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Entry version 172 (13 Feb 2019)
Sequence version 3 (18 May 2010)
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Protein

RE1-silencing transcription factor

Gene

REST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural specific splicing events (By similarity). Acts as a regulator of osteoblast differentiation (By similarity).By similarity8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri159 – 181C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 412C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1060 – 1082C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214815 HDACs deacetylate histones
R-HSA-8943724 Regulation of PTEN gene transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13127

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13127

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RE1-silencing transcription factor
Alternative name(s):
Neural-restrictive silencer factor
X2 box repressor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REST
Synonyms:NRSF, XBR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000084093.15

Human Gene Nomenclature Database

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HGNCi
HGNC:9966 REST

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600571 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Wilms tumor 6 (WT6)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.
See also OMIM:616806
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076333160R → P in WT6; inhibits transcriptional repression activity. 1 Publication1
Natural variantiVAR_076334290N → Y in WT6; inhibits transcriptional repression activity. 1 Publication1
Natural variantiVAR_076335322H → R in WT6; inhibits transcriptional repression activity. 1 PublicationCorresponds to variant dbSNP:rs869025312EnsemblClinVar.1
Natural variantiVAR_076336412H → Q in WT6. 1 Publication1
Fibromatosis, gingival, 5 (GINGF5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of hereditary gingival fibromatosis, a rare condition characterized by a slow, progressive overgrowth of the gingiva. The excess gingival tissue can cover part of or the entire crown, and can result in diastemas, teeth displacement, or retention of primary or impacted teeth.
See also OMIM:617626
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079529437 – 1097Missing in GINGF5. 1 PublicationAdd BLAST661

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi91E → G: Does not change transcriptional repression activity. 1 Publication1
Mutagenesisi420M → T: Inhibits transcriptional repression activity. 1 Publication1
Mutagenesisi593S → N: Does not change transcriptional repression activity. 1 Publication1
Mutagenesisi642A → T: Does not change transcriptional repression activity. 1 Publication1
Mutagenesisi918H → Y: Does not change transcriptional repression activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5978

MalaCards human disease database

More...
MalaCardsi
REST
MIMi616806 phenotype
617626 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000084093

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2024 Hereditary gingival fibromatosis
654 Nephroblastoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34334

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
REST

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002695471 – 1097RE1-silencing transcription factorAdd BLAST1097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei864PhosphoserineCombined sources1
Modified residuei971PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13127

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13127

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13127

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13127

PeptideAtlas

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PeptideAtlasi
Q13127

PRoteomics IDEntifications database

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PRIDEi
Q13127

ProteomicsDB human proteome resource

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ProteomicsDBi
59175
59176 [Q13127-2]
59177 [Q13127-3]
59178 [Q13127-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13127

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13127

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher levels in weakly invasive breast cancer cell lines and at lower levels in highly invasive breast cancer lines (at protein level) (PubMed:26053433). Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084093 Expressed in 216 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13127 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13127 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068222
HPA006079

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL. Interacts with EHMT1 and EHMT2 only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Interacts (via zinc-finger DNA-binding domain) with ZFP90 (via N- and C-termini); the interaction inhibits REST repressor activity (PubMed:21284946).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111910, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13127

Database of interacting proteins

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DIPi
DIP-35264N

Protein interaction database and analysis system

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IntActi
Q13127, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000311816

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11097
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CZYNMR-B43-57[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13127

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13127

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13127

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 122Interaction with SIN3A1 PublicationAdd BLAST91
Regioni43 – 57Interaction with SIN3B1 PublicationAdd BLAST15
Regioni145 – 418Interaction with ZFP901 PublicationAdd BLAST274
Regioni1009 – 1087Interaction with RCOR1Add BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 14Poly-Gly4
Compositional biasi400 – 603Lys-richAdd BLAST204
Compositional biasi595 – 815Pro-richAdd BLAST221

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 181C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 412C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1060 – 1082C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155341

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG093893

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13127

KEGG Orthology (KO)

