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Entry version 175 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Noggin

Gene

NOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-201451 Signaling by BMP

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13253

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Noggin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000183691.4

Human Gene Nomenclature Database

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HGNCi
HGNC:7866 NOG

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602991 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13253

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Symphalangism, proximal 1A (SYM1A)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by the hereditary absence of the proximal interphalangeal joints. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conductive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.
See also OMIM:185800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01136135P → R in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894611EnsemblClinVar.1
Natural variantiVAR_01832435P → S in SYM1A and BDB2. 2 PublicationsCorresponds to variant dbSNP:rs28937580EnsemblClinVar.1
Natural variantiVAR_018325184C → Y in SYM1A; sporadic; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs104894612EnsemblClinVar.1
Natural variantiVAR_011362189G → C in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894609EnsemblClinVar.1
Natural variantiVAR_037605205W → C in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894615EnsemblClinVar.1
Natural variantiVAR_011364220I → N in SYM1A. 1 Publication1
Natural variantiVAR_011365222Y → C in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894602EnsemblClinVar.1
Natural variantiVAR_011366222Y → D in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs121908948EnsemblClinVar.1
Natural variantiVAR_011367223P → L in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894608EnsemblClinVar.1
Multiple synostoses syndrome 1 (SYNS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.
See also OMIM:186500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011363217W → G in SYNS1. 1 PublicationCorresponds to variant dbSNP:rs104894603EnsemblClinVar.1
Natural variantiVAR_064541232C → W in SYNS1. 1 PublicationCorresponds to variant dbSNP:rs387906844EnsemblClinVar.1
Tarsal-carpal coalition syndrome (TCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.
See also OMIM:186570
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01136135P → R in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894611EnsemblClinVar.1
Natural variantiVAR_018326204R → L in TCC. 1 PublicationCorresponds to variant dbSNP:rs104894610EnsemblClinVar.1
Natural variantiVAR_011365222Y → C in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894602EnsemblClinVar.1
Stapes ankylosis with broad thumb and toes (SABTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.
See also OMIM:184460
Brachydactyly B2 (BDB2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination with distal symphalangism, fusion of carpal/tarsal bones and partial cutaneous syndactyly.
See also OMIM:611377
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03699735P → A in BDB2. 1 PublicationCorresponds to variant dbSNP:rs28937580EnsemblClinVar.1
Natural variantiVAR_01832435P → S in SYM1A and BDB2. 2 PublicationsCorresponds to variant dbSNP:rs28937580EnsemblClinVar.1
Natural variantiVAR_03699836A → P in BDB2. 1 Publication1
Natural variantiVAR_03699948E → K in BDB2. 1 Publication1
Natural variantiVAR_037000167R → G in BDB2. 1 PublicationCorresponds to variant dbSNP:rs121908949EnsemblClinVar.1
Natural variantiVAR_037001187P → S in BDB2. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9241

MalaCards human disease database

More...
MalaCardsi
NOG
MIMi184460 phenotype
185800 phenotype
186500 phenotype
186570 phenotype
611377 phenotype

Open Targets

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OpenTargetsi
ENSG00000183691

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
140908 Brachydactyly type B2
3237 Multiple synostoses syndrome
3250 Proximal symphalangism
140917 Stapes ankylosis with broad thumbs and toes
1412 Tarsal-carpal coalition syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31670

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NOG

Domain mapping of disease mutations (DMDM)

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DMDMi
15214099

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001981328 – 232NogginAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi155 ↔ 1921 Publication
Disulfide bondi178 ↔ 2281 Publication
Disulfide bondi184 ↔ 2301 Publication
Disulfide bondi207 ↔ 2151 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13253

PeptideAtlas

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PeptideAtlasi
Q13253

PRoteomics IDEntifications database

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PRIDEi
Q13253

ProteomicsDB human proteome resource

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ProteomicsDBi
59253

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13253

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13253

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000183691 Expressed in 94 organ(s), highest expression level in amniotic fluid

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13253 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA061318

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BMP2P126432EBI-1035205,EBI-1029262

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114668, 47 interactors

Protein interaction database and analysis system

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IntActi
Q13253, 3 interactors

Molecular INTeraction database

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MINTi
Q13253

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4UX-ray2.42A28-232[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13253

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13253

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13253

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the noggin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIR6 Eukaryota
ENOG410Z62S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006009

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000089944

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006514

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13253

KEGG Orthology (KO)

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KOi
K04658

Identification of Orthologs from Complete Genome Data

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OMAi
ITDCKCS

Database of Orthologous Groups

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OrthoDBi
976319at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13253

TreeFam database of animal gene trees

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TreeFami
TF353745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR008717 Noggin

