBI-359224,EBI-6427977
ZNF662Q6ZS27-33EBI-359224,EBI-10255155
ZNF688A0A0S2Z5X43EBI-359224,EBI-16429014

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113037, 236 interactors

Database of interacting proteins

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DIPi
DIP-27514N

Protein interaction database and analysis system

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IntActi
Q13077, 236 interactors

Molecular INTeraction database

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MINTi
Q13077

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362994

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13077

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13077

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 412MATHPROSITE-ProRule annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili182 – 264Add BLAST83

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.1 Publication
The MATH/TRAF domain binds to receptor cytoplasmic domains.1 Publication
Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISDN Eukaryota
ENOG410YE68 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231558

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13077

KEGG Orthology (KO)

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KOi
K03172

Identification of Orthologs from Complete Genome Data

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OMAi
MKQWKAQ

Database of Orthologous Groups

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OrthoDBi
918518at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13077

TreeFam database of animal gene trees

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TreeFami
TF321154

Family and domain databases

Conserved Domains Database

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CDDi
cd03779 MATH_TRAF1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.210.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027136 TRAF1
IPR037306 TRAF1_MATH
IPR032070 TRAF_BIRC3-bd

The PANTHER Classification System

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PANTHERi
PTHR10131:SF96 PTHR10131:SF96, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16673 TRAF_BIRC3_bd, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF015614 TRAF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00061 MATH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49599 SSF49599, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50144 MATH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13077-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE
60 70 80 90 100
DQICPKCRGE DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS
110 120 130 140 150
PQSVQEHEVT SQTSHLNLLL GFMKQWKARL GCGLESGPMA LEQNLSDLQL
160 170 180 190 200
QAAVEVAGDL EVDCYRAPCS ESQEELALQH FMKEKLLAEL EGKLRVFENI
210 220 230 240 250
VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ QTLAQKDQAL
260 270 280 290 300
GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK
310 320 330 340 350
YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL
360 370 380 390 400
DQNNREHAID AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY
410
VKDDTMFLKC IVETST
Length:416
Mass (Da):46,164
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA956A123A40D284A
GO
Isoform 2 (identifier: Q13077-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:294
Mass (Da):33,296
Checksum:i99A72217E03E143C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03449 differs from that shown. Reason: Frameshift at position 111.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054161139M → T1 PublicationCorresponds to variant dbSNP:rs113495277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430921 – 122Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U19261 mRNA Translation: AAA62309.1
AK090468 mRNA Translation: BAC03449.1 Frameshift.
AK295959 mRNA Translation: BAG58739.1
AK315476 mRNA Translation: BAG37860.1
AL832989 mRNA Translation: CAH56343.1
BT019408 mRNA Translation: AAV38215.1
AC006430 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87479.1
BC024145 mRNA Translation: AAH24145.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55335.1 [Q13077-2]
CCDS6825.1 [Q13077-1]

Protein sequence database of the Protein Information Resource

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PIRi
B55649

NCBI Reference Sequences

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RefSeqi
NP_001177874.1, NM_001190945.1 [Q13077-1]
NP_001177876.1, NM_001190947.1 [Q13077-2]
NP_005649.1, NM_005658.4 [Q13077-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373887; ENSP00000362994; ENSG00000056558 [Q13077-1]
ENST00000540010; ENSP00000443183; ENSG00000056558 [Q13077-1]
ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7185

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7185

UCSC genome browser

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UCSCi
uc004bku.3 human [Q13077-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19261 mRNA Translation: AAA62309.1
AK090468 mRNA Translation: BAC03449.1 Frameshift.
AK295959 mRNA Translation: BAG58739.1
AK315476 mRNA Translation: BAG37860.1
AL832989 mRNA Translation: CAH56343.1
BT019408 mRNA Translation: AAV38215.1
AC006430 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87479.1
BC024145 mRNA Translation: AAH24145.1
CCDSiCCDS55335.1 [Q13077-2]
CCDS6825.1 [Q13077-1]
PIRiB55649
RefSeqiNP_001177874.1, NM_001190945.1 [Q13077-1]
NP_001177876.1, NM_001190947.1 [Q13077-2]
NP_005649.1, NM_005658.4 [Q13077-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M0DX-ray2.80C181-244[»]
5E1TX-ray2.80A/B/C220-416[»]
5H10X-ray3.21A/B/C220-416[»]
SMRiQ13077
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113037, 236 interactors
DIPiDIP-27514N
IntActiQ13077, 236 interactors
MINTiQ13077
STRINGi9606.ENSP00000362994

PTM databases

iPTMnetiQ13077
PhosphoSitePlusiQ13077

Polymorphism and mutation databases

BioMutaiTRAF1
DMDMi6707734

Proteomic databases

jPOSTiQ13077
MaxQBiQ13077
PaxDbiQ13077
PeptideAtlasiQ13077
PRIDEiQ13077
ProteomicsDBi59136
59137 [Q13077-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7185
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373887; ENSP00000362994; ENSG00000056558 [Q13077-1]
ENST00000540010; ENSP00000443183; ENSG00000056558 [Q13077-1]
ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2]
GeneIDi7185
KEGGihsa:7185
UCSCiuc004bku.3 human [Q13077-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7185
DisGeNETi7185

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAF1
HGNCiHGNC:12031 TRAF1
HPAiCAB009593
HPA001852
MIMi601711 gene
neXtProtiNX_Q13077
OpenTargetsiENSG00000056558
PharmGKBiPA36708

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISDN Eukaryota
ENOG410YE68 LUCA
GeneTreeiENSGT00940000161076
HOGENOMiHOG000231558
InParanoidiQ13077
KOiK03172
OMAiMKQWKAQ
OrthoDBi918518at2759
PhylomeDBiQ13077
TreeFamiTF321154

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
SignaLinkiQ13077
SIGNORiQ13077

Miscellaneous databases

EvolutionaryTraceiQ13077

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7185
PMAP-CutDBiQ13077

Protein Ontology

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PROi
PR:Q13077

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000056558 Expressed in 117 organ(s), highest expression level in right coronary artery
GenevisibleiQ13077 HS

Family and domain databases

CDDicd03779 MATH_TRAF1, 1 hit
Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027136 TRAF1
IPR037306 TRAF1_MATH
IPR032070 TRAF_BIRC3-bd
PANTHERiPTHR10131:SF96 PTHR10131:SF96, 1 hit
PfamiView protein in Pfam
PF16673 TRAF_BIRC3_bd, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRAF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13077
Secondary accession number(s): B4DJ77, Q658U1, Q8NF13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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