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KOi
K09222

Identification of Orthologs from Complete Genome Data

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OMAi
VQKEPVQ

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13127

TreeFam database of animal gene trees

More...
TreeFami
TF332861

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027757 REST
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR45014 PTHR45014, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13127-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQVMGQSS GGGGLFTSSG NIGMALPNDM YDLHDLSKAE LAAPQLIMLA
60 70 80 90 100
NVALTGEVNG SCCDYLVGEE RQMAELMPVG DNNFSDSEEG EGLEESADIK
110 120 130 140 150
GEPHGLENME LRSLELSVVE PQPVFEASGA PDIYSSNKDL PPETPGAEDK
160 170 180 190 200
GKSSKTKPFR CKPCQYEAES EEQFVHHIRV HSAKKFFVEE SAEKQAKARE
210 220 230 240 250
SGSSTAEEGD FSKGPIRCDR CGYNTNRYDH YTAHLKHHTR AGDNERVYKC
260 270 280 290 300
IICTYTTVSE YHWRKHLRNH FPRKVYTCGK CNYFSDRKNN YVQHVRTHTG
310 320 330 340 350
ERPYKCELCP YSSSQKTHLT RHMRTHSGEK PFKCDQCSYV ASNQHEVTRH
360 370 380 390 400
ARQVHNGPKP LNCPHCDYKT ADRSNFKKHV ELHVNPRQFN CPVCDYAASK
410 420 430 440 450
KCNLQYHFKS KHPTCPNKTM DVSKVKLKKT KKREADLPDN ITNEKTEIEQ
460 470 480 490 500
TKIKGDVAGK KNEKSVKAEK RDVSKEKKPS NNVSVIQVTT RTRKSVTEVK
510 520 530 540 550
EMDVHTGSNS EKFSKTKKSK RKLEVDSHSL HGPVNDEESS TKKKKKVESK
560 570 580 590 600
SKNNSQEVPK GDSKVEENKK QNTCMKKSTK KKTLKNKSSK KSSKPPQKEP
610 620 630 640 650
VEKGSAQMDP PQMGPAPTEA VQKGPVQVEP PPPMEHAQME GAQIRPAPDE
660 670 680 690 700
PVQMEVVQEG PAQKELLPPV EPAQMVGAQI VLAHMELPPP METAQTEVAQ
710 720 730 740 750
MGPAPMEPAQ MEVAQVESAP MQVVQKEPVQ MELSPPMEVV QKEPVQIELS
760 770 780 790 800
PPMEVVQKEP VKIELSPPIE VVQKEPVQME LSPPMGVVQK EPAQREPPPP
810 820 830 840 850
REPPLHMEPI SKKPPLRKDK KEKSNMQSER ARKEQVLIEV GLVPVKDSWL
860 870 880 890 900
LKESVSTEDL SPPSPPLPKE NLREEASGDQ KLLNTGEGNK EAPLQKVGAE
910 920 930 940 950
EADESLPGLA ANINESTHIS SSGQNLNTPE GETLNGKHQT DSIVCEMKMD
960 970 980 990 1000
TDQNTRENLT GINSTVEEPV SPMLPPSAVE EREAVSKTAL ASPPATMAAN
1010 1020 1030 1040 1050
ESQEIDEDEG IHSHEGSDLS DNMSEGSDDS GLHGARPVPQ ESSRKNAKEA
1060 1070 1080 1090
LAVKAAKGDF VCIFCDRSFR KGKDYSKHLN RHLVNVYYLE EAAQGQE
Length:1,097
Mass (Da):121,872
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBC652EED19CA161
GO
Isoform 2 (identifier: Q13127-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-313: ERPYKCELCPYSS → KRSFLVHKFSSLF
     314-1097: Missing.

Show »
Length:313
Mass (Da):35,048
Checksum:i3B0F550EBD70F79D
GO
Isoform 3 (identifier: Q13127-3) [UniParc]FASTAAdd to basket
Also known as: N4

The sequence of this isoform differs from the canonical sequence as follows:
     329-329: E → W
     330-1097: Missing.

Show »
Length:329
Mass (Da):36,972
Checksum:iAD25D9BAC94FCAF7
GO
Isoform 4 (identifier: Q13127-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-326: Missing.

Show »
Length:1,074
Mass (Da):119,083
Checksum:i7D5F7CBD2C74EC0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
L0B3Z2L0B3Z2_HUMAN
RE1-silencing transcription factor ...
REST
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0B1S6L0B1S6_HUMAN
RE1-silencing transcription factor ...
REST
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1C2A0A087X1C2_HUMAN
RE1-silencing transcription factor,...
REST hCG_1746842
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0B1V4L0B1V4_HUMAN
RE1-silencing transcription factor ...
REST
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0B3M6L0B3M6_HUMAN
RE1-silencing transcription factor ...
REST
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQA1A0A1W2PQA1_HUMAN
RE1-silencing transcription factor
REST
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA98503 differs from that shown. Reason: Frameshift at positions 188, 198, 202, 212 and 1087.Curated
The sequence AAC50114 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC50115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH38985 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD92987 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295V → L in AAC50114 (PubMed:7871435).Curated1
Sequence conflicti596 – 599PQKE → SRNS in AAC50115 (PubMed:7871435).Curated4
Sequence conflicti630P → L in AAB17211 (PubMed:7697725).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076333160R → P in WT6; inhibits transcriptional repression activity. 1 Publication1
Natural variantiVAR_076334290N → Y in WT6; inhibits transcriptional repression activity. 1 Publication1
Natural variantiVAR_076335322H → R in WT6; inhibits transcriptional repression activity. 1 PublicationCorresponds to variant dbSNP:rs869025312EnsemblClinVar.1
Natural variantiVAR_076336412H → Q in WT6. 1 Publication1
Natural variantiVAR_079529437 – 1097Missing in GINGF5. 1 PublicationAdd BLAST661
Natural variantiVAR_029795626V → I1 PublicationCorresponds to variant dbSNP:rs2228991Ensembl.1
Natural variantiVAR_029796692E → D. Corresponds to variant dbSNP:rs2227902Ensembl.1
Natural variantiVAR_029797762K → Q. Corresponds to variant dbSNP:rs2227903Ensembl.1
Natural variantiVAR_029798797P → L1 PublicationCorresponds to variant dbSNP:rs3796529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022064301 – 313ERPYK…CPYSS → KRSFLVHKFSSLF in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_022067304 – 326Missing in isoform 4. CuratedAdd BLAST23
Alternative sequenceiVSP_022065314 – 1097Missing in isoform 2. 1 PublicationAdd BLAST784
Alternative sequenceiVSP_022066329E → W in isoform 3. Curated1
Alternative sequenceiVSP_022068330 – 1097Missing in isoform 3. CuratedAdd BLAST768