The PANTHER Classification System

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PANTHERi
PTHR10494 PTHR10494, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF008129 Noggin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57501 SSF57501, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP
60 70 80 90 100
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED
110 120 130 140 150
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW
160 170 180 190 200
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL
210 220 230
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
Length:232
Mass (Da):25,774
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCA0D8E1E2098580
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03699735P → A in BDB2. 1 PublicationCorresponds to variant dbSNP:rs28937580EnsemblClinVar.1
Natural variantiVAR_01136135P → R in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894611EnsemblClinVar.1
Natural variantiVAR_01832435P → S in SYM1A and BDB2. 2 PublicationsCorresponds to variant dbSNP:rs28937580EnsemblClinVar.1
Natural variantiVAR_03699836A → P in BDB2. 1 Publication1
Natural variantiVAR_03699948E → K in BDB2. 1 Publication1
Natural variantiVAR_037000167R → G in BDB2. 1 PublicationCorresponds to variant dbSNP:rs121908949EnsemblClinVar.1
Natural variantiVAR_018325184C → Y in SYM1A; sporadic; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs104894612EnsemblClinVar.1
Natural variantiVAR_037001187P → S in BDB2. 1 Publication1
Natural variantiVAR_011362189G → C in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894609EnsemblClinVar.1
Natural variantiVAR_018326204R → L in TCC. 1 PublicationCorresponds to variant dbSNP:rs104894610EnsemblClinVar.1
Natural variantiVAR_037605205W → C in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894615EnsemblClinVar.1
Natural variantiVAR_011363217W → G in SYNS1. 1 PublicationCorresponds to variant dbSNP:rs104894603EnsemblClinVar.1
Natural variantiVAR_011364220I → N in SYM1A. 1 Publication1
Natural variantiVAR_011365222Y → C in SYM1A and TCC. 2 PublicationsCorresponds to variant dbSNP:rs104894602EnsemblClinVar.1
Natural variantiVAR_011366222Y → D in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs121908948EnsemblClinVar.1
Natural variantiVAR_011367223P → L in SYM1A. 1 PublicationCorresponds to variant dbSNP:rs104894608EnsemblClinVar.1
Natural variantiVAR_064541232C → W in SYNS1. 1 PublicationCorresponds to variant dbSNP:rs387906844EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31202 Genomic DNA Translation: AAA83259.1
BC034027 mRNA Translation: AAH34027.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11589.1

NCBI Reference Sequences

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RefSeqi
NP_005441.1, NM_005450.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.248201

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332822; ENSP00000328181; ENSG00000183691

Database of genes from NCBI RefSeq genomes

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GeneIDi
9241

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9241

UCSC genome browser

More...
UCSCi
uc002iup.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31202 Genomic DNA Translation: AAA83259.1
BC034027 mRNA Translation: AAH34027.1
CCDSiCCDS11589.1
RefSeqiNP_005441.1, NM_005450.4
UniGeneiHs.248201

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4UX-ray2.42A28-232[»]
ProteinModelPortaliQ13253
SMRiQ13253
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114668, 47 interactors
IntActiQ13253, 3 interactors
MINTiQ13253
STRINGi9606.ENSP00000328181

PTM databases

iPTMnetiQ13253
PhosphoSitePlusiQ13253

Polymorphism and mutation databases

BioMutaiNOG
DMDMi15214099

Proteomic databases

PaxDbiQ13253
PeptideAtlasiQ13253
PRIDEiQ13253
ProteomicsDBi59253

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332822; ENSP00000328181; ENSG00000183691
GeneIDi9241
KEGGihsa:9241
UCSCiuc002iup.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9241
DisGeNETi9241
EuPathDBiHostDB:ENSG00000183691.4

GeneCards: human genes, protein and diseases

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GeneCardsi
NOG
HGNCiHGNC:7866 NOG
HPAiHPA061318
MalaCardsiNOG
MIMi184460 phenotype
185800 phenotype
186500 phenotype
186570 phenotype
602991 gene
611377 phenotype
neXtProtiNX_Q13253
OpenTargetsiENSG00000183691
Orphaneti140908 Brachydactyly type B2
3237 Multiple synostoses syndrome
3250 Proximal symphalangism
140917 Stapes ankylosis with broad thumbs and toes
1412 Tarsal-carpal coalition syndrome
PharmGKBiPA31670

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIR6 Eukaryota
ENOG410Z62S LUCA
GeneTreeiENSGT00390000006009
HOGENOMiHOG000089944
HOVERGENiHBG006514
InParanoidiQ13253
KOiK04658
OMAiITDCKCS
OrthoDBi976319at2759
PhylomeDBiQ13253
TreeFamiTF353745

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
SIGNORiQ13253

Miscellaneous databases

EvolutionaryTraceiQ13253

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Noggin_(protein)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9241

Protein Ontology

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PROi
PR:Q13253

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000183691 Expressed in 94 organ(s), highest expression level in amniotic fluid
GenevisibleiQ13253 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR008717 Noggin
PANTHERiPTHR10494 PTHR10494, 1 hit
PIRSFiPIRSF008129 Noggin, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOGG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13253
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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