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22314 mRNA Translation: AAB17211.1
U13877 mRNA Translation: AAC50114.1 Different initiation.
U13879 mRNA Translation: AAC50115.1 Different initiation.
U22680 mRNA Translation: AAA98503.1 Frameshift.
AB209750 mRNA Translation: BAD92987.1 Different initiation.
AC069307 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05517.1
BC038985 mRNA Translation: AAH38985.1 Sequence problems.
BC132859 mRNA Translation: AAI32860.1
BC136491 mRNA Translation: AAI36492.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3509.1 [Q13127-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56138
I38754
I38755

NCBI Reference Sequences

More...
RefSeqi
NP_001180437.1, NM_001193508.1 [Q13127-1]
NP_005603.3, NM_005612.4 [Q13127-1]
XP_011532703.1, XM_011534401.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.307836

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309042; ENSP00000311816; ENSG00000084093 [Q13127-1]
ENST00000619101; ENSP00000484836; ENSG00000084093 [Q13127-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5978

UCSC genome browser

More...
UCSCi
uc003hch.4 human [Q13127-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22314 mRNA Translation: AAB17211.1
U13877 mRNA Translation: AAC50114.1 Different initiation.
U13879 mRNA Translation: AAC50115.1 Different initiation.
U22680 mRNA Translation: AAA98503.1 Frameshift.
AB209750 mRNA Translation: BAD92987.1 Different initiation.
AC069307 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05517.1
BC038985 mRNA Translation: AAH38985.1 Sequence problems.
BC132859 mRNA Translation: AAI32860.1
BC136491 mRNA Translation: AAI36492.1
CCDSiCCDS3509.1 [Q13127-1]
PIRiA56138
I38754
I38755
RefSeqiNP_001180437.1, NM_001193508.1 [Q13127-1]
NP_005603.3, NM_005612.4 [Q13127-1]
XP_011532703.1, XM_011534401.2
UniGeneiHs.307836

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CZYNMR-B43-57[»]
ProteinModelPortaliQ13127
SMRiQ13127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111910, 46 interactors
CORUMiQ13127
DIPiDIP-35264N
IntActiQ13127, 16 interactors
STRINGi9606.ENSP00000311816

PTM databases

iPTMnetiQ13127
PhosphoSitePlusiQ13127

Polymorphism and mutation databases

BioMutaiREST
DMDMi296452989

Proteomic databases

EPDiQ13127
jPOSTiQ13127
MaxQBiQ13127
PaxDbiQ13127
PeptideAtlasiQ13127
PRIDEiQ13127
ProteomicsDBi59175
59176 [Q13127-2]
59177 [Q13127-3]
59178 [Q13127-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309042; ENSP00000311816; ENSG00000084093 [Q13127-1]
ENST00000619101; ENSP00000484836; ENSG00000084093 [Q13127-1]
GeneIDi5978
KEGGihsa:5978
UCSCiuc003hch.4 human [Q13127-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5978
DisGeNETi5978
EuPathDBiHostDB:ENSG00000084093.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
REST

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0031381
HGNCiHGNC:9966 REST
HPAiCAB068222
HPA006079
MalaCardsiREST
MIMi600571 gene
616806 phenotype
617626 phenotype
neXtProtiNX_Q13127
OpenTargetsiENSG00000084093
Orphaneti2024 Hereditary gingival fibromatosis
654 Nephroblastoma
PharmGKBiPA34334

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000155341
HOVERGENiHBG093893
InParanoidiQ13127
KOiK09222
OMAiVQKEPVQ
OrthoDBi1318335at2759
PhylomeDBiQ13127
TreeFamiTF332861

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-8943724 Regulation of PTEN gene transcription
SignaLinkiQ13127
SIGNORiQ13127

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
REST human
EvolutionaryTraceiQ13127

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RE1-silencing_transcription_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5978

Protein Ontology

More...
PROi
PR:Q13127

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084093 Expressed in 216 organ(s), highest expression level in kidney
ExpressionAtlasiQ13127 baseline and differential
GenevisibleiQ13127 HS

Family and domain databases

InterProiView protein in InterPro
IPR027757 REST
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45014 PTHR45014, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13127
Secondary accession number(s): A2RUE0
, B9EGJ0, Q12956, Q12957, Q13134, Q59ER1, Q8IWI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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